JP2002121140A - Malodor reducing agent for feces and food comprising the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a safe malodor reducing agent for feces capable of improving intestinal bacterial floras into a favorable state without adverse effects by a simple means, reducing putrefying bacteria of the intestinal bacterial floras and reducing the malodor of human feces and a food comprising the reducing agent for the feces. SOLUTION: This malodor reducing agent comprises a cow's milk protein concentrate containing 7-50 mass% of an active immunoglobulin derived from the cow's milk and further comprises the protein concentrate of the cow's milk in an amount so as to contain 100-300 mg of the active immunoglubulin.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention improves the intestinal flora to a desirable state, reduces spoilage of the intestinal flora, and reduces the odor of human stool by a simple method that is safe, has no side effects, and is simple. The present invention relates to a reducing stool odor reducing agent and a food containing the same.

[0002]

2. Description of the Related Art Conventionally, various measures have been taken to reduce, eliminate or isolate odor of stool. For example, a method is known in which volatile fragrance is emitted to a toilet or the like to mask fecal odor. There is also a deodorant spray used after defecation. These are palliative treatments to mask odors and do not fundamentally reduce stool odors. In recent years, those that absorb stool odor with an absorbent such as coconut husk activated carbon and those that use deodorant fibers that specifically adsorb ammonnia gas based on pungent odor have been proposed. The effect is small and the effect does not last.

[0003] In addition, a product is commercially available in which a champignon extract extracted from the fruit body of a mushroom is added to a beverage to chemically suppress the generation of fecal odor components generated in the intestine.

In addition, as a means for normalizing the intestinal flora, ingesting pantethines, peptides, nucleic acid-related substances, lactulose that is not digested by stomach acid, and an improvement agent for the intestinal flora consisting of the disaccharide primerobase are proposed. (Japanese Patent Laid-open No. Hei 10
-313822). Similarly, there is also a proposal of a dry preparation containing propionic acid bacteria and bifidobacteria that improves the intestinal flora (Japanese Patent Application Laid-Open No. 2000-502247). In addition, for the purpose of improving the intestinal flora, a method of increasing the number of lactic acid bacteria by ingesting oligosaccharides of growth factors of lactic acid bacteria in the intestine has been adopted.

[0005] However, the above proposals do not mention improving the intestinal flora and reducing the odor of feces, nor do they recognize and solve this problem.

[0006]

A toilet is provided in a living space. For this reason, various devices have been devised to remove or block fecal odor from the living environment. Today, with the proliferation of flush toilets, the task has been considerably improved. In addition, the usual stool odor of a healthy person is unavoidable, but the other stool odor is a general sense of life or emotion that one cannot endure at all.

[0007] The usual odor of feces of healthy people is unavoidable, but the odor of stools caused by the deterioration of the intestinal bacterial layer has been a problem for humans since ancient times and has been a difficult problem to be solved. It is an issue. In recent years, with the rapid progress of an aging society, the number of people requiring care has rapidly increased. In particular, among bedridden elderly people, in particular, it is said that stool of elderly people often has a bad smell.

Therefore, for both the caregiver and the cared person, the odor of the stool other than the usual odor of the stool is an urgent and urgent issue that one wants to improve by all means.

[0009] Further, as a recent custom of living for young people, there has been a tendency that all odors generated in places of daily life are extremely disliked. In particular, young people tend to dislike their own body odor and fecal odor. For this reason, it is well known that many commodities for reducing, absorbing or masking body odor and fecal odor are sold. For generations that are extremely sensitive to this odor, the stool odor generated by the elderly at home can be a serious problem that worsens family emotions.

[0010] The odor of stool, including the elderly, is mainly caused by toxic or odorous gas generated in the intestine, and the intestinal flora is closely related.

[0011] From the viewpoint of the intestinal bacterial layer, the number of bifidobacteria detected in stool is reduced to one-tenth in stool of healthy elderly people aged 70 years or older, as compared with adolescents. Studies have also reported that the detection of Welsh bacteria, a representative of spoilage bacteria, has increased 100-fold.

Therefore, although the usual stool odor is unavoidable, the stool odor exceeding the allowable limit makes the person uncomfortable and impairs a good living environment or living feeling. Reducing or preventing stool odor generation is an important issue for making daily life comfortable. Further, it is a problem that contributes to maintenance and promotion of a good relationship between a person who takes care of excretion and a person who takes care of it, and a solution is desired at an early stage.

