JP2002201108A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic having a high safety of the human body, excellent emulsifiability, characteristics of sense of use, appearance such as gloss, texture, etc., and excellent storage stability. SOLUTION: This cosmetic or oil-in-hydrophilic base type emulsion composition comprises a glycolipid obtained by subjecting a sugar substrate and a lipid substrate prepared by extraction from a plant to a bioconversion with a yeast and isolating the obtained fermented metabolite. The cosmetic or oil-in- hydrophilic base type emulsion composition comprises the glycolipid, water and a soluble alkali agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a cosmetic containing glycolipid, an oil-in-hydrophilic emulsion composition, and an emulsion obtained by dispersing the emulsion composition in water.

[0002]

2. Description of the Related Art Conventionally, conditions required for emulsifying cosmetics such as creams and emulsions include (1) high safety without irritation to skin, hair, etc., and (2) emulsion stability over a long period of time. High (no separation or precipitates),
(3) Good texture, gloss, etc., (3) Good feel during use (takes, spreads, and feels (freshness to skin, moist feeling, etc.)), (4) Skin and hair after use And (5) no deterioration (discoloration or odor) even after long-term storage.
However, in order to satisfy these conditions, selection of an emulsifier and a specific formulation such as a specific combination and a combination of a special base have been performed, but it is not easy to achieve the purpose.

Emulsifying cosmetics (eg, creams, emulsions, etc.) using ordinary synthetic emulsifying agents (anionic, nonionic, and cationic synthetic surfactants) as emulsifiers generally cause irritation to the skin and hair. There was a drawback that it was easy to wake up. On the other hand, phospholipid derivatives such as soybean-derived lecithin and lysolecithin are commonly used as relatively safe and naturally derived surfactants.However, when preparing emulsified cosmetics, there are great restrictions on the oily substances used. Therefore, the emulsifying power is not sufficient, and it is necessary to carefully study the production method and the like, and it is not easy to obtain a cosmetic excellent in appearance and stability over time. So the skin,
There has been a demand for an emulsified cosmetic which is highly safe for hair and the like, and has excellent emulsifying properties, usability characteristics, appearance (gloss, texture, etc.) and excellent storage stability.

[0004]

In view of the above situation, the present invention can uniformly emulsify an oily substance, has high safety for skin, hair, etc., and has emulsifying properties, feeling upon use, and appearance (gloss, texture). Etc.) and to provide an emulsion type cosmetic having excellent storage stability.

[0005]

Means for Solving the Problems The present inventors have found that a cosmetic containing a specific glycolipid has low irritation, high safety and excellent storage stability, and has completed the present invention. Reached. That is, the present invention provides a cosmetic containing glycolipid obtained by bioconversion of a sugar substrate and a lipid substrate obtained by extracting from a plant using yeast, and isolating the obtained fermentation metabolite.

[0006] The cosmetic of the present invention comprises an oil-in-water emulsion obtained by dispersing the hydrophilic oil-in-base emulsion composition in water as a hydrophilic base-in-oil emulsion composition containing the glycolipid. May be provided in the form of

That is, in another aspect, the present invention provides a method for preparing a glycolipid comprising 0.1 to 30% by weight, one or more hydrophilic bases selected from the group consisting of polyhydric alcohols and saccharides at 1 to 80% by weight, In addition, the present invention also provides an oil-in-hydrophilic base emulsion composition obtained by mixing 1 to 90% by weight of an oil phase component. The oil-in-hydrophilic base emulsion composition may further contain 0.1 to 10% by weight of a surfactant. The present invention further provides a cosmetic containing the hydrophilic oil-in-base emulsion composition.

[0008] In still another aspect of the present invention, the solubility of the glycolipid in water at 25 ° C is 1.0 or more, and the pH of the aqueous solution at 25 ° C is 7.0.
A cosmetic comprising the compound described above is provided. Such cosmetics have particularly high storage stability and are excellent in excellent foaming, emulsification degree, usability characteristics, appearance, that is, gloss, texture, and the like.

