JP2002205767A - Package of solid preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a package of a solid preparation, which is capable of being easily unsealed even by a person whose finger tips are weak in strength or by a person who can only use one hand. SOLUTION: The package of a solid preparation has a storing part for storing a solid preparation and a sealing part for closing a periphery of the storing part. At least one region of the sealing part is formed into a weak sealing part easily openable, and the weak sealing part has a length capable of defining an opening through which the solid preparation in the storing part can pass. The storing part is formed of a flexible packaging material which has one or more resin layers and which enables the solid preparation in the storing part to be held between finger tips.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a package for packaging solid preparations such as pharmaceuticals and foods. For example, solid medicines, foods, health foods, which can be used by doctors in medical institutions or purchased directly by general users in pharmacies,
Tablets, capsules, etc. used as bath salts, etc.
The present invention relates to a package for packaging a solid preparation such as a troche.

[0002]

2. Description of the Related Art When a solid preparation such as a tablet or a capsule is sealed with a packaging film, a four-side seal for sealing four sides, a three-side seal for sealing three sides,
A packaging form such as a strip packaging that seals around the solid preparation is used. In the case of these packaging forms, the solid preparation can be taken out by tearing the packaging film. As a packaging film used for such packaging, it is common to use a composite film in which the innermost material is formed of a heat-sealable material such as polyethylene or polypropylene.

[0003] PTP packaging combining a plastic sheet and aluminum foil is also a form often used for packaging solid preparations. In the case of PTP packaging, a solid preparation is stored in a pocket formed in a plastic sheet, and a lid material such as aluminum foil is attached and sealed. In this case, the lid material is broken by pressing the pocket portion with a finger from the plastic sheet side, and the stored solid preparation can be taken out.

[0004] However, these solid pharmaceutical packages have the following problems. First, there are cases where these solid pharmaceutical packages have insufficient openability. That is, some elderly people, injured persons, and the like have a weak fingertip force (pinch force), and may not be able to pinch and tear the seal portion on the side edge of the package with sufficient force. In addition, these solid product packages can easily take out the solid product if a person with normal grip strength uses both hands, but patients who can use only one hand can open the package and take out the solid product. Is very difficult.

[0005] Also, in the case of PTP packaging, the contents cannot be taken out without using both hands, and the rigid resin sheet is used. The problem is that the digestive tract is damaged. In Japan, since 1996, the PTP package was split into two tablets by slitting or perforating only in the horizontal direction, and the unloading diagram and precautionary statement were unified. Has not yet been resolved.

[0006]

SUMMARY OF THE INVENTION The present invention has been accomplished in view of the above problems, and has as its object the purpose of making it easy for a person who has a weak fingertip force (pinch force) or a person who can use only one hand. An object of the present invention is to provide an openable solid preparation package.

[0007]

Means for Solving the Problems As a result of intensive studies, the present inventors have found that at least one region of the seal portion on the periphery of the solid product package is provided with a weak seal portion having a size through which the solid product can pass. The present inventors have found that the solid preparation can be taken out (extruded) while peeling the weak seal portion by pressing the solid preparation against the inner edge of the weak seal portion, and the present invention has been completed based on this finding.

[0008] That is, the solid product package provided by the present invention is a solid product package comprising a storage portion for storing a solid product, and a seal portion for closing the periphery of the storage portion. At least one region of the portion is formed in an openable weak seal portion, the weak seal portion has a length capable of forming an opening through which the solid preparation of the storage portion can pass, and the storage portion is It is characterized by being formed of a soft packaging material having one or more resin layers capable of sandwiching the solid preparation in the storage section with a finger.

[0009] In the solid preparation package according to the present invention, at least one region of the seal section closing the storage section for storing the solid preparation is formed in the weak seal section. The solid preparation can be removed in such a way that the beans are extruded from the green soybean pods. Therefore, the solid preparation can be easily taken out even by a person with a very weak fingertip or a person who can use only one hand. Further, by holding the solid preparation package according to the present invention with one hand and extruding the solid preparation with the weak seal portion attached to the mouth, it is possible to drop the solid preparation from the package into the mouth with only one hand. is there.

[0010] The weak seal portion of the solid pharmaceutical package according to the present invention preferably has a seal width of 10 mm or less. Set the seal width of the weak seal portion (that is, the distance in the extrusion direction) to 1
When the thickness is 0 mm or less, no trouble is required when passing the solid preparation.