[0013] However, conventional methods for dealing with the odor of stool are so-called symptomatic treatments such as masking,
Improves intestinal flora, but the action of the substances used is strong,
Furthermore, there is a peculiar off-flavor, etc.
It was not always a satisfactory solution.

[0014]

DISCLOSURE OF THE INVENTION The present invention aims at improving the intestinal flora and reducing or improving the root cause of stool odor by a safe and simple means. The above-mentioned problem has been solved by a simple means of ingesting a protein concentrate of milk in a contained amount.

The inventor has noted a trace amount of an active immunity substance contained in a protein concentrate of milk, and the intake of a protein concentrate of milk containing this active immunity substance improves the intestinal flora, The inventors have found that the present invention has an effect of suppressing the generation of offensive odors, and completed the present invention.

In recent years, research on the intestinal flora has progressed rapidly, and the entire human intestinal flora forms an ecological system (ecosystem), which is closely related to the health condition of the host. It became clear. Also, research on intestinal flora has formed a discipline as intestinal bacteriology.

Among the intestinal bacteria, spoilage bacteria such as the anaerobic bacteria Welsh are typical of harmful bacteria. When the intestinal flora becomes unbalanced, these spoilage bacteria are activated immediately, causing spoilage in the intestine and causing stool to smell bad.
It was also revealed that the odor of this stool was caused by the production of odor-causing substances (methyl mercaptan, ammonia, amines) in the intestine.

When the condition of the intestinal flora worsens,
It has been shown to induce cancer, arteriosclerosis, liver damage and is also closely related to the progress of aging.

In the intestinal flora, Bifidobacterium is a typical bacterium, and it is preferable that this is the most dominant bacterium. The intestinal flora is balanced in a delicate balance, and individuals are empirically familiar with the changes in stool odor quality due to changes in diet and health.

That is, the present invention relates to a stool odor reducing agent, which is a protein concentrate of milk containing 7% to 50% by mass of active immunoglobulin derived from milk and containing 100 mg to 300 mg of the active immunoglobulin. The stool malodor reducing agent is characterized in that it contains a protein concentrate of the milk, and the milk is colostrum or normal milk, which is the stool malodor reducing agent as described above. Further, the protein concentrate of milk is a milk protein concentrate, a whey separated protein or a whey protein concentrate is the stool odor reducing agent as described above, characterized in that it is a stool odor reducing agent as described above. It is a food containing a odor reducing agent for stool characterized by containing it.

The stool odor reducing agent of the present invention is a protein concentrate of milk, containing 7% by mass to 5% by mass of active immunoglobulin.
Although the content was 0% by mass, as a result of the experiment, when 100 mg / day in terms of active immunoglobulin was continuously taken for 1 week, 50% of the users obtained the result that the odor of feces was reduced.

Next, in terms of active immunoglobulin, 300
If you continue to take mg / day for one week, 90%
However, the result was that the odor of the stool was reduced.

Further, in terms of active immunoglobulin, 50
If you continue to take 0 mg / day for 1 week, 90
% Resulted in a reduction in stool odor.

From the results of the above experiments, it was found that the dose of the stool odor reducing agent was 100 mg / in terms of active immunoglobulin.
More than one day up to 300 mg / day was found to be an effective dose.

[0025]

BEST MODE FOR CARRYING OUT THE INVENTION A protein concentrate of milk, which is a raw material of the odor reducing agent for feces of the present invention, will be described.

Typical products contained within the protein concentrate of milk are those commonly known, for example, milk protein concentrate, whey isolate protein and whey protein concentrate.

The milk protein concentrate is abbreviation MPC (M
The ilk protein concentrate is hereinafter referred to as MPC. ), And skim milk is filtered by ultrafiltration (U
Concentrated in F) and spray-dried of the total protein and contains 25-80% or more protein.

Next, whey separation protein is abbreviated as WP
I (Whey protein isolate or less W
It is called PI. ), Which is obtained by selectively separating only protein from whey. It is manufactured by a method of adsorbing and separating whey protein by a hydrophilic ion exchange membrane resin adsorption method, and contains almost no lactose and milk fat. % Protein or more.