The cosmetics of the present invention include cosmetics for cleansing, cosmetics for hair, basic cosmetics, makeup cosmetics, aromatic cosmetics, tanning / sunscreen cosmetics, nail cosmetics, eyeliner cosmetics, lips It is provided as a cosmetic, an oral cosmetic or a bathing cosmetic.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION Glycolipid used in the present invention is obtained by bioconversion of a sugar substrate and a lipid substrate obtained by extracting from a plant using yeast and isolating the resulting fermentation metabolite. is there. Wheat or the like is mentioned as a raw material of the sugar substrate. Raw materials for the lipid substrate include soybeans, rapeseed and sunflower, and rapeseed is preferably used. Examples of yeast include yeast belonging to the genus Candida. Particularly preferably, the sugar substrate obtained by extracting from wheat and the lipid substrate obtained by extracting from rapeseed oil are Candida bombicola (Ca), a yeast isolated from asteraceae plants.
Glycolipid obtained by isolating a fermentation metabolite obtained by biotransformation with N. ndida bombicola).

The glycolipid particularly preferably used in the present invention is a disaccharide having a hydrophilic group such as sophorose,
The compound whose hydrophobic group is a fatty acid or an ester thereof.
Hydrophobic groups in the structure of the glycolipid is a saturated or unsaturated fatty acids of C ₁₂ -C _22. Particularly preferred examples of the glycolipid include those having an acid or lactone structure represented by the following formulas (1) and (2).

Embedded image (In the formula, R represents H or an acetyl group, and n represents 11, 13, or 15.) The glycolipid used in the present invention may be a mixture containing two or more glycolipids.

In the present invention, the glycolipid includes:
Commercially available SOHOLIANCE (trade name, SOLIANCE
(Manufactured by Sharp Corporation) is particularly preferably used. Soholiance is a mixture of an acid and a lactone represented by the formulas (1) and (2), respectively, and the mixture ratio is mainly in the latter. Fatty acids or lactones that are hydrophobic groups include C18:
1 was the most common, followed by C18: 2.

The glycolipid shows protein denaturation
In the in vivo test Zein Test and MTT test,
It has been confirmed to be safe and non-irritant to the human body. The glycolipid is Bacillus subtilis (Baci
llus subtilis), Staphylococcus aureus (S
taphylococcus aureus, Streptococcus faecium, Propionibacterium acnes and Staphylococcus epidermidis
Epidermidis), Genre Streptococcus (Genre)
streptococcus, Corynebacterium xerosis (Cor)
It has antibacterial properties against ynebacterium xerosis and the like, and has a feature of having a role of keeping the skin flora normal.

The amount of the glycolipid in the oil-in-hydrophilic base emulsion composition of the present invention is 0 in view of the fact that the state of the resulting oil-in-hydrophilic base emulsion composition becomes a stable gel. It is at least 0.1% by weight, preferably at least 0.5% by weight. In consideration of the feel when the cosmetic is used, the content is 30% by weight or less, preferably 10% by weight or less.

The hydrophilic base used in the present invention is preferably a hydrophilic polyhydric alcohol and saccharide having two or more hydroxyl groups in the molecule. As polyhydric alcohols, for example, 1,3
-Butanediol, 3-methyl-1,3-butanediol, propylene glycol, dipropylene glycol,
Polyglycerin such as polypropylene glycol, 1,2-pentanediol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, glycerin, diglycerin, and tetraglycerin are exemplified.

Examples of the saccharide include glucose, sucrose, fructose, sorbitol, maltitol, pentaerythritol, xylitol, trehalose and the like.

The amount of the hydrophilic base in the oil-in-hydrophilic base emulsified composition of the present invention is set at 1. from the viewpoint that the state of the resulting oil-in-hydrophilic base emulsified composition becomes a stable gel. 0% by weight or more, preferably 5.0% or more. In consideration of the feel when the cosmetic is used, the content is 90% by weight or less, preferably 50% by weight or less.

As the oil phase component in the present invention, known oily substances for cosmetics may be used. Examples of the oily substance include hydrocarbons, silicones, esters, triglycerides, waxes, waxes, animal and vegetable fats and oils, and the like.