As one mode of the solid preparation package according to the present invention, a front wall portion and a rear wall portion formed by using a packaging film as the soft packaging material, and a portion between the front wall portion and the rear wall portion are provided. The storage portion and the seal portion are formed, and the storage portion and the weak seal portion are included by joining inner surfaces of a front wall portion and a rear wall portion facing each other at a peripheral edge of the storage portion. A form in which the seal portion is formed can be adopted.

[0012] In another embodiment of the solid pharmaceutical package according to the present invention, the soft packaging material is formed of a packaging material capable of causing cohesive failure in a layer. The opened portion of the wall and / or the rear wall may be whitened. When the weak seal portion is cohesively peeled, the opened portion is whitened, so that it can be visually recognized that the opened portion is opened.

As the soft packaging material for forming the solid pharmaceutical package according to the present invention, it is preferable to use an easy-opening film which can be adjusted so that the peel strength at a test speed of 100 mm / min is less than 5 N / 15 mm. As the easy-opening film, a polyolefin-based film containing polyethylene and / or polypropylene as a main component can be suitably used.

The soft packaging material forming the solid pharmaceutical package according to the present invention is a chlorine-free single-layer or multi-layer structure packaging material from the viewpoint of disposal and environmental friendliness. It preferably does not include a layer of metal foil.

It is preferable that the weakly sealed portion of the packaged solid product according to the present invention has a portion protruding toward the internal space of the storage portion. When the weak seal portion is formed to protrude toward the internal space side of the storage portion in this manner, the peeling can be started with a relatively weak force by using the top of the protruding portion as a trigger (starting point).

As one form of projecting the weak seal portion into the interior space side of the storage portion, the weak seal portion is formed in a V-shape or U-shape projecting into the interior space side of the storage portion, and A shape in which a U-shaped or U-shaped concave portion is cut out may be employed.

The weak seal portion of this embodiment can start peeling with a relatively weak force triggered by a V-shaped or U-shaped vertex protruding toward the internal space of the storage portion. In addition, when the outer edge side of the weak seal portion is cut out and dented into an appropriate shape and size, the solid preparation pushed out from the weak seal portion is caught on the outer edge of the cut weak seal portion, Easy to pick up and hard to drop.

[0018]

Next, the present invention will be described in detail by showing preferred embodiments of the present invention. The solid preparation to which the solid preparation package according to the present invention can be applied is a solid preparation used as a medicine used in medical institutions and homes for the treatment, prevention and diagnosis of injuries and diseases, health food, confectionery, and a bath preparation. And pills, suppositories, tablets, capsules, troches, and the like can be given as examples of the above. As the size of a typical solid preparation to which the present invention can be applied, tablets and troches have a diameter of 5 to 35 mm.
2 to 10 mm in thickness and 5 to 2 in long diameter for deformed tablets
A capsule having a diameter of 0 mm and a minor axis of 3 to 10 mm and a capsule having a major axis of 5 to 20 mm and a minor axis of 3 to 10 mm can be suitably used, but is not particularly limited.

The solid preparation package according to the present invention includes a storage section for storing the solid preparation, and a seal section for closing a periphery of the storage section, and the storage section stores the solid preparation in the storage section. It is formed of a soft packaging material that can be pinched by a finger, and at least one region of the seal portion is formed as a weak seal that can be opened.

At least a portion of the storage portion of the package is formed of a soft packaging material. The solid preparation in the storage portion is pinched and moved from above the packaging material by a finger, and the periphery of the storage portion (the seal portion) is moved. Inner edge). For example, in the case of strip packaging such as a three-sided seal or a four-sided seal, the front wall portion and the rear wall portion of the package are formed using a single or laminated film material as a soft package material, and The storage portion is formed by sealing a peripheral portion where the wall portion and the rear wall portion are overlapped.

As a soft packaging material for forming a package,
A film material or a sheet material having a single-layer structure or a multilayer structure having one or more resin layers can be used.Furthermore, a film-like or sheet-like composite laminate having a layer made of a material other than a resin together with a resin layer can be used. It can also be used. For example, films composed of plastics such as polyolefin, polyamide, polyester, polyvinyl alcohol, saponified ethylene-vinyl acetate copolymer, or vapor-deposited films or papers on which inorganic substances such as aluminum, silicon oxide, and aluminum oxide are vapor-deposited , Aluminum foil, cellophane film and the like, which are used as ordinary packaging materials, one or two or more types can be selected according to required performance such as content protection. As a method of laminating films to make the packaging material multilayer,
Techniques such as dry lamination, extrusion lamination, and wet lamination can be used. Also,
Layer formation by extrusion lamination or coating is also possible.

