JP2001524829A5 - - Google Patents

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Publication number
JP2001524829A5
JP2001524829A5 JP1998547413A JP54741398A JP2001524829A5 JP 2001524829 A5 JP2001524829 A5 JP 2001524829A5 JP 1998547413 A JP1998547413 A JP 1998547413A JP 54741398 A JP54741398 A JP 54741398A JP 2001524829 A5 JP2001524829 A5 JP 2001524829A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1998547413A
Other languages
English (en)
Japanese (ja)
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JP2001524829A (ja
Filing date
Publication date
Priority claimed from US08/846,247 external-priority patent/US6391594B1/en
Application filed filed Critical
Priority claimed from PCT/US1998/008792 external-priority patent/WO1998049315A2/en
Publication of JP2001524829A publication Critical patent/JP2001524829A/ja
Publication of JP2001524829A5 publication Critical patent/JP2001524829A5/ja
Withdrawn legal-status Critical Current

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JP54741398A 1997-04-30 1998-04-30 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー Withdrawn JP2001524829A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/846,247 US6391594B1 (en) 1993-09-20 1997-04-30 Modified modular PKS with retained scaffold
US7691998P 1998-03-05 1998-03-05
US08/846,247 1998-03-05
US60/076,919 1998-03-05
PCT/US1998/008792 WO1998049315A2 (en) 1997-04-30 1998-04-30 Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008061922A Division JP2008169226A (ja) 1997-04-30 2008-03-11 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー

Publications (2)

Publication Number Publication Date
JP2001524829A JP2001524829A (ja) 2001-12-04
JP2001524829A5 true JP2001524829A5 (https=) 2005-12-02

Family

ID=26758639

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54741398A Withdrawn JP2001524829A (ja) 1997-04-30 1998-04-30 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー

Country Status (7)

Country Link
EP (1) EP0979286B1 (https=)
JP (1) JP2001524829A (https=)
AU (1) AU732909B2 (https=)
CA (1) CA2288030A1 (https=)
IL (1) IL132590A0 (https=)
NZ (1) NZ500693A (https=)
WO (1) WO1998049315A2 (https=)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
GB9814006D0 (en) 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
CA2341640A1 (en) 1998-07-02 2000-01-13 Chaitan Khosla Methods for making polyketides using altered pks
MXPA01003376A (es) * 1998-10-02 2002-11-07 Kosan Biosciences Inc Enzimas policetido sintetasa y construcciones de acido desoxirribonucleico recombinante para las mismas.
AU1447700A (en) 1998-10-28 2000-05-15 Kosan Biosciences, Inc. Library of novel "unnatural" natural products
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
WO2000031247A2 (en) 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
CA2360011A1 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Ordered gene assembly
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
EP1754700A3 (en) * 1999-01-27 2007-05-09 Kosan Biosciences, Inc. Synthesis of oligoketides
CA2361040A1 (en) * 1999-01-27 2000-08-03 Kosan Biosciences, Inc. Synthesis of oligoketides
US6753173B1 (en) 1999-02-09 2004-06-22 Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
ATE331028T1 (de) * 1999-04-16 2006-07-15 Kosan Biosciences Inc Multi-plasmid verfahren zur herstellung von grossen bibliotheken von polyketiden und nicht- ribosomalen peptiden
CA2370743A1 (en) 1999-04-16 2000-10-26 Dennis Hlasta Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
GB9913694D0 (en) * 1999-06-11 1999-08-11 Simper Adrian M DNA manipulation methods and applications for synthetic enzymes
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
EP1224317B1 (en) 1999-10-25 2006-03-08 Kosan Biosciences, Inc. Production of polyketides
CA2388422A1 (en) 1999-10-27 2001-05-03 Kosan Biosciences, Inc. Heterologous production of polyketides
DE60033965T2 (de) 1999-10-29 2008-01-10 Kosan Biosciences, Inc., Hayward Rapamycin analoge
US7141660B2 (en) 2000-02-08 2006-11-28 Sinvent As Genes encoding a nystatin polyketide synthase and their manipulation and utility
AU4858801A (en) * 2000-04-13 2001-10-30 Biotica Tech Ltd Hybrid glycosylated products and their production and use
US6838265B2 (en) 2000-05-02 2005-01-04 Kosan Biosciences, Inc. Overproduction hosts for biosynthesis of polyketides
WO2001092991A2 (en) 2000-05-30 2001-12-06 Kosan Biosciences, Inc. Design of polyketide synthase genes
WO2002099113A1 (en) * 2001-06-01 2002-12-12 Ajinomoto Co., Inc. Macrolide compounds, antifungal agents using the same, macrolide compound-producing bacterium belonging to the genus sorangium and process for producing macrolide compounds using the same
US7189549B2 (en) * 2002-06-14 2007-03-13 Kosan Biosciences, Inc. Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
KR100549690B1 (ko) 2003-10-23 2006-02-07 상하이 지아오통 대학 에프알-008 폴리케타이드 합성에 관여하는 유전자
WO2005116200A2 (en) 2004-05-05 2005-12-08 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
US20050272166A1 (en) * 2004-05-06 2005-12-08 Li Jin Methods and systems for detection, identification and quantitation of macrolides and their impurities
US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
US8759031B2 (en) 2007-04-12 2014-06-24 Wisconsin Alumni Research Foundation Type I polyketide synthase extender units
BRPI0909839A2 (pt) 2008-03-28 2017-06-13 Univ California produção de ácidos dicarboxílicos usando policetídeo sintases
BRPI0909059A2 (pt) * 2008-04-29 2019-09-24 Univ California produção de biocombustíveis usando sintases de policetídeo.
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
GB201312318D0 (en) 2013-07-09 2013-08-21 Isomerase Therapeutics Ltd Novel methods and compounds
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN112301005B (zh) * 2020-11-09 2023-01-24 浙江大学 一种6-脱氧赤酮酸内酯b合酶复合体3的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
ES2244001T3 (es) 1996-07-05 2005-12-01 Biotica Technology Limited Eritromicinas y procedimiento para su preparacion.

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