The amount of the oil phase component in the oil-in-hydrophilic base emulsion composition is at least 10% by weight from the viewpoint that the state of the resulting oil-in-hydrophilic base emulsion composition becomes a stable gel.
It is preferably at least 20% by weight. In consideration of the stability of the resulting oil-in-hydrophilic base emulsion composition, the content is 90% by weight or less, preferably 70% by weight or less.

The oil-in-hydrophilic base emulsion composition of the present invention can be produced by uniformly mixing predetermined amounts of the above-mentioned glycolipid, hydrophilic base and oil phase components. The mixing method is not particularly limited as long as the predetermined amount of the above components can be uniformly mixed, and any general method may be used. For example, a commercially available homogenizer may be used.

The hydrophilic oil-in-base emulsion composition of the present invention may further contain a surfactant if necessary. The amount of the surfactant added is 0.1 to 10% by weight.
It is preferred that By adding a surfactant, emulsifiability can be improved and formulation can be easily performed.

Examples of surfactants that can be used in the composition of the present invention include phospholipid derivatives (eg, hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, soybean lysolecithin, etc.), sucrose fatty acid esters, and glycyrrhizic acid Derivatives, naturally occurring surfactants such as casein soda and the like can be mentioned. Further, other nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants may be mixed and added according to the purpose of use. The composition of the present invention may further contain water, alcohol, fatty acid and the like for the purpose of homogenous stabilization and viscosity adjustment.

The thus-obtained oil-in-hydrophilic base emulsion composition of the present invention is a uniform, transparent or translucent gel or a viscous liquid, and is stable even when water is added. Therefore, it can be suitably used as a cosmetic in the form as it is or as an emulsion by adding water.

The present invention further provides a cosmetic composition comprising, in addition to the glycolipid defined above, a compound having a solubility in water at 25 ° C. of at least 1.0 and a pH of the aqueous solution at 25 ° C. of at least 7.0. Offer a fee.

The compound used in the present embodiment, which has a solubility in water at 25 ° C. of not less than 1.0 and a pH of an aqueous solution at 25 ° C. of not less than 7.0 is not particularly limited. Any alkaline substance commonly used in the production of cosmetics is preferably used. Examples of such alkaline substances include alkaline inorganic chemicals, amines, amino acids and the like.

Examples of the alkaline inorganic chemicals include sodium hydroxide, potassium hydroxide, borax and the like. As amines, aqueous ammonia, monoethanolamine, diethanolamine, triethanolamine, aminomethylpropanol, aminomethylpropanediol, diisopropanolamine, triisopropanolamine, N, N, N ', N'-tetrakis (2-hydroxy (Isopropyl) -ethylenediamine, morpholine and the like can be used. As amino acids, histidine, lysine, ornithine, arginine and the like can be used.

In this embodiment, the amount of the alkaline substance to be added to the glycolipid is not limited, and may be appropriately selected depending on the kind of the cosmetic, other components used, purpose of use, and the like.

The amount of the alkaline substance to be added is typically 0.1 to 100% by weight based on the weight of glycolipid when an inorganic strong base compound such as potassium hydroxide or sodium hydroxide is used. When amines are added, the content is 0.5 to 100% by weight, and when amino acids are added, the content is 0.5 to 100% by weight, but is not limited thereto.

In this embodiment, the amount of glycolipid is not particularly limited, and may be appropriately selected according to the type of cosmetic and the purpose of use. Typically, it is 0.1% by weight or more, preferably 0.5% by weight or more of the cosmetic, and the upper limit is 90% by weight, preferably 90% by weight or less in consideration of the feeling of use of the cosmetic.

In another aspect, there is provided a hydrophilic base oil-in-water emulsion composition containing the above-mentioned glycolipid and the above-mentioned alkaline compound. In this embodiment, a compound having a solubility of 0.1 to 30% by weight of glycolipid in water at 25 ° C. of 1.0 or more and a pH of an aqueous solution of 7.0 or more is 0.1% or less based on the amount of glycolipid. 1 to 50% by weight, a hydrophilic group obtained by mixing 1 to 80% by weight of one or more hydrophilic bases selected from the group consisting of polyhydric alcohols and saccharides and 1 to 90% by weight of an oil phase component An oil-in-agent type emulsified composition is preferably used.

