JP2002177391A - Syringe also used as container - Google Patents

Abstract

PROBLEM TO BE SOLVED: To safely and certainly preserve a medical fluid in a cartridge, to keep smooth movement as a syringe even after long-term preservation and to minimize the amount of the medical fluid remaining in the tip part of a cylinder. SOLUTION: The outer periphery of the first rubber stopper set on the side nearest to a hub lure lock among a plurality of rubber stoppers is formed into such a shape that ring-shaped ridge parts 51 and trough parts 52 are alternately arranged. The outer diameter La of each of the ridge parts 51 of the first rubber stopper is set to 104-109% of the inner diameter of the cartridge and the outer diameter Lb of each of the trough parts 52 thereof is set to 92-98% of the inner diameter of the cartridge.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a container / syringe which is filled and stored in advance with a drug solution and can be used immediately after taking out of a package at the time of use.

[0002]

2. Description of the Related Art Japanese Patent No. 1451863 discloses a container / syringe of this type. As shown in FIG. 4, this container / injection syringe is provided with flanges 1 a having a slight height at both ends of a cylindrical cartridge 1.
A plastic hubble lock 3 and a flange 4 are attached to both ends of the cartridge 1 using the flange 1a. The Hubble luer lock 3 has a cylinder tip 3a that serves as a mounting portion for the injection needle. The cartridge 1 is made of glass or plastic. Inside the cartridge 1, a first rubber stopper 5 is provided on the hubble lock 3 side, and a second rubber stopper 6 is provided on the flange 4 side in a liquid-tight and air-tight manner. And a space 7 defined by the inner peripheral wall of the cartridge 1 and the rubber stoppers 5 and 6.
Is filled with the chemical solution 8 and stored.

[0003] When using the above-mentioned container / syringe,
When the injection needle 9 is attached to the hubble lock 3 or, as shown in FIG. 4, the injection needle cover 10 covering the injection needle 9 is removed, and the tip of the plunger rod 11 is removed. The male thread portion 11a is inserted into the thread portion of the second rubber stopper 6, and in this state, the plunger rod 11 is pushed toward the cylinder tip. The second rubber stopper 6, the chemical solution 8, and the first rubber stopper 5 pushed through the chemical solution 8 respectively move toward the cylinder tip 3 a, and the first rubber stopper 5 is provided in the hubble lock 3. Into the bypass chamber 3b.
Here, the inner diameter of the bypass chamber 3b is slightly larger than the outer diameter of the first rubber stopper 5, and furthermore, the bypass chamber 3b extends on the inner peripheral wall in parallel with the central axis of the cartridge 1 and is provided at every 90 degrees in the circumferential direction. , For example, four bypass grooves 12a,.
Therefore, when the first rubber stopper 5 is fitted in the bypass chamber 3a, the liquid medicine 8 filled and stored in the cartridge 1 is released from the sealing on the cylinder tip 3a side. The number of the bypass grooves 12a is not limited to four, but may be various.

[0004] Thereafter, when the plunger rod 11 is further pushed into the cylinder tip side and the second rubber stopper 6 is moved in the same direction, the chemical solution 8 filled and stored in the cartridge 1 is removed. , And a small gap between the inner diameter of the bypass chamber 3b and the outer diameter of the first rubber stopper 5, and passes through the cylinder tip 3a of the hubble lock 3. It is guided to the injection needle 9 from the outflow port 13 inside, and is poured out from the tip of the injection needle 9.

[0005]

However, the above-mentioned conventional container / syringe has the following problems. It is unavoidable that the chemical solution remains in the gap between the bypass chamber 3b provided in the hubble lock 3 and the first rubber stopper 5 fed into the hub chamber 3 and the bypass groove 12a. Considerably more than typical syringes. In order to eliminate such disadvantages, the first
Attempts have been made to use a rubber stopper 5 having a straight outer peripheral wall 5a as shown in FIGS. 5 and 6, or having a concave portion 5b at the center of the outer peripheral wall 5a as shown in FIG.

However, even though the first rubber stopper 5 having such a structure has an effect of reducing the amount of the residual chemical solution in the bypass chamber 3a, the first rubber stopper 5 can be used for a long time. After being inserted into the cartridge 1 and sealing and storing the liquid medicine 8, it is pushed through the liquid medicine 8 by the plunger rod 11 or the second rubber stopper 6 at the time of use, and the first rubber stopper 5 is When sliding inside, since the entire outer peripheral wall of the first rubber stopper 5 is in contact with the inner surface of the cartridge 1, the frictional resistance is significantly increased, and eventually, the first and second rubber stoppers 5, 6, and The movement of the entire encapsulation system in the cartridge 1 comprising the liquid medicine 8 sealed between them becomes heavy, and the function as a syringe is significantly impaired.

