JP2001520886A5 - - Google Patents

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Publication number
JP2001520886A5
JP2001520886A5 JP2000518092A JP2000518092A JP2001520886A5 JP 2001520886 A5 JP2001520886 A5 JP 2001520886A5 JP 2000518092 A JP2000518092 A JP 2000518092A JP 2000518092 A JP2000518092 A JP 2000518092A JP 2001520886 A5 JP2001520886 A5 JP 2001520886A5
Authority
JP
Japan
Prior art keywords
dna
protein
amino acid
acid consensus
diagnostically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000518092A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001520886A (ja
Filing date
Publication date
Priority claimed from DE19747418A external-priority patent/DE19747418C1/de
Application filed filed Critical
Publication of JP2001520886A publication Critical patent/JP2001520886A/ja
Publication of JP2001520886A5 publication Critical patent/JP2001520886A5/ja
Pending legal-status Critical Current

Links

JP2000518092A 1997-10-27 1998-10-27 ｗｎｔシグナル経路の阻害タンパク質 Pending JP2001520886A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19747418.7 1997-10-27
DE19747418A DE19747418C1 (de) 1997-10-27 1997-10-27 Inhibitor-Protein des wnt-Signalwegs
PCT/DE1998/003155 WO1999022000A1 (de) 1997-10-27 1998-10-27 Inhibitor-protein des wnt-signalwegs

Publications (2)

Publication Number Publication Date
JP2001520886A JP2001520886A (ja) 2001-11-06
JP2001520886A5 true JP2001520886A5 (https=) 2005-12-22

Family

ID=7846765

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000518092A Pending JP2001520886A (ja) 1997-10-27 1998-10-27 ｗｎｔシグナル経路の阻害タンパク質

Country Status (9)

Country Link
US (4) US6844422B1 (https=)
EP (2) EP1027440B2 (https=)
JP (1) JP2001520886A (https=)
AT (1) ATE391782T1 (https=)
DE (2) DE19747418C1 (https=)
DK (1) DK1027440T3 (https=)
ES (1) ES2306483T5 (https=)
PT (1) PT1027440E (https=)
WO (1) WO1999022000A1 (https=)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69842225D1 (de) * 1997-04-16 2011-05-26 Millennium Pharm Inc Zusammensetzung, umfassend einen Antikörper, der selektiv an ein cysteinreiches sekretiertes Protein (CRSP) bindet
US7057017B2 (en) 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
DE19747418C1 (de) 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
US7446181B2 (en) * 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins
US6344541B1 (en) 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
WO2000052047A2 (en) * 1999-03-05 2000-09-08 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
ATE283700T1 (de) * 1999-06-08 2004-12-15 Lorantis Ltd Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges
WO2001063295A2 (en) * 2000-02-24 2001-08-30 Oxford Glycosciences (Uk) Ltd. Dpi-6, a therapeutic biomarker in neurological disorders
EP1222933A1 (en) * 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway
US7927597B2 (en) 2001-04-10 2011-04-19 Agensys, Inc. Methods to inhibit cell growth
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7713526B2 (en) * 2001-05-01 2010-05-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US20040038860A1 (en) * 2002-05-17 2004-02-26 Allen Kristina M. Reagents and methods for modulating dkk-mediated interactions
IL149404A0 (en) * 2002-04-29 2002-11-10 Yissum Res Dev Co METHODS AND COMPOSITIONS FOR MODULATING β-CATENIN PHOSPHORYLATION
WO2004032838A2 (en) * 2002-10-04 2004-04-22 The Regents Of The University Of California Methods for treating cancer by inhibiting wnt signaling
US8637506B2 (en) * 2003-09-22 2014-01-28 Enzo Biochem, Inc. Compositions and methods for bone formation and remodeling
US8367822B2 (en) 2003-09-22 2013-02-05 Enzo Therapeutics, Inc. Compositions and methods for bone formation and remodeling
US8461155B2 (en) * 2003-09-22 2013-06-11 University Of Connecticut Sclerostin and the inhibition of WNT signaling and bone formation
US9046537B2 (en) 2003-09-22 2015-06-02 Enzo Biochem, Inc. Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
WO2005049797A2 (en) 2003-11-17 2005-06-02 Merck & Co., Inc. Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof
US7622553B2 (en) 2003-11-17 2009-11-24 Merck & Co., Inc. Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof
US7867699B2 (en) * 2004-03-23 2011-01-11 Wyeth Method of synthesizing and purifying Dkk proteins and Dkk proteins obtained thereby
CA2566498A1 (en) * 2004-05-14 2005-12-08 The Regents Of The University Of California Methods for treating cancer using anti-wnt2 monoclonal antibodies and sirna
US9052324B2 (en) 2004-05-19 2015-06-09 Enzo Biochem, Inc. Compounds and assays for controlling Wnt activity
US8343922B2 (en) * 2004-05-19 2013-01-01 Enzo Biochem, Inc. Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
US7618936B2 (en) 2004-05-21 2009-11-17 The Regents Of The University Of California Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
WO2006015373A2 (en) 2004-08-04 2006-02-09 Amgen Inc Antibodies to dkk-1
NZ555216A (en) * 2004-11-10 2010-05-28 Hubrecht Lab Treatment of an intestinal adenoma and/or adenocarcinoma by inhibition of notch pathway activation
EP1827470A2 (en) * 2004-12-09 2007-09-05 Neuro Therapeutics AB Materials and methods related to dickkopfs (dkk) and neurogenesis
EP1795198A1 (en) * 2005-12-09 2007-06-13 Hubrecht Laboratorium Treatment of Barret's esophagus
AR060017A1 (es) 2006-01-13 2008-05-21 Novartis Ag Composiciones y metodos de uso para anticuerpos de dickkopf -1
CA2677356A1 (en) * 2007-02-08 2008-08-14 Zhiqiang An Antibodies specific for dkk-1
US20090074668A1 (en) * 2007-09-14 2009-03-19 Farjo Rafal A Vldlr-/- mouse models and related methods
AR075989A1 (es) 2009-04-10 2011-05-11 Lilly Co Eli Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria
WO2010129284A1 (en) * 2009-04-27 2010-11-11 The Trustees Of The University Of Pennsylvania Inhibition of hair follicle growth by the wnt inhibitor dkk1
NZ596274A (en) 2009-05-12 2013-11-29 Pfizer Blocking anti-dkk-1 antibodies and their uses
EA201391248A1 (ru) 2011-03-01 2014-05-30 Эмджен Инк. Биспецифические связывающие агенты
EP2686347B1 (en) 2011-03-16 2018-05-02 argenx BVBA Antibodies to cd70
WO2013155447A1 (en) * 2012-04-13 2013-10-17 Children's Medical Center Corporation Tiki inhibitors
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US10391168B1 (en) 2014-08-22 2019-08-27 University Of Bern Anti-CD70 combination therapy
GB201800649D0 (en) 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
TWI848030B (zh) 2018-12-18 2024-07-11 比利時商阿根思公司 Ｃｄ７０組合治療

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133232A (en) * 1996-06-20 2000-10-17 The Regents Of The University Of California Endoderm, cardiac and neural inducing factors
JP2001507227A (ja) 1996-12-20 2001-06-05 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド 小脳および胚に特異的なタンパク質
US7057017B2 (en) 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
DE69842225D1 (de) * 1997-04-16 2011-05-26 Millennium Pharm Inc Zusammensetzung, umfassend einen Antikörper, der selektiv an ein cysteinreiches sekretiertes Protein (CRSP) bindet
DE19747418C1 (de) 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
US7446181B2 (en) 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins

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