As a soft packaging material, the test speed is 100 m
It is preferable to use an easy-opening film that can be adjusted so that the peel strength at m / min is less than 5 N / 15 mm. As the easy-opening film, a polyolefin-based film containing polyethylene and / or polypropylene as a main component can be suitably used. In particular, a packaging material having a single-layer structure made of heat-sealable biaxially oriented polypropylene or a multilayer material obtained by laminating a heat-sealable biaxially oriented polypropylene film and another film is preferably used.

In consideration of the disposability of the packaging material, chlorine-based films, such as a polyvinyl chloride film, a polyvinylidene chloride film, and a polyvinylidene chloride coated film, which generate chlorine gas during combustion are not preferred. Further, since metal foil such as aluminum foil has a problem in terms of disposability or incineration, use of metal foil such as aluminum foil or a composite film having such a metal foil layer as a packaging material is not recommended. It is preferable to avoid.

The kind of the soft wrapping material forming the front wall and the rear wall may be different, but both the front wall and the rear wall are formed of an opaque wrapping material such as paper or aluminum foil. Then, it is difficult to understand the position of the solid preparation in the storage section, and when the solid preparation in the storage section is pinched with a finger and pressed against the inner edge of the seal section, the movement amount of the solid preparation is not known, so at least one of the solid preparations is unknown. It is desirable that the solid preparation has such a degree of transparency that it can be recognized.

The total thickness of the soft packaging material is 10 to 30
A range of 0 μm is suitable, and a range of 20 to 100 μm is particularly desirable. However, if the following two requirements are satisfied,
The thickness is not particularly limited.

(A) The solid preparation in the storage section can be moved from the outside of the partition wall forming the storage section by being sandwiched between fingers and pressed against the periphery of the storage section. This requirement is essential for the function of the present invention.

(B) In the substitute characteristic test described below, 15
The maximum load when penetrating a laminate in which three aluminum foils of 3 μm are stacked is 0.2 N or more, or the laminate has such a softness that it does not penetrate the laminate. This requirement is not essential for the function of the present invention, but it is desirable to satisfy such requirement for the safety of the user. In particular, when it is desired to use a relatively thick sheet-like material as a soft packaging material for forming the solid pharmaceutical package of the present invention, the sheet-like material has a flexibility capable of extruding contents. However, when it is still swallowed, many of them have a hardness that easily damages the digestive tract such as the esophagus, so it is desirable to evaluate the softness by a substitute property test and use an appropriate one .

At least one region of the seal portion closing the periphery of the storage portion is formed as a weak seal portion, and the weak seal portion has a seal length capable of forming an opening through which the solid preparation in the storage portion can pass. (That is, the distance in the longitudinal direction of the seal portion), and the peel strength at a test speed of 100 mm / min was 5 N / 15 when the peel test described below was performed.
It is adjusted to be less than mm. Peel strength is 5N
In the case of / 15 mm or more, it is difficult to take out the solid preparation. A particularly preferred range of the peel strength is 1N / 15.
mm or more and less than 4 N / 15 mm.

The seal width of the weak seal portion (ie, the distance in the extrusion direction) is preferably 10 mm or less. If the seal width exceeds 10 mm, it takes time and effort to pass the solid preparation, which is not preferable. Further, when the seal width is less than 3 mm, there is a high risk that the sealability is impaired. A preferred seal width is 3 mm or more and 10 mm or less, and a particularly preferred range is a seal width of 5 mm or more and 8 mm or less.

As a method of forming the weak seal portion, for example, the following method can be adopted.
The forming method is not limited to the following method as long as the forming method has a peel strength at 5 mm / min of less than 5 N / 15 mm. (A) In such a manner that the entire periphery of the storage portion becomes a weak seal portion,
A method of laminating an easy-opening film as an innermost layer on both a packaging material to be a front wall portion and a packaging material to be a rear wall portion, and bonding them together. (B) so that the entire periphery of the storage portion is a weak seal portion,
A method in which the innermost surfaces of a packaging material to be a front wall portion and a packaging material to be a rear wall portion are extrusion-coated with an easily-openable resin layer, and then two pieces of packaging material are bonded. (C) A release agent or a weak sealant is applied to a predetermined region on the innermost surface of each of the packaging material to be the front wall portion and the packaging material to be the rear wall portion so that one region of the peripheral edge of the storage portion becomes a weak seal portion. After coating, two packaging materials are bonded together. (D) A method of partially lowering the sealing temperature and pressure so that one region of the periphery of the storage portion becomes a weak seal portion.

