JP2002509531A - 炎症の影響を低減するための組成物および物品 - Google Patents
炎症の影響を低減するための組成物および物品Info
- Publication number
- JP2002509531A JP2002509531A JP53405498A JP53405498A JP2002509531A JP 2002509531 A JP2002509531 A JP 2002509531A JP 53405498 A JP53405498 A JP 53405498A JP 53405498 A JP53405498 A JP 53405498A JP 2002509531 A JP2002509531 A JP 2002509531A
- Authority
- JP
- Japan
- Prior art keywords
- photosensitizer
- tissue
- composition
- injured
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.傷害組織から発生する炎症の影響を低減または防止するための方法であって 、該方法が: a.該傷害組織、または傷害前の組織を該組織に浸透し得る光増感剤と接触さ せ、その結果、1時間未満で所望の程度の体内分布を得る工程;および b.該接触をさせた組織を該光増感剤によって吸収される波長を有する光に曝 露する工程であって、曝露した組織中の炎症を低減または防止するのに十分な時 間であるが該曝露した組織の壊死または紅斑を引き起こすほど長くない時間、曝 露する工程、 を包含する、方法。 2.前記傷害組織が眼組織である、請求項1に記載の方法。 3.前記光増感剤が1種以上のモノヒドロベンゾポルフィリン化合物を含む、請 求項1に記載の方法。 4.前記光増感剤がBPD-MAを含む、請求項1に記載の方法。 5.前記接触工程a.が前記光増感剤の局所適用によって達成される、請求項1 に記載の方法。 6.前記光増感剤が2mg/mL以下の濃度を有する溶液の形態である、請求項5に 記載の方法。 7.前記傷害組織が薬物を浸漬したスポンジによって前記光増感剤と接触される 、請求項5に記載の方法。 8.前記接触工程a.において、前記光増感剤が5分未満、前記傷害組織と接触 したままにされる、請求項5に記載の方法。 9.前記工程a.が全身投与によって達成される、請求項1に記載の方法。 10.前記光増感剤の用量が0.30mg/Kg未満である、請求項9に記載の方法。 11.前記接触工程a.と前記曝露工程b.との間で、前記傷害組織に接触した 過剰の前記光増感剤が除去される、請求項1に記載の方法。 12.前記除去が、前記光増感剤を滅菌生理食塩水または平衡塩類溶液によって 流し去ることによって達成される、請求項11に記載の方法。 13.前記光の波長のうちの少なくともいくつかが電磁スペクトルの可視領域に ある、請求項1に記載の方法。 14.前記曝露工程b.の間の光の線量が約100J/cm2未満である、請求項1に記 載の方法。 15.前記接触工程a.と前記曝露工程b.との間の時間が約0時間と3時間と の間であり、そして該曝露工程b.の間の光の線量が約15J/cm2未満である、請 求項1に記載の方法。 16.前記曝露工程b.の光の線量が約7〜12J/cm2である、請求項15に記載の 方法。 17.前記接触工程a.と前記曝露工程b.との間の時間が約6時間より長く、 そして該曝露工程b.の間の光の線量が約15〜100J/cm2である、請求項1に記載 の方法。 18.傷害組織から発生する炎症の影響を低減または防止するための組成物であ って: a.該傷害組織、または傷害前の組織に浸透し得、その結果、1時間未満で所 望の程度の体内分布が得られる、約1μg/mLから約2mg/mLまでの光増感剤;お よび b.薬学的に受容可能なキャリア、 を含む、組成物。 19.前記傷害組織が眼組織である、請求項18に記載の組成物。 20.前記光増感剤が1種以上のモノヒドロベンゾポルフィリン化合物を含む、 請求項18に記載の組成物。 21.前記光増感剤がBPD-MAを含む、請求項18に記載の組成物。 22.前記組成物が局所適用のために処方される、請求項18に記載の組成物。 23.前記光増感剤が2mg/mL以下の濃度を有する溶液の形態である、請求項2 2に記載の組成物。 24.前記組成物が全身投与のために処方される、請求項18に記載の組成物。 25.前記光増感剤の用量が0.50mg/Kg未満である、請求項24に記載の組成物 。 26.前記光増感剤が、波長のうちの少なくともいくつかが電磁スペクトルの可 視領域にある光を吸収する、請求項18に記載の組成物。 27.傷害組織から発生する炎症の影響を低減または防止するための物品であっ て: a.光増感剤であって、該組織に浸透し得る光増感剤と接触した、該傷害組織 、または傷害前の組織に浸透し得、その結果、1時間未満で所望の程度の体内分 布が得られる、光増感剤;および b.吸着剤アプリケーター、 を含む、物品。 28.前記吸着剤アプリケーターが薬物浸漬スポンジである、請求項27に記載 の物品。 29.前記光増感剤が1種以上のモノヒドロベンゾポルフィリン化合物を含む、 請求項27に記載の物品。 30.前記光増感剤がBPD-MAを含む、請求項29に記載の物品。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79796397A | 1997-02-11 | 1997-02-11 | |
US08/797,963 | 1997-02-11 | ||
US08/942,883 US6274614B1 (en) | 1997-02-11 | 1997-10-02 | Methods, compositions and articles for reducing or preventing the effects of inflammation |
US08/942,883 | 1997-10-02 | ||
PCT/IB1998/000181 WO1998034644A1 (en) | 1997-02-11 | 1998-01-14 | Compositions and articles for reducing the effects of inflammation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005058215A Division JP2005272464A (ja) | 1997-02-11 | 2005-03-02 | 炎症の影響を低減するための組成物および物品 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002509531A true JP2002509531A (ja) | 2002-03-26 |
