JP2002519643A - 多層試験カラム - Google Patents
多層試験カラムInfo
- Publication number
- JP2002519643A JP2002519643A JP2000556253A JP2000556253A JP2002519643A JP 2002519643 A JP2002519643 A JP 2002519643A JP 2000556253 A JP2000556253 A JP 2000556253A JP 2000556253 A JP2000556253 A JP 2000556253A JP 2002519643 A JP2002519643 A JP 2002519643A
- Authority
- JP
- Japan
- Prior art keywords
- layer
- membrane
- chamber
- column
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012360 testing method Methods 0.000 title claims abstract description 74
- 239000012528 membrane Substances 0.000 claims abstract description 83
- 239000012491 analyte Substances 0.000 claims abstract description 65
- 239000000758 substrate Substances 0.000 claims abstract description 19
- 239000007787 solid Substances 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 62
- 239000003153 chemical reaction reagent Substances 0.000 claims description 33
- 239000011534 wash buffer Substances 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 239000003446 ligand Substances 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000000872 buffer Substances 0.000 claims description 8
- 230000005284 excitation Effects 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 7
- 239000012634 fragment Substances 0.000 claims description 6
- 108020003175 receptors Proteins 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 5
- 108090000790 Enzymes Proteins 0.000 claims description 5
- 230000004071 biological effect Effects 0.000 claims description 5
- 230000002452 interceptive effect Effects 0.000 claims description 5
- 239000002699 waste material Substances 0.000 claims description 5
- 239000000835 fiber Substances 0.000 claims description 4
- 239000012982 microporous membrane Substances 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 2
- 239000007790 solid phase Substances 0.000 claims 3
- 230000008901 benefit Effects 0.000 description 9
- 230000027455 binding Effects 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000002372 labelling Methods 0.000 description 5
- -1 antibody Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 230000009871 nonspecific binding Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 239000006226 wash reagent Substances 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 239000003570 air Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 108091023037 Aptamer Proteins 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 108010004469 allophycocyanin Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- GWQVMPWSEVRGPY-UHFFFAOYSA-N europium cryptate Chemical group [Eu+3].N=1C2=CC=CC=1CN(CC=1N=C(C=CC=1)C=1N=C(C3)C=CC=1)CC(N=1)=CC(C(=O)NCCN)=CC=1C(N=1)=CC(C(=O)NCCN)=CC=1CN3CC1=CC=CC2=N1 GWQVMPWSEVRGPY-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/52—Physical parameters
- G01N2030/524—Physical parameters structural properties
- G01N2030/527—Physical parameters structural properties sorbent material in form of a membrane
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1055—General features of the devices using the transfer device for another function for immobilising reagents, e.g. dried reagents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
- G01N30/6082—Construction of the column body transparent to radiation
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Memory System Of A Hierarchy Structure (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9046998P | 1998-06-24 | 1998-06-24 | |
| US60/090,469 | 1998-06-24 | ||
| PCT/US1999/014118 WO1999067647A1 (en) | 1998-06-24 | 1999-06-23 | Multi-layer testing column |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002519643A true JP2002519643A (ja) | 2002-07-02 |
| JP2002519643A5 JP2002519643A5 (enExample) | 2006-08-24 |
Family
