JP2002302458A5 - - Google Patents

Info

Publication number

JP2002302458A5

JP2002302458A5 JP2001392778A JP2001392778A JP2002302458A5 JP 2002302458 A5 JP2002302458 A5 JP 2002302458A5 JP 2001392778 A JP2001392778 A JP 2001392778A JP 2001392778 A JP2001392778 A JP 2001392778A JP 2002302458 A5 JP2002302458 A5 JP 2002302458A5

Authority

JP

Japan

Prior art keywords

disease

group

drugs

heart failure

myocardial infarction

Prior art date

2001-12-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

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• 229940079593 drug Drugs 0.000 claims description 43
• 239000003112 inhibitor Substances 0.000 claims description 22
• 208000010125 myocardial infarction Diseases 0.000 claims description 15
• 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 claims description 12
• 150000003431 steroids Chemical class 0.000 claims description 11
• 206010012438 Dermatitis atopic Diseases 0.000 claims description 10
• 230000003092 anti-cytokine Effects 0.000 claims description 10
• 206010003246 arthritis Diseases 0.000 claims description 10
• 201000008937 atopic dermatitis Diseases 0.000 claims description 10
• 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims description 10
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 10
• 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims description 10
• 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims description 10
• 230000006433 tumor necrosis factor production Effects 0.000 claims description 10
• 208000030507 AIDS Diseases 0.000 claims description 9
• 208000026872 Addison Disease Diseases 0.000 claims description 9
• 208000024827 Alzheimer disease Diseases 0.000 claims description 9
• 206010002383 Angina Pectoris Diseases 0.000 claims description 9
• 206010003210 Arteriosclerosis Diseases 0.000 claims description 9
• 206010004053 Bacterial toxaemia Diseases 0.000 claims description 9
• 208000014644 Brain disease Diseases 0.000 claims description 9
• 206010048962 Brain oedema Diseases 0.000 claims description 9
• 206010007556 Cardiac failure acute Diseases 0.000 claims description 9
• 206010007558 Cardiac failure chronic Diseases 0.000 claims description 9
• 206010007559 Cardiac failure congestive Diseases 0.000 claims description 9
• 206010008111 Cerebral haemorrhage Diseases 0.000 claims description 9
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 9
• 206010009900 Colitis ulcerative Diseases 0.000 claims description 9
• 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 9
• 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 9
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 9
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• 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims description 9
• 206010020772 Hypertension Diseases 0.000 claims description 9
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• 201000006704 Ulcerative Colitis Diseases 0.000 claims description 9
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• 206010000891 acute myocardial infarction Diseases 0.000 claims description 9
• 208000026935 allergic disease Diseases 0.000 claims description 9
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 9
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• 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 6
• 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 description 6
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• 125000005115 alkyl carbamoyl group Chemical group 0.000 description 6
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• 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 5
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• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 5
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• 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 5
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 5
• 239000003242 anti bacterial agent Substances 0.000 description 5
• 239000000496 cardiotonic agent Substances 0.000 description 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 5
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• 125000006618 5- to 10-membered aromatic heterocyclic group Chemical group 0.000 description 4
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 4
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 4
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• 125000001072 heteroaryl group Chemical group 0.000 description 4
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• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 4
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• 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 3
• 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 description 3
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• 125000004658 aryl carbonyl amino group Chemical group 0.000 description 3
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• AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 description 3
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• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 3
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• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
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• WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 2
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 2
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• BGRJTUBHPOOWDU-NSHDSACASA-N (S)-(-)-sulpiride Chemical compound CCN1CCC[C@H]1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-NSHDSACASA-N 0.000 description 2
• UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 description 2
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 2
• 125000002373 5 membered heterocyclic group Chemical group 0.000 description 2
• GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 description 2
• JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 2
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 2
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• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
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• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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