JP2001520878A5 - - Google Patents
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- Publication number
- JP2001520878A5 JP2001520878A5 JP2000518058A JP2000518058A JP2001520878A5 JP 2001520878 A5 JP2001520878 A5 JP 2001520878A5 JP 2000518058 A JP2000518058 A JP 2000518058A JP 2000518058 A JP2000518058 A JP 2000518058A JP 2001520878 A5 JP2001520878 A5 JP 2001520878A5
- Authority
- JP
- Japan
- Prior art keywords
- neural stem
- pluripotent neural
- stem cells
- neurons
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 18
- 210000001178 neural stem cell Anatomy 0.000 description 17
- 210000002569 neuron Anatomy 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 10
- 230000001939 inductive effect Effects 0.000 description 5
- 102000003951 Erythropoietin Human genes 0.000 description 4
- 108090000394 Erythropoietin Proteins 0.000 description 4
- 206010021143 Hypoxia Diseases 0.000 description 4
- 229940105423 erythropoietin Drugs 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000007954 hypoxia Effects 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 2
- 101800003838 Epidermal growth factor Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940116977 epidermal growth factor Drugs 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
- 208000029028 brain injury Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6304097P | 1997-10-24 | 1997-10-24 | |
| US60/063,040 | 1997-10-24 | ||
| PCT/CA1998/000991 WO1999021966A1 (en) | 1997-10-24 | 1998-10-23 | Erythropoietin-mediated neurogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001520878A JP2001520878A (ja) | 2001-11-06 |
| JP2001520878A5 true JP2001520878A5 (https=) | 2006-01-05 |
Family
ID=22046528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000518058A Pending JP2001520878A (ja) | 1997-10-24 | 1998-10-23 | エリスロポエチン媒介神経発生 |
Country Status (5)
| Country | Link |
|---|---|
| US (7) | US6165783A (https=) |
| JP (1) | JP2001520878A (https=) |
| AU (1) | AU9617398A (https=) |
| CA (1) | CA2307017C (https=) |
| WO (1) | WO1999021966A1 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6165783A (en) * | 1997-10-24 | 2000-12-26 | Neuro Spheres Holdings Ltd. | Erythropoietin-mediated neurogenesis |
| US6610540B1 (en) * | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| DE19857609A1 (de) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
| US7345019B1 (en) | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
| US7410941B1 (en) | 1999-04-13 | 2008-08-12 | The Kenneth S. Warren Institute, Inc. | Methods for treatment of neurodegenerative conditions by peripherally administered erythropoietin |
| DE19928210B4 (de) * | 1999-06-19 | 2005-08-18 | Neuroprogen Gmbh Leipzig | Neuronales Zellmaterial und Verfahren zu dessen Herstellung |
| JP2003505023A (ja) * | 1999-07-16 | 2003-02-12 | プレサイエント ニューロファーマ インコーポレイテッド | 細胞治療用細胞の産生および調製の方法 |
| AU3499801A (en) * | 2000-02-11 | 2001-08-20 | Schepens Eye Res Inst | Isolation and transplantation of retinal stem cells |
| US7259146B2 (en) * | 2000-05-26 | 2007-08-21 | Ortho-Mcneil Pharmaceutical, Inc. | Neuroprotective peptides |
| MXPA02011727A (es) * | 2000-05-26 | 2003-10-24 | Johnson & Johnson | Peptidos neuroprotectores. |
| JP5053499B2 (ja) * | 2000-06-30 | 2012-10-17 | 地方独立行政法人東京都健康長寿医療センター | 脱髄疾患の予防及び治療薬 |
| US20030072737A1 (en) | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| US7767643B2 (en) * | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| US6531121B2 (en) * | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
| DK1471871T3 (da) | 2001-02-02 | 2007-09-17 | Ortho Mcneil Pharm Inc | Behandling af neurologisk dysfunktion omfattende fructopyranosesulfamater og erytropoietin |
| US7838292B1 (en) | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
| AU2002325712C1 (en) * | 2001-08-30 | 2008-07-31 | Stem Cell Therapeutics Inc. | Differentiation of neural stem cells and therapeutic use theeof |
| KR100505152B1 (ko) * | 2001-09-10 | 2005-08-03 | (주)가이아진 | 아스코르브산을 이용한 에리트로포이에틴의 생산방법 |
| JP4906231B2 (ja) * | 2001-09-14 | 2012-03-28 | ステム セル セラピューティクス インコーポレイテッド | プロラクチン誘導性の神経幹細胞数の増加ならびにその治療用途 |