JP4012575B2 JP4012575B2 (ja) | 2007-11-21 |
Family
ID=27121943
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53405498A Expired - Lifetime JP4012575B2 (ja) | 1997-02-11 | 1998-01-14 | 炎症の影響を低減するための組成物および物品 |
JP2005058215A Withdrawn JP2005272464A (ja) | 1997-02-11 | 2005-03-02 | 炎症の影響を低減するための組成物および物品 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005058215A Withdrawn JP2005272464A (ja) | 1997-02-11 | 2005-03-02 | 炎症の影響を低減するための組成物および物品 |
Country Status (14)
Country | Link |
---|---|
US (1) | US6677366B2 (ja) |
EP (1) | EP0996465B1 (ja) |
JP (2) | JP4012575B2 (ja) |
CN (1) | CN1187089C (ja) |
AT (1) | ATE270114T1 (ja) |
AU (1) | AU734366B2 (ja) |
CA (1) | CA2279427C (ja) |
CZ (1) | CZ295734B6 (ja) |
DE (1) | DE69824853T2 (ja) |
ES (1) | ES2224355T3 (ja) |
HK (1) | HK1028190A1 (ja) |
NO (1) | NO327175B1 (ja) |
NZ (1) | NZ337077A (ja) |
WO (1) | WO1998034644A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001085212A2 (en) * | 2000-05-08 | 2001-11-15 | The University Of British Columbia | Drug delivery systems for photodynamic therapy |
AU2002233092A1 (en) * | 2001-02-15 | 2002-08-28 | Qlt Inc. | Reduction or prevention of pdt related inflammation |
NL1020336C2 (nl) * | 2002-04-09 | 2003-10-13 | Photobiochem Leiden N V | Toepassing van een verbinding voor de bereiding van een farmaceutisch preparaat voor het behandelen van brandwonden, en een werkwijze voor het behandelen van brandwonden. |
WO2006015016A2 (en) | 2004-07-30 | 2006-02-09 | Massachusetts Eye And Ear Infirmary | Photodynamic therapy and compositions for treating ocular glaucoma |
US20080269730A1 (en) | 2005-04-14 | 2008-10-30 | Dotson Robert S | Ophthalmic Phototherapy Device and Associated Treatment Method |
US7479136B2 (en) * | 2005-04-14 | 2009-01-20 | Dotson Robert S | Ophthalmic phototherapy treatment method |
US20130079759A1 (en) | 2005-04-14 | 2013-03-28 | Robert S. Dotson | Ophthalmic Phototherapy Device and Associated Treatment Method |
US20060235493A1 (en) * | 2005-04-14 | 2006-10-19 | Dotson Robert S | Ophthalmic phototherapy device and associated treatment method |
US8999933B2 (en) * | 2006-01-18 | 2015-04-07 | Biolitec Pharma Marketing Ltd | Photodynamic cosmetic procedure and healing method |
WO2015130944A1 (en) * | 2014-02-28 | 2015-09-03 | Massachusetts Eye & Ear Infirmary | Methods for cross-linking corneal collagen with verteporfin for the treatment of disorders of the eye |
NZ767766A (en) | 2014-09-09 | 2023-03-31 | Lumithera Inc | Multi-wavelength phototherapy devices, systems, and methods for the non-invasive treatment of damaged or diseased tissue |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4649151A (en) | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
