JP2001520380A - 触媒評価のための触媒ライブラリの照射活性化およびスクリーニング並びにそのための反応器 - Google Patents
触媒評価のための触媒ライブラリの照射活性化およびスクリーニング並びにそのための反応器Info
- Publication number
- JP2001520380A JP2001520380A JP2000516226A JP2000516226A JP2001520380A JP 2001520380 A JP2001520380 A JP 2001520380A JP 2000516226 A JP2000516226 A JP 2000516226A JP 2000516226 A JP2000516226 A JP 2000516226A JP 2001520380 A JP2001520380 A JP 2001520380A
- Authority
- JP
- Japan
- Prior art keywords
- catalyst
- product
- microreactor
- screening
- reactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003054 catalyst Substances 0.000 title claims abstract description 214
- 238000012216 screening Methods 0.000 title claims abstract description 91
- 230000004913 activation Effects 0.000 title claims abstract description 7
- 238000011156 evaluation Methods 0.000 title description 2
- 239000000376 reactant Substances 0.000 claims abstract description 100
- 238000012360 testing method Methods 0.000 claims abstract description 34
- 230000005855 radiation Effects 0.000 claims abstract description 21
- 239000000047 product Substances 0.000 claims description 152
- 238000000034 method Methods 0.000 claims description 95
- 238000001514 detection method Methods 0.000 claims description 47
- 230000003197 catalytic effect Effects 0.000 claims description 41
- 238000006243 chemical reaction Methods 0.000 claims description 35
- 239000000758 substrate Substances 0.000 claims description 32
- 239000007795 chemical reaction product Substances 0.000 claims description 28
- 150000002500 ions Chemical class 0.000 claims description 21
- 238000013467 fragmentation Methods 0.000 claims description 9
- 238000006062 fragmentation reaction Methods 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 6
- 239000010409 thin film Substances 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 4
- 230000001678 irradiating effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 14
- 238000011065 in-situ storage Methods 0.000 abstract description 3
- 239000007789 gas Substances 0.000 description 91
- 238000001561 resonance enhanced multiphoton ionisation spectroscopy Methods 0.000 description 74
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 56
- 230000008569 process Effects 0.000 description 30
- 239000007788 liquid Substances 0.000 description 24
- 239000000126 substance Substances 0.000 description 23
- 238000001228 spectrum Methods 0.000 description 20
- 239000000463 material Substances 0.000 description 19
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 18
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 18
- 238000006555 catalytic reaction Methods 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- 238000005516 engineering process Methods 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 239000002245 particle Substances 0.000 description 12
- 239000007787 solid Substances 0.000 description 12
- 238000009792 diffusion process Methods 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 229910052786 argon Inorganic materials 0.000 description 9
- 238000010586 diagram Methods 0.000 description 9
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 9
- 238000011144 upstream manufacturing Methods 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 238000001816 cooling Methods 0.000 description 8
- 239000002638 heterogeneous catalyst Substances 0.000 description 8
- 239000002815 homogeneous catalyst Substances 0.000 description 8
- 238000012545 processing Methods 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 239000007790 solid phase Substances 0.000 description 8
- 238000004949 mass spectrometry Methods 0.000 description 7
- 239000002002 slurry Substances 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 6
- 238000002679 ablation Methods 0.000 description 6
- 230000003213 activating effect Effects 0.000 description 6
- 238000013459 approach Methods 0.000 description 6
- 229910052697 platinum Inorganic materials 0.000 description 6
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000012018 catalyst precursor Substances 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 238000000151 deposition Methods 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 239000011949 solid catalyst Substances 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 238000001994 activation Methods 0.000 description 4
- 238000000429 assembly Methods 0.000 description 4
- 230000000712 assembly Effects 0.000 description 4
- 239000012159 carrier gas Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 239000007791 liquid phase Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229910052763 palladium Inorganic materials 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 3
- 238000001354 calcination Methods 0.000 description 3
- 239000012876 carrier material Substances 0.000 description 3
- 239000007806 chemical reaction intermediate Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000003889 chemical engineering Methods 0.000 description 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 2
- 238000006356 dehydrogenation reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000005281 excited state Effects 0.000 description 2