The rubber stopper 5 shown in FIGS.
In this case, since the outer peripheral wall has a straight shape, it comes into contact with the inner peripheral wall of the cartridge 1 on a flat surface, so that it is difficult to obtain complete sealing performance. If the sealing performance is to be increased, the outer diameter of the rubber stopper is increased. However, the contact pressure against the inner peripheral wall of the cartridge 1 must be increased. Then, the frictional force with respect to the cartridge 1 increases at the same time, and the function as a syringe remarkably decreases as described above. Although it is considered that the first rubber stopper 5 has a concave portion 5b at the center of the outer peripheral wall 5a as shown in FIG. 7, even when a rubber stopper having such a structure is used, the above-described problem is not solved. It cannot be completely solved.

The present invention has been made in view of the above circumstances, and an object of the present invention is to make the storage of a drug solution in a cartridge safe and secure, and at the same time, to make a syringe even after long-term storage. It is an object of the present invention to provide a syringe that can also be used as a container that can maintain a smooth movement and minimize the amount of the drug solution remaining in the cylinder tip.

[0009]

In order to solve the above problems, according to the first aspect of the present invention, there is provided a cartridge having a cylindrical shape, hubble locks and flanges respectively attached to both ends of the cartridge, and a cartridge inside the cartridge. And at least two rubber stoppers that are each air-tightly and liquid-tightly sealed at intervals, and a container / syringe that fills and stores a drug solution in a space defined in the cartridge. The outer periphery of the rubber stopper set on the side closest to the Hubble luer lock has a shape in which ring-shaped peaks and valleys are provided alternately, and the peak of the rubber stopper set on the side closest to the Hubble lure lock The outer diameter of the cartridge is 10 times the inner diameter of the cartridge.
4 to 109%, and the outer diameter of the valley is set to 92 to 98% of the inner diameter of the cartridge. In the invention according to claim 2, the inside diameter of the bypass chamber provided in the Hubble luer lock so as to communicate with the cartridge and inserted with the rubber stopper unsealed at the time of injection is set to the inner diameter of the cartridge. It is characterized in that it is set to 105 to 108% of the inner diameter. In the invention according to claim 3, the inner diameter of the tip portion of the lure portion of the Hubble luer lock is set to 1.3 to 1.3.
1.5 mm, the inner diameter of the base end of the lure part is 1.7 to
It is characterized by being set to 2.0 mm.

According to the present invention, the rubber stopper of the rubber stopper, which is set on the side closest to the hub lure lock, has a shape in which ring-shaped peaks and valleys are alternately arranged, and a cartridge is provided. Is made as small as possible in contact with the inner peripheral wall. Therefore, even when the cartridge abuts against the inner peripheral wall of the cartridge, the slidability with the inner peripheral wall of the cartridge is maintained smoothly. Further, since the inner peripheral wall of the cartridge is sealed by a plurality of ring-shaped peaks, there is no leakage of the chemical solution, and it is possible to prevent gas such as air and oxygen or bacteria from entering. Also, since the outer diameter of the peaks and the outer diameter of the valleys of the rubber stopper set on the side closest to the hubble luer lock are set within a predetermined range with respect to the inner diameter of the cartridge, the rubber stopper can be mounted on the cartridge. Slidability and sealing performance can be reliably ensured.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION The container / syringe according to the present invention will be described with reference to FIG.
Are substantially the same as those shown in FIG. That is, both ends are open,
A cylindrical glass or plastic cartridge 1 for filling and storing a chemical solution therein, and a rubber stopper 5 for sealing both ends of the cartridge 1 in an air-tight and liquid-tight manner.
0 and 6. Flange 1 at both ends of cartridge 1
The hub lure lock 30 and the flange 4 are attached to both ends of the cartridge 1 using the flange 1a. The above is the same as the conventional one.

