JP2002502884A - インターロイキン−１２および単純ヘルペスウイルス抗原を含んでなるワクチン - Google Patents
インターロイキン−１２および単純ヘルペスウイルス抗原を含んでなるワクチンInfo
- Publication number
- JP2002502884A JP2002502884A JP2000531189A JP2000531189A JP2002502884A JP 2002502884 A JP2002502884 A JP 2002502884A JP 2000531189 A JP2000531189 A JP 2000531189A JP 2000531189 A JP2000531189 A JP 2000531189A JP 2002502884 A JP2002502884 A JP 2002502884A
- Authority
- JP
- Japan
- Prior art keywords
- interleukin
- herpes simplex
- vaccine
- suspension
- simplex virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010065805 Interleukin-12 Proteins 0.000 title claims abstract description 79
- 102000013462 Interleukin-12 Human genes 0.000 title claims abstract description 79
- 108091007433 antigens Proteins 0.000 title claims abstract description 54
- 102000036639 antigens Human genes 0.000 title claims abstract description 54
- 239000000427 antigen Substances 0.000 title claims abstract description 52
- 229960005486 vaccine Drugs 0.000 title claims abstract description 50
- 241000700584 Simplexvirus Species 0.000 title claims abstract description 31
- 229940117681 interleukin-12 Drugs 0.000 title claims description 15
- 239000000203 mixture Substances 0.000 claims abstract description 47
- 239000000725 suspension Substances 0.000 claims abstract description 23
- 230000028993 immune response Effects 0.000 claims abstract description 22
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 13
- 239000011707 mineral Substances 0.000 claims abstract description 13
- 239000002671 adjuvant Substances 0.000 claims description 15
- 229940037003 alum Drugs 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 102100022717 Atypical chemokine receptor 1 Human genes 0.000 claims description 12
- 101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 claims description 12
- 230000002163 immunogen Effects 0.000 claims description 10
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 6
- 208000009889 Herpes Simplex Diseases 0.000 claims description 5
- 102000000589 Interleukin-1 Human genes 0.000 claims description 5
- 108010002352 Interleukin-1 Proteins 0.000 claims description 5
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical group [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 3
- 239000007900 aqueous suspension Substances 0.000 claims 3
- 229940040731 human interleukin-12 Drugs 0.000 claims 1
- 230000001681 protective effect Effects 0.000 abstract description 15
- 230000004044 response Effects 0.000 description 33
- 210000004027 cell Anatomy 0.000 description 28
- 241000699670 Mus sp. Species 0.000 description 17
- 210000002966 serum Anatomy 0.000 description 15
- 229910017119 AlPO Inorganic materials 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 239000002953 phosphate buffered saline Substances 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 11
- 229920001213 Polysorbate 20 Polymers 0.000 description 11
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 11
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 11
- 102000004127 Cytokines Human genes 0.000 description 10
- 108090000695 Cytokines Proteins 0.000 description 10
- 238000010790 dilution Methods 0.000 description 10
- 239000012895 dilution Substances 0.000 description 10
- 229940031626 subunit vaccine Drugs 0.000 description 9
- 238000002965 ELISA Methods 0.000 description 8
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 8
- 230000003053 immunization Effects 0.000 description 8
- 238000002649 immunization Methods 0.000 description 8
- 108010074328 Interferon-gamma Proteins 0.000 description 7
- 241000700605 Viruses Species 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 238000011260 co-administration Methods 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 244000052769 pathogen Species 0.000 description 7
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 6
- 102100037850 Interferon gamma Human genes 0.000 description 6
- 230000001461 cytolytic effect Effects 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 230000024932 T cell mediated immunity Effects 0.000 description 5
