JP2002241221A - Thermesthesia agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a thermesthesia agent having excellent usability and stability. SOLUTION: The objective thermesthesia base agent includes (1) zeolite, (2) polyethylene glycol with a number-average molecular weight of 4,000-30,000 and (3) polyethylene glycol with a number-average molecular weight of 300-600.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a thermal base containing zeolite. More specifically, it relates to a thermal base material having excellent usability and stability.

[0002]

2. Description of the Related Art Cosmetics that give a warm feeling can be obtained by highly blending humectants such as glycerin. It is widely used mainly as a body care product for massage. However, there were the following problems. 1) In terms of irritation, a thermal base containing a large amount of a moisturizer cannot be used on the face. 2) When polyethylene glycol is added to the thermal base,
An excellent warm feeling can be obtained, but there is a problem in the stability of the base.

On the other hand, US Pat. No. 3,250,680, JP-A-6-100411, and JP-A-54-126741.
Japanese Patent Application Publication No. JP-A-2003-115139 discloses a cosmetic and a toothpaste which contain activated zeolite in a non-aqueous system and generate heat when contacted with water.

Further, JP-A-9-157130 discloses a heat-generating aerosol composition containing zeolite, JP-A-8-59455, and JP-A-2000-383.
No. 31 discloses a face wash and a cosmetic each containing an activated zeolite.

[0005] In order to mix activated zeolite which generates heat upon contact with water, a non-aqueous dispersion technique is important.
In particular, in view of the ease of rinsing with water after application, a formulation technique using a polyhydric alcohol as a dispersed phase is particularly important.

As a technique for dispersing a non-aqueous inorganic powder using a polyhydric alcohol as a dispersed phase, a technique for dispersing an inorganic powder in a macrogol ointment base is known. Macrogol ointment base is listed in the Japanese Pharmacopoeia. This is Macrogol 4000 (polyethylene glycol 4000)
And Macrogol 400 (polyethylene glycol 40
0), and an amount of 100 g or less can be mixed to produce an ointment having a suitable consistency.

[0007] By kneading the inorganic powder into the macrogol ointment base, a base containing the inorganic powder is obtained. When kneaded near the melting point of the ointment base, the dispersibility of the inorganic powder is further improved. This base has no irritation to the skin.
Furthermore, since it has good solubility in water, it is easy to wash away.

Japanese Patent Application Laid-Open No. 11-309365 discloses a technique for forming a base using a polyhydric alcohol-soluble polymer.

However, macrogol ointment has the following problems. (1) The viscosity decreases at a high temperature, and the stability of the base decreases. (2) Spread is heavy. That is, the usability is not good. In particular, the above problem was remarkable in a base material in which a large amount of powder was dispersed.

[0010]

SUMMARY OF THE INVENTION The present inventors have conducted intensive studies in view of the above circumstances, and as a result, have found that microcrystals of polyethylene glycol having a high molecular weight can be obtained by combining zeolite or an inorganic salt with polyethylene glycol having a different average molecular weight. It has been found that a thickening warm base can be obtained without using a water-soluble polymer or a clay mineral by precipitating and gelling in low molecular weight polyethylene glycol.
This thermal base is excellent in dispersion stability of zeolite or anhydrous inorganic salt, and found that the spread on the skin is good,
The present invention has been completed.

The present invention is as follows.

1: A thermal base containing the following components: (1) Zeolite (2) Polyethylene glycol having a number average molecular weight of 4000 to 30,000 (3) Polyethylene glycol having a number average molecular weight of 300 to 600

2: Thermal base containing the following components: (1) Anhydrous inorganic salt (2) Polyethylene glycol having a number average molecular weight of 4,000 to 30,000 (3) Polyethylene glycol having a number average molecular weight of 300 to 600

3: The above-mentioned thermal base further containing (4) a polyhydric alcohol.

4: The above-mentioned thermal base, wherein the zeolite has a pore size of 3 to 4 angstroms.

5: The above-mentioned thermal base, wherein the polyhydric alcohol is at least one compound selected from the following group. Glycerin, diglycerin, polyglycerin, 1,3-
Butylene glycol, dipropylene glycol, trimethylolethane, trimethylolpropane, erythritol, pentaerythritol, sorbitan, glucose, sorbitol, maltitol, sucrose, raffinose, and trehalose.

6: The above-mentioned thermal base further containing (5) an oil component.

7: The above-mentioned thermal base substantially not containing a thickener comprising a water-soluble polymer or a clay mineral.

[0019]

DETAILED DESCRIPTION OF THE INVENTION The zeolite used in the present invention is preferably an activated zeolite. The anhydrous inorganic salt used in the present invention includes anhydrous magnesium sulfate, disodium hydrogen phosphate,
Calcium chloride, magnesium chloride and calcium sulfate are preferred. The zeolite preferably has a pore size of 3 to 4 angstroms.