The features of the present invention are as follows. Of the rubber stoppers 50 and 6, the first rubber stopper 50 set on the side closest to the hubble lock 30 is
As shown in FIG. 1, the outer periphery has a shape in which ring-shaped peaks 51 and valleys 52 are alternately arranged. The outer diameter La of the peak 51 of the first rubber stopper 50 is set to 104% to 109% of the inner diameter of the cartridge 1, and the valley 52 of the first rubber stopper is provided.
Is set to 92 to 98% of the inner diameter of the cartridge 1. At least one notch 55 is provided at the peripheral edge of the left and right sides of the first rubber stopper 50. In the embodiment shown in FIG. 2, a total of three cutouts 55, 55, 55 are provided at 120 ° intervals on the peripheral edge of both sides of the first rubber stopper 50. The cutout portion 55 has an end at a substantially central portion between the center of the side surface of the first rubber stopper 50 and the outer peripheral edge, and gradually becomes wider outward from the first rubber stopper 50, and is recessed inward of the rubber stopper 50 to be substantially concave. It is formed in a fan shape.

As shown in FIG. 3, a bypass chamber 31 is provided in the Hubble luer lock 30, into which the first rubber stopper 50 is inserted in an unsealed state at the time of injection. However, the inner diameter Lc of the bypass chamber 31 is equal to 105 to 1 of the inner diameter of the cartridge 1.
08%. By the way, the inner diameter of the bypass chamber 3b in the conventionally used hubble lock 3 is set to about 109 to 110% of the inner diameter of the cartridge.

The inner wall of the bypass chamber 31 has a circumferential direction 9 extending parallel to the central axis of the cartridge 1.
A bypass 32 composed of four bypass grooves 32a is formed at every 0 degree. The number of the bypass grooves 32a is not limited to four, but variously.

Further, the inner diameter Ld of the distal end portion of the lure portion 33 with which the injection needle of the Hubble luer lock 30 is engaged is set to 1.3 to 1.5 mm, and the inner diameter Le of the proximal end portion of the lure portion 33 is It is set to 1.7 to 2.0 mm.
Incidentally, the lure portion 33 of the conventionally used hub luer lock 3 has an inner diameter at the distal end set to about 1.6 to 1.9 mm and an inner diameter at the base end set to about 2.1 to 2.5 mm. Have been.

According to the container / syringe having the above structure, the first rubber stopper set on the side closest to the hubble lock 30 among the plurality of rubber stoppers 50 and 6 inserted into the cartridge 1. The outer periphery of 50 has a shape in which ring-shaped peaks 51 and valleys 52 are alternately arranged, and the contact area with the inner peripheral wall of the cartridge 1 is made as small as possible. Therefore, even if the inner peripheral wall of the cartridge 1 abuts very strongly,
Slidability with the inner peripheral wall is kept smooth. Further, since the inner peripheral wall of the cartridge 1 is sealed multiple times by a plurality of ring-shaped peaks 51, there is no leakage of the chemical solution, and gas and bacteria such as air and oxygen enter the space 7 in the cartridge 1. Intrusion can also be prevented.

The outer diameter La of the peak 51 and the outer diameter Lb of the valley 52 of the first rubber stopper 50 are set within a predetermined range with respect to the inner diameter of the cartridge 1.
In addition to ensuring the slidability and sealing performance of the rubber stopper 50 with respect to the cartridge 1, the remaining amount of the drug solution in the bypass chamber 31 can be minimized upon completion of the injection. Also, Hubble Lure Lock 3
The inner diameter Lc of the bypass chamber 31 provided on the inner peripheral wall and the width and depth of the bypass groove 32a are set within a range that does not hinder the chemical solution contained in the first and second rubber stoppers from flowing outside. Therefore, the remaining amount of the chemical solution can be reduced without affecting the outflow of the chemical solution.

Further, the inner diameter Le of the distal end portion of the lure portion 33 of the hub luer lock 30 and the inner diameter Ld of the proximal end portion of the lure portion 33 are respectively set within predetermined ranges smaller than in the prior art. Can be further reduced.

Generally, in the case of a plastic product that requires strict dimensional accuracy and roundness, such as when the syringe needle is used by engaging the injection needle like the lure portion 33 of the hubble lock 30, the molding is performed. In order to minimize the subsequent shrinkage of the resin due to cooling, it is necessary to reduce the thickness of the molded portion and make it as uniform as possible. For this reason, in the case where the outer diameter is fixed and cannot be made thinner like the lure part 33 which is the injection needle engaging part of the hubble luer lock 30, means for reducing the wall thickness by increasing the inner diameter is adopted. Has been taken. Therefore, when the outlet diameter of the chemical solution is made smaller than a certain size, the luer portion becomes thicker by that amount, and the molded part is deformed irregularly due to the so-called "shrinkage" phenomenon due to the shrinkage of the resin, and the dimensional accuracy is reduced. It was pointed out that it could not be obtained. The lure portion 33 in this embodiment also has a similar problem, but here, the injection pressure of the resin is increased to an appropriate value,
These shortcomings have been compensated. For this reason, it is possible to make the outflow diameter of the lure portion 33 smaller than before without causing the phenomenon of the above-mentioned "shrinkage".