When the solid preparation in the storage portion of the package according to the present invention is moved from the outside of the package by a finger to a position where the solid formulation comes into contact with the weak seal portion and further pressed against the inner edge of the weak seal portion, The packaging material that has been butted and joined at the seal portion is peeled off by the pushing force, and the solid preparation can be taken out.

The packaging form of the solid preparation package according to the present invention is not particularly limited. For example, a three-way seal or a pillow-type seal in which one package film is folded to seal the open end is used. It is possible to adopt a packaging form generally applied to solid preparations, such as a four-side seal in which the open ends of four sides are sealed by overlapping the packaging films of the above, and a strip packaging in which the periphery of the solid preparation is similarly sealed. it can.

Typical three-sided seals, four-sided seals, pillow-type packages and the like belonging to the solid preparation package of the present invention are as follows:
A front wall portion and a rear wall portion formed by a packaging film, and the storage portion formed between the front wall portion and the rear wall portion,
The seal portion for closing a peripheral edge of the storage portion. In this case, the housing portion is formed by joining the inner surfaces of the front wall portion and the rear wall portion facing each other at the peripheral edge of the housing portion, and the seal portion including the weak seal portion is formed.

FIG. 1 is a plan view showing a four-side sealed strip package (101) belonging to the solid preparation package according to the present invention, and FIG. 2 is a sectional view taken along the line AA of FIG. It is a thing. The package 101 includes a front wall portion 1 and a rear wall portion 2 formed of a packaging film, and a storage portion formed between the front wall portion and the rear wall portion for storing a tablet as a solid preparation 3. 4 and a seal part 5 for closing the storage part 4. In the package 101, the sealing portion 5 is arranged such that the front wall portion 1 facing the peripheral portion of the package is opposed to the front wall 1.
It is formed by joining the inner surfaces of the rear wall portion 2 to each other.

The sealing part 5 has a test speed of 100 mm / min.
Is adjusted so that the peel strength is less than 5 N / 15 mm. That is, the sealing portion 5 of the package 101
The whole area is formed in the weak seal portion, and the solid preparation 3 can be extruded from any position on the peripheral edge of the package. However, the weak seal portion may be formed only in one region of the seal portion, in which case, a weak seal portion having a length capable of forming an opening large enough to allow the solid preparation in the storage portion to pass therethrough is provided. .

One portion of the seal portion 5 is formed in a V-shape (5a) projecting toward the inner space side of the storage portion 4 and has a V-shaped concave portion (V-shaped outer edge side) cut out. Is missing. When the weak seal portion is formed to protrude toward the internal space side of the storage portion in this manner, the peeling can be started with a relatively weak force by using the apex of the protruding portion as a trigger (starting point).

In general, when the package is peeled off and opened, the resistance is the highest at the start of peeling, but once the peeling has started, the resistance becomes weak and the opening is performed with a smaller force than at the start. be able to. On the other hand, in the case where the inner edge side of the weak seal portion is projected in the present invention,
Since the pressing force of the solid preparation can be concentrated on one point of the weak seal portion, the peeling can be started with a relatively weak force.

It is preferable that the protruding portion of the weak seal portion is formed so as to gradually narrow from the base line of the inner edge of the weak seal portion toward the vertex of the protruding portion. When the inner edge side of the weak seal portion is projected in such a shape, the area that must be peeled at the same time gradually starts to spread from the top of the protruding portion and then gradually expands. Gradually become stronger. Therefore, the solid preparation can be slowly and surely taken out, instead of suddenly jumping out.

As a specific shape of the protruding portion of the weak seal portion, for example, it is preferable to have a left-right symmetrical shape such as a V shape, a U shape, a semicircle, a parabola, or the like.

The V-shaped portion (5
In the case where the outer edge side of the weak seal portion is cut into an appropriate shape and size and dented as in a), the outer edge of the weak seal portion in which the solid preparation extruded from the weak seal portion is cut out. It is easy to pick up and hard to drop. Even when the weak seal portion is formed in a U-shape and the concave portion on the outer edge side is cut out, the same effect as that in the V-shape can be obtained.

