JP2002253240A5 - - Google Patents
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- JP2002253240A5 JP2002253240A5 JP2001052798A JP2001052798A JP2002253240A5 JP 2002253240 A5 JP2002253240 A5 JP 2002253240A5 JP 2001052798 A JP2001052798 A JP 2001052798A JP 2001052798 A JP2001052798 A JP 2001052798A JP 2002253240 A5 JP2002253240 A5 JP 2002253240A5
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- JP
- Japan
- Prior art keywords
- protein
- substance
- molecule
- group
- covalent bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000126 substance Substances 0.000 claims 47
- 102000004169 proteins and genes Human genes 0.000 claims 32
- 108090000623 proteins and genes Proteins 0.000 claims 32
- 238000002372 labelling Methods 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 239000007790 solid phase Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 8
- 230000027455 binding Effects 0.000 claims 8
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 8
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 claims 8
- 102000000584 Calmodulin Human genes 0.000 claims 6
- 108010041952 Calmodulin Proteins 0.000 claims 6
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 4
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 4
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 4
- 108010024636 Glutathione Proteins 0.000 claims 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 4
- 229960002685 biotin Drugs 0.000 claims 4
- 235000020958 biotin Nutrition 0.000 claims 4
- 239000011616 biotin Substances 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 150000002009 diols Chemical group 0.000 claims 4
- 229960005309 estradiol Drugs 0.000 claims 4
- 229930182833 estradiol Natural products 0.000 claims 4
- 229960003180 glutathione Drugs 0.000 claims 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 4
- 125000000468 ketone group Chemical group 0.000 claims 4
- 229910021645 metal ion Inorganic materials 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 230000000975 bioactive effect Effects 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- RYSMHWILUNYBFW-GRIPGOBMSA-N 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine Chemical compound C1=NC=2C(N(C)C)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O RYSMHWILUNYBFW-GRIPGOBMSA-N 0.000 claims 2
- 102000021527 ATP binding proteins Human genes 0.000 claims 2
- 108091011108 ATP binding proteins Proteins 0.000 claims 2
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims 2
- 101710096438 DNA-binding protein Proteins 0.000 claims 2
- 108010085330 Estradiol Receptors Proteins 0.000 claims 2
- 102100038595 Estrogen receptor Human genes 0.000 claims 2
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- 102000005720 Glutathione transferase Human genes 0.000 claims 2
- 108010070675 Glutathione transferase Proteins 0.000 claims 2
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 claims 2
- 102000007466 Purinergic P2 Receptors Human genes 0.000 claims 2
- 108010085249 Purinergic P2 Receptors Proteins 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 2
- 102000043871 biotin binding protein Human genes 0.000 claims 2
- 108700021042 biotin binding protein Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229920002704 polyhistidine Polymers 0.000 claims 2
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 2
- 230000014616 translation Effects 0.000 claims 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 238000000137 annealing Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000000799 fluorescence microscopy Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000001215 fluorescent labelling Methods 0.000 claims 1
- 238000001243 protein synthesis Methods 0.000 claims 1
- 229950010131 puromycin Drugs 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001052798A JP2002253240A (ja) | 2001-02-27 | 2001-02-27 | 分子間の相互作用の分析方法 |
| PCT/JP2002/001719 WO2002074950A1 (fr) | 2001-02-27 | 2002-02-26 | Procede d'analyse d'interaction intermoleculaire |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001052798A JP2002253240A (ja) | 2001-02-27 | 2001-02-27 | 分子間の相互作用の分析方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002253240A JP2002253240A (ja) | 2002-09-10 |
| JP2002253240A5 true JP2002253240A5 (enExample) | 2005-09-22 |
Family
ID=18913373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001052798A Pending JP2002253240A (ja) | 2001-02-27 | 2001-02-27 | 分子間の相互作用の分析方法 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2002253240A (enExample) |
| WO (1) | WO2002074950A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3448654B2 (ja) | 2001-11-22 | 2003-09-22 | 北陸先端科学技術大学院大学長 | バイオチップ、バイオチップアレイ、及びそれらを用いたスクリーニング方法 |
| WO2004095008A1 (ja) * | 2003-04-23 | 2004-11-04 | Olympus Corporation | エバネッセント照明を用いる分子蛍光解析方法 |
| WO2006018706A2 (en) * | 2004-08-18 | 2006-02-23 | University Of Basel | Single analyte molecule detection by fibre fluorescence probe |
| JPWO2006062200A1 (ja) * | 2004-12-09 | 2008-06-12 | ユニバーサル・バイオ・リサーチ株式会社 | 核酸ライブラリー及びタンパク質ライブラリー |
| JP5219144B2 (ja) * | 2007-12-28 | 2013-06-26 | 公益財団法人新産業創造研究機構 | 新規アフィニティーラベル化方法及びラベル化方法を用いたスクリーニング方法 |
| CN103221539A (zh) * | 2010-08-27 | 2013-07-24 | 国立大学法人东京大学 | 蛋白质或胜肽的印刷方法、及蛋白质阵列或胜肽阵列、以及功能性蛋白质或功能性胜肽的鉴定方法 |
| JP2012202742A (ja) * | 2011-03-24 | 2012-10-22 | Fujifilm Corp | 検出方法および検出装置 |
| KR101167649B1 (ko) | 2011-04-20 | 2012-07-20 | 한국과학기술원 | 세포 환경 내에서의 단일 분자 수준의 단백질-단백질 상호작용 분석 장치 |
| JP5930286B2 (ja) * | 2012-02-10 | 2016-06-08 | 国立大学法人金沢大学 | 薬物と高分子化合物相互作用確認用試薬及び相互作用の検査方法 |
| KR20180117529A (ko) | 2017-04-19 | 2018-10-29 | 주식회사 프로티나 | 단백질-단백질 상호작용 분석에 의한 약물 반응성 예측 방법 |
| CN114471395B (zh) * | 2020-11-13 | 2025-07-08 | 北京百奥纳芯生物科技有限公司 | 一种通过组合方式制造的原位合成基因芯片探针用基片 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4240574B2 (ja) * | 1998-05-15 | 2009-03-18 | 三菱化学株式会社 | タンパク質のラベル化組成物およびタンパク質のラベル化方法 |
| JP4493125B2 (ja) * | 1999-05-07 | 2010-06-30 | 独立行政法人理化学研究所 | 相互作用するタンパク質の検出方法 |
| AU778194B2 (en) * | 1999-07-12 | 2004-11-18 | Bristol-Myers Squibb Company | C-terminal protein tagging |
| JP4122694B2 (ja) * | 1999-08-26 | 2008-07-23 | 三菱化学株式会社 | タンパク質−ｄｎａ連結分子及びその利用 |
| WO2001016600A1 (fr) * | 1999-08-31 | 2001-03-08 | Mitsubishi Chemical Corporation | Methode d'analyse d'une interaction mutuelle entre une proteine et une molecule |
-
2001
- 2001-02-27 JP JP2001052798A patent/JP2002253240A/ja active Pending
-
2002
- 2002-02-26 WO PCT/JP2002/001719 patent/WO2002074950A1/ja not_active Ceased
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