JP2002508751A - ワクチン接種および遺伝子治療のためのマイクロカプセル化dnaの作成方法 - Google Patents
ワクチン接種および遺伝子治療のためのマイクロカプセル化dnaの作成方法Info
- Publication number
- JP2002508751A JP2002508751A JP54894498A JP54894498A JP2002508751A JP 2002508751 A JP2002508751 A JP 2002508751A JP 54894498 A JP54894498 A JP 54894498A JP 54894498 A JP54894498 A JP 54894498A JP 2002508751 A JP2002508751 A JP 2002508751A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/165—Mumps or measles virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Manufacturing & Machinery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.DNA水溶液をポリマーマイクロパーティクルにカプセル化する方法であり 、該方法が、以下、 −有機溶媒およびサーファクタント中のポリマーを含有し、ならびに該DNA溶 液をまた含有する、水中(油中水)エマルジョンを提供する工程;ならびに −該エマルジョンに過剰のさらなる水相を添加し、油相を抽出し、そしてそれに よりマイクロパーティクルを形成する工程、 ここで、該さらなる水相は、該水中(油中水)エマルジョンよりも少なくとも5℃ 高い温度である、工程、 を包含する、方法。 2.前記油相の抽出が、25℃以上の温度でさらなる水相を使用して行われる、 請求項1に記載の方法。 3.前記油相の抽出が、30℃以上の温度でさらなる水相を使用して行われる、 請求項1または2に記載の方法。 4.請求項1、2または3に記載の方法であって、該方法が、1〜40%のアル コール含量を有するDNAとアルコールの水溶液を調製する工程を包含する、方 法。 5.請求項1〜4のいずれか1項に記載の方法であって、該方法が、0.01μ m〜30μmの範囲のサイズのマイクロパーティクルを形成する工程を包含する 、方法。 6.請求項1〜5のいずれか1項に記載の方法であって、ここで、該DNAが、 環状、プラスミドDNA、または環状プラスミド由来のDNAである、方法。 7.請求項1〜6のいずれか1項に記載の方法であって、以下の工程:− (a)DNA水溶液を調製する工程であって、該DNAは、少なくともプロモー ター配列、および必要に応じて該DNAの転写を調節および/または指向する他 の配列と作動可能に組み合わせられるポリペプチドをコードする配列を含み、該 DNAは哺乳動物レシピエントにおいてポリペプチドを発現するように適応され ている、工程; (b)有機溶媒中でポリマーの溶液を調製する工程; (c)該有機ポリマー溶液中で、該DNA水溶液のエマルジョンを形成する工程 ; (d)水性サーファクタント溶液を調製する工程; (e)該水性サーファクタント溶液中で、工程(c)からの該エマルジョンの2 重エマルジョンを形成する工程; (f)該DNAを含有する、直径10μmまでのサイズを有するポリマーのマイ クロパーティクルを形成するように、該有機溶媒を抽出する、工程;ならびに (g)該マイクロパーティクルを回収する工程、 を包含する、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9709900.6 | 1997-05-15 | ||
GBGB9709900.6A GB9709900D0 (en) | 1997-05-15 | 1997-05-15 | Microencapsulated DNA for vaccination and gene therapy |
PCT/GB1998/001403 WO1998051279A2 (en) | 1996-11-12 | 1998-05-15 | Method of making microencapsulated dna for vaccination and gene therapy |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011044526A Division JP2011105774A (ja) | 1997-05-15 | 2011-03-01 | ワクチン接種および遺伝子治療のためのマイクロカプセル化dnaの作成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002508751A true JP2002508751A (ja) | 2002-03-19 |
JP4827273B2 JP4827273B2 (ja) | 2011-11-30 |
Family
ID=10812381
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54894498A Expired - Fee Related JP4827273B2 (ja) | 1997-05-15 | 1998-05-15 | ワクチン接種および遺伝子治療のためのマイクロカプセル化dnaの作成方法 |
JP2011044526A Withdrawn JP2011105774A (ja) | 1997-05-15 | 2011-03-01 | ワクチン接種および遺伝子治療のためのマイクロカプセル化dnaの作成方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011044526A Withdrawn JP2011105774A (ja) | 1997-05-15 | 2011-03-01 | ワクチン接種および遺伝子治療のためのマイクロカプセル化dnaの作成方法 |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP2042599B1 (ja) |
JP (2) | JP4827273B2 (ja) |
AT (2) | ATE509104T1 (ja) |
AU (1) | AU735897B2 (ja) |
CA (1) | CA2289761C (ja) |
DE (1) | DE69840434D1 (ja) |
GB (1) | GB9709900D0 (ja) |
WO (1) | WO1998051279A2 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008208070A (ja) * | 2007-02-27 | 2008-09-11 | Yokohama City Univ | プラスミド送達用粒子 |
JP2009281696A (ja) * | 2008-05-26 | 2009-12-03 | T Rad Co Ltd | 凝縮器 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6197229B1 (en) * | 1997-12-12 | 2001-03-06 | Massachusetts Institute Of Technology | Method for high supercoiled DNA content microspheres |
GB9810236D0 (en) * | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
CA2276066A1 (en) * | 1999-03-11 | 2000-09-11 | Zycos Inc. | Microparticles for delivery of nucleic acid |
US10688026B2 (en) | 2009-04-27 | 2020-06-23 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
US9814657B2 (en) | 2009-04-27 | 2017-11-14 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62201816A (ja) * | 1985-02-07 | 1987-09-05 | Takeda Chem Ind Ltd | マイクロカプセルの製造法 |
WO1995035097A1 (en) * | 1994-06-18 | 1995-12-28 | University Of Nottingham | Polymer microparticles for drug delivery |
