JP2002308737A - Hair growing composition - Google Patents
Hair growing compositionInfo
- Publication number
- JP2002308737A JP2002308737A JP2002102372A JP2002102372A JP2002308737A JP 2002308737 A JP2002308737 A JP 2002308737A JP 2002102372 A JP2002102372 A JP 2002102372A JP 2002102372 A JP2002102372 A JP 2002102372A JP 2002308737 A JP2002308737 A JP 2002308737A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- minoxidil
- mass
- ethanol
- hair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 30
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229960003632 minoxidil Drugs 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940058015 1,3-butylene glycol Drugs 0.000 claims abstract description 15
- 235000019437 butane-1,3-diol Nutrition 0.000 claims abstract description 15
- 230000000694 effects Effects 0.000 claims abstract description 10
- 230000003779 hair growth Effects 0.000 claims description 11
- 238000013329 compounding Methods 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229960004756 ethanol Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008213 purified water Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- -1 fatty acid ester Chemical class 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- IHCCLXNEEPMSIO-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 IHCCLXNEEPMSIO-UHFFFAOYSA-N 0.000 description 1
- ZIMGGGWCDYVHOY-UHFFFAOYSA-N 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Chemical compound N=C1N(O)C(N)=CC(N2CCCCC2)=N1 ZIMGGGWCDYVHOY-UHFFFAOYSA-N 0.000 description 1
- 208000019300 CLIPPERS Diseases 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 1
- 229940043276 diisopropanolamine Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は育毛効果に優れた育
毛組成物に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restoring composition having an excellent hair restoring effect.
【０００２】[0002]
【従来の技術】ミノキシジルは、化学名を６−（１−ピ
ペリジニル）−２，４−ピリミジンジアミン−３−オキ
サイドと称し、米国特許第４，１３９，６１９号に育毛
剤としての適用が述べられている。そして、現在では日
本においてもミノキシジル含有の外用育毛剤が使用、販
売されている。2. Description of the Related Art Minoxidil has a chemical name of 6- (1-piperidinyl) -2,4-pyrimidinediamine-3-oxide, and its application as a hair restorer is described in U.S. Pat. No. 4,139,619. ing. At present, minoxidil-containing external hair growth agents are used and sold in Japan.
【０００３】[0003]
【発明が解決しようとする課題】本発明は、効果の増強
したミノキシジル含有育毛組成物を提供することを目的
とする。SUMMARY OF THE INVENTION An object of the present invention is to provide a minoxidil-containing hair growth composition having an enhanced effect.
【０００４】[0004]
【課題を解決するための手段】上記目的を達成するべく
鋭意検討を重ねた結果、ある特定の溶媒を特定量配合
し、特定のｐＨに調整したときにミノキシジルの育毛効
果が著しく向上することを見いだし、本発明を完成する
に至った。As a result of intensive studies to achieve the above object, it was found that the hair growth effect of minoxidil is remarkably improved when a specific solvent is blended in a specific amount and adjusted to a specific pH. They have found and completed the present invention.
【０００５】すなわち、本発明は、ミノキシジル、１，
３−ブチレングリコール、エタノール及び水を含有し、
ミノキシジルの配合量が１〜４質量％、１，３−ブチレ
ングリコールの配合量が１０〜３０質量％、エタノール
の配合量が４０〜７５質量％であり、かつ、ｐＨが７．
０〜９．５であることを特徴とする育毛組成物である。That is, the present invention relates to minoxidil,
Containing 3-butylene glycol, ethanol and water,
The amount of minoxidil is 1 to 4% by mass, the amount of 1,3-butylene glycol is 10 to 30% by mass, the amount of ethanol is 40 to 75% by mass, and the pH is 7.
0 to 9.5.
【０００６】[0006]
【発明の実施の形態】本発明の組成物においてミノキシ
ジルの濃度は組成物全体の１〜４質量％であるが、好ま
しくは２〜４質量％である。BEST MODE FOR CARRYING OUT THE INVENTION In the composition of the present invention, the concentration of minoxidil is 1 to 4% by mass of the whole composition, preferably 2 to 4% by mass.
