JP2001524320A - 組織標的に対する核酸リガンド - Google Patents

組織標的に対する核酸リガンド

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Publication number
JP2001524320A
JP2001524320A JP2000522279A JP2000522279A JP2001524320A JP 2001524320 A JP2001524320 A JP 2001524320A JP 2000522279 A JP2000522279 A JP 2000522279A JP 2000522279 A JP2000522279 A JP 2000522279A JP 2001524320 A JP2001524320 A JP 2001524320A
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Prior art keywords
nucleic acid
selex
ligand
tissue
binding
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JP2000522279A
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English (en)
Japanese (ja)
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JP2001524320A5 (https=
Inventor
スティーブンズ，アンドリュー
ゴールド，ラリー
スペック，ウルリッヒ
Original Assignee
ネクスター ファーマシューティカルズ，インコーポレイティド
シエーリング アクチエンゲゼルシャフト
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Publication of JP2001524320A publication Critical patent/JP2001524320A/ja
Publication of JP2001524320A5 publication Critical patent/JP2001524320A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
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    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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