The whey protein concentrate is abbreviated as W
PC (Whey protein concentrate
e and WPC. ) To remove fat from cow's milk, ultrafiltration (UF) concentration from whey to remove lactose and minerals as ultrafiltration (UF) permeate, and obtain the remaining fraction as WPC. This WPC has a protein content of 35 to 83% in the solid content depending on the difference in the processing conditions.

In recent years, with the improvement of milk production and production techniques, economical techniques for fractionating various components from milk have become possible. Currently, on the market, various fractionated products from milk are sold as food raw materials, intermediate raw materials, functional foods with specific functions, or raw materials for health foods. Among them, some contain 7% to 50% by mass of active immunoglobulin, and this can be used.

Therefore, the aforementioned MPC, WPI and WPC
For example, it is only necessary to select a product containing 7% by mass to 50% by mass of active immunoglobulin from raw materials sold as raw materials such as food raw materials fractionated from milk and health food raw materials. There is an advantage that the odor reducing agent of this stool can be obtained at a very low cost.

It is, of course, possible to use a protein concentrate of milk having a content of active immunoglobulin of 7% or less, but if a low content is used, a minimum amount of 100 mg in terms of active immunoglobulin can be used. In order to obtain it, it is necessary to ingest a large amount of protein concentrate of milk, which may impair the balance of the dietary life, and is not suitable because it causes pain to the user. If it is 7% by mass or more,
The daily dose is about 3 to 4 g, which is preferable because it does not burden the user.

In the process of producing a protein concentrate of milk, which is a raw material of a stool odor reducing agent, a liquid concentrate is concentrated to a desired concentration, spray-dried into a powder, and excipients are added. Tablets, and those added to food can be used.

The protein concentrate of milk can be obtained by any of the methods of concentration and separation from milk and separation from whey protein (whey). Further, it is also possible to freely prepare those having different concentrations.

Among the components contained in the odor reducing agent of stool of the present invention, the active immunoglobulin contained in milk is considered to be most important for improving the intestinal flora. This active immunoglobulin (immunoglobulin) includes Ig
G, IgA, etc., of which some 70% are mostly IgG (Immune Glob).
urin). IgG is taken by humans after
It is not absorbed in the intestine but stays in the intestine, hinders the growth of putrefactive bacteria and has the effect of growing lactic acid bacteria, which is presumed to contribute to the improvement of the intestinal flora.

The method for measuring the content of active immunoglobulin is as follows.
There are a method using an antigen-antibody reaction (RID method), a method using an enzyme reaction (ELLSA method), and a high-performance liquid chromatography (HPLC method). It goes without saying that any method may be used in the determination.

The active immunoglobulin is contained in the milk in the form of milk 1
Although it is contained in a very small amount of about 0.07 g per 00 g, it is a protein concentrate of milk in which the content is increased to 7% or more by concentrating milk and the like. For example, MPC, WPI and WP
C can be used as it is. In addition, active immunoglobulin is a protein that is extremely weak to heat.
Deactivated when heated to around 5 ° C.

Therefore, milk (city milk), yogurt, and skim milk powder manufactured by heat sterilization by a normal manufacturing method are sterilized at an ultra-high temperature at 120 to 150 ° C. for 1 to 3 seconds. However, all immunoglobulins are inactivated.

However, in recent years, milk processing technology has
Ultrafiltration UF (Ultra-Filtration)
n) With the development of membrane separation technology, including the practical use of membranes, it is possible to adopt processing methods that do not require heating,
High-quality products without heat denaturation (without inactivation of immunoglobulins) can be economically produced.

Therefore, it is possible to extract and separate only immunoglobulin from milk or the like in a treatment step that does not inactivate it and use it as a main component of the offensive odor reducing agent of the present invention. Extraction separation is costly and not economical. Furthermore, the effect of improving the intestinal flora obtained by the stool malodor reducing agent of the present invention can be attributed to active immunoglobulins and protein concentrates of milk containing the same, such as MPC, WPI
And the interaction with other substances contained in WPC and the like may have an effect of improving the intestinal flora. At this time, the mechanism of action is not clear. Among the protein concentrates of milk containing 〜50% by mass, for example, MPC, WPI and WPC are considered to be effective.

