JP2002249430A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002249430A5 JP2002249430A5 JP2001319000A JP2001319000A JP2002249430A5 JP 2002249430 A5 JP2002249430 A5 JP 2002249430A5 JP 2001319000 A JP2001319000 A JP 2001319000A JP 2001319000 A JP2001319000 A JP 2001319000A JP 2002249430 A5 JP2002249430 A5 JP 2002249430A5
- Authority
- JP
- Japan
- Prior art keywords
- agent composition
- total cholesterol
- lowering agent
- composition according
- ascorbic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 Blood Anatomy 0.000 claims 8
- 239000003529 anticholesteremic agent Substances 0.000 claims 8
- 239000008280 blood Substances 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 235000010323 ascorbic acid Nutrition 0.000 claims 6
- 229960005070 ascorbic acid Drugs 0.000 claims 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 5
- 239000011668 ascorbic acid Substances 0.000 claims 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 3
- AUNGANRZJHBGPY-OUCADQQQSA-N Riboflavin Natural products OC[C@@H](O)[C@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-OUCADQQQSA-N 0.000 claims 3
- 235000019192 riboflavin Nutrition 0.000 claims 3
- 239000002151 riboflavin Substances 0.000 claims 3
- 239000011732 tocopherol Substances 0.000 claims 3
- 125000002640 tocopherol group Chemical group 0.000 claims 3
- 235000019149 tocopherols Nutrition 0.000 claims 3
- 229930003799 tocopherols Natural products 0.000 claims 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-α-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 2
- MJNIWUJSIGSWKK-BBANNHEPSA-N [(2R,3S,4S)-2,3,4-tri(butanoyloxy)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)pentyl] butanoate Chemical compound CCCC(=O)OC[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)CN1C2=CC(C)=C(C)C=C2N=C2C1=NC(=O)NC2=O MJNIWUJSIGSWKK-BBANNHEPSA-N 0.000 claims 2
- 229960001452 alpha-Tocopherol Acetate Drugs 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 229940099418 D- ALPHA-TOCOPHEROL SUCCINATE Drugs 0.000 claims 1
- IELOKBJPULMYRW-NJQVLOCASA-N D-α-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 claims 1
- MFZCIDXOLLEMOO-GYSGTQPESA-N Inositol nicotinate Chemical compound O([C@H]1[C@@H]([C@H]([C@@H](OC(=O)C=2C=NC=CC=2)[C@@H](OC(=O)C=2C=NC=CC=2)[C@@H]1OC(=O)C=1C=NC=CC=1)OC(=O)C=1C=NC=CC=1)OC(=O)C=1C=NC=CC=1)C(=O)C1=CC=CN=C1 MFZCIDXOLLEMOO-GYSGTQPESA-N 0.000 claims 1
- 229960005436 Inositol nicotinate Drugs 0.000 claims 1
- 150000000996 L-ascorbic acids Chemical class 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Octadecanoic acid Natural products CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N Pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
- 229960002965 Pravastatin Drugs 0.000 claims 1
- 229960005055 SODIUM ASCORBATE Drugs 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 229940029983 VITAMINS Drugs 0.000 claims 1
- 229940021016 Vitamin IV solution additives Drugs 0.000 claims 1
- RHKRCMGVQNYYCS-DAYGRLMNSA-N [(2R,3S,4S)-1-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-3,4,5-trihydroxypentan-2-yl] butanoate Chemical compound CCCC(=O)O[C@@H]([C@@H](O)[C@@H](O)CO)CN1C2=CC(C)=C(C)C=C2N=C2C1=NC(=O)NC2=O RHKRCMGVQNYYCS-DAYGRLMNSA-N 0.000 claims 1
- -1 ascorbic acid stearic acid ester Chemical class 0.000 claims 1
- 235000010378 sodium ascorbate Nutrition 0.000 claims 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- 150000003611 tocopherol derivatives Chemical class 0.000 claims 1
- 229950000300 tocopherol succinate Drugs 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamins Natural products 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- 150000003772 α-tocopherols Chemical class 0.000 claims 1
Description
Claims (8)
- プラバスタチンと、リボフラビン類、トコフェロール類、アスコルビン酸類及びイノシトールヘキサニコチネートからなる群から選択される１種以上のビタミンとを、含有する血中総コレステロール低下剤組成物。
- リボフラビン類がリボフラビン又は酪酸リボフラビンである、請求項１に記載の血中総コレステロール低下剤組成物。
- リボフラビン類が酪酸リボフラビンである、請求項１に記載の血中総コレステロール低下剤組成物。
- トコフェロール類がｄ−α−トコフェロール類から選ばれる１種以上である、請求項１に記載の血中総コレステロール低下剤組成物。
- トコフェロール類がｄ−α−トコフェロール、酢酸ｄ−α−トコフェロール又はコハク酸ｄ−α−トコフェロールである、請求項１に記載の血中総コレステロール低下剤組成物。
- トコフェロール類が酢酸ｄ−α−トコフェロールである、請求項１に記載の血中総コレステロール低下剤組成物。
- アスコルビン酸類がアスコルビン酸、アスコルビン酸ナトリウム又はアスコルビン酸ステアリン酸エステルである、請求項１に記載の血中総コレステロール低下剤組成物。
- アスコルビン酸類がアスコルビン酸である、請求項１に記載の血中総コレステロール低下剤組成物。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001319000A JP4132773B2 (ja) | 2000-10-23 | 2001-10-17 | 血中脂質改善剤組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000322076 | 2000-10-23 | ||
| JP2000-322076 | 2000-10-23 | ||
| JP2000-383052 | 2000-12-18 | ||
| JP2000383052 | 2000-12-18 | ||
| JP2001319000A JP4132773B2 (ja) | 2000-10-23 | 2001-10-17 | 血中脂質改善剤組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008095945A Division JP2008189684A (ja) | 2000-10-23 | 2008-04-02 | 血中脂質改善剤組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002249430A JP2002249430A (ja) | 2002-09-06 |
| JP2002249430A5 true JP2002249430A5 (ja) | 2005-04-07 |
| JP4132773B2 JP4132773B2 (ja) | 2008-08-13 |
Family
ID=27345005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001319000A Expired - Fee Related JP4132773B2 (ja) | 2000-10-23 | 2001-10-17 | 血中脂質改善剤組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4132773B2 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002034261A1 (fr) * | 2000-10-23 | 2002-05-02 | Sankyo Company, Limited | Compositions hypocholesterolemiantes |
| JP2005187454A (ja) * | 2003-12-05 | 2005-07-14 | Sankyo Co Ltd | ビタミンｅ含有ｌｄｌ低下剤及び／又は動脈硬化抑制剤組成物 |
-
2001
- 2001-10-17 JP JP2001319000A patent/JP4132773B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4938960A (en) | Agents for the treatment and protection of the skin | |
| EP0903143A3 (en) | Use of daidzein for the manufacture of a medicament for incraesing HDL cholesterol levels | |
| DE59207907D1 (de) | Benzopyranone, verfahren zu ihrer herstellung und verwendung | |
| EP0976398A3 (en) | Use of 3,4-diphenyl chroman derivatives in the manufacture of a medicament for lowering serum cholesterol levels and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease | |
| IT1281337B1 (it) | Preparazione farmaceutica orale contenente ciclosporina come sostanza attiva ed un preconcentrato di emulsione multipla | |
| ATE495154T1 (de) | Pharmazeutische zusammensetzungen, die ccr5- antagonisierende piperazinderivate enthalten | |
| DE19581804T1 (de) | Pharmazeutische Zusammensetzungen | |
| EP0393493A3 (en) | Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | |
| WO2002000266A3 (en) | A method of treating and preventing infectious diseases | |
| RU99120669A (ru) | Способ подавления роста опухоли с помощью сочетаний изопреноидов и статинов | |
| JPH05194474A (ja) | ポリエトキシ化ビタミンｅ及びその製造方法並びにその用途 | |
| CA2367387A1 (en) | Composition comprising isoquercetin and ascorbic acid in a sustained release form | |
| EP0339579A3 (en) | Piperidine compositions and their preparation and use | |
| ITMI921123A1 (it) | Formulazioni farmaceutiche orali contenenti antocianosidi | |
| CA2525991A1 (en) | Skin care composition comprising skin lightening agent | |
| JP2002249430A5 (ja) | ||
| WO2003018064A3 (en) | Lipophilic drug compositions | |
| EP0328924A3 (en) | Thienotriazolodiazepine compounds and pharmaceutical uses thereof | |
| WO2000026399A3 (de) | Verfahren zur herstellung von quercetin- und isoquercetin-derivaten | |
| Takahashi et al. | Oxidation of lipids. XIV Inhibition of oxidation of methyl linoleate by fatty acid esters of L-ascorbic acid. | |
| ATE372760T1 (de) | Stabilisierung oxidations-und/oder uv- empfindlicher wirkstoffe | |
| KR940701251A (ko) | 콜레스테롤-강하 토코페롤 동족체 | |
| ATE93508T1 (de) | Kosmetische und pharmazeutische zusammensetzungen, die lipophile derivate von benzylidenkampfer enthalten und lipophile benzylidenkampfer-derivate. | |
| CA2123059A1 (en) | Method of Lowering Blood Lipid Levels | |
| KR100846641B1 (ko) | 동맥경화 억제 방법 및 조성물 |