JPH09504027A (ja) * | 1993-10-22 | 1997-04-22 | ジェネンテク,インコーポレイテッド | ワクチンとしての使用のための抗原のマイクロカプセル化のための方法および組成物 |
JPH09504523A (ja) * | 1993-10-22 | 1997-05-06 | ジェネンテク,インコーポレイテッド | アジュバントのマイクロカプセル化方法および組成物 |
Family Cites Families (12)
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US4686098A (en) | 1984-05-14 | 1987-08-11 | Merck & Co., Inc. | Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo |
EP0248531A3 (en) | 1986-05-02 | 1988-09-28 | Southern Research Institute | Encapsulated nucleic acids |
CA2050911C (en) | 1989-05-04 | 1997-07-15 | Thomas R. Tice | Encapsulation process and products therefrom |
AU629316B2 (en) | 1990-04-11 | 1992-10-01 | Flora Inc. | Periodontal disease treatment system |
JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
NZ265818A (en) * | 1993-04-19 | 1997-09-22 | Medisorb Technologies Internat | Compositions of nucleic acids encapsulated with molecules that facilitate uptake and integration into living cells |
EP0714308A4 (en) | 1993-08-26 | 1998-07-29 | Univ California | METHOD, COMPOSITIONS AND DEVICES FOR THE DELIVERY OF NAKED POLYNUCLEOTIDES THAT ENCODE BIOLOGICALLY ACTIVE PEPTIDES |
EP0740704A1 (en) * | 1994-01-27 | 1996-11-06 | University Of Massachusetts Medical Center | Immunization by inoculation of dna transcription unit |
AU710504B2 (en) * | 1994-03-15 | 1999-09-23 | Brown University Research Foundation | Polymeric gene delivery system |
AUPM572294A0 (en) | 1994-05-18 | 1994-06-09 | Vaccine Technologies Pty. Ltd. | Delivery vehicle for bioactive molecule |
US5571531A (en) | 1994-05-18 | 1996-11-05 | Mcmaster University | Microparticle delivery system with a functionalized silicone bonded to the matrix |
EP0862419B2 (en) * | 1995-11-09 | 2010-11-17 | Microbiological Research Authority | Microencapsulated dna for vaccination and gene therapy |
-
1997
- 1997-05-15 GB GBGB9709900.6A patent/GB9709900D0/en active Pending
-
1998
- 1998-05-15 CA CA002289761A patent/CA2289761C/en not_active Expired - Lifetime
- 1998-05-15 DE DE69840434T patent/DE69840434D1/de not_active Expired - Lifetime
- 1998-05-15 EP EP09150109A patent/EP2042599B1/en not_active Expired - Lifetime
- 1998-05-15 WO PCT/GB1998/001403 patent/WO1998051279A2/en active IP Right Grant
- 1998-05-15 AU AU74408/98A patent/AU735897B2/en not_active Expired
- 1998-05-15 AT AT09150109T patent/ATE509104T1/de not_active IP Right Cessation
- 1998-05-15 JP JP54894498A patent/JP4827273B2/ja not_active Expired - Fee Related
- 1998-05-15 AT AT98921621T patent/ATE420194T1/de not_active IP Right Cessation
- 1998-05-15 EP EP98921621A patent/EP0971693B1/en not_active Expired - Lifetime
-
2011
- 2011-03-01 JP JP2011044526A patent/JP2011105774A/ja not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62201816A (ja) * | 1985-02-07 | 1987-09-05 | Takeda Chem Ind Ltd | マイクロカプセルの製造法 |
JPH09504027A (ja) * | 1993-10-22 | 1997-04-22 | ジェネンテク,インコーポレイテッド | ワクチンとしての使用のための抗原のマイクロカプセル化のための方法および組成物 |
JPH09504523A (ja) * | 1993-10-22 | 1997-05-06 | ジェネンテク,インコーポレイテッド | アジュバントのマイクロカプセル化方法および組成物 |
WO1995035097A1 (en) * | 1994-06-18 | 1995-12-28 | University Of Nottingham | Polymer microparticles for drug delivery |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008208070A (ja) * | 2007-02-27 | 2008-09-11 | Yokohama City Univ | プラスミド送達用粒子 |
JP2009281696A (ja) * | 2008-05-26 | 2009-12-03 | T Rad Co Ltd | 凝縮器 |
Also Published As
Publication number | Publication date |
---|---|
AU7440898A (en) | 1998-12-08 |
EP0971693B1 (en) | 2009-01-07 |
JP2011105774A (ja) | 2011-06-02 |
DE69840434D1 (de) | 2009-02-26 |
CA2289761A1 (en) | 1998-11-19 |
CA2289761C (en) | 2008-08-26 |
ATE509104T1 (de) | 2011-05-15 |
EP0971693A2 (en) | 2000-01-19 |
ATE420194T1 (de) | 2009-01-15 |
EP2042599A1 (en) | 2009-04-01 |
WO1998051279A3 (en) | 1999-02-18 |
GB9709900D0 (en) | 1997-07-09 |
EP2042599B1 (en) | 2011-05-11 |
JP4827273B2 (ja) | 2011-11-30 |
WO1998051279A2 (en) | 1998-11-19 |
AU735897B2 (en) | 2001-07-19 |
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