[0041] Immunoglobulin is a component contained in a large amount in milk (so-called colostrum), which is obtained when a newborn baby of a human, cattle or other mammal is first fed from a mother. Colostrum containing these immunizing substances is believed to complete the intestinal immunity of the newborn and play a major role in the systemic immunity and growth system. Colostrum contains a large amount of immunoglobulin. Milk other than colostrum is called normal milk. It is known that immunoglobulin accounts for around 30% of the total protein contained in colostrum. The use of this colostrum is very efficient because the content of immunoglobulin can be easily increased.

Although the details of the mechanism by which the protein concentrate of milk reduces the odor of feces are not clear, continuous ingestion daily improves the intestinal flora by active immunoglobulin, and is preferred because of its superiority to bifidobacteria. A flora is formed.
As a result, it is presumed that the ratio of putrefactive bacteria decreases, the putrefactive odor produced by putrefactive bacteria decreases in the stool, and the odor of the stool decreases.

It has been empirically recognized that stool odors are an empirical sign of poor human health since ancient times. Intestinal flora rapidly changes with age, food habits, illness, and mental stress. Therefore, it is preferable that healthy people take preventive and daily ingestion to maintain and improve their health.

In addition, as a person ages, changes in the intestinal flora occur, and the state of dominance of lactic acid bacteria cannot be maintained, and this is the main cause of stool odor. It may be taken prophylactically.

As a result of the comparison test shown in FIG. 2, the stool odor reducing agent containing the active immunoglobulin in an amount of 100 mg / day or more has a remarkable effect.
Ingestion of an amount less than 100 mg / day has little effect on reducing the odor of stool.

(Production method) The method for producing the odor reducing agent for stool is, for example, a method for preparing an M containing 8% of active immunoglobulin.
When using PC, 1 day per day in terms of active immunoglobulin
Since the intake of 00 mg to 300 mg is required, the daily intake is 3.75 g of MPC. Based on the result of calculating the content of active immunoglobulin in advance, the daily dose of the milk protein concentrate may be weighed and divided into small portions, which may be packed and taken. Since this amount is a daily dose, it may be further divided and taken in two or three doses.

An excipient such as casein and other binders are added to the milk protein concentrate to form capsules, tablets, powders, syrups, emulsions, jellies, gels, etc. Flavors and sweeteners can be added and taken as beverages in the form of a mixture added to food or drink.

(Method of use) The method of using this stool odor reducing agent is, for example, when using MPC having an active immunoglobulin content of 8%, the daily intake is 3.75 g. Based on the calculated result, the daily dose may be subdivided and packaged. The daily dose may be further divided into two or three doses.

If this is continued for one week, the effect of reducing the odor of the stool can be obtained. Therefore, taking daily prophylactically and continuously is the most desirable use.

The amount of the odor-reducing agent in stool of the present invention is calculated in terms of active immunoglobulin for a normal healthy adult.
It is preferable to take 100 mg to 300 mg / day.

It is natural that it is necessary to adjust the amount of the protein concentrate of the milk to be taken according to the content of the active immunoglobulin. In addition, when the amount of intake is 100 mg, half of them have the effect of reducing the odor of stool (Table 2), so that it is necessary to take at least more than this. Further, even if the dose exceeds 300 mg, the effect is not remarkably increased (Table 2), and some people have a disadvantage that the stool becomes soft, which is not preferable.

This stool odor reducing agent is characterized in that all components contained in the stool odor reducing agent are substances contained in milk.
Naturally, there is no significant side effect if humans continue to take this.

(Test Example 1) The following dose test was carried out using the stool odor reducing agent of Example 1.

The stool odor reducing agent was continuously used for 3.7 times.
After ingesting 5 g / day (taken three times a day; 300 mg in terms of active immunoglobulin) using water or milk for 7 consecutive days, stool was collected and the stool odor was measured. This is a sensory test in comparison with the stool odor before taking. Male 85
A total of 124 women and 45 women, A group 15
Young people under the age of 30 by name, 54 in Group B, 31
The middle-aged people aged 60 to 60 and the C group were divided into 3 groups of 55 elderly people aged 61 and over, and the results of comparing the fecal smell before and after taking the drug were obtained. is there.

The subject continued his daily eating habits and did not perform any dietary restrictions (FIG. 1). The results are A, B,
In each group of C, a remarkable effect was obtained. There are also reports that the number of flatus has decreased and the smell has decreased.