【０００７】本発明の組成物は、ｐＨ７．０〜９．５が
好ましく、さらに好ましくはｐＨ８．０〜９．５であ
る。本発明の組成物のｐＨ調整は、通常使用されるｐＨ
調整剤を使用することができ、具体的には、例えば、ク
エン酸、リンゴ酸、乳酸などの有機酸やその塩、リン
酸、塩酸、硫酸などの無機酸やその塩、水酸化ナトリウ
ムなどの塩基を挙げることができる。The composition of the present invention preferably has a pH of 7.0 to 9.5, and more preferably has a pH of 8.0 to 9.5. Adjustment of the pH of the composition of the present invention is carried out by using a commonly used pH.
Modifiers can be used, specifically, for example, citric acid, malic acid, organic acids and salts thereof such as lactic acid, phosphoric acid, hydrochloric acid, inorganic acids and salts thereof such as sulfuric acid, sodium hydroxide and the like Bases can be mentioned.
【０００８】本発明の組成物は、その使用感の点からエ
タノール及び水を配合する。エタノールの配合量は、組
成物全体の４０〜７５質量％である。水の配合量は、組
成物全体の３０質量％以下であることが好ましい。[0008] The composition of the present invention contains ethanol and water in view of its feeling of use. The blending amount of ethanol is 40 to 75% by mass of the whole composition. The amount of water is preferably not more than 30% by mass of the whole composition.
【０００９】本発明の組成物では、本発明の効果を損な
わない範囲で１，３−ブチレングリコールとともに他の
多価アルコールを溶媒として配合することができる。In the composition of the present invention, other polyhydric alcohols can be blended with 1,3-butylene glycol as a solvent as long as the effects of the present invention are not impaired.
【００１０】本発明の組成物の形態は、特に限定される
ものではなく、ローション剤、エアゾール剤、ゲル剤等
いずれでも採ることができ、その製造方法は、医薬品又
は化粧料の製剤化における一般的な方法で調製すること
ができる。[0010] The form of the composition of the present invention is not particularly limited, and may be any of lotions, aerosols, gels, and the like. Can be prepared by a conventional method.
【００１１】なお、本発明の組成物は、必要に応じ、溶
解補助剤（脂肪酸エステル、多価アルコール、多価アル
コール脂肪酸エステル、中鎖脂肪酸グリセリド、植物
油、アルキルグリセリルエーテル）、界面活性剤（非イ
オン性界面活性剤、レシチン誘導体、高分子乳化剤）、
乳化安定剤、吸収促進剤などを配合することができる。The composition of the present invention may contain, if necessary, a solubilizing agent (fatty acid ester, polyhydric alcohol, polyhydric alcohol fatty acid ester, medium-chain fatty acid glyceride, vegetable oil, alkyl glyceryl ether), a surfactant (non- Ionic surfactant, lecithin derivative, polymer emulsifier),
An emulsion stabilizer, an absorption promoter and the like can be blended.
【００１２】[0012]
【発明の効果】本発明により、効果の増強したミノキシ
ジル含有育毛組成物の提供が可能となった。According to the present invention, it has become possible to provide a hair growth composition containing minoxidil with enhanced effects.
【００１３】[0013]
【実施例】以下、実施例および試験例により本発明をさ
らに詳細に説明する。The present invention will be described in more detail with reference to the following Examples and Test Examples.
【００１４】実施例１ ミノキシジル１ｇ、1,3-ブチレングリコール１０ｇ、エ
タノール６５ｇを混合溶解し、精製水で全量を１００ｍ
Ｌとし、撹拌溶解してローションタイプの組成物を調製
した。組成物のｐＨは８．５であった。Example 1 1 g of minoxidil, 10 g of 1,3-butylene glycol and 65 g of ethanol were mixed and dissolved, and the total amount was 100 m with purified water.
L, and stirred and dissolved to prepare a lotion-type composition. The pH of the composition was 8.5.