FIGS. 3A to 3E show the above-mentioned package 10.
7 shows an operation procedure and an intermediate process when a solid preparation is extruded from a V-shaped portion 5a of the seal portion 5 of FIG. First, the solid preparation 3 in the storage section 4 of the package 101 is
3A is moved forward with fingers between the front wall 1 side and the rear wall 2 side of the package, and as shown in the plan view of FIG. 3A-1 and the cross-sectional view of FIG. In contact with the top of the V-shaped portion 5a. Next, the solid preparation 3
When further pressed against the vertex of the character-shaped portion 5a, FIG.
As shown in the plan view of FIG. 3 and the cross-sectional view of FIG. 3B-2, the vertex of the weak seal portion is broken, and the packaging film joined at the weak seal portion starts to peel. At this time, since the force for pushing out the solid preparation concentrates on only one vertex of the weak seal portion, the peeling can be started smoothly with a relatively small force.

When the solid preparation 3 is further pushed, FIG.
As shown in the plan view of FIG. -1 and the cross-sectional view of FIG. 3C-2, the weak seal portion is opened, the opening gradually widens, and the solid preparation 3 is pushed out from the concave portion of the V-shaped portion. come. At this time, the area of the weak seal portion which must be peeled off at the same time gradually increases, so that the resistance of the weak seal portion gradually increases. Therefore, the solid preparation can be slowly and surely taken out, instead of suddenly jumping out.

When the solid preparation 3 is completely extruded from the V-shaped portion of the weak seal, the plan view of FIG.
As shown in the cross-sectional view of -2, the peripheral portion of the solid preparation 3 that swells in an arc shape is hooked and held by the straight edge 5b of the V-shaped notch of the weak seal portion. In this state, the solid preparation 3 can be easily picked up and hard to drop.

After the solid preparation 3 is taken out from the V-shaped part of the weak seal, the plan view of FIG. 3E-1 and the plan view of FIG.
The opening 6 is left as shown in the sectional view of FIG. The weak seal portion may be peeled off at the interface between the packaging film forming the front wall portion 1 and the packaging film forming the rear wall portion 2, or the packaging film of either the front wall portion 1 or the rear wall portion 2 may be formed. May be caused by cohesive failure in the layer of the above-mentioned layer to cause cohesive peeling. When the weak seal portion is cohesively peeled, the opened portion of the opening 6 is whitened, so that it can be visually recognized that the opening has been opened. That is, a virgin seal function is exhibited.

As described above, the solid preparation stored in the solid preparation package according to the present invention can be taken out by a method in which beans are extruded from pods of green soybeans. Therefore,
A solid preparation can be easily taken out even by a user who has a very weak force of pinching an object with a fingertip (a pinch force) or a person who can use only one hand. Further, by holding the solid preparation package according to the present invention with one hand and extruding the solid preparation with the weak seal portion attached to the mouth, the solid preparation can be dropped from the package into the mouth with only one hand. is there.

As described above, a substitute property test was performed to evaluate the safety of the solid pharmaceutical package of the present invention at the time of accidental ingestion, and the peel strength of the weakly sealed portion of the solid pharmaceutical package of the present invention was evaluated. A peel test is performed for evaluation, and these tests can be specifically performed by the following method.

(1) Substitution Characteristics Test This is a test for evaluating the possibility of damaging the lining of the digestive tract, such as the esophagus and stomach, when the solid preparation package is swallowed by a user.

When a package of a solid preparation such as a pharmaceutical strip package or a blister package is ingested by mistake,
It is considered that the corners (corners) of the seal are most likely to pierce or get caught in the digestive tract, particularly the inner wall of the esophagus, and cause damage.

Therefore, as shown in FIG. 4, the heat-sealed portion of the package of the solid preparation is 5 mm wide by using sharp scissors.
A sample 51 is prepared by cutting into a rectangular shape having a length of 30 mm. On the other hand, as shown in FIG. 5, a soft aluminum foil 54 having a thickness of 15 μm is placed on a plate 52 having a hole 53 having a diameter of 50 mm.
Are stacked and fixed to prepare a simplified model 55 of the inner wall of the esophagus.