The amount of zeolite is not limited. Usually it is 5 to 40% by mass, but preferably 10 to 25% by mass. If the amount is too large, the dispersibility and the fluidity may decrease, and the usability may deteriorate.

The polyethylene glycol used in the present invention is of two types having different average molecular weights. One having a large average molecular weight and one having a small average molecular weight are blended. Average molecular weight means number average molecular weight. Number-average molecular weight is based on cosmetic raw materials, 2nd edition, Comment I (Yakuji Nippo 1984)
On page 942.

In the present invention, (2) the number average molecular weight of 4
000 to 30,000 polyethylene glycol,
(3) Polyethylene glycol having a number average molecular weight of 300 to 600 is used. The polyethylene glycol of (2)
It is solid at normal temperature (20 ° C). When the number average molecular weight of the polyethylene glycol of (3) is low, the viscosity of the base may decrease or the stability at high temperature may decrease.

As the polyethylene glycol (2), those having a number average molecular weight of about 20,000 are particularly preferred. As the polyethylene glycol of (3), a liquid at room temperature (20 ° C.) is selected, and the number average molecular weight is
Those having about 0 are more preferable.

The amount of polyethylene glycol (2) is usually 5 to 20% by mass (particularly preferably 10 to 15% by mass) based on the total amount of the base, and the amount of polyethylene glycol (3) is the total amount of the base. Usually 10 to 50% by mass
(Particularly 20 to 40% by mass). The blending amount of (2) is 2
If it exceeds 0% by mass, the feeling of use becomes heavy and the spread becomes poor,
If it is less than mass%, stability (especially high-temperature stability) may deteriorate.

In the present invention, it is preferable to further blend a polyhydric alcohol. Examples include ethylene glycol, propylene glycol, butylene glycol, isoprene glycol, hexylene glycol, diethylene glycol, dipropylene glycol, diethylene glycol monomethyl ether, glycerin, diglycerin, sorbitol, and polypropylene glycol.

In particular, 1,3-butylene glycol and dipropylene glycol are preferred in terms of stability and usability. The compounding amount is usually 10 to 30% by mass based on the total amount of the base.

In the present invention, it is preferable to further blend an oil component. Particularly, silicone oil and POE-modified dimethyl silicone are preferable. Silicone oil, for example, dimethylpolysiloxane, methylphenyl polysiloxane, chain polysiloxane such as methylhydrogenpolysiloxane, decamethylpolysiloxane, dodecamethylpolysiloxane, cyclic polysiloxane such as tetramethyltetrahydrogenpolysiloxane, Silicone resin and silicon rubber forming a three-dimensional network structure are exemplified. The POE-modified dimethyl silicone preferably has an HLB of 6 or less. The blending amount of the oil component is not limited, but is usually up to 20% by mass based on the total amount of the base. In particular, 5
When blended by 15 mass%, the usability can be further improved.

The present invention may further contain a nonionic surfactant. For example, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester,
Polyoxyethylene hardened castor oil can be blended. These nonionic surfactants have an effect of improving the dispersibility of zeolite. In addition, the ease of rinsing at the time of washing and removal is improved.

Nonionic surfactants of HLB 7 to 18 are preferred, and those of HLB 10 to 16 are particularly preferred.
Specifically, polyoxyethylene (60) hardened castor oil, polyoxyethylene (40) hardened castor oil, polyoxyethylene (20) cetyl ether, polyoxyethylene (20) sorbitan monooleate, decaglyceryl monoisostearate, etc. No. It is preferable that the nonionic surfactant is incorporated in the total composition in an amount of 0.1 to 10% by mass.

The thermal base of the present invention may contain components used as bases for external preparations for skin as long as the effects of the present invention are not impaired. For example, surfactants, powders, blood circulation promoters, anti-inflammatory agents, cooling agents, cooling agents, chelating agents, antioxidants,
They are humectants, preservatives, coloring agents and fragrances. Since it is a thermal base that generates heat due to the heat of hydration of zeolite or anhydrous inorganic salt, the content of water is limited so that it can come into contact with external water to generate heat of hydration during use. The content of water is about 0 to 5% by mass based on the total amount of the base, but a non-aqueous base containing substantially no water is preferable. Further, in the base of the present invention, a viscosity having preferable usability can be obtained without substantially blending a thickener comprising a water-soluble polymer or a clay mineral.

The thermal base of the present invention can be produced by mixing the above components at a temperature equal to or higher than the melting point of polyethylene glycol and cooling the mixture while stirring. After solidification, kneading may be performed using a kneader or a roller.
In the case of solidification without stirring, crystals of polyethylene glycol grow and the hardness increases, making application difficult.

The thermal base of the present invention is used for an external preparation for skin such as cosmetics, and is particularly preferably used as a massage gel having a warm feeling. The thermal base of the present invention spreads little when applied to the skin and has good usability. Also,
It is a zeolite-containing thermal base with excellent stability. The thermal base of the present invention can provide the effects of improving the usability and the stability without blending a water-soluble polymer or a clay mineral.

