JP2002511431A5 - - Google Patents
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- Publication number
- JP2002511431A5 JP2002511431A5 JP2000543171A JP2000543171A JP2002511431A5 JP 2002511431 A5 JP2002511431 A5 JP 2002511431A5 JP 2000543171 A JP2000543171 A JP 2000543171A JP 2000543171 A JP2000543171 A JP 2000543171A JP 2002511431 A5 JP2002511431 A5 JP 2002511431A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- αgal
- composition
- cross
- heterologous antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 description 74
- 238000000034 method Methods 0.000 description 23
- 101000718529 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) Alpha-galactosidase Proteins 0.000 description 19
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 19
- 239000000203 mixture Substances 0.000 description 19
- 239000000427 antigen Substances 0.000 description 17
- 102000036639 antigens Human genes 0.000 description 17
- 108091007433 antigens Proteins 0.000 description 17
- 125000000524 functional group Chemical group 0.000 description 16
- 238000006880 cross-coupling reaction Methods 0.000 description 9
- 150000002482 oligosaccharides Chemical class 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 7
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 description 7
- 108010005774 beta-Galactosidase Proteins 0.000 description 7
- 229920006037 cross link polymer Polymers 0.000 description 6
- 229920001542 oligosaccharide Polymers 0.000 description 6
- 150000001350 alkyl halides Chemical class 0.000 description 5
- 239000003431 cross linking reagent Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 230000000269 nucleophilic effect Effects 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- GVJXGCIPWAVXJP-UHFFFAOYSA-N 2,5-dioxo-1-oxoniopyrrolidine-3-sulfonate Chemical compound ON1C(=O)CC(S(O)(=O)=O)C1=O GVJXGCIPWAVXJP-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 125000005647 linker group Chemical group 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 description 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 150000001720 carbohydrates Chemical group 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 150000003871 sulfonates Chemical class 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 101710145634 Antigen 1 Proteins 0.000 description 1
- 230000019970 B cell anergy Effects 0.000 description 1
- 239000007848 Bronsted acid Substances 0.000 description 1
- 239000003341 Bronsted base Substances 0.000 description 1
- 102000030902 Galactosyltransferase Human genes 0.000 description 1
- 108060003306 Galactosyltransferase Proteins 0.000 description 1
- 239000002841 Lewis acid Substances 0.000 description 1
- 239000002879 Lewis base Substances 0.000 description 1
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 description 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Chemical group 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-alpha-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-ABVWGUQPSA-N 0.000 description 1
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001266 acyl halides Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 150000001408 amides Chemical group 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- RAABOESOVLLHRU-UHFFFAOYSA-N diazene Chemical group N=N RAABOESOVLLHRU-UHFFFAOYSA-N 0.000 description 1
- 229910000071 diazene Inorganic materials 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Substances NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000002256 galaktoses Chemical class 0.000 description 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- 150000007527 lewis bases Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000010452 phosphate Chemical group 0.000 description 1
- 150000003003 phosphines Chemical class 0.000 description 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- -1 phosphoryl halide Chemical class 0.000 description 1
- 150000003958 selenols Chemical class 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 150000003568 thioethers Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6052598A | 1998-04-15 | 1998-04-15 | |
| US09/060,525 | 1998-04-15 | ||
| PCT/US1999/008326 WO1999052561A1 (en) | 1998-04-15 | 1999-04-15 | Inhibition of xenoreactive antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002511431A JP2002511431A (ja) | 2002-04-16 |
| JP2002511431A5 true JP2002511431A5 (https=) | 2006-06-08 |
Family
ID=22030043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000543171A Pending JP2002511431A (ja) | 1998-04-15 | 1999-04-15 | 異種反応性抗体の阻害 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6572867B1 (https=) |
| EP (1) | EP1087791B1 (https=) |
| JP (1) | JP2002511431A (https=) |
| AT (1) | ATE304865T1 (https=) |
| AU (1) | AU761831B2 (https=) |
| CA (1) | CA2326618A1 (https=) |
| DE (2) | DE69927369T2 (https=) |
| ES (1) | ES2249890T3 (https=) |
| WO (1) | WO1999052561A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399578B1 (en) | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
| JP2002531531A (ja) * | 1998-12-09 | 2002-09-24 | ラ ホヤ ファーマシューティカル カンパニー | 循環している抗体を減少させるための方法および処方物 |
| EP1257558A1 (en) * | 2000-01-13 | 2002-11-20 | Alchemia Pty Ltd | Methods for synthesis of alpha-d-gal (1- 3) gal-containing oligosaccharides |
