JP2002517999A5 - - Google Patents
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- Publication number
- JP2002517999A5 JP2002517999A5 JP2000554765A JP2000554765A JP2002517999A5 JP 2002517999 A5 JP2002517999 A5 JP 2002517999A5 JP 2000554765 A JP2000554765 A JP 2000554765A JP 2000554765 A JP2000554765 A JP 2000554765A JP 2002517999 A5 JP2002517999 A5 JP 2002517999A5
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- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8968998P | 1998-06-17 | 1998-06-17 | |
US60/089,689 | 1998-06-17 | ||
US12617599P | 1999-03-25 | 1999-03-25 | |
US60/126,175 | 1999-03-25 | ||
PCT/US1999/013737 WO1999065940A1 (en) | 1998-06-17 | 1999-06-17 | Anti-angiogenic proteins and methods of use thereof |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007244618A Division JP2008019271A (ja) | 1998-06-17 | 2007-09-21 | 抗血管形成タンパク質およびその使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002517999A JP2002517999A (ja) | 2002-06-25 |
JP2002517999A5 true JP2002517999A5 (US07585860-20090908-C00150.png) | 2005-12-22 |
Family
ID=26780845
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000554765A Ceased JP2002517999A (ja) | 1998-06-17 | 1999-06-17 | 抗血管形成タンパク質およびその使用方法 |
JP2007244618A Pending JP2008019271A (ja) | 1998-06-17 | 2007-09-21 | 抗血管形成タンパク質およびその使用方法 |
JP2008164926A Pending JP2008301823A (ja) | 1998-06-17 | 2008-06-24 | 抗血管形成タンパク質およびその使用方法 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007244618A Pending JP2008019271A (ja) | 1998-06-17 | 2007-09-21 | 抗血管形成タンパク質およびその使用方法 |
JP2008164926A Pending JP2008301823A (ja) | 1998-06-17 | 2008-06-24 | 抗血管形成タンパク質およびその使用方法 |
Country Status (8)
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440729B1 (en) | 1995-06-30 | 2002-08-27 | University Of Kansas Medical Center | Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen |
US6358735B1 (en) | 1995-06-30 | 2002-03-19 | University Of Kansas Medical Center | Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen |
US7387779B2 (en) | 1998-06-17 | 2008-06-17 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6962974B1 (en) | 1998-06-17 | 2005-11-08 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6759047B1 (en) | 1998-06-17 | 2004-07-06 | Beth Israel Deaconess Hospital Corp. | Anti-angiogenic proteins and methods of use thereof |
US8128922B2 (en) | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
JP2003519630A (ja) * | 2000-01-07 | 2003-06-24 | ベス イスラエル ディーコネス メディカル センター | 抗血管新生タンパク質およびその断片ならびに使用方法 |
EP1171602A1 (en) * | 2000-02-10 | 2002-01-16 | ZymoGenetics, Inc. | Anti-angiogenic intestinal peptides, zdint5 |
ES2454640T3 (es) | 2000-08-03 | 2014-04-11 | Johns Hopkins University | Vacuna molecular que lleva unida un polipéptido de chaperona del retículo endoplasmático a un antígeno |
JP2004517117A (ja) | 2001-01-05 | 2004-06-10 | バイロメッド・リミテッド | 抗血管新生タンパク質をコードする遺伝子またはその部分を含む慢性関節リウマチ治療用医薬組成物 |
EP1389997B1 (en) * | 2001-04-13 | 2010-12-08 | Boyce Thompson Institute For Plant Research | Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives |
CN100447155C (zh) * | 2001-05-23 | 2008-12-31 | 中国科学院上海上海生命科学研究院 | 具有抑制内皮细胞生长活性的重组人内皮生长抑制蛋白 |
AU2002329643B2 (en) * | 2001-07-27 | 2006-11-16 | University Of Kansas Medical Center | Crystallized structure of type IV collagen NC1 domain hexamer |
EP1644048B1 (en) | 2003-05-05 | 2015-04-29 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
CA2594040A1 (en) | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
JP4843767B2 (ja) * | 2005-08-31 | 2011-12-21 | 国立大学法人 岡山大学 | がん細胞特異的遺伝子発現法を用いた血管新生阻害薬 |
US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
CN101962404A (zh) * | 2010-06-17 | 2011-02-02 | 中国热带农业科学院热带生物技术研究所 | 一种用于治疗血管瘤的蛋白质 |
PT2744831T (pt) * | 2011-08-17 | 2018-03-05 | Univ Colorado Regents | Proteína de fusão de transferrina-tumstatina e métodos para a produzir e utilizar |
DK2995626T3 (en) * | 2013-05-06 | 2018-10-29 | Univ China Pharma | BIFUNCTIONAL FUSION PROTEINS TO INHIBIT ANGIOGENESIS IN TUMOR ENVIRONMENTS AND ACTIVATE ADAPTIVE IMMUNE RESPONSE, AND THE GENES AND APPLICATIONS THEREOF |
CN111087477B (zh) * | 2020-01-03 | 2021-10-08 | 四川大学华西医院 | GBM-7S(α1)-NC1(α3)融合蛋白及其制备方法 |
CN113735966B (zh) * | 2021-09-29 | 2022-11-01 | 陕西巨子生物技术有限公司 | 一种抗肿瘤重组胶原蛋白及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4876332A (en) * | 1987-10-08 | 1989-10-24 | Regents Of The Univeristy Of Minnesota | Polypeptides with type IV collagen activity |
US5354690A (en) * | 1989-07-07 | 1994-10-11 | Karl Tryggvason | Immunological methods for the detection of the human type IV collagen α5 chain |
US5114840A (en) * | 1989-07-07 | 1992-05-19 | Karl Tryggvason | Method for determining the nucleotide sequence of a novel α5(IV) chain of human type IV collagen |
US5081031A (en) * | 1989-12-14 | 1992-01-14 | Regents Of The University Of Minnesota | Synthetic polypeptide with type iv collagen activity |
US5082926A (en) * | 1989-12-14 | 1992-01-21 | Regents Of The University Of Minnesota | Polypeptide with type iv collagen cell adhesion, spreading and motility activity |
US5424408A (en) * | 1990-11-30 | 1995-06-13 | Yale University | α-3 chain type IV collagen polynucleotides |
US5731192A (en) * | 1993-08-27 | 1998-03-24 | Yale University | Collagen COL4A6: gene, protein and method of detecting collagen deficiency |
US5567609A (en) * | 1994-06-30 | 1996-10-22 | University Of Kansas Medical Center | Use of isolated domains of type IV collagen to modify cell and tissue interactions |
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1999
- 1999-06-17 JP JP2000554765A patent/JP2002517999A/ja not_active Ceased
- 1999-06-17 AU AU45755/99A patent/AU753249B2/en not_active Ceased
- 1999-06-17 IL IL14023999A patent/IL140239A0/xx unknown
- 1999-06-17 CN CN99808686A patent/CN1309663A/zh active Pending
- 1999-06-17 CA CA002331332A patent/CA2331332A1/en not_active Abandoned
- 1999-06-17 EP EP99928762A patent/EP1086129A1/en not_active Ceased
- 1999-06-17 WO PCT/US1999/013737 patent/WO1999065940A1/en active IP Right Grant
- 1999-06-17 KR KR1020007014426A patent/KR100682666B1/ko not_active IP Right Cessation
-
2007
- 2007-09-21 JP JP2007244618A patent/JP2008019271A/ja active Pending
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2008
- 2008-06-24 JP JP2008164926A patent/JP2008301823A/ja active Pending