JP2002322075A - Composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new composition for preventing decayed teeth and for preventing and improving gingivitis and periodontal diseases. SOLUTION: This composition uses the protein coagulation reaction characteristic of astringent persimmon and is useful for dentifrices and mouth wash solutions.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a composition for preventing caries, preventing and improving gingivitis and periodontal disease.

[0002]

2. Description of the Related Art At present, the mainstream of tooth decay prevention and periodontal disease prevention and improvement has been to brush teeth without using toothpaste. A commercially available dentifrice contains an abrasive, which has been accused of causing a wedge-like loss of teeth as a harmful effect due to the act of brushing teeth.
However, if you brush without anything, the taste of the food you eat will remain, or if you have teeth that have pus due to periodontal disease, people complain that "the mouth is sticky and uncomfortable." On the other hand, in the past, he instructed, "If you do the brushing and gum massage carefully and in a correct way and take enough time, the periodontal tissue will eventually improve and be refreshed, so please do your best." Was.

[0003] Current commercial dentifrices are based on the idea of polishing plaque with an abrasive, and the problem of abrasive content at issue has not been solved at all.

On the other hand, the mouthwash is a surfactant and is intended to remove dirt, but is evaluated as having no effect at all. It only sees the same effect as rinsing with water. Bactericidal effects may also have the effect of killing bacteria on the surface of the plaque, but cannot be killed by the dental community as they cannot kill the entire plaque colony. It is a conventional theory that there is only mechanical removal of plaque with a toothbrush or the like.

[0005] Periodontal treatment consists of two methods: bacterial disinfection and environmental improvement.
It is roughly classified into two. As part of periodontal treatment, treatment with antibiotics and antifungals has been attempted, but has not reached the stage of completion. It is not preferable to use these on a daily basis in terms of producing resistant bacteria. Attempts have been made to eliminate bacteria by washing the mouth with a disinfectant, but this has not been successful for the reasons described above. on the other hand,
Environmental improvement methods include toothbrush instruction, periodontal surgery, occlusal adjustment, and correction. The present composition also belongs to this, and, as much as possible, removes the inducing substance by the property of the protein coagulation reaction of the composition, and also aims to alleviate the inflammation by the medicinal component, antibiotics, anti- Contains no fungicides, disinfectants or surfactants. Thereby, it can withstand long-term continuous use.

[0006]

SUMMARY OF THE INVENTION The present invention is directed to preventing tooth decay,
It is an object of the present invention to provide a novel composition effective for preventing and improving gingivitis and periodontal disease.

[0007]

Means for Solving the Problems As a result of research conducted to solve the above problems, the present inventor surprisingly found that persimmon juice is extremely effective in preventing caries, preventing and improving gingivitis, periodontal disease and the like. And completed the present invention.

The following are the main chemical characteristics of persimmon astringent discovered by the present inventors. Protein agglutination-coagulates with plaque floating in the mouth, pus and dirt in pockets, and solidifies these. Bacteriostatic (antibacterial) action-stops bacterial activity in the plaque. Astringent action-Dirt, tartar and other stored matter in the pocket are wrigged and discharged out of the pocket to enhance the cleaning effect. Others-anti-inflammatory action, vasodilator action, etc.

[0009] The present invention provides the above-mentioned chemical properties,
In connection with a composition containing an active ingredient of persimmon juice, the composition is a dentifrice and a mouthwash.

[0010]

DETAILED DESCRIPTION OF THE INVENTION It is a common wisdom that caries, gingivitis and periodontal disease are caused by bacteria in the plaque. In the clinical cases, the effect of periodontal disease improvement was taken up, and the effect of removing the causative substance in teeth and pockets by the dentifrice of the present invention was verified. The reason why tooth brushing is not effective for poor dentists is that even if the inflammatory substance is solidified with the dentifrice of the present invention, it is not removed by brushing the teeth. did.

Persimmon astringent: As a persimmon astringent, for example, a persimmon fruit is put into a container, added with water, and decomposed supernatant liquid, or
Juice obtained by directly pressing persimmon fruit can be used. The quality of astringent persimmon can be represented, for example, by the Baume frequency. The former is usually 2-4 degrees Baume and the latter is usually 5-6 degrees Baume. As the persimmon fruit, there can be used astringent persimmons, for example, Tenno, small astringent, Tsurunoko, Ao persimmon and the like. As the persimmon fruit, immature fruits, for example, healthy persimmons collected from late August to early October can be used.