In any of the embodiments, the hydrophilic oil-in-base emulsion composition containing glycolipid of the present invention can be used in cosmetics as it is or as an emulsion obtained by dispersing the same in an aqueous solvent. Examples of the form of cosmetics include creams, emulsions, basic cosmetics such as lotions, lipsticks, makeup cosmetics such as foundations,
Examples include hair cosmetics such as suntan / sunscreen cosmetics, hair creams, and hair lotions, cleaning cosmetics, aromatic cosmetics, nail cosmetics, eyeliner cosmetics, lip cosmetics, oral cosmetics, bath cosmetics, and the like. Cosmetics containing the glycolipids or hydrophilic oil-type emulsified groups containing the glycolipids of the present invention may contain various components and additives usually used in cosmetics, if necessary, such as inorganic pigments, organic pigments, and inorganic powders. Body, organic powder, hydrocarbons, silicones,
Esters, triglycerides, waxes, waxes, animal and vegetable oils, surfactants, polyhydric alcohols, sugars,
Vitamins, amino acids, antioxidants, preservatives, fragrances,
What is necessary is just to mix and prepare a thickener, an ultraviolet-ray inhibitor, alcohols, a pH adjuster, water, etc. by a method known per se.
The components and additives used in each cosmetic are well known to those skilled in the art.

The pH of the final product as a cosmetic is 4 to 13.
Is preferably within the range. The final pH is known p
What is necessary is just to adjust using an H adjuster.

The cosmetic of the present invention thus obtained can be used in the same manner as ordinary cosmetics, has high safety on skin, hair, etc., and has emulsifying properties, feeling upon use, and appearance (gloss, texture). Etc.) and excellent storage stability.

[0034]

The present invention will be described in more detail with reference to the following examples, which should not be construed as limiting the invention. In addition, all the compounding amounts shown below are% by weight.

Examples 1 to 13 In the formulations shown in Table 1, component A was heated and stirred to prepare a uniform solution at 75 ° C. While operating the homogenizer, the B component heated to 75 ° C. was slowly added to the solution, and the mixture was further stirred for 20 minutes. Thereafter, the C component was slowly added, and the mixture was cooled to room temperature to prepare a hydrophilic base oil-in-base emulsion composition shown in Table 1.

Comparative Examples 1 to 8 As comparative examples, compositions having the formulations shown in Table 2 were prepared in the same manner as in Examples 1 to 13.

The states of the oil-in-hydrophilic base emulsion compositions prepared in Examples 1 to 13 and Comparative Examples 1 to 8 were observed. Further, water was added to this hydrophilic base oil-in-water emulsion composition while stirring at room temperature to prepare an oil-in-water emulsion. The state of the emulsion was observed, and the state after one month in a 40 ° C. environment was also observed. The storage stability after one month in a 40 ° C environment is measured using a digital microscope VH.
-7000 (manufactured by KEYENCE) to emulsify 1000
At the same time, and the presence or absence of coalescence of the dispersed phase (oil) particles was determined according to the following criteria. The results are shown in Table 1 for Examples and Table 2 for Comparative Examples together with the prescription. In addition,
The numbers for each component are parts by weight. Judgment of O / W emulsion (after 1 month at 40 ° C.) ：: No coalescence of dispersed phase (oil) particles, and emulsion is stable. Δ: Cohesion of dispersed phase (oil) particles was slightly observed, but no destruction of the emulsion was observed. ×: Cohesion of dispersed phase (oil) particles is observed, and destruction of the emulsion is observed.

[0038]

[Table 1]

[0039]

[Table 2]

Example 14 (Liquid face wash) The components A shown in Table 3 were mixed and heated to 75 ° C. The B component was added to this mixture, and the mixture was stirred until it was uniformly dissolved, and then cooled to room temperature. The C component was added to this solution to make the whole uniform. Thereafter, defoaming was performed to obtain a liquid face wash. Similarly, a control sample was prepared. Since the glycolipid used in this example has an antibacterial effect, the anti-acne effect was evaluated using the obtained liquid face wash. Female panelists (15) use this liquid facial cleanser twice daily in the morning and evening for one month in a usual manner, and are extremely useful, useful, or somewhat useful for acne. , No effect, worsened. Table 4 shows the results. Thus, it was found that the liquid facial cleanser of this example had an anti-acne effect.

[0041]

[Table 3]

[0042]

[Table 4]

Example 15 (Antimicrobial detergent) The component C shown in Table 5 was heated and stirred to 60 ° C. to form a uniform solution, which was cooled to room temperature. While stirring the solution, the component A was slowly added to prepare a uniform solution.
Thereafter, the B component was added to this solution in order to make the whole uniform. Thereafter, defoaming was performed to obtain a cleaning agent. The resulting detergent is Corynebacterium xerosis (Corynebacteriu
m xerosis), Propionibacterium acnes (Pro
Pionibacterium acnes) had a good antibacterial effect and was suitable as a face wash for acne prevention.

[0044]

[Table 5]

Example 16 (Moisture gel cream) The component A described in Table 6 was heated and stirred to prepare a uniform solution at 75 ° C. While operating the homogenizer, component B was slowly added to this solution to form a gel, and the mixture was further stirred for 30 minutes. Thereafter, the component C was slowly added and stirred for 20 minutes. Separately, the D component was mixed, dissolved by heating, and then cooled to room temperature to prepare a uniform solution. The E component was added to this solution to prepare a homogeneous mixture. A,
The mixture of each component of B and C was added to the mixture of each component of D and E to make the whole uniform. Thereafter, defoaming was performed to obtain a moisture gel cream.

[0046]

[Table 6]

The obtained moisture gel cream is O
/ W emulsion, the dispersed phase particles are 1-3 μm,
The appearance was white and shiny, and no change was observed even after 6 months.

Example 17 (Whitening Milky) Component A shown in Table 7 was heated and stirred to prepare a uniform solution at 75 ° C. While operating the homogenizer, component B was slowly added to this solution to form a gel, and the mixture was further stirred for 30 minutes. Thereafter, the component C was slowly added and stirred for 20 minutes. Separately, the D component was mixed, dissolved by heating, and then cooled to room temperature to prepare a uniform solution. A,
The mixture of each component of B and C was added to the mixture of each component of D to make the whole uniform. Thereafter, defoaming was performed to obtain whitening milky.

[0049]

[Table 7]

The obtained whitening milky was O / W
It was an emulsion, and the dispersed phase particles had a size of 2 to 5 μm, had a white and glossy appearance, and did not show any state change even after 3 months.

[Use test] "Appearance", "Expansion at the time of application", "Moist feeling after application"
Was subjected to a sensory evaluation. Female panelists (15 persons) applied the whitening milky obtained according to the present embodiment by the usual method of use, and applied: 5: very good, 4. good, 3. normal, 2. somewhat bad, 1. bad. The evaluation was made in five steps. The total score evaluated was divided by the number of panelists, and the evaluation code of Table 8 was assigned. Further, the presence or absence of a stimulus was also confirmed, and the results were displayed in percentage. As shown in Table 9, it was found that the whitening milky material obtained in this example was a cosmetic having excellent appearance and usability, no irritation, and high safety.

[0052]

[Table 8]

[0053]

[Table 9]

Example 18 (Anti-acne liquid face wash) contains no surfactant other than glycolipid of the present invention.
A liquid face wash was prepared. A component described in Table 10 was mixed and heated to 80 ° C. The B component is added to this mixture, and the mixture is stirred until it is uniformly dissolved, and then cooled to room temperature.
The C component was added to this solution to make the whole uniform. Thereafter, defoaming was performed to obtain a liquid face wash. Similarly, a control sample was prepared.

[0055]

[Table 10]

Usage Test Sensory evaluation was conducted for "healing effect on acne", "foaming", and "freshness after rinsing". Fifteen female panelists used the anti-acne liquid facial cleanser obtained in Example 18 twice daily in the morning and evening for one month in a usual manner for 5 months. Normally, it was evaluated on a five-point scale of 2. Slightly bad and 1. Bad. The total score evaluated was divided by the number of panelists, and the following judgment symbols were assigned as scores. Further, the presence or absence of a stimulus was also confirmed, and the results were displayed in percentage. It was found that the anti-acne liquid face wash containing only glycolipid as the surfactant obtained in Example 18 had an anti-acne action, foamed, and was excellent in freshness after face washing. On the other hand, the control face wash containing no water-soluble alkaline substance was excellent in anti-acne action, but foamed and had a slightly inferior refreshing feeling after face washing.

[0057]

[Table 11]

[0058]

[Table 12]

Examples 19 to 31 (oil-in-hydrophilic base emulsified composition) For the formulation shown in Table 13, the component A was heated and dissolved.
A homogeneous solution at 5 ° C. was prepared. While operating the homogenizer, the B component heated to 75 ° C. was slowly added to the solution, and the mixture was further stirred for 20 minutes. Thereafter, the component C was slowly added, and the mixture was cooled to room temperature to prepare a hydrophilic base oil-in-base emulsion composition.

Comparative Examples 9 to 21 As comparative examples, the same method as in Examples 19 to 31 was used.
Compositions of the formulations in Table 14 were prepared.

Examples 19 to 31 and Comparative Examples 9 to 21
The state of the oil-in-hydrophilic base emulsified composition prepared in Example 2 was observed. The results are shown in Tables 13 and 14. Further, purified water was added to this hydrophilic base oil-in-water emulsion composition while stirring at room temperature to prepare an oil-in-water emulsion.

The state of the emulsion was observed immediately after preparation of the emulsion and after three months in a 40 ° C. environment. The storage stability after 3 months in a 40 ° C environment was determined by observing the emulsified state at a magnification of 1000 using a digital microscope VH-7000 (manufactured by KEYENCE) and determining whether or not the dispersed phase (oil) particles were united. Judged. The results are shown in Tables 13 and 14, and photographs showing the state of each of the emulsions of Example 22 and Comparative Example 11 after 3 months are shown in FIGS.

[0063]

[Table 13]

[0064]

[Table 14]

The determination of the O / W emulsion after 3 months at 40 ° C. was made based on the following: ：: No dispersion phase (oil) particles were united, and the emulsion was stable. Δ: Cohesion of dispersed phase (oil) particles was slightly observed, but no destruction of the emulsion was observed. ×: Cohesion of dispersed phase (oil) particles is observed, and destruction of the emulsion is observed.

From Tables 13 and 14, the emulsions of Examples and Comparative Examples show good emulsifiability, but when subjected to long-term storage for 3 months, Examples 19 to 31 containing a water-soluble alkaline compound were added. The emulsion of
It can be seen that the storage stability is more improved.

Example 32 (Moisture Gel Cream) The components B described in Table 15 were mixed, dissolved by heating and cooled to room temperature to prepare a uniform solution. The C component was added to this solution to prepare a homogeneous mixture. A component, which is an oil-in-hydrophilic base emulsion composition obtained in Example 22 shown in Table 13, was added to a mixture of B and C to make the whole uniform.
Thereafter, defoaming was performed to obtain a moisture gel cream.

[0068]

[Table 15]

The obtained moisture gel cream is O
/ W emulsion, and the dispersed phase particles are about 0.5 to 2 μm
The appearance was white and shiny, and no change was observed even after 6 months.

Example 33 (Brightening Milky) Components A and B described in Table 16 were heated and stirred at 75 ° C.
Was prepared. While operating the homomixer, the component B was slowly added to the component A to emulsify and cooled to room temperature to prepare a uniform solution. The component C was added to the mixture of the components A and B to make the whole uniform. afterwards,
Defoaming was performed to obtain a brightening milky.

[0071]

[Table 16]

The resulting brightening milky was O / W
Emulsion, and the dispersed phase particles are about 0.5 to 2 μm
The appearance was white and shiny, and no change was observed even after 6 months.

Usage Test "Appearance", "Expansion at the time of application", "Moist feeling after application"
Was subjected to a sensory evaluation. Fifteen female panelists applied the brightening milky key obtained in Example 33 in the usual manner, and applied: 5: very good, 4. good, 3. ordinary, 2. somewhat bad, 1. bad 5. It was evaluated on a scale. The total score evaluated was divided by the number of panelists, and the following judgment symbols were assigned as scores. Further, the presence or absence of a stimulus was also confirmed, and the results were displayed in percentage. The brightening milky key obtained in Example 33 is excellent in appearance and usability,
It was found that the cosmetic was highly safe without irritation.

[0074]

[Table 17]

[0075]

[Table 18]

Example 34 (Body soap) The A component described in Table 19 was mixed and heated to 80 ° C.
The B component is added to this mixture, and the mixture is stirred until it is uniformly dissolved, and then cooled to room temperature. The C component was added to this solution to make the whole uniform. Thereafter, defoaming was performed to obtain a body soap.

[0077]

[Table 19]

[Usage Test] Sensory evaluation was performed on “foaming” and “freshness after rinsing”. Fifteen female panelists used the body soap obtained in Example 34 daily in the morning and evening in the usual manner 2 times.
The test was used continuously for one month, and evaluated on a five-point scale of 5: very good, 4: good, 3: normal, 2: somewhat bad, and 1: bad. The total score evaluated was divided by the number of panelists, and the following judgment symbols were assigned as scores. Further, the presence or absence of a stimulus was also confirmed, and the results were displayed in percentage. The results are shown in Table 20.
As a result of a use test, it was found that the body soap of Example 34 was foamed and had an excellent refreshing feeling after rinsing.

[0079]

[Table 20]

[0080]

[Table 21]

Example 35 (Emollient cream) The components A and B described in Table 22 were heated and stirred at 75 ° C.
Was prepared. While operating the homomixer, the component B was slowly added to the component A to emulsify and cooled to room temperature to make the whole uniform. Thereafter, defoaming was performed to obtain an emollient cream. Similarly, a control sample was prepared.

[0082]

[Table 22]

[Usage Test] "Appearance", "Expansion at the time of application", "Moist feeling after application"
Was subjected to a sensory evaluation. Fifteen female panelists made up and evaluated the emollient cream obtained in Example 35 using the usual method of use. The evaluation was performed in five stages: 5: very good, 4: good, 3: normal, 2: somewhat bad, and 1: bad. Divide the total score evaluated by the number of panelists,
The following judgment symbols were assigned as scores. Further, the presence or absence of a stimulus was also confirmed, and the results were displayed in percentage. As a result of a use test, it was found that the emollient cream obtained from Example 35 was a cosmetic having excellent appearance and usability, no irritation, and high safety.

[0084]

[Table 23]

[0085]

[Table 24]

[0086]

As is apparent from the above description, emulsified cosmetics utilizing glycolipid obtained by bioconversion of a sugar substrate and a lipid substrate obtained by extracting from a plant with yeast and isolating the resulting fermentation metabolite. The preparation was highly safe for skin, hair, etc., and was excellent in emulsifying properties, antibacterial and anti-acne effects, usability characteristics, appearance (gloss, texture, etc.), and storage stability.

A water-soluble alkali agent, that is, a compound having a water solubility at 25 ° C. of at least 1.0 and a pH of an aqueous solution at 25 ° C. of at least 7.0 in a cosmetic composition containing the glycolipid of the present invention. In the case of containing, more favorable foaming and use feeling characteristics could be obtained.

[Brief description of the drawings]

FIG. 1 is a photograph showing the O / W emulsified state after the emulsion of Example 22 was stored at 40 ° C. for 3 months.