ID=22222904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000556253A Pending JP2002519643A (ja) | 1998-06-24 | 1999-06-23 | 多層試験カラム |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040105782A1 (enExample) |
| EP (1) | EP1004025B1 (enExample) |
| JP (1) | JP2002519643A (enExample) |
| CN (1) | CN1158530C (enExample) |
| AT (1) | ATE257944T1 (enExample) |
| AU (1) | AU4827999A (enExample) |
| CA (1) | CA2301077C (enExample) |
| DE (1) | DE69914164T2 (enExample) |
| ES (1) | ES2214865T3 (enExample) |
| WO (1) | WO1999067647A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006231326A (ja) * | 2005-02-05 | 2006-09-07 | Eppendorf Ag | フィルターピペットチップ |
| JP2008215880A (ja) * | 2007-02-28 | 2008-09-18 | Toray Ind Inc | 免疫分析チップ |
| JP2011517773A (ja) * | 2008-03-28 | 2011-06-16 | バイオティクス， インコーポレイテッド | サンプル調製デバイスおよび分析物の処理方法 |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799521B2 (en) * | 1998-06-24 | 2010-09-21 | Chen & Chen, Llc | Thermal cycling |
| US6780617B2 (en) | 2000-12-29 | 2004-08-24 | Chen & Chen, Llc | Sample processing device and method |
| US20030032029A1 (en) * | 1998-12-21 | 2003-02-13 | Nanogen, Inc. | Three dimensional apparatus and method for integrating sample preparation and multiplex assays |
| EP1218743B1 (en) * | 1999-07-26 | 2006-05-31 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Layered device with capture regions for cellular analysis |
| US7214477B1 (en) | 1999-07-26 | 2007-05-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Layered device with capture regions for cellular analysis |
| EP1360480A2 (en) * | 2001-02-13 | 2003-11-12 | Universiteit Gent | Device and method for detecting the presence of an analyte |
| WO2003022435A2 (en) | 2001-09-11 | 2003-03-20 | Iquum, Inc. | Sample vessels |
| AU2003297301A1 (en) | 2002-11-25 | 2004-06-18 | The United States Of America As Represented By The Secretary Of Health And Human Services, Nih | Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array |
| EP1603674B1 (en) | 2003-02-05 | 2016-01-06 | Iquum, Inc. | Sample processing |
| US20070017870A1 (en) | 2003-09-30 | 2007-01-25 | Belov Yuri P | Multicapillary device for sample preparation |
| CN101432698B (zh) * | 2004-06-07 | 2012-06-06 | 伊库姆公司 | 处理样品的方法 |
| US20080003564A1 (en) * | 2006-02-14 | 2008-01-03 | Iquum, Inc. | Sample processing |
| GB2435511A (en) | 2006-02-23 | 2007-08-29 | Mologic Ltd | Protease detection |
| GB2435510A (en) | 2006-02-23 | 2007-08-29 | Mologic Ltd | Enzyme detection product and methods |
| GB2435512A (en) | 2006-02-23 | 2007-08-29 | Mologic Ltd | A binding assay and assay device |
| ES2736726T3 (es) * | 2006-03-09 | 2020-01-07 | Aethlon Medical Inc | Eliminación extracorpórea de partículas microvesiculares |
| WO2007140961A1 (en) | 2006-06-06 | 2007-12-13 | Roche Diagnostics Gmbh | Differential hemolysis of a whole blood sample |
| US20080113357A1 (en) * | 2006-06-29 | 2008-05-15 | Millipore Corporation | Filter device for the isolation of a nucleic acid |
| CN102841167A (zh) * | 2011-06-20 | 2012-12-26 | 苏州赛分科技有限公司 | 一种液相吸附色谱分离柱 |
| EP3052932B1 (en) | 2013-09-30 | 2021-06-09 | Board of Regents, The University of Texas System | Method and apparatus for scanning detection |
| US11260386B2 (en) | 2015-06-05 | 2022-03-01 | The Emerther Company | Component of a device, a device, and a method for purifying and testing biomolecules from biological samples |
| CN109477835B (zh) * | 2016-07-25 | 2022-08-16 | 生物辐射实验室股份有限公司 | 侧流装置及使用方法 |
| WO2020214224A1 (en) * | 2019-04-18 | 2020-10-22 | Siemens Healthcare Diagnostics Inc. | Integrated microfluidic device with pipette adaptation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2942674B1 (de) * | 1979-10-23 | 1981-05-07 | Drägerwerk AG, 2400 Lübeck | Pruefroehrchen zur Messung von Nickel-Aerosolen |
| EP0139373A1 (en) * | 1983-08-26 | 1985-05-02 | The Regents Of The University Of California | Multiple immunoassay system |
