AU732909B2 - Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold - Google Patents
Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold Download PDFInfo
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- AU732909B2 AU732909B2 AU71722/98A AU7172298A AU732909B2 AU 732909 B2 AU732909 B2 AU 732909B2 AU 71722/98 A AU71722/98 A AU 71722/98A AU 7172298 A AU7172298 A AU 7172298A AU 732909 B2 AU732909 B2 AU 732909B2
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- Prior art keywords
- alkyl
- pks
- polyketide
- compound
- substituted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU57805/01A AU769288B2 (en) | 1997-04-30 | 2001-08-03 | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/846247 | 1997-04-30 | ||
| US08/846,247 US6391594B1 (en) | 1993-09-20 | 1997-04-30 | Modified modular PKS with retained scaffold |
| US7691998P | 1998-03-05 | 1998-03-05 | |
| US60/076919 | 1998-03-05 | ||
| PCT/US1998/008792 WO1998049315A2 (en) | 1997-04-30 | 1998-04-30 | Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU57805/01A Division AU769288B2 (en) | 1997-04-30 | 2001-08-03 | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
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| AU7172298A AU7172298A (en) | 1998-11-24 |
| AU732909B2 true AU732909B2 (en) | 2001-05-03 |
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|---|---|
| EP (1) | EP0979286B1 (https=) |
| JP (1) | JP2001524829A (https=) |
| AU (1) | AU732909B2 (https=) |
| CA (1) | CA2288030A1 (https=) |
| IL (1) | IL132590A0 (https=) |
| NZ (1) | NZ500693A (https=) |
| WO (1) | WO1998049315A2 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6063561A (en) * | 1991-01-17 | 2000-05-16 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
| US6066721A (en) * | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
| US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
| US6399789B1 (en) | 1996-12-18 | 2002-06-04 | Kosan Biosciences, Inc. | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides |
| GB9814006D0 (en) | 1998-06-29 | 1998-08-26 | Biotica Tech Ltd | Polyketides and their synthesis |
| EP1100927A2 (en) | 1998-07-02 | 2001-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for making polyketides using altered pks |
| NZ510819A (en) * | 1998-10-02 | 2004-03-26 | Kosan Biosciences Inc | Polyketide synthase enzymes and recombinant DNA constructs therefor |
| WO2000024907A2 (en) * | 1998-10-28 | 2000-05-04 | Kosan Biosciences, Inc. | Library of novel "unnatural" natural products |
| NZ511722A (en) | 1998-11-20 | 2004-05-28 | Kosan Biosciences Inc | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| WO2000040715A2 (en) | 1999-01-05 | 2000-07-13 | Trustees Of Boston University | Improved nucleic acid cloning |
| US6358712B1 (en) | 1999-01-05 | 2002-03-19 | Trustee Of Boston University | Ordered gene assembly |
| AU3353500A (en) * | 1999-01-27 | 2000-08-18 | Kosan Biosciences, Inc. | Synthesis of oligoketides |
| EP1754700A3 (en) * | 1999-01-27 | 2007-05-09 | Kosan Biosciences, Inc. | Synthesis of oligoketides |
| US7001748B2 (en) | 1999-02-09 | 2006-02-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of making polyketides using hybrid polyketide synthases |
| CA2359801A1 (en) | 1999-02-09 | 2000-08-17 | Rajesh S. Gokhale | Methods to mediate polyketide synthase module effectiveness |
| DE60028956T2 (de) * | 1999-04-16 | 2006-11-30 | Kosan Biosciences, Inc., Hayward | Multi-plasmid verfahren zur herstellung von grossen bibliotheken von polyketiden und nicht-ribosomalen peptiden |
| IL145976A0 (en) | 1999-04-16 | 2002-07-25 | Ortho Mcneil Pharm Inc | Ketolide antibacterials |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| GB9912563D0 (en) * | 1999-05-28 | 1999-07-28 | Biotica Tech Ltd | Polyketides and their synthesis |
| GB9913694D0 (en) * | 1999-06-11 | 1999-08-11 | Simper Adrian M | DNA manipulation methods and applications for synthetic enzymes |
| US6569867B2 (en) | 1999-10-01 | 2003-05-27 | Kosan Biosciences, Inc. | Polyketide derivatives |
| US6524841B1 (en) | 1999-10-08 | 2003-02-25 | Kosan Biosciences, Inc. | Recombinant megalomicin biosynthetic genes and uses thereof |
| US7033818B2 (en) | 1999-10-08 | 2006-04-25 | Kosan Biosciences, Inc. | Recombinant polyketide synthase genes |