FIG. 2 is a photograph showing an O / W emulsified state after the emulsion of Comparative Example 11 was stored at 40 ° C. for 3 months.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/02 A61K 7/02 7/025 7/025 7/032 7/032 7/06 7/06 7 / 16 7/16 7/42 7/42 7/50 7/50 (72) Inventor Takayuki Kado 1-7-1, Doshu-cho, Chuo-ku, Osaka-shi, Osaka F term in Iwase Cosfa Co., Ltd. 4C083 AA112 AA122 AB032 AB052 AB312 AC022 AC072 AC102 AC111 AC122 AC172 AC352 AC402 AC422 AC442 AC482 AC522 AC542 AC582 AC712 AC782 AD092 AD112 AD191 AD222 AD262 AD282 AD332 AD352 AD391 AD392 AD412 AD422 AD572 AD662 BB01 BB11 CC03 CC05 CC13 CC31 CC31 CC31 CC31 CC31 CC31 CC31 CC31 CC31 CC21 EE09 EE11

Claims (13)

[Claims] 1. A cosmetic composition containing a glycolipid obtained by subjecting a sugar substrate obtained by extracting from a plant and a lipid substrate to bioconversion with a yeast and isolating the resulting fermentation metabolite. 2. Glycolipid is represented by the following formula: The cosmetic according to claim 1, which is a mixture of the compounds described in (1). 3. A hydrophilic base containing glycolipid obtained by subjecting a sugar substrate and a lipid substrate obtained by extracting from a plant to bioconversion using yeast, and isolating the obtained fermentation metabolite. Medium oil type emulsified composition. 4. Glycolipid is represented by the following formula: 4. The oil-in-hydrophilic base emulsion composition according to claim 3, which is a mixture of the compounds described in (1). 5. Glycolipid in an amount of 0.1 to 30% by weight,
The composition is obtained by mixing 1 to 80% by weight of at least one hydrophilic base selected from the group consisting of polyhydric alcohols and saccharides and 1 to 90% by weight of an oil phase component.
20. The oil-in-hydrophilic base emulsified composition according to the above. 6. The method according to claim 1, wherein the surfactant is 0.1 to 10%.
The oil-in-hydrophilic base emulsified composition according to claim 5, which is contained by weight. 7. A glycolipid obtained by isolating a fermentation metabolite obtained by (A) a sugar substrate and a lipid substrate obtained by extracting a sugar substrate and a lipid substrate from a plant, and (B) water at 25 ° C. The cosmetic according to claim 1 or 2, comprising a compound having a solubility in water of at least 1.0 and a pH of an aqueous solution at 25 ° C of 7.0 or more. 8. A) Glycolipid obtained by isolating a fermentation metabolite obtained by bioconversion of a sugar substrate and a lipid substrate obtained from a plant with yeast, and (B) water at 25 ° C. 5. The oil-in-hydrophilic base emulsion composition according to claim 3, which contains a compound having a solubility of 1.0 or more and a pH of an aqueous solution of 7.0 or more. 9. Glycolipid in an amount of 0.1 to 30% by weight,
A compound having a solubility in water at 25 ° C of 1.0 or more and a pH of an aqueous solution of 7.0 or more is selected from the group consisting of 0.1 to 100% by weight based on the amount of glycolipid and a polyhydric alcohol and a saccharide. One or more selected hydrophilic bases
The oil-in-hydrophilic base emulsified composition according to claim 7, which is obtained by mixing 1 to 90% by weight of an oil phase component with 1 to 90% by weight. 10. The oil-in-hydrophilic base emulsion composition according to claim 8, further comprising 0.1 to 10% by weight of a surfactant. 11. A cosmetic comprising the oil-in-hydrophilic base emulsion composition according to any of claims 3 to 6, 8 to 10. 12. The cosmetic according to claim 11, comprising an oil-in-water emulsion obtained by dispersing the emulsion composition in a water-based solvent. 13. Cosmetic is a cleansing cosmetic, a hair cosmetic, a basic cosmetic, a make-up cosmetic, an aromatic cosmetic, a tanning / sunscreen cosmetic, a nail cosmetic, an eyeliner cosmetic, a lip cosmetic. The cosmetic according to any one of claims 1, 2, 7, 11 and 12, which is provided as any one selected from the group consisting of oral cosmetics and bath cosmetics.