| WO2003024471A2 (en) * | 2001-09-18 | 2003-03-27 | Stem Cell Therapeutics Inc. | Effect of growth hormone and igf-1 on neural stem cells and therapeutic application |
| US7981863B2 (en) * | 2001-09-19 | 2011-07-19 | Neuronova Ab | Treatment of Parkinson's disease with PDGF |
| EP1471970A4 (en) * | 2002-01-14 | 2006-08-02 | Univ Illinois | NOVEL MULTIPOTENT STEM CELLS OF MAMMALIAN ORIGIN, METHODS OF PREPARATION AND METHODS OF ADMINISTRATION OF SAID CELLS |
| WO2003078959A2 (en) * | 2002-03-11 | 2003-09-25 | Ortho Mcneil Pharmaceutical, Inc | Methods for shp1 mediated neuroprotection |
| WO2003103608A2 (en) * | 2002-06-11 | 2003-12-18 | The Burnham Institute | Neuroprotective synergy of erythropoietin and insulin-like growth factor |
| CA2491567A1 (en) * | 2002-07-01 | 2004-01-08 | The Kenneth S. Warren Institute, Inc. | Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs |
| WO2004011497A1 (en) * | 2002-07-31 | 2004-02-05 | Stem Cell Therapeutics Inc. | Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap) |
| US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
| WO2004075818A2 (en) * | 2003-02-26 | 2004-09-10 | Proteosys Ag | Stress specific molecular response in neurons |
| NZ542092A (en) * | 2003-03-27 | 2008-04-30 | Janssen Pharmaceutica Nv | Use of erythropoietin (EPO) in stroke recovery wherein the EPO is formulated for administration for a particular dosage regime |
| US7459152B2 (en) * | 2003-04-23 | 2008-12-02 | Rush University Medical Center | Erythropoietin administration to improve graft survival |
| CN1867678B (zh) * | 2003-09-12 | 2012-10-03 | 干细胞技术公司 | 神经集落形成分析 |
| US7546127B2 (en) * | 2003-09-26 | 2009-06-09 | Siemens Communications, Inc. | System and method for centrally-hosted presence reporting |
| BRPI0414887A (pt) * | 2003-09-29 | 2006-12-12 | Warren Pharmaceuticals Inc E T | métodos de tratamento, prevenção, retardo do inìcio ou redução dos efeitos de citocinas pró-inflamatórias em um mamìfero e de tratamento, prevenção, retardo do inìcio de uma condição associada com um efeito de citocinas pró-inflamatórias em um mamìfero, e, composição farmacêutica |
| EP1550715A1 (de) * | 2003-12-30 | 2005-07-06 | Bionethos Holding Gmbh | Verfahren zur Regenation von Gewebe |
| AU2004309083B2 (en) | 2003-12-30 | 2010-11-11 | Augustinus Bader | Tissue regeneration method |
| WO2005077404A1 (en) | 2004-02-13 | 2005-08-25 | Stem Cell Therapeutics Corp. | Use of luteinizing hormone (lh) and chorionic gonadotropin (hcg) for proliferation of neural stem cells and neurogenesis |
| WO2005079250A2 (en) * | 2004-02-13 | 2005-09-01 | Cornell Research Foundation, Inc. | Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom |
| US7588745B2 (en) * | 2004-04-13 | 2009-09-15 | Si Options, Llc | Silicon-containing products |
| AU2006269231A1 (en) * | 2005-07-08 | 2007-01-18 | Braincells, Inc. | Methods for identifying agents and conditions that modulate neurogenesis |
| US7776592B2 (en) * | 2005-08-31 | 2010-08-17 | Stc.Unm | Human renal stem cells |
| US7534765B2 (en) | 2005-09-27 | 2009-05-19 | Stem Cell Therapeutics Corp. | Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin |
| US20070077200A1 (en) * | 2005-09-30 | 2007-04-05 | Baker Clark R | Method and system for controlled maintenance of hypoxia for therapeutic or diagnostic purposes |
| US8124095B2 (en) * | 2005-10-07 | 2012-02-28 | Armagen Technologies, Inc. | Fusion proteins for delivery of erythropoietin to the CNS |
| US8741260B2 (en) * | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| AR053416A1 (es) * | 2005-11-10 | 2007-05-09 | Protech Pharma S A | Combinacion de glicoisoformas para el tratamiento o prevencion de la septicemia, linea celular transgenica productora de glicoformas de eritropoyetina, composicion farmaceutica que comprende a dicha combinacion, procedimientos para obtener la linea celular, procedimiento para producir dicha combinac |
| US8899228B2 (en) | 2006-02-08 | 2014-12-02 | Cvac Systems, Inc. | Combination pressure therapy for treatment of chronic pain |
| US20070193578A1 (en) * | 2006-02-08 | 2007-08-23 | Cvac Systems, Inc. | Combination Pressure Therapy for Treatment of Ischemia & Heart Conditions, Diabetes, Alzheimer's Disease and Cancer |
