JP2002508737A - 骨粗鬆症を含む骨吸収障害を治療するための方法および組成物 - Google Patents
骨粗鬆症を含む骨吸収障害を治療するための方法および組成物Info
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- JP2002508737A JP2002508737A JP51189298A JP51189298A JP2002508737A JP 2002508737 A JP2002508737 A JP 2002508737A JP 51189298 A JP51189298 A JP 51189298A JP 51189298 A JP51189298 A JP 51189298A JP 2002508737 A JP2002508737 A JP 2002508737A
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- cathepsin
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- bone
- cells
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/704,473 | 1996-08-28 | ||
| US08/704,473 US5830850A (en) | 1996-08-28 | 1996-08-28 | Methods for the treatment of bone resorption disorders, including osteoporosis |
| PCT/US1997/015121 WO1998008494A1 (en) | 1996-08-28 | 1997-08-28 | Methods and compositions for the treatment of bone resorption disorders, including osteoporosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508737A true JP2002508737A (ja) | 2002-03-19 |
| JP2002508737A5 JP2002508737A5 (https=) | 2005-04-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51189298A Pending JP2002508737A (ja) | 1996-08-28 | 1997-08-28 | 骨粗鬆症を含む骨吸収障害を治療するための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5830850A (https=) |
| EP (1) | EP0961613A4 (https=) |
| JP (1) | JP2002508737A (https=) |
| AU (1) | AU4165797A (https=) |
| CA (1) | CA2264715A1 (https=) |
| WO (1) | WO1998008494A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7832771B2 (ja) | 2012-01-27 | 2026-03-18 | バイオマリン テクノロジーズ ベー．フェー． | デュシェンヌ型及びベッカー型筋ジストロフィーの治療のための改善された特徴を有するｒｎａ調節オリゴヌクレオチド |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5501969A (en) | 1994-03-08 | 1996-03-26 | Human Genome Sciences, Inc. | Human osteoclast-derived cathepsin |
| IL117175A (en) * | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| SK48198A3 (en) * | 1995-10-30 | 1998-10-07 | Smithkline Beecham Corp | Cathepsin k molecule, a peptid being bonded to the hollow of active positon of cathepsin k, a composition, method for identification of inhibiting compound and inhibitors being competitively bonded to the active position of cathepsin k |
| WO1997016433A1 (en) * | 1995-10-30 | 1997-05-09 | Smithkline Beecham Corporation | Protease inhibitors |
| US6586466B2 (en) | 1995-10-30 | 2003-07-01 | Smithkline Beecham Corporation | Carbohydrazide-protease inhibitors |
| JP4268684B2 (ja) * | 1997-09-24 | 2009-05-27 | 第一三共株式会社 | 骨代謝異常症の診断方法 |
| US20030044399A1 (en) * | 1998-12-23 | 2003-03-06 | Smithkline Beecham Corporation | Method of treatment |
| US20030144175A1 (en) * | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2000061785A2 (en) * | 1999-04-14 | 2000-10-19 | Smithkline Beecham Corporation | Polynucleotide and polypeptide sequences of monkey cathepsin k |
| US20040214889A1 (en) * | 1999-07-31 | 2004-10-28 | Smithkline Beecham Corporation | Calcilytic compounds |
| US6770468B1 (en) | 1999-09-14 | 2004-08-03 | Genzyme Glycobiology Research Institute, Inc. | Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway |
| US6534300B1 (en) | 1999-09-14 | 2003-03-18 | Genzyme Glycobiology Research Institute, Inc. | Methods for producing highly phosphorylated lysosomal hydrolases |
| WO2001034600A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| US6534498B1 (en) | 1999-11-10 | 2003-03-18 | Smithkline Beecham Corporation | Protease inhibitors |
| JP2003513971A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
| JP2001158736A (ja) * | 1999-11-30 | 2001-06-12 | Snow Brand Milk Prod Co Ltd | 骨関節疾患の予防及び改善剤 |
| EP2095817A1 (en) * | 1999-12-07 | 2009-09-02 | Rutgers, The State University Of New Jersey | Therapeutic compositions and methods |
| AU2001243441B2 (en) * | 2000-03-21 | 2004-11-25 | Smithkline Beecham Corporation | Protease inhibitors |
| AU2001272981A1 (en) * | 2000-06-22 | 2002-01-02 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the slc26a2 gene |
| US7332494B2 (en) * | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
| EP1309591B1 (en) * | 2000-08-14 | 2007-01-24 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
| US20070105841A1 (en) * | 2000-08-14 | 2007-05-10 | Breitenbucher J G | Method for treating allergies using substituted pyrazoles |
| US6369032B1 (en) * | 2000-09-06 | 2002-04-09 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating allergies |
| US20030073672A1 (en) * | 2001-09-05 | 2003-04-17 | Breitenbucher J. Guy | Method for treating allergies using substituted pyrazoles |
| US7799326B2 (en) * | 2001-09-24 | 2010-09-21 | Mount Sinai School Of Medicine | Methods and compositions for cathespin k complex-mediated disorders |
| US6800472B2 (en) | 2001-12-21 | 2004-10-05 | Genzyme Glycobiology Research Institute, Inc. | Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase |
| US6905856B2 (en) | 2001-12-21 | 2005-06-14 | Genzyme Glycobiology Research Institute, Inc. | Soluble GlcNAc phosphotransferase |
| US20040138162A1 (en) * | 2002-08-30 | 2004-07-15 | Roodman G. David | Method of resisting osteoclast formation |
| US20040170621A1 (en) * | 2002-08-30 | 2004-09-02 | Roodman G. David | Method of resisting osteoclast formation |
| EP1585750B1 (en) * | 2002-12-09 | 2008-10-15 | Arizona Board Of Regents | Narcistatin prodrugs |
| US20060020001A1 (en) * | 2002-12-23 | 2006-01-26 | Allan Shepard | Use of cathepsin k inhibitors for the treatment of glaucoma |
| WO2005089736A2 (en) * | 2004-03-05 | 2005-09-29 | The Arizona Board Of Regents, On Behalf Of, Arizona State University | Methods for treating inflammatory and autoimmune diseases |
| WO2009076490A1 (en) * | 2007-12-12 | 2009-06-18 | Velcura Therapeutics, Inc. | Use of cathepsin l antagonists in the treatment of bone disease |
| CN105456292B (zh) * | 2009-10-30 | 2019-03-26 | 北卡罗来纳大学教堂山分校 | 来自肝外胆管树的专能干细胞及其分离方法 |
| WO2013037770A1 (en) * | 2011-09-15 | 2013-03-21 | Bayer Intellectual Property Gmbh | Method for the continuous production of water-dispersible vinyl polymers |
Family Cites Families (15)
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| US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4902505A (en) * | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US5116742A (en) * | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) * | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5158936A (en) * | 1986-12-22 | 1992-10-27 | Syntex (U.S.A.) Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
| US4904582A (en) * | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| ATE117375T1 (de) * | 1987-09-11 | 1995-02-15 | Whitehead Biomedical Inst | Transduktionsveränderte fibroblasten und ihre anwendung. |
| US5399349A (en) * | 1992-02-06 | 1995-03-21 | Paunescu; Calin | Treatment of acne |
| US5550138A (en) * | 1992-03-25 | 1996-08-27 | Takeda Chemical Industries, Ltd. | Condensed thiadiazole derivative, method of its production, and use thereof |
| US5374623A (en) * | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
| US5525623A (en) * | 1993-03-12 | 1996-06-11 | Arris Pharmaceutical Corporation | Compositions and methods for the treatment of immunomediated inflammatory disorders |
| US5486623A (en) * | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
| IL112759A0 (en) * | 1994-02-25 | 1995-05-26 | Khepri Pharmaceuticals Inc | Novel cysteine protease inhibitors |
| US5501969A (en) * | 1994-03-08 | 1996-03-26 | Human Genome Sciences, Inc. | Human osteoclast-derived cathepsin |
| TW438591B (en) * | 1995-06-07 | 2001-06-07 | Arris Pharm Corp | Reversible cysteine protease inhibitors |
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1996
- 1996-08-28 US US08/704,473 patent/US5830850A/en not_active Expired - Lifetime
-
1997
- 1997-08-28 CA CA002264715A patent/CA2264715A1/en not_active Withdrawn
- 1997-08-28 EP EP97939609A patent/EP0961613A4/en not_active Ceased
- 1997-08-28 JP JP51189298A patent/JP2002508737A/ja active Pending
- 1997-08-28 AU AU41657/97A patent/AU4165797A/en not_active Abandoned
- 1997-08-28 WO PCT/US1997/015121 patent/WO1998008494A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7832771B2 (ja) | 2012-01-27 | 2026-03-18 | バイオマリン テクノロジーズ ベー．フェー． | デュシェンヌ型及びベッカー型筋ジストロフィーの治療のための改善された特徴を有するｒｎａ調節オリゴヌクレオチド |
Also Published As
| Publication number | Publication date |
|---|---|
| AU4165797A (en) | 1998-03-19 |
| CA2264715A1 (en) | 1998-03-05 |
| US5830850A (en) | 1998-11-03 |
| EP0961613A1 (en) | 1999-12-08 |
| EP0961613A4 (en) | 2003-07-23 |
| WO1998008494A1 (en) | 1998-03-05 |
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