JP2002138037A - Food product for improving atopic dermatitis - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a food product and an improving agent for improving skin symptoms of atopic dermatitis by oral intake which are absorbed with high efficiency and cause no side effect. SOLUTION: The food product of this invention contains ceramides as an active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a food containing a factor for improving skin symptoms of atopic dermatitis and an agent for improving skin symptoms of atopic dermatitis.

[0002]

2. Description of the Related Art In recent years, the number of patients suffering from atopic dermatitis has been increasing, and there is a strong demand for an effective therapy that is safe and less burdensome on patients. By the way, ceramide is one of the constituents of human skin and belongs to sphingolipids, and its bioregulatory function, such as moisturizing and protecting skin, and preventing and improving skin roughness, has attracted attention in recent years. As cosmetics using ceramides, skin cosmetics containing a ceramide glycoside (glycosphingolipid) such as ceramide, glucosylceramide, galactosylceramide, and diisopropylamine dichloroacetate or γ-aminobutyric acid are disclosed ( JP-A-1-22810). In addition, a hair-growth cosmetic in which ceramides such as ceramide, glucosylceramide, and galactosylceramide are blended with vitamin E has been disclosed (Japanese Patent Application Laid-Open No. 63-243061). Further, it has been disclosed that a coating agent containing glycosphingolipids improves the symptoms of atopic dermatitis (Japanese Patent Application Laid-Open Nos. 08-294395 and 10-33).
No. 0273). In these technologies, a method of blending natural or synthetic ceramide with skin cosmetics, bath salts, coating agents, etc., and replenishing it from the epidermis with the aim of moisturizing, preventing rough skin, improving atopic skin irritations, etc. is adopted. ing.

[0003] However, it has been pointed out that ceramide supplied to the epidermis is difficult to reach the inside of the skin due to the lipids of the epidermis and is difficult to be absorbed, and that it is effective only on the applied portion. There are also problems such as rash and inflammation caused by cosmetic components and bath additive components other than ceramide. On the other hand, there has been disclosed a technique for achieving a cosmetic effect by ingesting a food containing ceramide (JP-A-11-113530). However, this document does not describe the effect of improving the symptoms of atopic dermatitis as a disease.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a technique for improving the skin symptoms of atopic dermatitis by oral ingestion with good absorption efficiency and without side effects.

[0005]

Means for Solving the Problems The present inventors have found that oral ingestion of highly safe ceramide has an effect of improving the skin symptoms of atopic dermatitis, and has completed the present invention. Reached. That is, the present invention is a food and an improving agent having an effect of improving skin symptoms of atopic dermatitis, comprising ceramide as an active ingredient. In the present invention, the skin symptoms of atopic dermatitis include pruritus, erythema, papules, lichenification, erosion, and the like derived from atopic dermatitis.
It refers to any one of scales and dry skin.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail.
The ceramide used in the present invention has a structure in which sphingosine, a fatty acid and a sugar are bonded, and is derived naturally. For example, those derived from animals extracted from bovine brain and the like, those derived from plants extracted from wheat, rice, soybean, maize, spinach, and the like, those derived from microorganisms extracted from yeast and the like, those extracted from erythrocytes, and the like are exemplified. These ceramides can be obtained by a known extraction method. For example,
A method of extracting from a raw material of wheat or rice bran using a polar solvent such as ethanol and water and recrystallizing the same in an organic solvent such as cold acetone (Japanese Patent Application Laid-Open No. 06-507653,
JP-T-07-508496). Among them, ceramides extracted from wheat or rice bran as a raw material are preferable from the viewpoint of availability and safety.

The form of the product of the present invention can be in the form of powder such as tablets, capsules and powders, or liquid such as beverages. These foods can be produced by mixing and homogenizing ceramide and various raw materials, and then adding a surfactant or the like as necessary. As the surfactant, for example, sorbitan fatty acid ester, glycerin fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, lecithin and the like can be used. In addition, as a mixture of other ingredients, for example, candy, drop,
Examples include confectionery such as tablet confectionery, chewing gum and jelly, cookies, bread such as bread and confectionery bread, lactic acid bacteria beverages, alcoholic beverages, and beverages such as vitamin and mineral beverages.
When ceramide is blended in these foods, generally known formulations such as ceramide extract or powder can be used.

The amount of ceramide ingested from the food of the present invention is, for example, 1 to 1000 mg, preferably 5 to 100 mg per day for an adult wheat extract containing 3% by weight of ceramide glycoside. If the amount is less than 1 mg, the effect of improving atopic dermatitis is small, and if it exceeds 1,000 mg, it may not be able to be completely digested and absorbed, and it is difficult to obtain an effect proportional to the amount of intake.

[0009]

INDUSTRIAL APPLICABILITY The present invention relates to a food and an improving agent containing ceramide, which can be easily orally ingested. By ingesting these orally, it has good absorption efficiency and has no side effects. An effect of improving skin symptoms can be obtained.

[0010]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in more detail with reference to specific examples. Production Examples and Examples include ceramide-containing products, trade name Nissan N-Ceramide (Nippon Oil & Fats Co., Ltd.)
(Hereinafter abbreviated as N-ceramide). This ceramide is a wheat extract powder containing 3% by weight of glucosylceramide, one of ceramide glycosides, 47% by weight of glycolipid, and other phospholipids.

Production Example 1 (Wafer) Shortening (Nippon Yushi Co., Ltd.) 487.5 g (4
8.75% by weight) was whipped, and there were 365 g (36.5% by weight) of powdered sugar (manufactured by Shoei Food Industry Co., Ltd.) and 122 g (12.2% by weight) of hydrated glucose (manufactured by Daizo Japan Co., Ltd.) ), And 25 g (2.5% by weight) of N-ceramide. The mixture was whipped until the specific gravity became 85% of the initial state. Finally, 0.5 g (0.05% by weight) of vanilla oil (manufactured by Edelman KK) was mixed to prepare a sand cream. The sand cream was rolled with a roller to form a sheet. The sheet-shaped sand cream coming out of the roller is transferred to a wafer plate (Chushin Seika Co., Ltd.)
) And sanded on another wafer plate. Sand cream was further placed thereon, and was sandwiched with a wafer plate. Roll it lightly with a roller and make it adhere, cream 2
Layer wafers were made. This wafer was cut so that the amount of the sand cream was about 4 g per piece.
One wafer (about 8 g) contains about 20 mg of N-ceramide.

Example 1 [Clinical test] A test was conducted using the wafer prepared in Production Example 1. The subjects were 14 patients (A to N) with atopic dermatitis in their 18s and 50s, and the wafers were administered on a daily basis.
I took it between single meals. The symptoms of the skin on the day of taking the drug and after taking the drug were calculated based on the following evaluation criteria. This evaluation was performed by a dermatologist at a university hospital.

[Judgment of the effect of the dermatologist] First, the degree of each of the symptoms of the subject was evaluated by the degree of pruritus, erythema, papule, lichenification, erosion, scale, and dry skin characteristic of atopic dermatitis. 4 points), medium (3 points), mild (2 points), slight (1 point), none (0 points)
The results are shown in FIG. Furthermore, the skin symptoms after the start of the test were evaluated in 5 steps in the same manner as above, and the degree of improvement compared to before the start of the test was evaluated in 5 steps of significant, effective, slightly effective, ineffective, and worsened. Tables 1 to 14 also show the results. In addition, the case where the improvement score was -1 to 1 was evaluated as "invalid", the case of 2 as "slightly effective", the case of 3 to 9 as "effective", and the case of 10 to 17 as "excellent effect".

[0014]

[Table 1]

[0015]

[Table 2]

[0016]

[Table 3]

[0017]

[Table 4]

[0018]

[Table 5]

[0019]

[Table 6]

[0020]

[Table 7]

[0021]

[Table 8]

[0022]

[Table 9]

[0023]

[Table 10]

[0024]

[Table 11]

[0025]

[Table 12]

[0026]

[Table 13]

[0027]

[Table 14]

From the examination after the end of the test, 2 out of 14 patients showed significant effect.
Name, effective 5 people, slightly effective 3 people, invalid 4 people,
The improvement effect was seen in 10 out of 14 or 71% who were slightly more effective. In addition, the improvement effect for each specific symptom of dermatitis was scored and shown in Table 15. The evaluation criteria are the same as described above.

[0029]

[Table 15]

As a result, according to the symptoms, the improvement effect was confirmed in the order of scaling, pruritus, dry skin, erythema / papule, and lichen. In addition, a marked improvement effect was observed on scales, pruritus and dry skin. [Questionnaire survey] A questionnaire survey was conducted for the same patients. After the test, the subject's impression was obtained based on the following evaluation criteria as to whether or not skin irritations such as bulkiness were improved compared to before the test. [Questionnaire evaluation criteria] Clearly effective (effective),
There are four types: effective (effective), rather effective (somewhat effective), and unclear (ineffective).

There were 14 respondents to the questionnaire, 7 subjects who felt "effective", 3 "moderately effective",
"Invalid" was 4 people. Based on the above comprehensive results, 70% or more of the subjects evaluated as “slightly effective” or more by diagnosis by a dermatologist at a university hospital, and judged that the food was effective in improving the symptoms of atopic dermatitis. Was. In particular, all nine patients who received a diagnosis of a little more than effective showed improvement in pruritus that patients with atopic dermatitis felt most painful. Therefore, it was found that the food of the present invention has an effect of improving the symptoms of atopic dermatitis. In addition, all subjects were evaluated as having no side effects and no safety problems. In addition, in the questionnaire survey, 10/14 patients showed improvement effect.

Examples in which N-ceramide is blended in various foods will be described below. Production Example 2 (Tablets) 2 g (2% by weight) of N-ceramide, 96 g (96% by weight) of dried corn starch (manufactured by Nippon Food Processing Co., Ltd.), 1.8 g (1) of talc (manufactured by Wako Pure Chemical Industries, Ltd.) 0.8% by weight)
And calcium stearate (manufactured by NOF Corporation)
0.2 g (0.2% by weight) was mixed with a rocking mixer for 10 minutes, and 0.52 g of a tablet was prepared using a tableting machine. This tablet contains 0.3% of N-ceramide.
mg.

Production Example 3 (Capsule) 5 g (3.7% by weight) of N-ceramide, 35 g (26.2% by weight) of crystalline cellulose (manufactured by Asahi Kasei Kogyo Co., Ltd.), dried corn starch (Japan Food Processing Co., Ltd.) 67g (5
0% by weight), lactose (manufactured by Wako Pure Chemical Industries, Ltd.) 22 g (1
6.4% by weight), 2 g (1.5% by weight) of calcium stearate (manufactured by NOF CORPORATION), and 3 g (2.2% by weight) of polyvinylpyrrolidone as a binder, followed by powdering, followed by hard gelatin capsules Was filled. 0.3 per tablet
g capsules were prepared. This capsule contains N-
Contains 0.3 mg of ceramide.

Production Example 4 (powder) 1 part by weight of N-ceramide 99 parts by weight of lactose The above materials were powder-mixed with a rocking mixer for 30 minutes.
It was subdivided into 4.8 g / package. One packet of this powder contains about 48 mg of N-ceramide.

Production Example 5 (Beverage) N-Ceramide 0.2 parts by weight Carboxymethylcellulose 20 parts by weight Single syrup 179.8 parts by weight With the above composition, a single syrup was gradually added to carboxymethylcellulose while being mixed. N- of Production Example 1
Ceramide was added and further mixed to obtain a uniform beverage syrup. This beverage syrup was diluted 5-fold with water to obtain a beverage. 100 mL of this beverage contains about 20 N-ceramides.
mg.

Production Example 6 (Bread) Bread was produced by the sponge method under the following operating conditions. Composition of "medium species" 70 parts by weight of flour 70 parts by weight of yeast 42 parts by weight of water Working conditions Mixing 2 minutes at low speed, 2 minutes at medium and high speed Fermentation 28 ° C, 4 hours Salt 2 parts by weight N-ceramide 0.1 parts by weight Margarine 5 parts by weight Water 25 parts by weight Working conditions Mixing low speed 2 minutes, medium and high speed 5 minutes Fermentation 28 ° C, 4 hours Wheeler 38 ° C, 80%, 45 minutes Firing 200 ° C, A bread was trial-produced by a blending recipe of 30 minutes or more and a usual medium-class method.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) // A23L 2/52 A23L 2/38 J 2/38 2/00 F (72) Inventor Hitoshi Nakata Tokyo 1-26-3 Nishigahara, Kita-ku F-term in the Food and Supply Research Center of Japan (Reference) 4B017 LC03 LE10 LK07 LL09 4B018 LB01 LB08 MD08 MD49 ME07 MF02 4B032 DB02 DK06 DL20 4C088 AB73 AB74 AC04 BA08 BA13 BA18 MA52 NA11 ZA89 4206 AA02 GA25 MA01 MA72 ZA89

Claims (6)

[Claims] 1. A food containing a factor for improving skin symptoms of atopic dermatitis, wherein the factor is ceramide. 2. An adult daily intake of the ceramide is 1 to 1000 mg.
Food as described. 3. The food according to claim 1, wherein the ceramide is obtained from wheat or rice bran. 4. An agent for improving skin symptoms of atopic dermatitis, which comprises ceramide and is taken orally. 5. An adult daily intake of said ceramide is 1 to 1000 mg.
The improving agent as described above. 6. The improving agent according to claim 4, wherein the ceramide is obtained from wheat or rice bran.