For example, persimmon fruit can be manufactured by adding water to persimmon fruit, leaving it to stand, and then squeezing the resulting juice to ripen the juice. For example, usually 1 to 50 parts by weight, preferably 5 to 20 parts by weight per 100 parts by weight of persimmon fruit
It can be squeezed after adding water by weight and leaving to stand. Also, after adding water to the persimmon fruit and leaving it for 3 to 9 months, preferably 5 to 6 months, it can be pressed.
Juice obtained by pressing can be ripened by placing it in an appropriate container, sealing and leaving it to stand. In a cool dark place,
It can be aged by leaving it for 3 to 9 months, preferably 4 to 7 months.

Further, for example, by quickly crushing and squeezing persimmon fruit, it is possible to obtain the most astringent about 30%. By adding a small amount of water to the residue and squeezing it to obtain the second and third astringents, the yield can be reduced to about 45%. By leaving these together, the fermentation starts spontaneously, the sugar content gradually decreases, and it is possible to mature. For example, the supernatant which has been stored in a cool and dark place for 1 to 2 years and whose cage has settled out is called "Yamashibu" and is commercially available.

In general, persimmon components include sugars (glucose, fructose, sucrose, mannitol), polysaccharides (pectin) triterpenoids (oleanolic acid, ursolic acid, betulinic acid), carotenoids (lycopene, zeaxanthin, carotene), naphthoquinone , (Geospirin, Isodispirin, Neodispirin, 7-Methyljuglone, Plumbagin, Shinanolone, Magmegaquinone), Vitamin C, Tannin, Galloyl Compounds (Epicatechin, Epigallocatechin), Tannin Condensed with Galloyl Compounds .

As persimmon astringent, for example, tannin 1-1
0% by weight, preferably 4 to 6% by weight, specific gravity 1.02 to
1.04, Baume 2-7 °, preferably 4.5-6
°, pH 3-4.5, total acid 2-3 weight%, dry matter 7-11
A persimmon astringent with an ash content of 0.4 to 0.5% by weight can be used.

Composition: The composition of the present invention can be produced by diluting persimmon juice alone or, if necessary, with a diluent. Examples of the diluent include water, wood vinegar, mouthwash, juice, coffee, black tea, oolong tea, glycerin and other liquids, and various pastes. As the vinegar water, for example, an acetic acid concentration of 3
の 木 15% by weight, preferably 5-10% by weight of wood vinegar can be used. As the mouthwash, a commercially available mouthwash, for example, Mondamine (trade name) manufactured by Earth Pharmaceutical Co., Ltd. can be used.

For example, 10 to 300 ml, preferably 30 to 200 ml of persimmon juice is added to 300 ml of diluent.
More preferably, the composition of the present invention can be produced by dissolving at a ratio of 50 to 150 ml.
When insolubles precipitate when adding and dissolving persimmon juice to the diluent, the insolubles can be removed. Filtration and decantation can be used to remove insolubles.

The whole amount of persimmon juice can be added to and dissolved in the diluent at once. In addition, persimmon astringent can be divided and added. For example, when dissolving 100 ml or 150 ml of persimmon astringent in 300 ml of diluent, adding and dissolving 50 ml of persimmon astringent to remove insoluble components, and then adding and dissolving 50 ml of persimmon astringent, If necessary, 50 ml of persimmon juice can be added and dissolved.

Method of using the composition: By brushing using the composition of the present invention, periodontal diseases such as alveolar pyorrhea can be improved. Specifically, a periodontal disease such as alveolar pyorrhea can be improved by applying the composition of the present invention to a toothbrush and brushing the part to be treated, for example, gums, teeth, and gums.

Brushing can be carried out, for example, by a polishing method called the Phones method. In other words, it is preferable to brush in a circular manner on the basis of circular polishing from the viewpoint of gum massage.

Where to apply the toothbrush, the amount of the composition used,
The number of times (frequency) of brushing and the time per brushing can be determined in consideration of the condition of periodontal disease, gingival sensitivity, and the like.

In general, the larger the amount of the composition used at one time, the higher the therapeutic effect. Typically, 30 ml of the composition is administered for 30 days, preferably 20 days, more preferably 7 to 1 day.
It can be treated effectively by using it for 4 days.