- 230000005875 antibody response Effects 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 230000006698 induction Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 210000004988 splenocyte Anatomy 0.000 description 5
- 238000002255 vaccination Methods 0.000 description 5
- 241000282412 Homo Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 210000001744 T-lymphocyte Anatomy 0.000 description 4
- 230000000240 adjuvant effect Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000012636 effector Substances 0.000 description 4
- -1 ethanol polyols Chemical class 0.000 description 4
- 230000028996 humoral immune response Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 241000283707 Capra Species 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 108090000288 Glycoproteins Proteins 0.000 description 3
- 102000003886 Glycoproteins Human genes 0.000 description 3
- 108090000978 Interleukin-4 Proteins 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 210000000612 antigen-presenting cell Anatomy 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- 230000000306 recurrent effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 210000004989 spleen cell Anatomy 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000003656 tris buffered saline Substances 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- 210000003501 vero cell Anatomy 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 101100152731 Arabidopsis thaliana TH2 gene Proteins 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 102000000588 Interleukin-2 Human genes 0.000 description 2
- 108010074338 Lymphokines Proteins 0.000 description 2
- 102000008072 Lymphokines Human genes 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 102100029251 Phagocytosis-stimulating peptide Human genes 0.000 description 2
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 2
- 108010084754 Tuftsin Proteins 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 description 2
- 230000003308 immunostimulating effect Effects 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 230000001589 lymphoproliferative effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 description 2
- 229940035670 tuftsin Drugs 0.000 description 2
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 description 1
- PYAFUXYGTYWWBP-UHFFFAOYSA-N 19-methoxynonadecane-1,2,3-triol Chemical compound COCCCCCCCCCCCCCCCCC(O)C(O)CO PYAFUXYGTYWWBP-UHFFFAOYSA-N 0.000 description 1
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 description 1
- LYFYWXLKKQIOKO-UHFFFAOYSA-N 3,3-diaminopentan-1-ol Chemical compound CCC(N)(N)CCO LYFYWXLKKQIOKO-UHFFFAOYSA-N 0.000 description 1
- IITIZHOBOIBGBW-UHFFFAOYSA-N 3-ethyl-2h-1,3-benzothiazole Chemical compound C1=CC=C2N(CC)CSC2=C1 IITIZHOBOIBGBW-UHFFFAOYSA-N 0.000 description 1
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 101710121417 Envelope glycoprotein Proteins 0.000 description 1
- 101710126486 Envelope glycoprotein D Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- 208000029433 Herpesviridae infectious disease Diseases 0.000 description 1
- 101900228213 Human herpesvirus 2 Envelope glycoprotein D Proteins 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 208000004554 Leishmaniasis Diseases 0.000 description 1
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 102100021696 Syncytin-1 Human genes 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000010530 Virus Neutralization Effects 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001745 anti-biotin effect Effects 0.000 description 1
- 230000003092 anti-cytokine Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 108010030694 avidin-horseradish peroxidase complex Proteins 0.000 description 1
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000001707 blastogenic effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229960000633 dextran sulfate Drugs 0.000 description 1
- 108700003601 dimethylglycine Proteins 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000008102 immune modulation Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000002794 lymphocyte assay Methods 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000009696 proliferative response Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000004017 serum-free culture medium Substances 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 238000003211 trypan blue cell staining Methods 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7450398P | 1998-02-12 | 1998-02-12 | |
| US60/074,503 | 1998-02-12 | ||
| PCT/US1999/002923 WO1999040938A2 (en) | 1998-02-12 | 1999-02-10 | Vaccines comprising interleukin-12 and herpes simplex viral antigen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002502884A true JP2002502884A (ja) | 2002-01-29 |
| JP2002502884A5 JP2002502884A5 (OSRAM) | 2006-03-02 |
Family
ID=22119907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000531189A Pending JP2002502884A (ja) | 1998-02-12 | 1999-02-10 | インターロイキン−１２および単純ヘルペスウイルス抗原を含んでなるワクチン |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6488936B1 (OSRAM) |
| EP (1) | EP1053017B1 (OSRAM) |
| JP (1) | JP2002502884A (OSRAM) |
| KR (1) | KR100622716B1 (OSRAM) |
| CN (1) | CN1224422C (OSRAM) |
| AT (1) | ATE275421T1 (OSRAM) |
| AU (1) | AU764036B2 (OSRAM) |
| BR (1) | BR9907883A (OSRAM) |
| CA (1) | CA2320041A1 (OSRAM) |
| DE (1) | DE69919984T2 (OSRAM) |
| DK (1) | DK1053017T3 (OSRAM) |
| ES (1) | ES2226338T3 (OSRAM) |
| IL (1) | IL137811A (OSRAM) |
| PT (1) | PT1053017E (OSRAM) |
| WO (1) | WO1999040938A2 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE516046T1 (de) * | 1999-05-13 | 2011-07-15 | Wyeth Corp | Adjuvans kombinationsformulierungen |
| KR100773390B1 (ko) * | 1999-12-17 | 2007-11-09 | 와이어쓰 홀딩스 코포레이션 | 단순 포진 바이러스 백신 키트 |
| AU2002232560A1 (en) | 2000-10-27 | 2002-05-06 | Immuno-Rx, Inc | Vaccine immunotherapy for immune suppressed patients |
| US20070025958A1 (en) | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
| JP2004523483A (ja) * | 2000-11-10 | 2004-08-05 | ワイス・ホールデイングス・コーポレーシヨン | アジュバントの組合せ製剤 |
| US6867000B2 (en) | 2000-12-07 | 2005-03-15 | Wyeth Holdings Corporation | Method of enhancing immune responses to herpes |
| JP2004099584A (ja) * | 2002-05-02 | 2004-04-02 | Keio Gijuku | Ｈｓｖを用いた抗腫瘍剤 |
| CN1301749C (zh) * | 2005-12-09 | 2007-02-28 | 复旦大学 | 抗单纯疱疹病毒－2感染的多表位dna疫苗及其制备方法 |
| US7790203B2 (en) * | 2005-12-13 | 2010-09-07 | Lowder Tom R | Composition and regimen for the treatment of herpes simplex virus, herpes zoster, and herpes genitalia epidermal herpetic lesions |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| PT2484375T (pt) | 2006-09-26 | 2018-07-09 | Infectious Disease Res Inst | Composição para vacina contendo adjuvante sintético |
| ES2679043T3 (es) | 2009-05-15 | 2018-08-21 | Irx Therapeutics, Inc. | Inmunoterapia de vacuna |
| HRP20161585T1 (hr) | 2009-06-05 | 2016-12-30 | Infectious Disease Research Institute | Sintetski glukopiranozilni lipidi kao adjuvansi i cjepivni pripravci koji ih sadrže |
| US8729058B2 (en) | 2009-10-27 | 2014-05-20 | Michael Zasloff | Methods and compositions for treating and preventing viral infections |
| AU2010328197B2 (en) | 2009-12-08 | 2015-07-16 | Irx Therapeutics, Inc. | Method of reversing immune suppression of Langerhans cells |
| EP3632463A1 (en) | 2011-04-08 | 2020-04-08 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| US9555099B2 (en) | 2012-05-16 | 2017-01-31 | Immune Design Corp. | Vaccines for HSV-2 |
| AU2014253791B2 (en) | 2013-04-18 | 2019-05-02 | Immune Design Corp. | GLA monotherapy for use in cancer treatment |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| AU2017261687B2 (en) | 2016-05-10 | 2023-10-19 | Hennepin Healthcare Research Institute | Cytokine signaling immunomodulators and methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994022473A1 (en) * | 1993-04-01 | 1994-10-13 | University Of Washington | Use of interleukin 7 to improve vaccine potency |
| US5571515A (en) * | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
| IL114576A0 (en) * | 1994-07-22 | 1995-11-27 | Merck & Co Inc | Polynucleotide herpes virus vaccine |
| GB9422990D0 (en) * | 1994-11-15 | 1995-01-04 | Cortecs Ltd | Immunogenic compositions |
| AU5507098A (en) * | 1995-12-19 | 1998-03-19 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Enhancement of dna immunization through the use of cytokines |
-
1999
- 1999-02-10 JP JP2000531189A patent/JP2002502884A/ja active Pending
- 1999-02-10 PT PT99905946T patent/PT1053017E/pt unknown
- 1999-02-10 AT AT99905946T patent/ATE275421T1/de not_active IP Right Cessation
- 1999-02-10 CN CNB998043311A patent/CN1224422C/zh not_active Expired - Fee Related
- 1999-02-10 CA CA 2320041 patent/CA2320041A1/en not_active Abandoned
- 1999-02-10 AU AU25981/99A patent/AU764036B2/en not_active Ceased
- 1999-02-10 DK DK99905946T patent/DK1053017T3/da active
- 1999-02-10 US US09/247,635 patent/US6488936B1/en not_active Expired - Fee Related
- 1999-02-10 WO PCT/US1999/002923 patent/WO1999040938A2/en not_active Ceased
- 1999-02-10 KR KR1020007008769A patent/KR100622716B1/ko not_active Expired - Fee Related
- 1999-02-10 EP EP19990905946 patent/EP1053017B1/en not_active Expired - Lifetime
- 1999-02-10 DE DE1999619984 patent/DE69919984T2/de not_active Expired - Fee Related
- 1999-02-10 IL IL13781199A patent/IL137811A/en not_active IP Right Cessation
- 1999-02-10 ES ES99905946T patent/ES2226338T3/es not_active Expired - Lifetime
- 1999-02-10 BR BR9907883A patent/BR9907883A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9907883A (pt) | 2000-11-14 |
| ATE275421T1 (de) | 2004-09-15 |
| US6488936B1 (en) | 2002-12-03 |
| AU2598199A (en) | 1999-08-30 |
| WO1999040938A3 (en) | 2000-08-24 |
| IL137811A0 (en) | 2001-10-31 |
| DE69919984D1 (de) | 2004-10-14 |
| ES2226338T3 (es) | 2005-03-16 |
| KR100622716B1 (ko) | 2006-09-13 |
| KR20010040867A (ko) | 2001-05-15 |
| CN1224422C (zh) | 2005-10-26 |
| CA2320041A1 (en) | 1999-08-19 |
| AU764036B2 (en) | 2003-08-07 |
| EP1053017B1 (en) | 2004-09-08 |
| PT1053017E (pt) | 2004-12-31 |
| DK1053017T3 (da) | 2004-11-22 |
| EP1053017A2 (en) | 2000-11-22 |
| WO1999040938A2 (en) | 1999-08-19 |
| DE69919984T2 (de) | 2005-11-17 |
| CN1299287A (zh) | 2001-06-13 |
| IL137811A (en) | 2005-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002502884A (ja) | インターロイキン−１２および単純ヘルペスウイルス抗原を含んでなるワクチン | |
| JP3530526B2 (ja) | ＨＳＶ糖蛋白質ｇＤおよび３脱アシル化モノホスホリルリピッドＡからなる単純ヘルペスワクチン | |
| Hu et al. | Immunostimulating complexes (ISCOMs) for nasal vaccination | |
| SK159294A3 (en) | Vaccine composition, method of its preparation and using | |
| KR102363359B1 (ko) | 대상포진 백신 조성물 | |
| Villacres-Eriksson et al. | IMMUNOMODULATION BYQUILLAJA SAPONARIAADJUVANT FORMULATIONS: IN VIVO STIMULATION OF INTERLEUKIN 12 AND ITS EFFECTS ON THE ANTIBODY RESPONSE | |
| Hassan et al. | Immune responses in mice induced by HSV-1 glycoproteins presented with ISCOMs or NISV delivery systems | |
| Kohama et al. | Immunostimulatory oligodeoxynucleotide induces TH1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice | |
| Fernando et al. | Vaccine‐induced Th1‐type responses are dominant over Th2‐type responses in the short term whereas pre‐existing Th2 responses are dominant in the longer term | |
| Iosef et al. | Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes | |
| Dotsika et al. | Influence of Quillaja saponaria triterpenoid content on the immunomodulatory capacity of Epstein–Barr virus Iscoms | |
| Villacres‐Eriksson et al. | The induction of cell‐associated and secreted IL‐1 by iscoms, matrix or micelles in murine splenic cells | |
| US20100233117A1 (en) | Adjuvant combination formulations | |
| JP2002526420A (ja) | 脊椎動物における実質的に無毒で生物学的に活性な粘膜アジュバント | |
| HANCOCK et al. | QS-21 synergizes with recombinant interleukin-12 to create a potent adjuvant formulation for the fusion protein of respiratory syncytial virus | |
| EP0604727A1 (en) | Improved immunogenicity of a vaccine by incorporation of a cytokine within an immune-stimulating complex containing an antigen | |
| TWI239848B (en) | Adjuvant combination formulations | |
| MXPA00007878A (OSRAM) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060112 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060112 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20080509 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090224 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090623 |