The present invention relates to Japanese Patent Application No. 53-15814.
In addition to the single-chamber type container / syringe represented by Japanese Patent Application No. 3 (1994) -147, for example, a two-chamber type container / multiple use syringe having a bypass structure represented by Japanese Patent Application No. 61-147223, and Japanese Patent Application No. Hei.
No. 4 as well as a two-chamber container / syringe, and assembling type 2 with a bypass structure as typified by Japanese Utility Model Application No. 3-57218.
The present invention is also applicable to a chamber-type combined use syringe.

[0021]

According to the present invention, of the plurality of rubber stoppers, the outer periphery of the rubber stopper set on the side closest to the hubble lock has a shape in which ring-shaped peaks and valleys are alternately arranged. The contact area with the inner peripheral wall of the cartridge is made as small as possible. Therefore, even if the cartridge abuts against the inner peripheral wall of the cartridge, the slidability with the inner peripheral wall of the cartridge is kept smooth, and the inner peripheral wall of the cartridge is sealed by a plurality of ring-shaped peaks. In addition, there is no leakage of the chemical solution, and gas and bacteria such as air and oxygen can be prevented from entering. Thus, the sliding property and the sealing property of the rubber stopper to the cartridge can be reliably ensured. In addition, it is possible to minimize the amount of the drug solution remaining in the bypass chamber 31 when the injection is completed. Further, the inner diameter of the bypass chamber provided on the inner peripheral wall of the hubble luer lock is set as small as possible within a range that does not hinder the flow of the chemical solution contained in the cartridge to the outside. Since the inner diameter is set small within a range that does not affect the outflow of the drug solution, the remaining amount of the drug solution can be reduced without affecting the outflow of the drug solution.

[Brief description of the drawings]

FIG. 1 is a half sectional view of a first rubber stopper used in a container / syringe showing an embodiment of the present invention.

FIG. 2 is a view taken in the direction of the arrow X in FIG.

FIG. 3 is a sectional view of a hubble lock used in the container / syringe.

FIG. 4A is an overall front view showing a conventional container / syringe, and FIG. 4B is a side view of the conventional container / syringe.

FIG. 5 is a half cross-sectional view of a rubber stopper used in a conventional container / syringe.

FIG. 6 is a side view of the rubber stopper.

FIG. 7 is a half cross-sectional view showing another example of a rubber stopper used in a conventional combined use syringe.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Cartridge 6 2nd rubber stopper 7 Space 8 Chemical solution 30 Hubble lock 31 Bypass chamber 33 Luer part 50 1st rubber stopper 51 Mountain part 52 Valley part

Claims (3)

[Claims] 1. A cylindrical cartridge; Hubble locks and flanges respectively attached to both ends of the cartridge; and at least two rubber stoppers for sealing the inside of the cartridge air-tightly and liquid-tightly at intervals. With
A container / filling syringe that fills and stores a drug solution in a space defined in the cartridge, wherein, among the rubber stoppers, a rubber stopper that is set on a side closest to the Hubble luer lock has ring-shaped peaks and valleys. Parts are provided alternately, and the outer diameter of the peak of the rubber stopper set on the side closest to the Hubble lure lock is set to 104 to the inner diameter of the cartridge.
A container-and-syringe wherein the outer diameter of the valley is set to 92 to 98% of the inner diameter of the cartridge. 2. An inner diameter of a bypass chamber which is provided in the hubble lock so as to communicate with the cartridge, and which is inserted with the rubber stopper being unsealed at the time of injection, has an inner diameter of 105 times the inner diameter of the cartridge. ~ 1
2. The container / syringe according to claim 1, wherein the value is set at 08%. 3. The hub luer lock according to claim 1, wherein the inner diameter of the front end portion of the lure portion is set to 1.3 to 1.5 mm, and the inner diameter of the base end portion of the lure portion is set to 1.7 to 2.0 mm. The syringe also used as a container according to claim 1 or 2,