JP2002514067A - 神経栄養因子nnt−1 - Google Patents
神経栄養因子nnt−1Info
- Publication number
- JP2002514067A JP2002514067A JP53325898A JP53325898A JP2002514067A JP 2002514067 A JP2002514067 A JP 2002514067A JP 53325898 A JP53325898 A JP 53325898A JP 53325898 A JP53325898 A JP 53325898A JP 2002514067 A JP2002514067 A JP 2002514067A
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- nnt
- polypeptide
- nucleic acid
- seq
- acid molecule
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.(a)配列番号1の核酸分子; (b)配列番号3の核酸分子; (c)配列番号2のポリペプチドまたはその生物学的活性フラグメントをコー ドする核酸分子; (d)配列番号2のポリペプチドに少なくとも70%同一のポリペプチドをコ ードする核酸分子; (e)前記(a)〜(d)のいずれかにストリンジェント条件下にハイブリダ イズする核酸分子;および (f)前記(a)〜(e)のいずれかの相補体である核酸分子 からなる群より選択される,ポリペプチドをコードする核酸分子。 2.(a’)配列番号4の核酸分子; (b’)配列番号5のポリペプチドまたはその生物学的活性フラグメントをコ ードする核酸分子; (c’)配列番号5のポリペプチドに少なくとも70%同一のポリペプチドを コードする核酸分子; (d’)前記(a’)〜(c’)のいずれかにストリンジェント条件下にハイ ブリダイズする核酸分子;および (e’)前記(a’)〜(d’)のいずれかの相補体である核酸分子 からなる群より選択される,ポリペプチドをコードする核酸分子。 3.配列番号1の核酸分子。 4.配列番号3の核酸分子。 5.配列番号2のポリペプチドをコードする核酸分子。 6.配列番号2のアミノ酸1〜198をコードする核酸分子。 7.請求項1〜6のいずれかの核酸分子を含むベクター。 8.請求項7のベクターを含む宿主細胞。 9.(a)適当な宿主内において請求項1〜6のいずれかの核酸によりコードさ れるポリペプチドを発現する工程;および (b)そのポリペプチドを単離する工程 を含んでなるNNT−1ポリペプチドを製造する方法。 10.(a)配列番号2のポリペプチド; (b)配列番号2のアミノ酸1〜198であるポリペプチド; (c)(a)または(b)のポリペプチドに少なくとも70%同一のポリペプ チド;および (d)(a)〜(c)のいずれかの生物学的活性フラグメント からなる群より選択されるNNT−1ポリペプチド。 11.(a’)配列番号5のポリペプチド; (b’)配列番号5のアミノ酸1〜198であるポリペプチド; (c’)(a’)または(b’)のポリペプチドに少なくとも70%同一のポ リペプチド;および (d’)(a’)〜(c’)のいずれかの生物学的活性フラグメント からなる群より選択されるNNT−1ポリペプチド。 12.配列番号2のポリペプチドまたはその生物学的に活性なフラグメントであ るNNT−1ポリペプチド。 13.配列番号5のポリペプチドまたはその生物学的に活性なフラグメントであ るNNT−1ポリペプチド。 14.アミノ末端メチオニンを有さない請求項12または13のNNT−1ポリ ペプチド。 15.アミノ末端メチオニンをさらに有する請求項12または13のNNT−1 ポリペプチド。 16.特異的にヒトNNT−1と結合する抗体またはそのフラグメント。 17.モノクローナル抗体である請求項16に記載の抗体。 18.神経または免疫疾患または不全を患っている患者を治療する方法であって 、前記患者に請求項12〜15のいずれかに記載のNNT−1ポリペプチドの有 効量を投与することを含んでなる方法。 19.前記疾患または不全が、アルツハイマー病、パーキンソン病、筋萎縮性側 索硬化、シャルコー−マリー−ツース症候群、ハンチントン病、末梢神経障害、 ジストロフィー、または神経性網膜の退化から選択される請求項18に記載の方 法。 20.前記疾患または不全がB−細胞またはT−細胞の欠損により特徴付けられ る請求項18に記載の方法。 21.前記疾患または不全が、後天性免疫グロブリン血症(CVID)、選択的 IgA不全、低γ−グロブリン血症、および伴性無ガンマグロブリン血症である 請求項20に記載の方法。 22.ワクチン摂取時に免疫反応性および抗体生成を促進する 方法であって、それを必要としている患者に詰求項12〜15のいずれかに記載 のNNT−1ポリペプチドの有効量を投与することを含んでなる方法。 23.それを必要としている患者における炎症条件を治療する方法であって、前 記患者に請求項12〜15のいずれかに記載のNNT−1ポリペプチドの有効量 を投与することを含んでなる方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/792,019 | 1997-02-03 | ||
US08/792,019 US5741772A (en) | 1997-02-03 | 1997-02-03 | Neurotrophic factor NNT-1 |
US09/016,534 | 1998-01-30 | ||
US09/016,534 US6143874A (en) | 1997-02-03 | 1998-01-30 | Antibodies to the neurotrophic factor NNT-1 |
PCT/US1998/002363 WO1998033922A1 (en) | 1997-02-03 | 1998-02-02 | The neurotrophic factor nnt-1 |
Publications (2)
Publication Number | Publication Date |
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JP2002514067A true JP2002514067A (ja) | 2002-05-14 |
JP2002514067A5 JP2002514067A5 (ja) | 2005-06-16 |
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ID=26688735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53325898A Pending JP2002514067A (ja) | 1997-02-03 | 1998-02-02 | 神経栄養因子nnt−1 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0977859B1 (ja) |
JP (1) | JP2002514067A (ja) |
CN (1) | CN1195853C (ja) |
AT (1) | ATE273391T1 (ja) |
AU (1) | AU718882B2 (ja) |