Then, as shown in FIG. 6, the sample 51 is mounted by being sandwiched between push-pull gauges 56 such that the right-angled corners (tips) protrude 2.5 mm. The corner of the sample 51 was aligned with the hole 53 of the simple model 55 on the inner wall of the esophagus.
A maximum load (N) required when the aluminum foil is penetrated by applying a load to the surface of the aluminum foil. In this way, the penetration between samples can be relatively evaluated.

In the above substitute characteristic test, it can be evaluated that a sample having a smaller maximum load is sharper and more easily penetrates, and the inner wall of the digestive tract is easily damaged.

(2) Peeling Test The peeling strength at a test speed of 100 mm / min was measured in accordance with the item of JIS-Z1707 heat seal strength.

[0053]

EXAMPLES Example 1 A PET film (IB-PET, manufactured by Dai Nippon Printing Co., Ltd.) on which silicon oxide was deposited and an easy-open heat-seal OPP film (EP-1, manufactured by Gunze Co., Ltd.) Was dry-laminated to obtain a laminated film having the following structure. In addition, the thickness of each layer is added.

<Layer Structure> Silicon oxide-deposited PET (12 μm) / easy-opening heat-sealable OPP (50 μm) Two laminated films were prepared, and the OPP surfaces of both films were set at 130 ° C., 0.2 MPa, 0 MPa. The peel strength when heat-sealed under a sealing condition of 0.5 sec was 3 N / 15 m when the above-mentioned peel test was performed at a test speed of 100 mm / min.
m. Two sheets of the laminated film are prepared again and used as the front wall and the rear wall of the package, and the OPP surfaces of both films are faced to each other, and the three sides of the periphery are subjected to the same conditions as in the peel test. Heat sealing was performed to a width of 5 mm to obtain a three-sided bag having a size of 35 mm × 35 mm. A tablet having a tablet diameter of 8.1 mm and a tablet thickness of 4.3 mm was put into the three-sided bag through the opening, and the opening was heat-sealed to a width of 5 mm under the same conditions as described above and sealed.

(Example 2) PET on which silicon oxide was deposited
A film (IB-PET, manufactured by Dai Nippon Printing Co., Ltd.) and an easily-openable CPP film (TAF650C, manufactured by Tosero) were dry-laminated to obtain a laminated film having the following structure. In addition, the thickness of each layer is added. <Layer structure>-Silicon oxide vapor-deposited PET (12 μm) / easy-opening CPP
(30 μm) The peel strength when two laminated films were prepared and the two CPP surfaces were heat-sealed under the sealing conditions of 130 ° C., 0.2 MPa, and 0.5 sec was tested at a test speed of 100 m.
It was 2.5 N / 15 mm at m / min.

The above two laminated films were again prepared and used as the front wall and the rear wall of the package.
The surfaces are faced to each other, and the three sides of the peripheral portion are heat-sealed to a width of 5 mm under the same conditions as those in the peeling test,
A three-sided bag with dimensions of 35 mm × 35 mm was obtained. In this three-sided bag, the tablet diameter is 8.1 mm and the tablet thickness is 4.3 mm from the opening.
And the opening was heat-sealed to a width of 5 mm under the same conditions as above and sealed.

(Example 3) Using the laminated film prepared in Example 1, under the same heat sealing conditions as in Example 1, a deformed bag having a shape as shown in FIG. A three-sided bag with a cutout side opening was obtained. The tablets were put into the three-sided bag in the same manner as in Example 1, and the opening was sealed by heat sealing. The obtained package has a size of 35 mm × 35 mm and a seal width of 5 mm.
In one side, both ends are heat-sealed to have a straight portion with a seal length of 9 mm at each end and a V-shaped portion with a vertex angle of 120 ° C. protruding inward at an angle of 120 ° C. Was cut out along the shape of the heat seal.

(Example 4) Using the laminated film prepared in Example 2, under the same heat sealing conditions as in Example 2, a deformable bag having a shape as shown in FIG. A three-sided bag with a cutout side opening was obtained. The tablets were put into the three-sided bag in the same manner as in Example 2, and the opening was sealed by heat sealing. The obtained package has a size of 35 mm × 35 mm and a seal width of 5 m.
m, with a seal length of 9 m at each end on one side.
m, and has a V-shaped portion protruding inward at an angle of 120 ° C. at the apex, and the outer edge of the V-shaped portion is cut out along the shape of the heat seal. Had been.

