JP2002161038A5 - - Google Patents
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- Publication number
- JP2002161038A5 JP2002161038A5 JP2001269266A JP2001269266A JP2002161038A5 JP 2002161038 A5 JP2002161038 A5 JP 2002161038A5 JP 2001269266 A JP2001269266 A JP 2001269266A JP 2001269266 A JP2001269266 A JP 2001269266A JP 2002161038 A5 JP2002161038 A5 JP 2002161038A5
- Authority
- JP
- Japan
- Prior art keywords
- ophthalmic
- eye
- clinical symptoms
- trehalose
- sensation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Description
【特許請求の範囲】
【請求項１】
有効成分として、非還元性糖質生成酵素及びトレハロース遊離酵素を澱粉部分加水分解物に作用させる方法により得られるトレハロースを含み、パイロジェン及び防腐剤としての塩化ベンザルコニウムを含まないことを特徴とする眼科用点眼剤。
【請求項２】
シェーグレン症候群における眼の臨床症状の治療及び／又は予防のための請求項１記載の眼科用点眼剤。
【請求項３】
シェーグレン症候群における眼の臨床症状が、眼の臨床症状としての異物感、灼熱感及び掻痒感から選ばれる少なくとも１種又は２種以上であることを特徴とする請求項２記載の眼科用点眼剤。
【請求項４】
トレハロースと共に、マルトース及びマルトトリオース以上のオリゴ糖から選ばれる１種又は２種以上の糖質を含んでなる請求項１乃至３の何れかに記載の眼科用点眼剤。
[Claims]
(1)
As an active ingredient, it sees containing trehalose obtained by the method of reacting a non-reducing saccharide-forming enzyme and trehalose-releasing enzyme in the partial starch hydrolyzate, and characterized in that it does not contain benzalkonium chloride as pyrogen and preservatives ophthalmic eye drops to.
(2)
The ophthalmic ophthalmic solution according to claim 1 , which is for treating and / or preventing clinical symptoms of the eye in Sjogren's syndrome.
(3)
3. The ophthalmic ophthalmic solution according to claim 2 , wherein the clinical symptoms of the eye in Sjogren's syndrome are at least one or two or more selected from the group consisting of a foreign body sensation, a burning sensation, and a pruritus sensation as the clinical symptoms of the eye .
[Claim 4 ]
With trehalose, ophthalmic eyedrops according to any one of claims 1 to 3 comprising one or more saccharides selected from maltose and maltotriose more oligosaccharide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001269266A JP4982643B2 (en) | 2000-09-14 | 2001-09-05 | Ophthalmic pharmaceutical composition |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000280023 | 2000-09-14 | ||
| JP2000-280023 | 2000-09-14 | ||
| JP2000280023 | 2000-09-14 | ||
| JP2001269266A JP4982643B2 (en) | 2000-09-14 | 2001-09-05 | Ophthalmic pharmaceutical composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002161038A JP2002161038A (en) | 2002-06-04 |
| JP2002161038A5 true JP2002161038A5 (en) | 2008-10-09 |
| JP4982643B2 JP4982643B2 (en) | 2012-07-25 |
Family
ID=26600000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001269266A Expired - Lifetime JP4982643B2 (en) | 2000-09-14 | 2001-09-05 | Ophthalmic pharmaceutical composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4982643B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101587412B1 (en) * | 2014-10-17 | 2016-01-21 | 주식회사 휴온스 | Ophthalmic Composition Comprising Cyclosporine and Trehalose |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69325700T2 (en) * | 1992-12-28 | 1999-12-30 | Hayashibara Biochem Lab | Non-reducing saccharide-forming enzyme, and its production and uses |
| JP3559585B2 (en) * | 1993-06-03 | 2004-09-02 | 株式会社林原生物化学研究所 | Trehalose-releasing enzyme, its production method and use |
| JP3559609B2 (en) * | 1994-03-07 | 2004-09-02 | 株式会社林原生物化学研究所 | Recombinant enzyme, its production method and use |
| JP3557277B2 (en) * | 1994-06-25 | 2004-08-25 | 株式会社林原生物化学研究所 | Thermostable trehalose releasing enzyme, its production method and use |
| JP3557287B2 (en) * | 1994-06-24 | 2004-08-25 | 株式会社林原生物化学研究所 | Thermostable non-reducing saccharide-forming enzyme, its production method and use |
| JP3557289B2 (en) * | 1994-07-21 | 2004-08-25 | 株式会社林原生物化学研究所 | Recombinant thermostable enzyme that releases trehalose from non-reducing carbohydrates |
| JP3557288B2 (en) * | 1994-07-21 | 2004-08-25 | 株式会社林原生物化学研究所 | Recombinant thermostable enzyme that produces non-reducing carbohydrates with terminal trehalose structure from reducing starch sugars |
| JP3059092B2 (en) * | 1995-11-15 | 2000-07-04 | 田辺製薬株式会社 | Agent for preventing and treating dry eye and diseases caused by dry eye |
| JP4033510B2 (en) * | 1995-12-27 | 2008-01-16 | ロート製薬株式会社 | Ophthalmic pharmaceutical composition containing trehalose |
| JP2000007570A (en) * | 1998-06-24 | 2000-01-11 | Hayashibara Biochem Lab Inc | Anti-endocrinosis agent |
| JP2000095703A (en) * | 1998-07-24 | 2000-04-04 | Hayashibara Biochem Lab Inc | Oral-administering remedy and/or preventive for htlv-1- associated disease |
| US6162393A (en) * | 1998-08-06 | 2000-12-19 | Ndt, Inc. | Contact lens and ophthalmic solutions |
-
2001
- 2001-09-05 JP JP2001269266A patent/JP4982643B2/en not_active Expired - Lifetime
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