| US5057438A (en) * | 1986-09-24 | 1991-10-15 | Agency Of Industrial Science And Technology | Electrophoretic antigen-antibody determination with laminate of multiple membranes |
| US4874691A (en) * | 1987-10-16 | 1989-10-17 | Quadra Logic Technologies Inc. | Membrane-supported immunoassays |
| US5438128A (en) * | 1992-02-07 | 1995-08-01 | Millipore Corporation | Method for rapid purifiction of nucleic acids using layered ion-exchange membranes |
| AU6360994A (en) * | 1993-03-08 | 1994-09-26 | Steven H Boyd | Aligned fiber diagnostic chromatography |
-
1999
- 1999-06-23 AT AT99931860T patent/ATE257944T1/de not_active IP Right Cessation
- 1999-06-23 CN CNB998010111A patent/CN1158530C/zh not_active Expired - Lifetime
- 1999-06-23 CA CA2301077A patent/CA2301077C/en not_active Expired - Lifetime
- 1999-06-23 AU AU48279/99A patent/AU4827999A/en not_active Abandoned
- 1999-06-23 JP JP2000556253A patent/JP2002519643A/ja active Pending
- 1999-06-23 EP EP99931860A patent/EP1004025B1/en not_active Expired - Lifetime
- 1999-06-23 DE DE69914164T patent/DE69914164T2/de not_active Expired - Lifetime
- 1999-06-23 ES ES99931860T patent/ES2214865T3/es not_active Expired - Lifetime
- 1999-06-23 WO PCT/US1999/014118 patent/WO1999067647A1/en not_active Ceased
-
2003
- 2003-09-30 US US10/605,459 patent/US20040105782A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006231326A (ja) * | 2005-02-05 | 2006-09-07 | Eppendorf Ag | フィルターピペットチップ |
| JP2012071306A (ja) * | 2005-02-05 | 2012-04-12 | Eppendorf Ag | フィルターピペットチップ |
| JP2008215880A (ja) * | 2007-02-28 | 2008-09-18 | Toray Ind Inc | 免疫分析チップ |
| JP2011517773A (ja) * | 2008-03-28 | 2011-06-16 | バイオティクス， インコーポレイテッド | サンプル調製デバイスおよび分析物の処理方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69914164T2 (de) | 2004-11-25 |
| AU4827999A (en) | 2000-01-10 |
| ES2214865T3 (es) | 2004-09-16 |
| WO1999067647A1 (en) | 1999-12-29 |
| ATE257944T1 (de) | 2004-01-15 |
| CA2301077A1 (en) | 1999-12-29 |
| EP1004025A1 (en) | 2000-05-31 |
| CN1273638A (zh) | 2000-11-15 |
| CA2301077C (en) | 2010-05-25 |
| US20040105782A1 (en) | 2004-06-03 |
| EP1004025B1 (en) | 2004-01-14 |
| CN1158530C (zh) | 2004-07-21 |
| DE69914164D1 (de) | 2004-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002519643A (ja) | 多層試験カラム | |
| JP3521144B2 (ja) | 自動連続ランダム・アクセス分析システムおよびその構成要素 | |
| JP2948318B2 (ja) | 特異的結合アッセイ用の赤血球の分離方法 | |
| JP3464793B2 (ja) | 自動連続ランダムアクセス分析システムおよびその構成要素 | |
| JP3384567B2 (ja) | 自動連続ランダム・アクセス分析システム | |
| EP1226434B1 (en) | Methods for performing magnetic chromatography assays | |
| JP3439467B2 (ja) | 自動連続ランダム・アクセス分析システム及びその構成要素 | |
| KR100639776B1 (ko) | 측방 유동 정량 검정 방법 및 이를 위한 스트립과 레이저유발 표면형광 검출 장치 및 소형 스캐너 | |
| JPH11316226A (ja) | 自動測定用カートリッジ及び自動測定法 | |
| JP2769245B2 (ja) | 検定結果を検証する方法及び自動連続ランダムアクセス分析システムを作動する方法 | |
| US20020025583A1 (en) | Analytical rotor and method for detecting analytes in liquid samples | |
| EP1512012B1 (en) | Biomolecular kinetics method using a flow-through microarray | |
| US20250130227A1 (en) | Diagnostic assay device having microreactor | |
| JP2001503847A (ja) | 検定装置 | |
| WO2010042355A1 (en) | Sample preparation device | |
| JP2007212263A (ja) | マイクロチップ及びマイクロチップの使用方法 | |
| MXPA00001785A (en) | Multi-layer testing column | |
| EP3978619A1 (en) | Automated silver enhancement system | |
| JP2007178316A (ja) | マトリックス効果の低減方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060623 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060623 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20081003 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20081125 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090225 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090304 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090325 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090428 |