(Comparative Example 1) PET on which silicon oxide was deposited
A film (IB-PET, manufactured by Dai Nippon Printing Co., Ltd.) and a heat-sealable OPP film (Silphan SS, manufactured by Gunze KK) were dry-laminated to obtain a laminated film having the following structure. In addition, the thickness of each layer is added. <Layer configuration>-Silicon oxide vapor-deposited PET (12 μm) / heat-sealable OPP (50 μm) Two laminated films were prepared, and the OPP surfaces of both were sealed at 130 ° C., 0.2 MPa, 0.5 sec. Strength when heat-sealed with a test speed of 100 m
It was 8 N / 15 mm at m / min.

The above two laminated films were prepared again and used as the front wall and the rear wall of the package.
The surfaces are faced to each other, and the three sides of the peripheral portion are heat-sealed to a width of 5 mm under the same conditions as those in the peeling test,
A three-sided bag with dimensions of 35 mm × 35 mm was obtained. In this three-sided bag, the tablet diameter is 8.1 mm and the tablet thickness is 4.3 mm from the opening.
And the opening was heat-sealed to a width of 5 mm under the same conditions as above and sealed.

(Comparative Example 2) PET on which silicon oxide was deposited
Film (IB-PET, manufactured by Dai Nippon Printing Co., Ltd.) and CP
A P film (Trefane 3501, manufactured by Toray Gosei) was dry-laminated to obtain a laminated film having the following structure.
In addition, the thickness of each layer is added. <Layer configuration>-Silicon oxide evaporated PET (12 μm) / CPP (30 μm)
m) The peel strength when two laminated films were prepared and the two CPP surfaces were heat-sealed with each other under the sealing conditions of 130 ° C., 0.2 MPa and 0.5 sec was tested at a test speed of 100 m.
It was 18 N / 15 mm at m / min.

The above two laminated films were prepared again and used as the front wall and the rear wall of the package.
The surfaces are faced to each other, and the three sides of the peripheral portion are heat-sealed to a width of 5 mm under the same conditions as those in the peeling test,
A three-sided bag with dimensions of 35 mm × 35 mm was obtained. In this three-sided bag, the tablet diameter is 8.1 mm and the tablet thickness is 4.3 mm from the opening.
And the opening was heat-sealed to a width of 5 mm under the same conditions as above and sealed.

Comparative Example 3 An aluminum foil having a thickness of 15 μm was used as a front wall, and a polypropylene sheet having a thickness of 250 μm was used as a rear wall. First, the polypropylene sheet is pre-heated and a hydraulic press molding machine (600 UB, CKD
The product was embossed to form a pocket (storage portion), and tablets were put into the pocket. Next, an aluminum foil was overlaid on the opening surface of the pocket portion of the polypropylene sheet, heat-sealed under the same conditions as in Example 1, and the tablets were sealed. An attempt was made to measure the peel strength of the heat-sealed portion by the same method as in Example 1, but the peel strength could not be measured because the aluminum foil was cut without being peeled cleanly.

<Evaluation Method> (1) Peel Strength The peel test was performed as described above, and the peel strength at 100 mm / min (unit: N / 15 mm) was measured.

(2) Take-out property Using the solid preparation package obtained in each of the examples and comparative examples, it was tested whether or not tablets could be actually taken out with only one hand. Five trials were performed per sample, and the average time required to remove the tablets was determined for each sample.

(3) Safety at the time of accidental ingestion Using the solid preparation package obtained in each of the examples and comparative examples, the heat-sealed portion was cut into a rectangular shape having a size of 5 mm × 30 mm. A test was performed to determine the maximum load for each sample. Compare the measured maximum load,
The possibility of damaging the esophageal lining during ingestion was relatively evaluated.

<Results> Table 1 shows the structure of the solid preparation package obtained in each of the examples and comparative examples. Table 2 shows the results of each evaluation.

[0068]

[Table 1]

[0069]

[Table 2]

[0070]

As described above, the package of the solid preparation provided by the present invention can be easily opened with one hand by a user having a weak fingertip or a person who can use only one hand.

When the solid preparation package of the present invention is formed using a substance having sufficient softness in the above-mentioned substitute property test, even if the user accidentally swallows the whole package, the esophagus, stomach wall, etc. Less likely to damage the digestive tract.

The packaged solid preparation of the present invention is mainly used for packaging a solid preparation for oral use, but can be widely used for packaging solid preparations in general.