[0033]

Next, the present invention will be described more specifically with reference to examples. The present invention is not limited to the following examples.

A thermal base having the composition shown in Table 1 was prepared and evaluated. The evaluation method is as follows.

(1) Stability after One Month at 50 ° C. The thermal base was left in a constant temperature layer at 50 ° C. for one month. The appearance was visually evaluated according to the following criteria. ：: No change in appearance, stable without any problem. Δ: Separation of powder was slightly observed. X: Separation of powder is observed.

(2) Usability The thermal base was applied to the faces of 30 female panelists and massaged. A questionnaire was conducted and judged based on the following criteria. ：: 20 or more panelists answered that the growth was very light. ○: 10 or fewer panelists answered that the growth was very light
19 people. Δ: 5-9 panelists answered that the growth was very light
Name. ×: The number of panelists who answered that the growth was very light was 4 or less.

(3) Thermal sensation during use The thermal base was applied to the faces of 30 female panelists, used, and evaluated. A questionnaire was conducted and judged based on the following criteria. ◎: 20 panelists answered that they had a very warm feeling
More than names. ○: 10 panelists answered that they had a very warm feeling
~ 19 people. Δ: Five or five panelists answered that they had a very warm feeling
9 people. ×: The number of panelists who answered that the feeling of warmth was very low was 4 or less.

[0038]

[Table 1]

(Preparation method)
Stirring with a homomixer at 0 ° C under reduced pressure is 7000 rpm
m, 30 minutes, and 100
Stirred at rpm for 2 hours. The obtained slurry was cooled to 30 ° C. while stirring to obtain an external preparation for skin.

The following is clear from Table 1. Low molecular polyethylene glycol (polyethylene glycol 40
Comparative Examples 1 and 2 prepared in (0, 1500) have poor high-temperature stability. Comparative Example 3, in which high molecular weight polyethylene glycol (polyethylene glycol 6000, 20000) was prepared, had good stability but was heavy in usability. In Examples 1 to 3 in which low-molecular-weight polyethylene glycol and high-molecular-weight polyethylene glycol were combined in an appropriate amount, both high-temperature stability, usability, and thermal sensation were good. In addition,
Examples 1 to 3 contain 1,3-butylene glycol, but the same effect can be obtained without blending 1,3-butylene glycol.

An external preparation for skin having a thermal sensation having the composition shown in Table 2 was produced from the thermal base of the present invention, and its stability, usability,
The feeling of warmth was evaluated by the above method.

[0042]

[Table 2]

(Preparation method) 1 to 10, 14 and 16 were stirred at 7000 rpm for 30 minutes at 90 ° C. under reduced pressure by an azimomixer at 7000 rpm, and further stirred at 100 rpm for 2 hours while maintaining the reduced pressure. In addition, 11
~ 13,15,17,18 with stirring and added,
The mixture was further stirred for 10 minutes and cooled to 30 ° C. to obtain an external preparation for skin.

As is clear from Table 2, Examples 4 to 10 of the present invention were excellent in high-temperature stability, usability, and thermal sensation.

[0045]

The effects of the thermal base of the present invention are as follows. 1) It has an excellent feeling of warmth. 2) Excellent usability. Especially light. 3) Excellent stability. In particular, the high-temperature separation stability of zeolite is good.

 ────────────────────────────────────────────────── ─── Continuing from the front page (72) Fumiaki Matsuzaki 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama-shi, Kanagawa Prefecture F-term (reference) in Shiseido Research Center (Shin-Yokohama) 4C083 AB282 AB352 AB441 AB442 AC111 AC121 AC122 AC131 AC432 AC472 AC532 AC841 AD041 AD042 AD111 AD112 AD152 AD172 AD201 AD211 AD221 AD662 BB13 CC02 DD41 EE01 EE05 EE11

Claims (7)

[Claims] 1. A thermal base comprising the following components: (1) Zeolite (2) Polyethylene glycol having a number average molecular weight of 4000 to 30,000 (3) Polyethylene glycol having a number average molecular weight of 300 to 600 2. A thermal base comprising the following components. (1) Anhydrous inorganic salt (2) Polyethylene glycol having a number average molecular weight of 4,000 to 30,000 (3) Polyethylene glycol having a number average molecular weight of 300 to 600 3. The thermal base according to claim 1, further comprising (4) a polyhydric alcohol. 4. The thermal base according to claim 1, wherein the zeolite has a pore size of 3 to 4 angstroms. 5. The thermal base according to claim 1, wherein the polyhydric alcohol is at least one compound selected from the following group. Glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, dipropylene glycol, trimethylolethane, trimethylolpropane, erythritol, pentaerythritol, sorbitan, glucose, sorbitol, maltitol, sucrose, raffinose, and trehalose. 6. The method according to claim 1, further comprising (5) an oil component.
5. The thermal base according to 5. 7. The thermal base according to claim 1, which does not substantially contain a thickener comprising a water-soluble polymer or a clay mineral.