US5171749A (en) | 1987-01-20 | 1992-12-15 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US5283255A (en) | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
US5112946A (en) * | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
CA2089005C (en) | 1991-06-21 | 1999-01-19 | John Chapman | Method for inactivating pathogens in a body fluid |
US5422362A (en) | 1993-07-29 | 1995-06-06 | Quadra Logic Technologies, Inc. | Method to inhibit restenosis |
US5707986A (en) | 1994-03-14 | 1998-01-13 | Miller; Joan W. | Angiographic method using green porphyrins in primate eyes |
US6008211A (en) * | 1995-07-27 | 1999-12-28 | Pdt Pharmaceuticals, Inc. | Photoactivatable compounds comprising benzochlorin and furocoumarin |
US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
-
1998
- 1998-01-14 DE DE69824853T patent/DE69824853T2/de not_active Expired - Lifetime
- 1998-01-14 AT AT98901446T patent/ATE270114T1/de not_active IP Right Cessation
- 1998-01-14 JP JP53405498A patent/JP4012575B2/ja not_active Expired - Lifetime
- 1998-01-14 EP EP98901446A patent/EP0996465B1/en not_active Expired - Lifetime
- 1998-01-14 CA CA002279427A patent/CA2279427C/en not_active Expired - Lifetime
- 1998-01-14 ES ES98901446T patent/ES2224355T3/es not_active Expired - Lifetime
- 1998-01-14 CZ CZ19992822A patent/CZ295734B6/cs not_active IP Right Cessation
- 1998-01-14 NZ NZ337077A patent/NZ337077A/en not_active IP Right Cessation
- 1998-01-14 WO PCT/IB1998/000181 patent/WO1998034644A1/en active IP Right Grant
- 1998-01-14 AU AU57772/98A patent/AU734366B2/en not_active Expired
- 1998-01-14 CN CNB988024225A patent/CN1187089C/zh not_active Expired - Lifetime
-
1999
- 1999-08-10 NO NO19993841A patent/NO327175B1/no not_active IP Right Cessation
-
2000
- 2000-10-11 HK HK00106449A patent/HK1028190A1/xx not_active IP Right Cessation
-
2001
- 2001-08-13 US US09/929,558 patent/US6677366B2/en not_active Expired - Lifetime
-
2005
- 2005-03-02 JP JP2005058215A patent/JP2005272464A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU5777298A (en) | 1998-08-26 |
AU734366B2 (en) | 2001-06-14 |
NO327175B1 (no) | 2009-05-04 |
CA2279427A1 (en) | 1998-08-13 |
ATE270114T1 (de) | 2004-07-15 |
CZ295734B6 (cs) | 2005-10-12 |
US6677366B2 (en) | 2004-01-13 |
NO993841L (no) | 1999-10-08 |
WO1998034644A1 (en) | 1998-08-13 |
CN1187089C (zh) | 2005-02-02 |
CN1269729A (zh) | 2000-10-11 |
ES2224355T3 (es) | 2005-03-01 |
DE69824853D1 (de) | 2004-08-05 |
HK1028190A1 (en) | 2001-02-09 |
NZ337077A (en) | 2001-06-29 |
NO993841D0 (no) | 1999-08-10 |
CA2279427C (en) | 2009-11-24 |
EP0996465B1 (en) | 2004-06-30 |
CZ282299A3 (cs) | 2000-02-16 |
DE69824853T2 (de) | 2006-01-12 |
US20020103180A1 (en) | 2002-08-01 |
EP0996465A1 (en) | 2000-05-03 |
JP4012575B2 (ja) | 2007-11-21 |
JP2005272464A (ja) | 2005-10-06 |
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