JP2002272418A - Health food and method for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a health food usable for maintaining beauty and health, taking a measure for pollinosis and preventing lifestyle-related diseases such as cancer and usable as another immunodepression preventive or the like. SOLUTION: This health food is obtained by formulating a ceramide to an extract of Agaricus; more specifically, a powdered plant ceramide is mixed with the Agaricus extract at 0.5-2 wt.% per 1 g granular Agaricus extract and the resultant is formed to a tablet-type, a soft capsule-type, a cream-type for wafer sandwiches, a powdered food-type, an emulsified liquid-type or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to maintenance of beauty and health, measures against hay fever, prevention of lifestyle-related diseases such as cancer,
The present invention relates to other health foods that can be used as immunity lowering preventive agents and the like and a method for producing the same.

[0002]

2. Description of the Related Art Conventionally, maintenance of beauty and health, hay fever measures,
Many health foods have been proposed as preventive agents for lifestyle-related diseases such as cancer and other agents for preventing a decrease in immunity. However, there is no known health food that can be used for hay fever control.

[0003]

Ceramide is a substance belonging to sphingolipids, which comprises a long-chain base such as sphingosine and a fatty acid, and bovine brain has been used as a natural raw material of ceramide along with synthetic products. However, since the occurrence of mad cow disease in 1986, a shift phenomenon from ceramide products derived from animal tissues to plant ceramide products has occurred.
In addition, there are many examples in which ceramide improves the moisturizing effect in external use, but it has been pointed out that external use has an effect only on the applied portion.

Accordingly, the present invention has been made in view of the above-mentioned various circumstances, and maintains beauty and health, countermeasures against hay fever, prevents cancer and other lifestyle-related diseases, and provides other immunity. An object of the present invention is to provide a health food that can be used as an anti-decrease agent and a method for producing the same.

[0005]

In order to achieve the above-mentioned object, a health food according to the present invention comprises an extract of Agaricus mushroom and a ceramide. In addition, the ceramide is formed by using a plant substance belonging to glycosphingolipid in which a saccharide such as glucose or galactose is added to the ceramide. Further, the ceramide used is a wheat germ extract containing about 3% by weight of glucosylceramide, and is used in the form of a tablet product type, a soft capsule type, a wafer sand cream type, a powdered food type, a liquid type by emulsification, and the like. Applicable to On the other hand, in the manufacturing method of health food, about 1 gram of the extract granules of Agaricus mushrooms, about 0.5 g
About 2% by weight of plant ceramide powder is mixed,
This is processed and formed into a tableting product type, a soft capsule type, a wafer sand cream type, a powdered food type, a liquid type by emulsification, and the like.

In the health food according to the present invention and the method for producing the same as described above, ceramide is a component present in the skin, blood, brain and the like of humans and animals, and connects keratinocytes of skin epidermis to moisturize. For example, by taking ceramide contained in wheat germ as a food, ceramide can be replenished to the epidermis of the whole body, and it is possible to maintain the freshness and firmness of the skin because it plays an important role to strengthen the surface .
In addition, ceramide is not only a cosmetic material to be eaten, but also enhances the water retention function of the skin, so it is also effective in preventing hay fever. Agaricus mushrooms, on the other hand, have the function of enhancing the immunity of the human body in a well-balanced manner, improving the natural healing power inherent in humans, and making the body beautiful. In general, the synergistic effect of agaricus mushrooms and ceramide exerts a sufficient effect not only on beauty and health maintenance but also on measures against pollinosis caused by cedar pollen and the like.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described below with reference to the drawings. The health food of the present embodiment is composed of a granule of an extract of Agaricus mushroom which is effective in preventing lifestyle-related diseases including cancer, and a plant ceramide powder which has an effect of maintaining beautiful skin. I have. Specifically, for 1 gram of the extract granules of Agaricus mushroom,
It is formed by mixing about 0.5% by weight to about 2% by weight of wheat ceramide powder.

The origin and structure of Agaricus mushroom will be described. Agaricus mushrooms are mainly Brazilian mushrooms of the basidiomycete Agaricaceae family, referred to as "Agaricus brazei muril" and Japanese name "Kawariharatake", and have a function of enhancing human immunity in a well-balanced manner. Among the polysaccharides of Agaricus mushroom, there is a so-called induce effect that activates the production of interferon, a function to prevent the virus from entering the body, a function to protect the immunosuppressive effect, and a further antitumor effect. It has various functions such as effects.

It is known that the antitumor component contained in the Agaricus mushroom is a nucleic acid such as β-D-glucan, heteroglucan, glycoprotein, lectin, steroid and the like. In addition, it is known that an extract of Agaricus mushroom has an activating effect on IL-1β, TNF-α and mRNA expression of peritoneal macrophages and has a cancer preventive effect.

The nutritional components of Agaricus mushrooms are carbohydrates, proteins, ash, fibers, lipids, water, sodium, etc. (Japan Food Research Laboratories 1980119922-0)
No. 01).

The vitamins of Agaricus mushrooms include choline, inositol, niacin, pantothenic acid, riboflavin (vitamin B2), thiamine (vitamin B1), biotin, vitamin D2, etc. (Japan Food Analysis Center No. 198102620-002). issue).

The minerals of Agaricus mushrooms include phosphorus, chlorine, magnesium, calcium, iron, sodium, copper,
Examples thereof include zinc, potassium, manganese, sulfur, silicon, aluminum, and cobalt (Japan Food Analysis Center No. 198102620-001).

The nucleic acids of Agaricus mushrooms are the nucleic acid bases adenine, thymine, cytosine and guanine.

Agaricus mushroom enzymes include peroxidase, esterase, lecithinase, tannase, pectase, saccharase, invertase, maltase, trehalase, cellulase, lactase, glutamul oxidase, mannanase, ligninase, emulsin,
Trypsin, urease, phenolase, laccase,
Peroxylase, dehydrogenase, sucrase, pectinase, decarboxylase, enterokinase,
Fumarase, catalase, ligenase, titase, hemicellulase, inulase, pentozanase, raffinase, amygulase, rennin, pepsin, elepsin, asparaginase, tyrosinase, chymase, adenyl cyclase, lipase, alinase, luciferase, pakimanase, etc. (Pennsylvania State University) Magazine No. 482).

The amino acids of Agaricus mushrooms include arginine, lysine, histidine, phenylalanine, tyrosine, leucine, isoleucine, methionine, valine, alanine, glycine, proline, glutamic acid, serine,
Threonine, aspartic acid, tryptophan, cystine, etc. (Japan Food Research Laboratories 198102)
620-003).

Next, the origin and structure of ceramide will be described. As shown in FIGS. 1 and 2, ceramide is a fatty acid amide of sphingosine and is a substance belonging to sphingolipids composed of a long-chain base and a fatty acid. Sphingosine ceramide is an important component of cereproside (glycoside of ceramide) and sphingomyelin (choline phosphate of ceramide) in the human body. In particular, oligosaccharide phosphates, which are phytosphingosine ceramides, are contained in plant seeds. In the plant kingdom, soybeans, rice, wheat, and the like, especially wheat germ, contain a high concentration of ceramide, and can be used by extraction using ethanol or the like.

Most of vegetable ceramides are sugar ceramides or cerebrosides obtained by adding sugars such as glucose and galactose to ceramide, and belong to glycosphingolipids. Glucose ceramide is a substance very similar to ceramide contained in keratinocyte lipids (hereinafter referred to as SCL) of the human body. Wheat stores ceramide as glucosylceramide to which glucose is added. In the present embodiment, for example, a wheat germ extract powder containing about 3% by weight of this glucosylceramide is used.

Next, the function of ceramide will be described. In the epidermis, ceramide is deeply involved in the moisture permeability barrier function of the stratum corneum of the skin, that is, moisturizing. Collagen and the like can be compared to a water retention capacity, that is, a skin water storage tank, but the barrier function of ceramide can be considered as a lid that prevents water from evaporating from the tank. A lipid called SCL exists between cells in the stratum corneum, which is the outermost layer of the skin.
L has a completely different composition from sebum floating on the skin surface, and ceramide accounts for more than half of that. It has been found that by selectively removing SCL from the skin with an organic solvent, the amount of water in the stratum corneum is remarkably reduced and, at the same time, the skin is roughened, and the degree thereof is almost proportional to the amount of SCL eluted. It has also been found that returning the SCL to the solvent-treated skin reversibly restores the stratum corneum moisture retention function and improves skin roughness. It has been reported that ceramide recovers the stratum corneum water retention function most clearly when the components of SCL are applied individually, whereas when squalene or triglyceride derived from sebum is applied, little improvement effect is observed. I have. For these reasons, ceramide plays the most important role in keeping the water in the stratum corneum, and has the effect of keeping the skin fresh and firm. For this reason, ceramide has been applied to moisturizing cosmetics and remedies used for external use.

Next, the effect of oral intake of wheat ceramide will be described with reference to FIG. There are many examples in which ceramide improves the moisturizing effect for external use. However, it has been pointed out that external use has an effect only on the applied portion. In contrast, if ceramide can be taken as food, ceramide can be replenished to the epidermis of the whole body. When ceramide is produced in the human body, it is once stored in the form of sugar ceramide and metabolized to ceramide by the skin as needed. Further, in the mouse experiment, most of the administered sugar ceramide is absorbed from the small intestine digestive tract and enters between the keratinocytes via the capillaries to exert its effect. Even in the case of the human body, taking a plant-derived sugar ceramide is expected to have an effect of supplementing ceramide to the skin.

In order to confirm the effect of taking sugar ceramide,
Using a beverage containing a wheat germ extract powder containing about 3% by weight of glucosylceramide of the present embodiment, a monitor test as shown in FIG. 4 was carried out using a double blind.
As a result, in all the test items, a remarkable improvement effect of the skin surface condition in the ceramide intake group was obtained. The placebo group showed almost no improvement effect, and the statistical results showed that there was a significant difference between the two groups at a significance level of 5% or less.

Not only ceramides, but also the effects of such beauty foods have been evaluated by sensory evaluation of questionnaire, doctor's findings, and observation of skin surface condition. Therefore, in the present embodiment, a test was performed by measuring the amount of water evaporation (transepidermal water loss: TEWL) in order to examine an evaluation method capable of quantifying the result. The measurement target is the amount of water evaporation from the skin keratin different from the sweat on the skin surface. This is also valid as an evaluation of the moisture barrier effect, which is a mechanism of ceramide.
If the EWL decreases, it can be considered that the moisturizing property of the skin has increased. As shown in FIG. 5, the second monitoring test was performed by applying the TEWL measurement, and as a result, TEWL was reduced at a significance level of 5% or less as compared to before the start of ingestion.
In the questionnaire survey as well, the longer the test period was, the more responses felt the effect. Subsequently, we commissioned Hamamatsu Medical University, an external institution, to conduct clinical tests (blood tests, diagnosis by doctors, TEWL measurements, questionnaires, etc.) in hospitals. As a result, as shown in FIG. 6 and FIG.
L was also statistically significantly reduced. In this way, it is demonstrated by numerical data in both internal and external tests that the moisturizing effect of the skin is enhanced when wheat ceramide is taken,
It was also clarified that the sensory evaluation could be realized.

Hitherto, there has been no method for determining ceramide in foods. Therefore, in the present embodiment, as shown in FIG. 8, a method for quantifying glucosylceramide as an active ingredient was developed for quality assurance. First, the whole amount of a wheat germ extract containing about 3% by weight of glucosylceramide is subjected to thin-layer chromatography to determine the content of steryl glycoside, which is a glycolipid. In this state, there are many impurities, and glucosylceramide cannot be separated. Next, neutral lipids, glyceroglycolipids, and the like are decomposed by subjecting them to weak alkaline decomposition with a 0.4N (normal) aqueous potassium hydroxide solution and subjected to TLC to obtain a clear separation spot of steryl glycoside and glucosylceramide. Then, the ratio between the two is determined. The glucosylceramide content can be calculated from the steryl glycoside content and the ratio between the two. In addition, as for the said quantification method, the same measured value was obtained as a result of rubbing with the Food Sanitation Research Institute. In addition, the wheat germ extract containing about 3% by weight of glucosylceramide in the present embodiment can be applied to forms such as tablet products, soft capsules, sand cream of wafers, powdered foods and the like. In the case of powder, 99% of the powder is lipid and is hardly soluble in water, so that it can be made into a liquid type by a unique emulsification technique. This also results in a formulation that can be easily dispersed in a beverage. Thus, wheat-extracted ceramide can be widely applied to various forms of food, and a large skin effect can be expected even with a small amount of addition, as evidenced by the dose data.

A description will be given of the experience results when the health food of the present embodiment is used for monitors of six experienced persons. 34
Aged women suffered from allergic rhinitis from October to April every year from around the age of 18 and suffered from sneezing, runny nose, and itchy eyes. In severe cases, there were frequent days when they could not sleep at night. If you drink a ceramide-containing agaricus health food (about 2g) three times a day and sleep,
Within a week, my sneezing, runny nose stopped, and my eyes had subsided.

In the case of a 6-year-old boy (19 kg) who suffered asthma attacks, he took one agaric health food containing ceramide (about 2 g) once a day for 3 to 4 days. The sound of breath caused by the attack stopped right. When I was always taking medicine and drinking at a hospital, it took only a week and it was finally settled down, but agaricus health food containing ceramide is effective for a short period of time and even in small quantities, and it can be given to children with confidence. Was saved. Since then, he hasn't had a terrible seizure since he started drinking once a day, and has never been to a hospital he has been to since.

In the case of a 51-year-old man, in the spring, sneezing and runny nose caused by hay fever were annoying every year.
If one person (about 2 g) of this ceramide-containing agaricus health food was to be taken twice a day, in about a week, both of them stopped perfectly and they could concentrate on their work comfortably.

In the case of a 28-year-old woman, her eyes are itchy in the spring, her nose is tingling, and her skin is white. I was An acquaintance who knew such a trouble introduced and tried a ceramide-containing agaricus health food, and after about one week itchy eyes and tingling nose returned to normal,
One month later, the skin became moist and moist as before.

In the case of a 52-year-old woman, she thought that it had nothing to do with hay fever or allergies, but that came suddenly. When I get up in the morning, I sneeze in a row and cannot stop. After calming down for a while, the daily routine of preparing for breakfast continued. At that time, I was told to drink ceramide-containing agaricus health food, so I tried it at first. It was said that it was effective to drink one packet (about 2 g) on an empty stomach once in the morning and once in the night. After three or four days, the sneezing that was so bad almost disappeared,
I also lost my constipation. A month later, I felt that my face was moist and my wrinkles around my eyes were less. At night, the cream did not need to be applied. In addition, I have no colds.

Also, in the case of a 35-year-old man, although his father was in the last stage of lung cancer, after drinking agaricus, he improved steadily and went out for a long time with his grandchild, but he was tired and well. I was able to spend every day. After that, when I tried to drink a ceramide-containing agaricus health food that was effective for hay fever, I was able to feel the effect after 2 to 3 days with less itchiness in my eyes. 2
The snot stopped in about a week, and I was able to spend a comfortable day. As described above, taking the Agaricus health food containing ceramide showed remarkable improvement.

[0029]

EFFECTS OF THE INVENTION Since the present invention is constituted as described above, it is used as an agent for maintaining beauty and health, preventing hay fever, preventing cancer and other lifestyle-related diseases, and other agents for preventing a decrease in immunity. Possible health food can be provided. That is, ceramide is a component present in the skin, blood, and brain of humans and animals, for example, is included in wheat germ because it plays an important role in connecting keratinocytes of the skin epidermis and strengthening the moisturizing surface. By ingesting ceramide as food, ceramide can be replenished to the epidermis of the whole body and the freshness and firmness of the skin can be maintained. In addition, ceramide is not only a cosmetic material to be eaten, but also enhances the water retention function of the skin, so that it can be sufficiently effective in preventing hay fever. Agaricus mushrooms, on the other hand, have the function of enhancing the immunity of the human body in a well-balanced manner, improving the natural healing power inherent in humans, and making the body beautiful. In general, the synergistic effect of agaricus mushrooms and ceramide exerts a sufficient effect not only on beauty and health maintenance but also on measures against pollinosis caused by cedar pollen and the like.

[Brief description of the drawings]

FIG. 1 is an explanatory diagram showing classification of ceramide by lipid in an embodiment of the present invention.

FIG. 2 is a view showing a chemical formula of a polymer structure of sugar ceramide.

FIG. 3 is an explanatory diagram showing the metabolic pathway of ceramide by oral ingestion.

FIG. 4 is an explanatory diagram showing the contents of a monitor test.

FIG. 5 is an explanatory diagram showing the contents of execution of a second monitor test.

FIG. 6 is a graph showing measurement results of the amount of water evaporation.

FIG. 7 is a diagram showing a questionnaire result as a graph.

FIG. 8 is an explanatory diagram showing a method for quantifying wheat ceramide.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 9/48 A61K 9/48 4C206 31/164 31/164 31/7032 31/7032 35/84 35/84 A38 / 00 A61P 3/02 A61P 3/02 35/00 35/00 37/00 37/00 37/04 37/04 A61K 37/22 F term (reference) 4B018 LE01 LE02 LE03 LE05 MD07 MD49 MD84 ME02 ME07 MF01 MF08 4C076 AA17 AA29 AA36 AA56 AA99 CC03 CC07 CC27 4C084 AA02 BA48 MA02 MA22 MA35 MA37 MA43 MA52 MA70 NA14 ZB131 ZB261 ZC211 4C086 AA01 AA02 EA05 MA02 MA05 MA22 MA35 MA37 MA43 MA70 NA14 ZB13 ZB22 MA17 MA08 MA70 ZB13 ZB26 ZC21 4C206 AA01 AA02 GA26 MA42 MA55 MA57 MA63 MA72 MA90 NA14 ZB13 ZB26 ZC21

Claims (4)

[Claims] 1. A health food comprising an extract of Agaricus mushroom mixed with ceramide. 2. The health food according to claim 1, wherein the ceramide is a plant-derived glycidyl sphingolipid obtained by adding a sugar such as glucose or galactose to the ceramide. 3. Ceramide is obtained by converting glucosylceramide to about 3%.
A wheat germ extract containing 1% by weight of a wheat germ extract, which can be applied to forms such as a tableting product type, a soft capsule type, a wafer sand cream type, a powdered food type, and an emulsified liquid type. Health food as described. 4. An amount of about 0.5% to about 2% by weight of plant ceramide powder is mixed with 1 g of Agaricus mushroom extract extract granules, and the mixture is compressed into a tablet type, a soft capsule type, and a wafer sand. A health food manufacturing method characterized by being processed into cream type, powder food type, liquid type by emulsification, etc.