JP2002523053A - 標的化されたアルファウイルスおよびアルファウイルスベクター - Google Patents

標的化されたアルファウイルスおよびアルファウイルスベクター

Info

Publication number
JP2002523053A
JP2002523053A JP2000566453A JP2000566453A JP2002523053A JP 2002523053 A JP2002523053 A JP 2002523053A JP 2000566453 A JP2000566453 A JP 2000566453A JP 2000566453 A JP2000566453 A JP 2000566453A JP 2002523053 A JP2002523053 A JP 2002523053A
Authority
JP
Japan
Prior art keywords
alphavirus
cells
virus
cell
recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000566453A
Other languages
English (en)
Japanese (ja)
Inventor
ボロ ドロプューリック,
リーシャ ドロプューリック,
ジェイ. マリー ハードウィック,
Original Assignee
ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン filed Critical ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン
Publication of JP2002523053A publication Critical patent/JP2002523053A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141Use of virus, viral particle or viral elements as a vector
    • C12N2770/36145Special targeting system for viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00Vectors comprising a targeting moiety
    • C12N2810/40Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
    • C12N2810/405Vectors comprising RGD peptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00Vectors comprising a targeting moiety
    • C12N2810/50Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/855Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2000566453A 1998-07-30 1999-07-30 標的化されたアルファウイルスおよびアルファウイルスベクター Pending JP2002523053A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9513898P 1998-07-30 1998-07-30
US60/095,138 1998-07-30
PCT/US1999/017345 WO2000011201A1 (fr) 1998-07-30 1999-07-30 Alphavirus cible et vecteurs alphaviraux

Publications (1)

Publication Number Publication Date
JP2002523053A true JP2002523053A (ja) 2002-07-30

Family

ID=22250057

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000566453A Pending JP2002523053A (ja) 1998-07-30 1999-07-30 標的化されたアルファウイルスおよびアルファウイルスベクター

Country Status (7)

Country Link
EP (1) EP1100944A1 (fr)
JP (1) JP2002523053A (fr)
AU (1) AU5247199A (fr)
CA (1) CA2337905A1 (fr)
IL (1) IL141176A0 (fr)
WO (1) WO2000011201A1 (fr)
ZA (1) ZA200104382B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014017A1 (fr) * 2003-08-08 2005-02-17 Yuji Shino Composition medicinale pour traiter le cancer

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001279193A1 (en) * 2000-08-02 2002-02-13 Xencor Methods and compositions for the construction and use of viral envelops as display particles
WO2014151855A1 (fr) 2013-03-14 2014-09-25 Inviragen, Inc. Compositions et procédés pour formulations d'alphavirus atténué vivant
CN104814984B (zh) 2014-08-26 2017-09-15 广州威溶特医药科技有限公司 甲病毒在制备抗肿瘤药物方面的应用
US12097257B2 (en) * 2018-03-05 2024-09-24 New York University Induction and enhancement of antitumor immunity involving Sindbis virus vectors expressing immune checkpoint proteins
WO2023230675A1 (fr) * 2022-06-03 2023-12-07 Alphinia Pty Ltd Procédé, utilisation et kit se rapportant à un virus à arn

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091309A (en) * 1986-01-16 1992-02-25 Washington University Sindbis virus vectors
US5811407A (en) * 1997-02-19 1998-09-22 The University Of North Carolina At Chapel Hill System for the in vivo delivery and expression of heterologous genes in the bone marrow
US6432699B1 (en) * 1997-03-28 2002-08-13 New York University Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A
ZA988446B (en) * 1997-09-18 2000-03-22 Res Dev Foundation Production of vaccines using arthropod vectored viruses.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014017A1 (fr) * 2003-08-08 2005-02-17 Yuji Shino Composition medicinale pour traiter le cancer

Also Published As

Publication number Publication date
IL141176A0 (en) 2002-02-10
EP1100944A1 (fr) 2001-05-23
AU5247199A (en) 2000-03-14
WO2000011201A1 (fr) 2000-03-02
CA2337905A1 (fr) 2000-03-02
ZA200104382B (en) 2002-08-28

Similar Documents

Publication Publication Date Title
US6432699B1 (en) Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A
Vashishtha et al. A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit
JP4018479B2 (ja) Dna発現系
ES2718546T3 (es) Células productoras para vectores retrovirales de replicación competente
WO2006031996A2 (fr) Ciblage de virus a l'aide d'une glycoproteine sindbis modifiee
JP2001521369A (ja) 細胞巨大分子合成の阻害が減少したアルファウイルスベクター
US10435712B2 (en) Evolution of high-titer virus-like vesicles for vaccine applications
US5635385A (en) Multi-unit ribozyme inhibition of oncogene gene expression
JP2002320475A (ja) 標的化感染特異性を有するポックスウイルス
US6982087B2 (en) Vectors derived from South African Arbovirus No. 86
US20110071214A1 (en) Methods and compositions for the treatment of cancer
Sparkowski et al. E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cells.
JP2002523053A (ja) 標的化されたアルファウイルスおよびアルファウイルスベクター
JP2002538182A (ja) 新脈管形成を阻害するための方法および試薬
Lundstrom et al. Semliki Forest virus vectors for in vitro and in vivo applications
WO1999060110A2 (fr) Proteines a enveloppe stable pour des vecteurs retroviraux
CN112368007A (zh) 抗原隐匿的溶瘤病毒
WO1996021416A2 (fr) Procedes et compostions de traitement de tumeurs solides in vivo
Piper et al. Recombinant Sindbis virus as an expression system for cell biology
US7378272B2 (en) Packaging cell lines for the continuous production of alphavirus vectors
White et al. The src oncogene can regulate a human glucose transporter expressed in chicken embryo fibroblasts
Diatta et al. Semliki Forest virus-derived virus-like particles: characterization of their production and transduction pathways
US20080096274A1 (en) Recombinant alphavirus vectors and methods of using same
US11970708B2 (en) Gene therapy vector with minimizing recombination, recombinant retrovirus comprising the vector, and pharmaceutical composition for preventing or treating cancer comprising the recombinant retrovirus
Lundstrom Virus-based vectors for gene expression in mammalian cells: Semliki Forest virus