| AU1231701A (en) | 1999-10-25 | 2001-05-08 | Kosan Biosciences, Inc. | Production of polyketides |
| AU1105201A (en) | 1999-10-27 | 2001-05-08 | Kosan Biosciences, Inc. | Heterologous production of polyketides |
| WO2001034816A1 (en) | 1999-10-29 | 2001-05-17 | Kosan Biosciences, Inc. | Rapamycin analogs |
| CA2399689A1 (en) | 2000-02-08 | 2001-08-16 | Trond Erling Ellingsen | Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility |
| ATE453719T1 (de) | 2000-04-13 | 2010-01-15 | Biotica Tech Ltd | Glycosylierte hybrid-verbindungen, deren herstellung und verwendung |
| US6838265B2 (en) | 2000-05-02 | 2005-01-04 | Kosan Biosciences, Inc. | Overproduction hosts for biosynthesis of polyketides |
| US7680601B1 (en) | 2000-05-30 | 2010-03-16 | Kosan Biosciences | Design of polyketide synthase genes |
| WO2002099113A1 (en) * | 2001-06-01 | 2002-12-12 | Ajinomoto Co., Inc. | Macrolide compounds, antifungal agents using the same, macrolide compound-producing bacterium belonging to the genus sorangium and process for producing macrolide compounds using the same |
| US7189549B2 (en) | 2002-06-14 | 2007-03-13 | Kosan Biosciences, Inc. | Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof |
| US7427493B2 (en) | 2002-06-28 | 2008-09-23 | Kosan Biosciences Incorporated | Recombinant genes for polyketide modifying enzymes |
| KR100549690B1 (ko) | 2003-10-23 | 2006-02-07 | 상하이 지아오통 대학 | 에프알-008 폴리케타이드 합성에 관여하는 유전자 |
| EP1751279A4 (en) | 2004-05-05 | 2008-03-19 | Univ Minnesota | NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN THE PREPARATION OF CRYPTOPHYCIN |
| US20050272166A1 (en) * | 2004-05-06 | 2005-12-08 | Li Jin | Methods and systems for detection, identification and quantitation of macrolides and their impurities |
| US7566558B2 (en) | 2006-07-28 | 2009-07-28 | Regents Of The University Of Michigan | Nucleic acids and polypeptides involved in the production of cryptophycin |
| US8759031B2 (en) | 2007-04-12 | 2014-06-24 | Wisconsin Alumni Research Foundation | Type I polyketide synthase extender units |
| US8569023B2 (en) | 2008-03-28 | 2013-10-29 | The Regents Of The University Of California | Producing dicarboxylic acids using polyketide synthases |
| JP2011519860A (ja) * | 2008-04-29 | 2011-07-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ポリケチドシンターゼを使用するバイオ燃料の生成 |
| US8852902B2 (en) | 2010-11-22 | 2014-10-07 | The Regents Of The University Of California | Producing a trimethylpentanoic acid using hybrid polyketide synthases |
| GB201312318D0 (en) * | 2013-07-09 | 2013-08-21 | Isomerase Therapeutics Ltd | Novel methods and compounds |
| US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
| CN112301005B (zh) * | 2020-11-09 | 2023-01-24 | 浙江大学 | 一种6-脱氧赤酮酸内酯b合酶复合体3的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040968A1 (en) * | 1995-06-07 | 1996-12-19 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
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| AP1029A (en) | 1996-07-05 | 2001-12-11 | Biotica Tech Limited | Erythromycins and process for their preparation. |
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1998
- 1998-04-30 WO PCT/US1998/008792 patent/WO1998049315A2/en not_active Ceased
- 1998-04-30 CA CA002288030A patent/CA2288030A1/en not_active Abandoned
- 1998-04-30 NZ NZ500693A patent/NZ500693A/en active Application Revival
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- 1998-04-30 IL IL13259098A patent/IL132590A0/xx unknown
- 1998-04-30 EP EP98918891.7A patent/EP0979286B1/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040968A1 (en) * | 1995-06-07 | 1996-12-19 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
Non-Patent Citations (1)
| Title |
|---|
| SCIENCE 22 JULY 1994, 265(5171), PAGES 509-12 * |
Also Published As
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|---|---|
| AU7172298A (en) | 1998-11-24 |
| EP0979286B1 (en) | 2014-01-29 |
| WO1998049315A3 (en) | 1999-01-14 |
| CA2288030A1 (en) | 1998-11-05 |
| NZ500693A (en) | 2004-01-30 |
| EP0979286A2 (en) | 2000-02-16 |
| IL132590A0 (en) | 2001-03-19 |
| WO1998049315A2 (en) | 1998-11-05 |
| JP2001524829A (ja) | 2001-12-04 |
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