【００１５】実施例２ ミノキシジル２ｇ、1,3-ブチレングリコール２５ｇ、エ
タノール４０ｇ、ジブチルヒドロキシトルエン０．１ｇ
を攪拌溶解し、精製水で全量を１００ｍＬとし、ローシ
ョンタイプの組成物を調製した。組成物のｐＨは８．６
であった。Example 2 Minoxidil 2 g, 1,3-butylene glycol 25 g, ethanol 40 g, dibutylhydroxytoluene 0.1 g
Was dissolved by stirring, and the total amount was adjusted to 100 mL with purified water to prepare a lotion-type composition. The pH of the composition is 8.6
Met.
【００１６】実施例３ ミノキシジル３ｇ、1,3-ブチレングリコール２５ｇ、エ
タノール５０ｇ、ジブチルヒドロキシトルエン０．５ｇ
を攪拌溶解し、精製水で全量を１００ｍＬとし、ローシ
ョンタイプの組成物を調製した。組成物のｐＨは８．８
であった。Example 3 Minoxidil 3g, 1,3-butylene glycol 25g, ethanol 50g, dibutylhydroxytoluene 0.5g
Was stirred and dissolved, and the total amount was adjusted to 100 mL with purified water to prepare a lotion-type composition. The pH of the composition is 8.8
Met.
【００１７】実施例４ ミノキシジル３ｇ、1,3-ブチレングリコール１５ｇ、エ
タノール６０ｇ、ブチルヒドロキシアニソール０．５ｇ
を攪拌溶解し、精製水で全量を１００ｍＬとし、ローシ
ョンタイプの組成物を調製した。組成物のｐＨは８．８
であった。Example 4 3 g of minoxidil, 15 g of 1,3-butylene glycol, 60 g of ethanol, 0.5 g of butylhydroxyanisole
Was dissolved by stirring, and the total amount was adjusted to 100 mL with purified water to prepare a lotion-type composition. The pH of the composition is 8.8
Met.
【００１８】実施例５ ミノキシジル４ｇ、1,３-ブチレングリコール１０ｇ、
エタノール６０ｇを攪拌溶解し、精製水で全量を１００
ｍＬとし、ローションタイプの組成物を調製した。組成
物のｐＨは９．１であった。Example 5 Minoxidil 4 g, 1,3-butylene glycol 10 g,
Ethanol (60 g) was dissolved by stirring, and the total amount was adjusted to 100 with purified water.
mL, and a lotion-type composition was prepared. The pH of the composition was 9.1.
【００１９】実施例６ ミノキシジル３ｇ、1,3-ブチレングリコール１０ｇ、エ
タノール６０ｇを攪拌溶解し、精製水で全量を１００ｍ
Ｌとし、ローションタイプの組成物を調製した。リン酸
を適量添加しｐＨを７．１に調整した。Example 6 3 g of minoxidil, 10 g of 1,3-butylene glycol and 60 g of ethanol were dissolved by stirring, and the total amount was adjusted to 100 m with purified water.
L, and a lotion type composition was prepared. Phosphoric acid was added in an appropriate amount to adjust the pH to 7.1.
【００２０】実施例７ 精製水１６．６ｇにヒドロキシプロピルセルロース０．
２５ｇおよびカルボキシビニルポリマー０．５ｇを攪拌
しながら分散、膨潤させた。これにミノキシジル３ｇ、
1,３-ブチレングリコール１５ｇ、エタノール５４．１
５ｇ、ジイソプロパノールアミン０．５ｇおよび精製水
１０ｇを攪拌溶解させた液を添加し、混合攪拌して透明
なゲルタイプの育毛組成物を得た。組成物のｐＨは７．
７であった。EXAMPLE 7 Hydroxypropylcellulose was added to 16.6 g of purified water at a concentration of 0.1%.
25 g and 0.5 g of carboxyvinyl polymer were dispersed and swelled while stirring. 3 g of minoxidil,
1,3-butylene glycol 15 g, ethanol 54.1
A solution in which 5 g, 0.5 g of diisopropanolamine and 10 g of purified water were stirred and dissolved was added, and the mixture was stirred to obtain a transparent gel-type hair growth composition. The pH of the composition is 7.