| US7270961B2 (en) * | 2002-04-16 | 2007-09-18 | Hui Sunny Chang | In vitro assay for quantitating secreted antibodies in lymphocyte supernatant for evaluation of vaccine or antigen induced specific antibody secretion from ex vivo circulating antibody-secreting lymphocytes |
| AU2005295708A1 (en) * | 2004-10-13 | 2006-04-27 | Relypsa, Inc. | Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle |
| US20060078534A1 (en) * | 2004-10-13 | 2006-04-13 | Dominique Charmot | Toxin binding compositions |
| FR2886298A1 (fr) * | 2005-05-24 | 2006-12-01 | Ifremer | Anticorps ou fragment d'anticorps couple a un agent immunogene |
| WO2008101177A2 (en) * | 2007-02-16 | 2008-08-21 | University Of Virginia Patent Foundation | Ige antibodies to chimeric or humanized igg therapeutic monoclonal antibodies as a screening test for anaphylaxis |
| EP2095829A1 (en) * | 2008-02-27 | 2009-09-02 | LEK Pharmaceuticals D.D. | Selenium containing modifying agents and conjugates |
| US9891219B2 (en) * | 2008-10-10 | 2018-02-13 | Mayo Foundation For Medical Education And Research | Methods for treating neuromyelitis optica (NMO) by administration of eculizumab to an individual that is aquaporin-4 (AQP4)-IgG autoantibody positive |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| US9642899B2 (en) | 2010-05-06 | 2017-05-09 | Mayo Foundation For Medical Education And Research | Implantation of a cardiac xenograft from a B4GALNT2KO and GTKO transgenic pig to reduce immunogenicity |
| US20130149331A1 (en) * | 2011-05-03 | 2013-06-13 | Peng George Wang | Rhamnose and forssman conjugated immunogenic agents |
| US9533214B2 (en) | 2012-09-25 | 2017-01-03 | Igt | Gaming system and method for providing plays of multiple games |
| SI3116887T1 (sl) | 2014-03-13 | 2021-06-30 | Universitaet Basel | Ogljikohidratni ligandi, ki se vežejo na protitelesa img proti glikoproteinu, ki je povezan z mielinom |
| EP2987503A1 (en) * | 2014-08-22 | 2016-02-24 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Methods and reagents for prevention and/or treatment of infection |
| KR102659529B1 (ko) | 2014-10-22 | 2024-04-23 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 이종이식에 적합한 삼중 트랜스제닉 돼지 |
| US11091591B2 (en) | 2015-09-16 | 2021-08-17 | Universität Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
| WO2021234676A1 (en) | 2020-05-22 | 2021-11-25 | Aab Therapeutics, Llc | Compounds and methods for suppressing an immune response to substances containing polyethylene glycol |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8001748L (sv) * | 1980-03-05 | 1981-09-06 | Kaellenius Gunilla | Kompositioner for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutik |
| US5126131A (en) * | 1983-01-24 | 1992-06-30 | The Johns Hopkins University | Therapeutic suppression of specific immune responses by administration of antigen-competitive conjugates. |
| US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| US5219564A (en) * | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
| US5191066A (en) * | 1990-12-07 | 1993-03-02 | Abbott Laboratories | Site-specific conjugation of immunoglobulins and detectable labels |
| AU666128B2 (en) * | 1991-08-23 | 1996-02-01 | Alberta Research Council Inc. | Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients |
| GB9202219D0 (en) * | 1992-02-03 | 1992-03-18 | Connaught Lab | A synthetic heamophilus influenzae conjugate vaccine |
| DE69517683T2 (de) * | 1994-03-15 | 2001-06-07 | Medical College Of Pennsylvania And Hahnemann University, Philadelphia | Alpha-galactosyl-epitope enthaltende zusammensetzungen und verfahren für impfstoffe |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| JP2000502565A (ja) * | 1995-12-21 | 2000-03-07 | プロクル・アクトボラーゲン | ガラクトピラノシド類とそれらの使用 |
| AU6319198A (en) * | 1997-02-05 | 1998-08-25 | Biotransplant Incorporated | Induction of b cell tolerance |
| US6676946B2 (en) * | 1997-03-27 | 2004-01-13 | Institut Pasteur | Multiple antigen glycopeptide carbohydrate vaccine comprising the same and use thereof |
| CA2284729A1 (en) * | 1997-04-18 | 1998-10-29 | Novartis Ag | Neoglycoproteins |
| US6096725A (en) * | 1997-07-02 | 2000-08-01 | Neose Technologies, Inc. | Methods of using αGal oligosaccharides as immune system targeting agents |
-
1999
- 1999-04-15 ES ES99917553T patent/ES2249890T3/es not_active Expired - Lifetime
- 1999-04-15 WO PCT/US1999/008326 patent/WO1999052561A1/en not_active Ceased
- 1999-04-15 CA CA002326618A patent/CA2326618A1/en not_active Abandoned
- 1999-04-15 JP JP2000543171A patent/JP2002511431A/ja active Pending
- 1999-04-15 AU AU35645/99A patent/AU761831B2/en not_active Ceased
- 1999-04-15 EP EP99917553A patent/EP1087791B1/en not_active Expired - Lifetime
- 1999-04-15 DE DE69927369T patent/DE69927369T2/de not_active Expired - Fee Related
- 1999-04-15 US US09/292,153 patent/US6572867B1/en not_active Expired - Fee Related
- 1999-04-15 AT AT99917553T patent/ATE304865T1/de not_active IP Right Cessation
- 1999-04-15 DE DE1087791T patent/DE1087791T1/de active Pending
-
2003
- 2003-03-28 US US10/402,845 patent/US20040141944A1/en not_active Abandoned
-
2007
- 2007-10-31 US US11/932,737 patent/US20080124396A1/en not_active Abandoned
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