No significant difference was observed between the age group and the gender. There was no difference with irregular dose times.

(Test Example 2) Using the stool odor reducing agent of Test Example 1, a comparative test was conducted as to whether or not there was a difference in effect depending on the following dose.

The daily dose is converted into active immunoglobulin, and the group taking 100 mg / day (A group), the group taking 300 mg / day (Otsu group), and the group taking 500 mg / day ( Hei group). As in Test Example 1, the MP
C to the specified amount of each group continuously (1
This is a sensory test in which stool was collected and the stool odor was compared with the stool odor before taking the stool after ingestion of water or milk for three consecutive days using water or milk.

Each of the groups A, B, and Hei has 10 members each, and each group is composed of half men and women. This is the result obtained by comparing the results of comparing the fecal odor before and after taking the stool.

The subject ate a normal diet and did not perform any dietary restrictions (FIG. 2). As a result, when active immunoglobulin was taken at a dose of 100 mg / day (group A), it was determined that half of the active immunoglobulins had no change, and half of them were effective.
Taking 300 mg / day of active immunoglobulin (Otsu group) is 90% effective and can be judged to be extremely effective. In addition, a case was reported in which the odor during flatus was reduced.

In the case of taking 500 mg / day of active immunoglobulin (group C), there was no difference in effect from that of group (group B).

As a result of the above comparative test, 100
Taking 〜300 mg / day was effective in reducing stool odor. In the Hei group, there were cases where the flights became softer.

From the results of the above comparative tests, this stool odor reducing agent was effective in improving stool odor. As a result, bedridden elderly people, patients who cannot go to the toilet on their own, immediately after surgery, care recipients, and their caregivers are released from the odor of stool, improving the mental quality of life of those involved. Help and are welcomed.

[0064]

Example 1 A stool odor reducing agent mainly composed of powdered MPC sold in the market was manufactured (manufactured by Biocorp, New Zealand). The content of active immunoglobulin in this MPC was 8 mass%. % And contains 80 mg of active immunoglobulin per gram. In order to be able to take 300 mg of active immunoglobulin a day, the MPC
1,000 g was wrapped in a stick containing about 3.75 g, and about 250 odor-suppressing agents for stool packed in the stick were obtained. As the packaging material, a commercially available material having moisture resistance was used. For the stick wrapping machine, a normal wrapping machine is sufficient.

[0065]

Example 2 A milk protein concentrate having an active immunoglobulin content of 8% was added to 3.75 g per 500 cc.
A coffee milk drink was produced by adding the raw material to a coffee milk drink according to a conventional method to obtain a food containing a stool odor reducing agent.

[0066]

The stool odor reducing agent of the present invention containing a protein concentrate of milk as a main component can be used to reduce the stool odor by taking a predetermined amount of the odor reducing agent continuously. If a bedridden elderly person, a patient immediately after surgery who cannot go to the toilet on his own, and a care recipient need to take the medicine, the caregiver can be released from the odor of the stool. In addition, even if taken by a healthy person, the intestinal flora is improved and becomes a lactic acid bacteria-dominant flora, contributing to the maintenance and promotion of health.

Since the raw material of the agent for reducing stool odor is a protein concentrate of milk, if a commercially available raw material is selected and used,
It can be manufactured at low cost and can be taken with confidence because there is no risk of harm to the human body even if it is taken continuously.

Further, when the stool odor reducing agent is added to the food, it is possible to take a preventive method of taking the food by taking the food without having to take the stool odor reducing agent. .

[Brief description of the drawings]

FIG. 1 is a table and a graph showing a comparison of a dose test of the present invention.

FIG. 2 is a table and a graph showing a comparison regarding the difference in dosage.

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Claims (4)

[Claims] 1. A stool odor reducing agent, comprising a milk protein concentrate containing 7% to 50% by mass of active immunoglobulin derived from milk, wherein said active immunoglobulin is 100%.
A stool odor reducing agent, which comprises a protein concentrate of the milk in an amount of from 0.5 to 300 mg. 2. The stool odor reducing agent according to claim 1, wherein the milk is colostrum or normal milk. 3. The stool odor reducing agent according to claim 1, wherein the milk protein concentrate is a milk protein concentrate, whey separated protein or whey protein concentrate. 4. A food containing a stool odor reducing agent, comprising the stool odor reducing agent according to claim 1.