It was 7.
【００２１】実施例８ 実施例１で得たローション剤５０ｍＬをエアゾール缶に
充填し、さらにジメチルエーテル５０ｍＬを充填し、エ
アゾールタイプの組成物を調製した。Example 8 An aerosol can was filled with 50 mL of the lotion obtained in Example 1 and further charged with 50 mL of dimethyl ether to prepare an aerosol type composition.
【００２２】実施例９ ミノキシジル１ｇ、1,3-ブチレングリコール１０ｇ、エ
タノール６０．０５ｇを混合溶解し、精製水で全量を１
００ｍＬとし、撹拌溶解してローションタイプの組成物
を調製した。組成物のｐＨは８．６であった。Example 9 1 g of minoxidil, 10 g of 1,3-butylene glycol and 60.05 g of ethanol were mixed and dissolved, and the whole amount was adjusted to 1 with purified water.
The solution was made up to 00 mL, stirred and dissolved to prepare a lotion-type composition. The pH of the composition was 8.6.
【００２３】比較例１ ミノキシジル１ｇ、プロピレングリコール１０．４ｇ、
エタノール６０．０５ｇを混合溶解し、精製水で全量を
１００ｍＬとし、撹拌溶解してローションタイプの組成
物を調製した。組成物のｐＨは８．４であった。Comparative Example 1 Minoxidil 1 g, propylene glycol 10.4 g,
60.05 g of ethanol was mixed and dissolved, the total amount was adjusted to 100 mL with purified water, and the mixture was dissolved by stirring to prepare a lotion-type composition. The pH of the composition was 8.4.
【００２４】試験例 背部体毛を電気バリカンで剃毛した生後５０日のＣ３Ｈ
マウス（雄性）を無作為に１群９匹に群分けし、検体を
剃毛部（約3×4.5cm）上に１日１回、１週間に５日、15
0μL塗布した。試験開始日より５６日間、発毛状態の観
察を１週間毎に下記の判定基準に基づき行い、比較例と
実施例９の育毛効果を比較した。その結果、図１に表
す。実施例９は比較例に比較し、高い発毛効果を示すこ
とが明らかになった。 判定基準 症状 スコア 毛の伸長は認められない … ０ 毛の伸長が認められる（剃毛部の30％未満） … １ 毛の伸長が認められる（剃毛部の30％以上−60％未満） … ２ 毛の伸長が認められる（剃毛部の60％以上−100％未満） … ３ 全面に毛の伸長が認められる（剃毛部の100％） … ４ Test Example C3H 50 days old after shaving the back body hair with an electric clipper
The mice (male) were randomly divided into groups of 9 animals, and the samples were placed on the shaved area (about 3 × 4.5 cm) once a day for 5 days a week for 5 days.
0 μL was applied. For 56 days from the test start date, the hair growth was observed every week based on the following criteria, and the hair growth effect of Comparative Example and Example 9 was compared. The result is shown in FIG. It was found that Example 9 exhibited a higher hair growth effect than the Comparative Example. Judgment criteria symptoms Score No hair elongation is observed ... 0 Hair elongation is observed (less than 30% of shaved portion) ... 1 Hair elongation is observed (30% or more and less than -60% of shaved portion) ... 2 Hair extension is observed (60% or more and less than -100% of shaved portion) 3 Hair extension is observed on the entire surface (100% of shaved portion) 4
【図面の簡単な説明】[Brief description of the drawings]
【図１】マウス発毛効果試験の結果を表す。FIG. 1 shows the results of a mouse hair growth effect test.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 岡島 孝子 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 (72)発明者 森岡 進 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 (72)発明者 堀江 太郎 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 Ｆターム(参考） 4C083 AC101 AC102 AC121 AC122 AC851 AC852 CC37 DD23 EE22 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Takako Okajima 3-24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Inventor Susumu Morioka 3-24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Inventor Taro Horie 3-24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. F-term (reference) 4C083 AC101 AC102 AC121 AC122 AC851 AC852 CC37 DD23 EE22
Claims (3)
ール、エタノール及び水を含有し、ミノキシジルの配合
量が１〜４質量％、１，３−ブチレングリコールの配合
量が１０〜３０質量％、エタノールの配合量が４０〜７
５質量％であり、かつ、ｐＨが７．０〜９．５であるこ
とを特徴とする育毛組成物。1. Minoxidil, 1,3-butylene glycol, ethanol and water, wherein the compounding amount of minoxidil is 1 to 4% by mass, the compounding amount of 1,3-butylene glycol is 10 to 30% by mass, 40 to 7
A hair-growing composition characterized by being 5% by mass and having a pH of 7.0 to 9.5.
項１記載の育毛組成物。2. The hair growth composition according to claim 1, wherein the amount of water is 30% by mass or less.
育毛組成物において、１，３−ブチレングリコール、エ
タノール及び水を配合し、１，３−ブチレングリコール
の配合量を１０〜３０質量％、エタノールの配合量を４
０〜７５質量％とし、かつ、該育毛組成物のｐＨを７．
０〜９．５とすることを特徴とする育毛効果増強方法。3. A hair-growing composition containing 1 to 4% by weight of minoxidil, wherein 1,3-butylene glycol, ethanol and water are mixed, and the amount of 1,3-butylene glycol is 10 to 30% by weight; Increase the amount of ethanol to 4
0 to 75% by mass, and the pH of the hair restoring composition is 7.
0 to 9.5, a method for enhancing hair growth effect.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US01/02950 | 2001-04-05 | ||
| PCT/JP2001/002950 WO2001076542A1 (en) | 2000-04-06 | 2001-04-05 | Hair growth stimulant compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002308737A true JP2002308737A (en) | 2002-10-23 |
Family
ID=11737230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002102372A Pending JP2002308737A (en) | 2001-04-05 | 2002-04-04 | Hair growing composition |
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| Country | Link |
|---|---|
| JP (1) | JP2002308737A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014017573A1 (en) * | 2012-07-27 | 2014-01-30 | 大正製薬株式会社 | Composition for agent for external use |
| JP2014214099A (en) * | 2013-04-24 | 2014-11-17 | ロート製薬株式会社 | Composition for external application containing minoxidil |
| JP2017078044A (en) * | 2015-10-21 | 2017-04-27 | 大正製薬株式会社 | Hair Restorer Composition |
| JP2017186309A (en) * | 2016-03-30 | 2017-10-12 | 大正製薬株式会社 | Aerosol agent |
| JP2017206558A (en) * | 2017-08-22 | 2017-11-24 | ロート製薬株式会社 | Minoxidil-containing external composition |
| JP2019014764A (en) * | 2018-11-06 | 2019-01-31 | ロート製薬株式会社 | Minoxidil-containing external composition |
-
2002
- 2002-04-04 JP JP2002102372A patent/JP2002308737A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014017573A1 (en) * | 2012-07-27 | 2014-01-30 | 大正製薬株式会社 | Composition for agent for external use |
| JPWO2014017573A1 (en) * | 2012-07-27 | 2016-07-11 | 大正製薬株式会社 | External preparation composition |
| JP2014214099A (en) * | 2013-04-24 | 2014-11-17 | ロート製薬株式会社 | Composition for external application containing minoxidil |
| JP2017078044A (en) * | 2015-10-21 | 2017-04-27 | 大正製薬株式会社 | Hair Restorer Composition |
| JP2017186309A (en) * | 2016-03-30 | 2017-10-12 | 大正製薬株式会社 | Aerosol agent |
| JP2017206558A (en) * | 2017-08-22 | 2017-11-24 | ロート製薬株式会社 | Minoxidil-containing external composition |
| JP2019014764A (en) * | 2018-11-06 | 2019-01-31 | ロート製薬株式会社 | Minoxidil-containing external composition |
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