In general, the greater the frequency of brushing the teeth, the higher the therapeutic effect. Usually 1 to 6 times a day, preferably 2 to 4 times
By brushing the teeth three times, for example, three times in the morning, noon, and evening, the sway of the teeth can be stopped, and the pocket can be improved.

In general, the longer the time per toothpaste, the higher the therapeutic effect. However, if tooth brushing is continuously performed for a long time, the gums may become bulky or swollen. Usually, once per 1 to 10 minutes,
It can be effectively treated by brushing the teeth for preferably 2 to 6 minutes.

Patients with little experience of brushing should preferably brush lightly at first. If it hurts in particular, it is preferable to brush the teeth so that it is rubbed. Experiencing tooth brushing will enable you to brush strongly.

[0026]

[Example] Examination method: The degree of alveolar pyorrhea was examined by a Perio test (alveolar pyorrhea test). The PERIO test is a test for examining the depth of the pocket (EPP) and the degree of tooth movement, that is, the degree of tooth movement (TM). From the results of the PERI test, the degree of alveolar pyorrhea can be known. That is, the greater the value of EPP and the value of TM, the worse the alveolar pyorrhea is.

The pocket is a portion where a gap between a tooth and a gum is formed as a valley. The pockets are a place where plaque and tartar accumulate, causing alveolar purulence. The deeper the depth of the pocket (EPP), the easier it is for bacteria to accumulate, and the alveolar pyorrhea is also progressing.

For healthy teeth, the EPP is 1-2 mm.
For mild alveolar pyorrhea, the EPP is 3-4 mm. For moderate alveolar pyorrhea, the EPP is 5-6 mm. In severe alveolar pyorrhea, the EPP is 7 mm or more. Severe alveolar pyorrhea is an end-stage symptom that can cause tooth wobbles with bad pain and cause bad breath.
It is almost hopeless and has traditionally been the subject of tooth extraction.

The tooth sway (TM) can be represented by a number. TM0 teeth show firm teeth. TM1
Has a periodontal pyorrhea and is at the stage of caution,
Moving teeth may or may not have subjective symptoms. TM2 teeth have severe alveolar pyorrhea and have subjective symptoms of tooth movement. In TM3 teeth, the alveolar pyorrhea is at a late stage, and the teeth are shaky in a state that it is painful and cannot be recovered by conventional methods. TM4
'S teeth are about to be torn. In the following embodiments, the case of TM0 is not specified.

Generally, there is a correlation between the depth of the pocket (EPP) and the degree of motion (TM), and the deeper the teeth of the EPP, the larger the TM.

Production of a composition: 300 ml of commercially available mouthwash (Mondamine manufactured by Earth Pharmaceutical Co., Ltd.) was added to commercially available persimmon juice 5
After 0 ml was added and dissolved, the insolubles precipitated were removed by filtration. Composition A was obtained by adding and dissolving 50 ml of commercially available persimmon juice to the filtrate, and composition B was obtained by further adding and dissolving 50 ml of commercially available persimmon juice.

As the persimmon astringency, a ball astringency manufactured by Osaka Nishikawa Co., Ltd. was used. Yutamushi has tannin (persimmon tannin) as a main component and is marketed as a liquor clarifier, a protein-based food clarifier, or a food additive. Tamadabu is a light brown to dark brown liquid with a peculiar smell, easily soluble in water, ethanol, acetone, hardly soluble or insoluble in ether, benzene, chloroform, etc., lime, potassium carbonate, lead acetate, etc. Precipitates with heavy metals, alkaloids, proteins, etc., and becomes dark green, dark blue or dark black due to iron salts, and precipitates.

Example 1: Two teeth of EPP 4 mm, EP
Composition for a patient with alveolar pyorrhea (40-year-old woman) having 27 teeth of P3mm (9 of TM1 teeth) and 1 of EPP2mm (TM1) teeth twice a day at a time. It was formulated to perform brushing for 2 minutes using A3 drops (about 0.3 ml).

When a periodical examination was performed 1.5 months after the start of treatment, eight teeth of EPP 3 mm and EPP 2 mm
Markedly improved to 22 teeth (including four TM0.5 teeth).

Example 2: 11 teeth of EPP 4 mm, E
For a patient with alveolar pyorrhea (64-year-old woman) having 9 PP3 mm teeth and 8 EPP2 mm (TM1) teeth, using a composition A 0.4 ml per time for 2 minutes twice a day for 2 minutes It was prescribed to perform tooth brushing.