CA (1) | CA2279999C (ja) |
DE (1) | DE69825580T2 (ja) |
DK (1) | DK0977859T3 (ja) |
ES (1) | ES2226097T3 (ja) |
HK (1) | HK1025125A1 (ja) |
HU (1) | HU225307B1 (ja) |
IL (2) | IL131103A0 (ja) |
PT (1) | PT977859E (ja) |
WO (1) | WO1998033922A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2295326A1 (en) * | 1997-06-30 | 1999-01-07 | Human Genome Sciences, Inc. | Cardiotrophin-like cytokine |
US6800460B1 (en) | 1999-03-11 | 2004-10-05 | Schering Corporation | Mammalian cytokine complexes |
DE60041393D1 (de) * | 1999-03-11 | 2009-03-05 | Schering Corp | Cytokine aus säugetieren, verwandte reagenzien und verfahren |
FR2804434A1 (fr) * | 2000-01-27 | 2001-08-03 | Pf Medicament | Heterocomplexe nnt-1/clf-1 et son utilisation en tant qu'activateur du recepteur complexe cntrfalpha/gp130/lifrbet a |
FR2804436B1 (fr) * | 2000-01-27 | 2002-08-02 | Pf Medicament | PROTEINE DE FUSION scsCNTFR/NNT-1 |
FR2804435A1 (fr) * | 2000-01-27 | 2001-08-03 | Pf Medicament | COMPLEXE ISOLE COMPRENANT UNE PROTEINE NNT-1 ET EN OUTRE AU MOINS UNE PROTEINE CLF-1 ET/OU UNE PROTEINE sCNTFRalpha |
US6849260B2 (en) | 2000-08-18 | 2005-02-01 | Amgen Inc. | Methods and compositions for treating IgE-related disease using NNT-1 inhibitors |
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1998
- 1998-02-02 HU HU0001969A patent/HU225307B1/hu not_active IP Right Cessation
- 1998-02-02 AT AT98906215T patent/ATE273391T1/de not_active IP Right Cessation
- 1998-02-02 WO PCT/US1998/002363 patent/WO1998033922A1/en active IP Right Grant
- 1998-02-02 EP EP98906215A patent/EP0977859B1/en not_active Expired - Lifetime
- 1998-02-02 IL IL13110398A patent/IL131103A0/xx not_active IP Right Cessation
- 1998-02-02 JP JP53325898A patent/JP2002514067A/ja active Pending
- 1998-02-02 IL IL15454398A patent/IL154543A0/xx active IP Right Grant
- 1998-02-02 AU AU61495/98A patent/AU718882B2/en not_active Ceased
- 1998-02-02 DE DE69825580T patent/DE69825580T2/de not_active Expired - Fee Related
- 1998-02-02 PT PT98906215T patent/PT977859E/pt unknown
- 1998-02-02 ES ES98906215T patent/ES2226097T3/es not_active Expired - Lifetime
- 1998-02-02 CA CA002279999A patent/CA2279999C/en not_active Expired - Fee Related
- 1998-02-02 CN CNB988036428A patent/CN1195853C/zh not_active Expired - Fee Related
- 1998-02-02 DK DK98906215T patent/DK0977859T3/da active
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2000
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Also Published As
Publication number | Publication date |
---|---|
CA2279999C (en) | 2004-07-27 |
IL154543A0 (en) | 2003-09-17 |
AU6149598A (en) | 1998-08-25 |
WO1998033922A1 (en) | 1998-08-06 |
EP0977859B1 (en) | 2004-08-11 |
HU225307B1 (en) | 2006-09-28 |
PT977859E (pt) | 2004-12-31 |
DK0977859T3 (da) | 2004-12-06 |
HK1025125A1 (en) | 2000-11-03 |
DE69825580D1 (de) | 2004-09-16 |
CA2279999A1 (en) | 1998-08-06 |
IL131103A0 (en) | 2001-01-28 |
CN1195853C (zh) | 2005-04-06 |
HUP0001969A2 (hu) | 2000-10-28 |
ES2226097T3 (es) | 2005-03-16 |
DE69825580T2 (de) | 2005-09-29 |
AU718882B2 (en) | 2000-04-20 |
CN1251134A (zh) | 2000-04-19 |
HUP0001969A3 (en) | 2002-01-28 |
ATE273391T1 (de) | 2004-08-15 |
EP0977859A1 (en) | 2000-02-09 |
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