JP2002234836A5 - - Google Patents
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- Publication number
- JP2002234836A5 JP2002234836A5 JP2001034840A JP2001034840A JP2002234836A5 JP 2002234836 A5 JP2002234836 A5 JP 2002234836A5 JP 2001034840 A JP2001034840 A JP 2001034840A JP 2001034840 A JP2001034840 A JP 2001034840A JP 2002234836 A5 JP2002234836 A5 JP 2002234836A5
- Authority
- JP
- Japan
- Prior art keywords
- stress
- skin
- group
- tranexamic acid
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 229960000401 tranexamic acid Drugs 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 8
- 125000003342 alkenyl group Chemical group 0.000 description 7
- 125000003277 amino group Chemical group 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- -1 and among these Chemical group 0.000 description 6
- 230000003938 response to stress Effects 0.000 description 6
- 206010013786 Dry skin Diseases 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 238000009395 breeding Methods 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004215 skin function Effects 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000011707 mineral Chemical class 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001034840A JP2002234836A (ja) | 2001-02-13 | 2001-02-13 | ストレス対応皮膚外用剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001034840A JP2002234836A (ja) | 2001-02-13 | 2001-02-13 | ストレス対応皮膚外用剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002234836A JP2002234836A (ja) | 2002-08-23 |
| JP2002234836A5 true JP2002234836A5 (enExample) | 2008-03-06 |
Family
ID=18898374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001034840A Pending JP2002234836A (ja) | 2001-02-13 | 2001-02-13 | ストレス対応皮膚外用剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2002234836A (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4723899B2 (ja) * | 2005-04-26 | 2011-07-13 | 日光ケミカルズ株式会社 | 皮膚外用組成物 |
| CN101378747A (zh) * | 2006-02-06 | 2009-03-04 | 昭和电工株式会社 | 增白皮肤病制剂 |
| WO2008050173A1 (en) * | 2006-10-26 | 2008-05-02 | Chanel Parfums Beaute | Topical skin care composition comprising a tranexamic acid ester |
| US8647650B2 (en) | 2009-12-11 | 2014-02-11 | Chanel Parfums Beaute | Composition for external use and method for producing the same |
| JP5753435B2 (ja) * | 2010-04-26 | 2015-07-22 | 第一三共ヘルスケア株式会社 | 抗潰瘍剤組成物 |
| JP5165736B2 (ja) | 2010-08-06 | 2013-03-21 | 株式会社シャネル化粧品技術開発研究所 | トラネキサム酸エステルの生理学的に許容される塩を含む外用組成物の製造方法 |
| JP5570442B2 (ja) | 2011-01-24 | 2014-08-13 | 株式会社シャネル化粧品技術開発研究所 | 水中油型乳化組成物及びその製造方法 |
| JP6822648B2 (ja) * | 2015-06-30 | 2021-01-27 | 第一三共ヘルスケア株式会社 | トリプターゼ阻害剤組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3888651B2 (ja) * | 1997-02-07 | 2007-03-07 | 株式会社資生堂 | 皮膚バリアー機能の回復能の評価方法およびその方法により有効性を示す薬物の使用 |
| JPH11193207A (ja) * | 1997-12-26 | 1999-07-21 | Shiseido Co Ltd | 皮膚外用剤 |
-
2001
- 2001-02-13 JP JP2001034840A patent/JP2002234836A/ja active Pending
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