A 1.1 month after the start of the treatment, a periodical examination was carried out. As a result, 14 teeth of EPP 3 mm and EPM 2 m
The number of teeth of m was 14 (including one tooth of TM1 and six teeth of TM0.5), which was remarkably improved.

Example 3: Four teeth of EPP 4 mm, EP
Composition A or composition per once per twice a day in a patient with alveolar pyorrhea (33-year-old woman) with 15 P3mm teeth and 9 EPP2mm teeth (including 5 TM1 teeth) It was formulated to perform a toothpaste for 2 minutes using 0.4 ml of Material B. Composition A was used for the first month and composition B was used thereafter.

When a periodical examination was performed 1.1 months after the start of treatment, one tooth of EPP 4 mm, 21 teeth of EPP 3 mm (including one tooth of TM0.5) and EPP2
The number of teeth was 6 mm (2 of which were TM0.5), which was remarkably improved.

Example 4: One tooth of EPP 6 mm (TM0.5), one tooth of EPP 5 mm (TM3), EPP
5 teeth of 4mm (including 1 tooth of TM0.5), EP
15 P3mm teeth (including 2 TM1 teeth, TM
0.6 ml of composition A or B at a time twice a day for patients with alveolar pyorrhea (35-year-old woman) having 5 teeth with 0.5 teeth and 5 teeth with 2 mm EPP Then 2
For a minute. Composition A was used for the first month and composition B was used thereafter.

When a periodical examination was performed 1.1 months after the start of the treatment, 15 teeth with an EPP of 3 mm (including TM0.5
2 teeth) and 11 teeth with 2 mm EPP (of which T
M0.5 teeth) (3 teeth).

Example 5: One tooth of EPP 7 mm (TM1), two teeth of EPP 5 mm (TM1), EPP 4 m
m teeth (including three TM1 teeth) and EPP
For a patient with alveolar pyorrhea (35-year-old woman) who has 8 3mm teeth (including 2 TM1 teeth), uses A3 drops (about 0.3 ml) of the composition A twice a day twice a day. And brushed for 2 minutes.

When a periodical examination was carried out 1.5 months after the start of the treatment, one tooth of EPP4 mm (TM0.5)
13 PP3mm teeth (including 1 TM1 tooth, TM
The number of teeth was significantly improved to three (0.5 teeth) and six (2) EPP teeth (including one TM0.5 tooth).

Example 6: One tooth of EPP 6 mm (TM2) and fifteen teeth of EPP 4 mm (including one tooth of TM1)
4) and 8 patients with alveolar pyorrhea (55-year-old female) having 3 teeth of EPP (5 teeth of TM1) using 30 ml of composition B at a time twice a day. For a minute.

When a perio examination was performed 10 days after the start of the treatment, two teeth of EPP 4 mm (including one of TM2 teeth 1) were obtained.
11) 3 teeth of EPP 3mm (including 1 tooth of TM1)
The number of teeth was 3 and the number of teeth of TM0.5 was 3), and the number of teeth of EPP 2 mm was 11 (of which 7 were TM0.5).

Example 7: A patient with alveolar pyorrhea (41-year-old woman) having 9 teeth of 4 mm of EPP and 18 teeth of 3 mm of EPP was given a composition A0.4 m / time three times a day.
1 to brush for 1 minute.

A 1.5-period examination was performed 1.5 months after the start of the treatment. As a result, one tooth of EPP 4 mm and EPP 3 mm
Had remarkably improved to 26 teeth.

Example 8: One tooth of 9 mm EPP, EP
One tooth of P6mm, two teeth of EPP4mm and E
For a patient with alveolar pyorrhea (44-year-old woman) having 21 PP3mm teeth (including 7 TM1 teeth), brushing for 2 minutes using 0.7 ml of the composition A at a frequency of 3 times a day. Was performed.

When a perio examination was performed 14 days after the start of the treatment, one tooth of EPP 9 mm and one tooth of EPP 5 mm
5 teeth with 3 mm EPP (including 1 tooth with TM0.5)
19) and 19 teeth of EPP2mm (including TM0.5)
Had 7 teeth).

