JP2001524304A - システイン−ノットファミリー組換えヒト成長因子の生物学的に活性な二量体の製造方法および生成した二量体の使用 - Google Patents

システイン−ノットファミリー組換えヒト成長因子の生物学的に活性な二量体の製造方法および生成した二量体の使用

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Publication number
JP2001524304A
JP2001524304A JP2000522131A JP2000522131A JP2001524304A JP 2001524304 A JP2001524304 A JP 2001524304A JP 2000522131 A JP2000522131 A JP 2000522131A JP 2000522131 A JP2000522131 A JP 2000522131A JP 2001524304 A JP2001524304 A JP 2001524304A
Authority
JP
Japan
Prior art keywords
seq
growth factor
dimer
cell inclusion
inclusion body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000522131A
Other languages
English (en)
Japanese (ja)
Inventor
ケルスト ウーベ
ミューラー カルステン
リーナス ウルスラ
ヴァイヒ ヘルベルト
Original Assignee
ゲゼルシャフト フュア ビオテヒノロジッシェ フォルシュング エムベーハー （ゲーベーエフ）
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ゲゼルシャフト フュア ビオテヒノロジッシェ フォルシュング エムベーハー （ゲーベーエフ） filed Critical ゲゼルシャフト フュア ビオテヒノロジッシェ フォルシュング エムベーハー （ゲーベーエフ）
Publication of JP2001524304A publication Critical patent/JP2001524304A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000522131A 1997-11-05 1998-11-05 システイン−ノットファミリー組換えヒト成長因子の生物学的に活性な二量体の製造方法および生成した二量体の使用 Pending JP2001524304A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19748734.3 1997-11-05
DE1997148734 DE19748734A1 (de) 1997-11-05 1997-11-05 Verfahren zur Gewinnung von biologisch aktiven Dimeren von rekombinanten humanen Wachstumsfaktoren aus der Cystein-Knoten-Familie sowie Verwendung der gewonnenen Dimere
PCT/EP1998/007051 WO1999026975A2 (de) 1997-11-05 1998-11-05 Verfahren zur gewinnung von biologisch aktiven dimeren von rekombinanten humanen wachstumsfaktoren aus der cystein-knoten-familie sowie verwendung der gewonnenen dimere

Publications (1)

Publication Number Publication Date
JP2001524304A true JP2001524304A (ja) 2001-12-04

Family

ID=7847606

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000522131A Pending JP2001524304A (ja) 1997-11-05 1998-11-05 システイン−ノットファミリー組換えヒト成長因子の生物学的に活性な二量体の製造方法および生成した二量体の使用

Country Status (4)

Country Link
EP (1) EP1028976A2 (de)
JP (1) JP2001524304A (de)
DE (1) DE19748734A1 (de)
WO (1) WO1999026975A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT848755E (pt) 1995-09-08 2003-12-31 Genentech Inc Proteina relacionada com o vegf
KR100869400B1 (ko) * 2002-02-05 2008-11-21 게이모나트 에스.피.에이. 재조합 태반성장인자의 제조방법
ITRM20020277A1 (it) * 2002-05-17 2003-11-17 Geymonat Spa Muteine del fattore di crescita placentare tipo 1, metodo di preparazione e loro applicazioni.
EP1449848A1 (de) * 2003-02-20 2004-08-25 GBF German Research Centre for Biotechnology Verfahren zur Herstellung von Proteinen aus der Cystine-Knoten-Familie
US8501424B2 (en) 2003-11-03 2013-08-06 Danisco Us Inc. Cd4+ epitopes of bone morphogenetic proteins
EP2975120A1 (de) * 2014-07-17 2016-01-20 Institut Pasteur Monomeres und funktionelles Adenylatcyclase-CyaA-Toxin
EP3341397A2 (de) * 2015-08-25 2018-07-04 Histide AG Verbindungen zur induzierung von gewebebildung und verwendungen davon
JP7056932B2 (ja) * 2015-08-25 2022-04-19 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1247484B (it) * 1991-03-22 1994-12-17 Ceinge Societa Consortile A R Metodo per la preparazione di interleuchina 6
AU648214B2 (en) * 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.

Also Published As

Publication number Publication date
WO1999026975A3 (de) 1999-08-12
EP1028976A2 (de) 2000-08-23
WO1999026975A2 (de) 1999-06-03
DE19748734A1 (de) 1999-05-06

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