| CN101495078B (zh) * | 2006-02-08 | 2013-02-13 | Cvac系统有限公司 | 组合压力疗法 |
| KR20080103108A (ko) * | 2006-03-17 | 2008-11-26 | 스템 셀 테라퓨틱스 코포레이션 | 신경 장애 치료를 위한 lh 또는 hcg 및 epo의 투여방법 |
| WO2008022349A2 (en) | 2006-08-18 | 2008-02-21 | Armagen Technologies, Inc. | Agents for blood-brain barrier delivery |
| EP2081956B1 (en) * | 2006-11-13 | 2013-03-20 | Charité - Universitätsmedizin Berlin | Method of cell culture and method of treatment comprising a vepo protein variant |
| EP2124722A4 (en) | 2007-02-26 | 2012-01-04 | Cvac Systems Inc | COMBINATION PRESSURE THERAPY FOR SERUM FAT, STEROID MIRROR AND STEROIDOGENESIS |
| WO2008137066A1 (en) * | 2007-05-02 | 2008-11-13 | The Board Of Regents Of The University Of Oklahoma | Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases |
| AU2008282496B2 (en) | 2007-07-27 | 2013-04-04 | Armagen Technologies, Inc. | Methods and compositions for increasing alpha-iduronidase activity in the CNS |
| NZ586947A (en) | 2008-02-08 | 2012-11-30 | Ambrx Inc | Modified leptin polypeptides and their uses |
| PT2318029T (pt) | 2008-07-23 | 2018-01-10 | Ambrx Inc | Polipéptidos de g-csf bovino modificados e suas utilizações |
| MX2011003272A (es) | 2008-09-26 | 2011-04-28 | Ambrx Inc | Polipeptidos de eritropoyetina animal modificados y sus usos. |
| US8790638B2 (en) * | 2009-02-04 | 2014-07-29 | Stemedica Cell Technologies, Inc. | Compositions of stem cells and stem cell factors and methods for their use and manufacture |
| CA2748889A1 (en) | 2009-03-18 | 2010-09-23 | Armagen Technologies, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
| JP2013507131A (ja) | 2009-10-09 | 2013-03-04 | アーメイゲン・テクノロジーズ・インコーポレイテッド | Cnsにおけるイズロン酸2−スルファターゼ活性を増加させるための方法および組成物 |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| AU2012346448B2 (en) | 2011-12-02 | 2017-09-14 | Armagen, Inc. | Methods and compositions for increasing arylsulfatase A activity in the CNS |
| CN108588025A (zh) | 2012-02-17 | 2018-09-28 | 斯格本斯眼科研究所 | 人视网膜祖细胞的表型谱 |
| US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
| KR102056447B1 (ko) * | 2018-03-16 | 2019-12-16 | (주)메디노 | 신경줄기세포를 이용한 혈관형성 유도 방법 |
| CN110713982A (zh) * | 2019-11-25 | 2020-01-21 | 深圳科学之门生物工程有限公司 | 一种用于神经干细胞快速扩增的培养基 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2198404T5 (es) * | 1991-07-08 | 2008-05-01 | Neurospheres Holdings Ltd. | Celulas progenitoras neurales que responden a factor de crecimiento y que se pueden hacer proliferar in vitro. |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| EP0669973B9 (en) * | 1992-10-28 | 2007-10-10 | NeuroSpheres Holdings Ltd. | Biological factors and neural stem cells |
| US5700909A (en) * | 1993-07-30 | 1997-12-23 | The Regents Of The University Of California | Prosaposin and cytokine-derived peptides |
| CA2175992C (en) * | 1993-11-09 | 2008-04-01 | Samuel Weiss | In situ modification and manipulation of stem cells of the central nervous system |
| FI971956L (fi) * | 1994-11-14 | 1997-07-04 | Neurospheres Holdings Ltd | Hermosolujen lisääntymisen säännöstely |
| US6165783A (en) * | 1997-10-24 | 2000-12-26 | Neuro Spheres Holdings Ltd. | Erythropoietin-mediated neurogenesis |
-
1998
- 1998-10-20 US US09/175,890 patent/US6165783A/en not_active Expired - Lifetime
- 1998-10-23 JP JP2000518058A patent/JP2001520878A/ja active Pending
- 1998-10-23 CA CA2307017A patent/CA2307017C/en not_active Expired - Fee Related
- 1998-10-23 AU AU96173/98A patent/AU9617398A/en not_active Abandoned
- 1998-10-23 WO PCT/CA1998/000991 patent/WO1999021966A1/en not_active Ceased
-
2000
- 2000-12-20 US US09/742,484 patent/US6368854B2/en not_active Expired - Fee Related
-
2002
- 2002-02-21 US US10/080,161 patent/US20020094571A1/en not_active Abandoned
- 2002-03-12 US US10/095,727 patent/US20020098585A1/en not_active Abandoned
- 2002-12-31 US US10/335,477 patent/US20030104619A1/en not_active Abandoned
-
2004
- 2004-08-31 US US10/930,115 patent/US6924142B2/en not_active Expired - Fee Related
-
2005
- 2005-06-23 US US11/165,546 patent/US20060127372A1/en not_active Abandoned
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