Example 9: Two teeth of EPP 6 mm (including one tooth of TM1 and one tooth of TM0.5), EPP4
3 mm teeth (including one TM1 tooth and two TM0.5 teeth), 19 EPP3 mm teeth (including five TM1 teeth and six TM0.5 teeth), And EPP2m
For patients with alveolar pyorrhea (51-year-old woman) having two teeth of m (including one tooth of TM0.5), three times a day using 0.9 ml of the composition B at a time three times a day. For a minute.

One month after the start of the treatment, a perio examination was performed. As a result, one tooth of EPP 6 mm (TM1) and one EPP 3 m
m teeth (including one TM1 tooth and four TM0.5 teeth) and 15 teeth having an EPP of 2 mm (including TM)
0.5 teeth (9 teeth).

Example 10: Two teeth of EPP 6 mm, E
6 teeth of PP5mm, 6 teeth of EPP4mm (including 1 tooth of TM1), 7 teeth of EPP3mm (including T
A patient with alveolar pyorrhea (58-year-old woman) having one tooth of M1) and three teeth of EPP 2 mm (TM1) was used three times a day at a frequency of three times a day using 1.4 ml of composition A per time. For a minute.

When a periodical examination was performed 1.5 months after the start of the treatment, 10 teeth of EPP 3 mm and EPM 2 m
The number of teeth m was 13 (of which four were TM0.5), which was remarkably improved.

Example 11: Two teeth of EPP 4 mm, E
16 teeth of PP3mm (including 2 teeth of TM1) and 10 teeth of EPP2mm (including 2 teeth of TM1)
(57-year-old woman) were prescribed to brush for 3 minutes a day using 0.5 ml of Composition A three times a day for 2 minutes.

When a periodical examination was performed 0.9 months after the start of the treatment, 12 teeth of EPP 3 mm and EPP 2 m
The number of teeth of m was remarkably improved to 16 teeth.

Example 12: 5 teeth of EPP 4 mm, E
20 teeth of PP3mm (including 2 teeth of TM1 and TM
For a patient with alveolar pyorrhea (a 67-year-old woman) who has 5 teeth of 0.5 (0.5 teeth) and 4 teeth of 2 mm of EPP (including 3 teeth of TM0.5), once a day at a frequency of 3 times a day Composition A 0.7m
1 to brush for 2 minutes.

A 14 day period after the start of the treatment, a Perio examination was performed. As a result, 22 teeth of EPP 3 mm (including 2 teeth of TM0.5) and 7 teeth of 2 mm of EPP (including TM0.
5 teeth 2).

Example 13: One tooth of EPP 4 mm, E
Brushing a patient with alveolar pyorrhea (male 44 years old) with 18 PP3mm teeth and 8 EPP2mm teeth for 2 minutes, once a day, using 0.3 ml of composition B per time for 2 minutes Was prescribed.

When a perio test was performed 38 days after the start of the treatment, the number of teeth with EPP of 3 mm was significantly improved and the number of teeth of EPP 2 mm was significantly improved to 19.

Example 14: 18 teeth of EPP 4 mm
And 14 teeth of 3 mm EPP (including 3 teeth of TM1)
The patient with alveolar pyorrhea of this book (male 59 years old) was prescribed to brush for 3 minutes twice a day using 0.3 ml of composition A at a time.

One month after the start of the treatment, a perio examination revealed that the number of teeth of EPP was 3 mm and the number of teeth was 15 and the number of teeth of EPP 2 mm was 16.

[0061]

The effect of the dentifrice of the present invention lies in the protein coagulation reaction which is a characteristic of persimmon juice. As a result, plaque, pus, exudate, and blood in the teeth and pockets (gingival sac) can be solidified and removed outside the mouth without using an abrasive.

There are the following advantages as compared with conventional dentifrices. Since no abrasive is contained, wedge-shaped loss due to tooth brushing can be prevented. Produces a protein coagulation reaction with plaque, food residue, food residue juice, suspended matter (bacteria, plaque, exudate, pus, blood, food juice) and captures it as a solid, so it efficiently removes inflammatory substances in the mouth , Can be excluded outside the mouth. Plaque, exudate, pus, and blood in the pockets can also be removed from the pockets by the protein coagulation reaction and the astringent action, which is effective in preventing and improving periodontal disease.

Claims (3)

[Claims] 1. A composition containing an active ingredient of persimmon juice. 2. The composition according to claim 1, which is a dentifrice. 3. The composition according to claim 1, which is a mouthwash.