[Brief description of the drawings]

FIG. 1 is a plan view showing an example of a solid preparation package according to the present invention.

FIG. 2 is a schematic cross-sectional view showing one example of a solid preparation package according to the present invention.

FIG. 3 is a diagram illustrating a procedure for taking out a solid preparation from a solid preparation package according to the present invention.

FIG. 4 is a diagram illustrating a sample of a seal portion used in a substitute characteristic test performed in the present invention.

FIG. 5 is a diagram illustrating a simplified model of the inner wall of the esophagus used in the substitute characteristic test performed in the present invention.

FIG. 6 is a diagram illustrating a procedure of a substitute characteristic test performed in the present invention.

FIG. 7 is a view showing the shape of a deformed bag in the third and fourth embodiments.

[Explanation of symbols]

 101 ... solid preparation package 1 ... front wall part 2 ... rear wall part 3 ... solid preparation 4 ... storage part 5 ... seal part 6 ... opening 51 ... seal Sample for substitution property test of part 52 ・ ・ ・ Plate 53 ・ ・ ・ Hole 54 ・ ・ ・ Aluminum foil 55 ・ ・ ・ Simple model of inner wall of esophagus 56 ・ ・ ・ Push-pull gauge (tip part)

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Naoto Kasahara 1-1-1, Ichigaya-Kagacho, Shinjuku-ku, Tokyo Inside Dai Nippon Printing Co., Ltd. (72) Inventor Shigeto Tezuka 1-chome, Ichigaya-cho, Shinjuku-ku, Tokyo No. 1-1 Dai Nippon Printing Co., Ltd. (72) Inventor Tatsuyuki Iwasaki 588, Kanaya-Kawahara, Kanaya-cho, Haibara-gun, Shizuoka Prefecture Daiichi Pharmaceutical Co., Ltd. Ichiyaku Co., Ltd. (72) Inventor Yasuhiro Yamamoto 588 Kanaya Kawara, Kanaya-cho, Haibara-gun, Shizuoka Prefecture F-term (in reference) 3E067 AA05 AA11 AB01 AB82 BA31A BB14A BB16A BB18A BB25A CA24 EB07 EE59 GD08

Claims (9)

[Claims] 1. A solid preparation package comprising: a storage section for storing a solid preparation; and a seal section for closing a peripheral edge of the storage section, wherein at least one region of the seal section is a weak seal section that can be opened. The weak seal portion has a length capable of forming an opening through which the solid preparation of the storage portion can pass,
A solid preparation package, wherein the storage section is formed of a soft packaging material having one or more resin layers capable of sandwiching a solid preparation in the storage section with a finger. 2. The method according to claim 1, wherein the peel strength of the weak seal portion is a test speed of 1.
The solid preparation package according to claim 1, wherein the solid preparation package is less than 5 N / 15 mm at 00 mm / min. 3. The solid preparation package according to claim 1, wherein the seal width of the weak seal portion is 10 mm or less. 4. A front wall portion and a rear wall portion formed by using a packaging film as the soft packaging material, the storage portion formed between the front wall portion and the rear wall portion, and the seal portion. The seal portion including the storage portion and the weak seal portion is formed by joining inner surfaces of a front wall portion and a rear wall portion facing each other at a peripheral edge of the storage portion. The packaged solid preparation according to any one of claims 1 to 3. 5. The flexible packaging material is formed of a packaging material capable of causing cohesive failure in a layer, and when the weak seal portion is opened, the opened portion of the front wall and / or the rear wall is whitened. The package of a solid preparation according to any one of claims 1 to 4, characterized in that: 6. The packaging material according to claim 1, wherein the flexible packaging material has a single-layer structure made of a heat-sealable stretched polypropylene or a multilayer structure in which a heat-sealable stretched polypropylene film and another film are laminated. Item 6. The solid preparation package according to any one of Items 1 to 5. 7. The packaging material according to claim 1, wherein the flexible packaging material is a chlorine-free single-layered or multilayered packaging material and does not include a metal foil layer. 20. A package of a solid preparation according to the above. 8. The solid product package according to claim 1, wherein the weak seal portion has a portion protruding toward the internal space of the storage portion. 9. The weak seal portion is formed in a V-shape or a U-shape protruding toward the internal space of the storage portion, and has a V-shaped or U-shaped recessed portion. The package of a solid preparation according to claim 8, wherein: