JP2002501047A - Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体 - Google Patents

Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体

Info

Publication number
JP2002501047A
JP2002501047A JP2000528538A JP2000528538A JP2002501047A JP 2002501047 A JP2002501047 A JP 2002501047A JP 2000528538 A JP2000528538 A JP 2000528538A JP 2000528538 A JP2000528538 A JP 2000528538A JP 2002501047 A JP2002501047 A JP 2002501047A
Authority
JP
Japan
Prior art keywords
compound according
compound
azetidine
carboxamide
hydroxypropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000528538A
Other languages
English (en)
Japanese (ja)
Inventor
デイビッド レギナルド アダムス，
イアン アンソニー クリフ，
ハワード ランガム マンセル，
ナザニエル ジュリアス モンク，
Original Assignee
バーナリス リサーチ リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バーナリス リサーチ リミテッド filed Critical バーナリス リサーチ リミテッド
Publication of JP2002501047A publication Critical patent/JP2002501047A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2000528538A 1998-01-23 1999-01-22 Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体 Withdrawn JP2002501047A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9801501.9 1998-01-23
GBGB9801501.9A GB9801501D0 (en) 1998-01-23 1998-01-23 Chemical compounds - II
PCT/GB1999/000224 WO1999037614A1 (fr) 1998-01-23 1999-01-22 Derives d'azetidinecarboxamide destines au traitement de troubles du systeme nerveux central

Publications (1)

Publication Number Publication Date
JP2002501047A true JP2002501047A (ja) 2002-01-15

Family

ID=10825809

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000528538A Withdrawn JP2002501047A (ja) 1998-01-23 1999-01-22 Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体

Country Status (8)

Country Link
US (1) US6514961B1 (fr)
EP (1) EP1049671B1 (fr)
JP (1) JP2002501047A (fr)
AT (1) ATE264840T1 (fr)
AU (1) AU2178199A (fr)
DE (1) DE69916577D1 (fr)
GB (1) GB9801501D0 (fr)
WO (1) WO1999037614A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011513374A (ja) * 2008-03-04 2011-04-28 ヴァーナリス アールアンドディー リミテッド アゼチジン誘導体
JP2019536757A (ja) * 2016-10-13 2019-12-19 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 造血器型プロスタグランジンｄシンターゼ阻害剤としての１，３二置換シクロブタンまたはアゼチジン誘導体

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9917385D0 (en) * 1999-07-23 1999-09-22 Cerebrus Ltd Chemical compounds-I
GB9917386D0 (en) * 1999-07-23 1999-09-22 Cerebrus Ltd Chemical compounds-II

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226861A (en) * 1978-04-18 1980-10-07 A. H. Robins Company, Inc. N-Lower-alkyl 3-phenoxy-1-azetidinecarboxamides
US4505907A (en) * 1982-09-02 1985-03-19 A. H. Robins Company, Inc. N-Formyl and N-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides
US5068231A (en) 1985-02-28 1991-11-26 A. H. Robins Company Incorporated Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
FI87559C (fi) * 1985-02-28 1993-01-25 Robins Co Inc A H Foerfarande foer framstaellning av aktiva 3-fenyloxiazetidinkarboxamider
US5183903A (en) 1991-11-26 1993-02-02 A. H. Robins Company, Incorporated Urea fusion process for the synthesis of 3-phenoxy-1-azetidinecarboxamides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011513374A (ja) * 2008-03-04 2011-04-28 ヴァーナリス アールアンドディー リミテッド アゼチジン誘導体
JP2015038105A (ja) * 2008-03-04 2015-02-26 ヴァーナリス アールアンドディー リミテッドVernalis R&D Limited アゼチジン誘導体
JP2019536757A (ja) * 2016-10-13 2019-12-19 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 造血器型プロスタグランジンｄシンターゼ阻害剤としての１，３二置換シクロブタンまたはアゼチジン誘導体

Also Published As

Publication number Publication date
EP1049671A1 (fr) 2000-11-08
GB9801501D0 (en) 1998-03-18
EP1049671B1 (fr) 2004-04-21
ATE264840T1 (de) 2004-05-15
WO1999037614A1 (fr) 1999-07-29
DE69916577D1 (de) 2004-05-27
AU2178199A (en) 1999-08-09
US6514961B1 (en) 2003-02-04

Similar Documents

Publication Publication Date Title
US7504522B2 (en) Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders
US20090181939A1 (en) Azetidinecarboxamide Derivatives And Their Use In The Treatment Of CB1 Receptor Mediated Disorders
EP1617839B1 (fr) Utilisation de derives d'azetidinecarboxamide a des fins therapeutiques
JP2002523491A (ja) ５−ｈｔ２ｂおよび／または５−ｈｔ２ｃレセプターリガンドとしてのインドール誘導体
EP1049672B1 (fr) Derives d'azetidinecarboxamides utilises pour traiter des troubles du systeme nerveux central
JP2002501047A (ja) Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体
JP4542264B2 (ja) Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体
JP2003505414A (ja) Ｃｎａおよび眼疾患におけるアゼチジン化合物
JP2003505418A (ja) Ｃｎｓ障害の処置のためのアゼチジンカルボキサミド誘導体
WO2001007022A2 (fr) Composes chimiques iii
JP2002501919A (ja) 神経学的障害の治療用の１，４−ジアザシクロヘプタン誘導体
JP2003246732A (ja) １，２−エタンジオール誘導体またはその塩を含有する神経断裂治療剤

Legal Events

Date Code Title Description
A300 Application deemed to be withdrawn because no request for examination was validly filed

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20060404