- 239000000446 fuel Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000005470 impregnation Methods 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 238000000608 laser ablation Methods 0.000 description 2
- 238000001307 laser spectroscopy Methods 0.000 description 2
- 238000002898 library design Methods 0.000 description 2
- 239000012263 liquid product Substances 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- 150000002736 metal compounds Chemical class 0.000 description 2
- 238000005459 micromachining Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000001451 molecular beam epitaxy Methods 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 125000002524 organometallic group Chemical group 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 238000004549 pulsed laser deposition Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000006722 reduction reaction Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 238000004544 sputter deposition Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000007736 thin film deposition technique Methods 0.000 description 2
- 238000000427 thin-film deposition Methods 0.000 description 2
- QIJNJJZPYXGIQM-UHFFFAOYSA-N 1lambda4,2lambda4-dimolybdacyclopropa-1,2,3-triene Chemical compound [Mo]=C=[Mo] QIJNJJZPYXGIQM-UHFFFAOYSA-N 0.000 description 1
- 235000006576 Althaea officinalis Nutrition 0.000 description 1
- CAHQGWAXKLQREW-UHFFFAOYSA-N Benzal chloride Chemical class ClC(Cl)C1=CC=CC=C1 CAHQGWAXKLQREW-UHFFFAOYSA-N 0.000 description 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 description 1
- 229910039444 MoC Inorganic materials 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000007824 aliphatic compounds Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 229910000428 cobalt oxide Inorganic materials 0.000 description 1
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical compound [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- GZTMNDOZYLMFQE-UHFFFAOYSA-N coumarin 500 Chemical compound FC(F)(F)C1=CC(=O)OC2=CC(NCC)=CC=C21 GZTMNDOZYLMFQE-UHFFFAOYSA-N 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000005137 deposition process Methods 0.000 description 1
- 238000007323 disproportionation reaction Methods 0.000 description 1
- 239000002019 doping agent Substances 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 238000001312 dry etching Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005566 electron beam evaporation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000000695 excitation spectrum Methods 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000010574 gas phase reaction Methods 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000006713 insertion reaction Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 238000000050 ionisation spectroscopy Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000001459 lithography Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000002230 thermal chemical vapour deposition Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000001039 wet etching Methods 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/10—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using catalysis
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
- H01J49/162—Direct photo-ionisation, e.g. single photon or multi-photon ionisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00745—Inorganic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00745—Inorganic compounds
- B01J2219/00747—Catalysts
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/08—Methods of screening libraries by measuring catalytic activity
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/18—Libraries containing only inorganic compounds or inorganic materials
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Catalysts (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94920397A | 1997-10-10 | 1997-10-10 | |
US08/949,203 | 1997-10-10 | ||
GBGB9807836.3A GB9807836D0 (en) | 1998-04-14 | 1998-04-14 | Reactors |
US8741798A | 1998-05-29 | 1998-05-29 | |
US09/087,417 | 1998-05-29 | ||
US9807836.3 | 1998-05-29 | ||
PCT/GB1998/003023 WO1999019724A1 (fr) | 1997-10-10 | 1998-10-08 | Activation de rayonnement et criblage de bibliotheques de catalyseurs permettant d'evaluer un catalyseur et reacteurs correspondants |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001520380A true JP2001520380A (ja) | 2001-10-30 |
Family
ID=27269278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000516226A Pending JP2001520380A (ja) | 1997-10-10 | 1998-10-08 | 触媒評価のための触媒ライブラリの照射活性化およびスクリーニング並びにそのための反応器 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1019713A1 (fr) |
JP (1) | JP2001520380A (fr) |
KR (1) | KR20010031021A (fr) |
CN (1) | CN1281551A (fr) |
AU (1) | AU736438B2 (fr) |
BR (1) | BR9812909A (fr) |
CA (1) | CA2306256A1 (fr) |
ID (1) | ID24631A (fr) |
NO (1) | NO20001787L (fr) |
NZ (1) | NZ503731A (fr) |
PL (1) | PL339834A1 (fr) |
WO (1) | WO1999019724A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002540386A (ja) * | 1999-03-23 | 2002-11-26 | ハーン−シッカート−ゲゼルシャフト フュア アンゲヴァンテ フォルシュンク エー ファウ | フォーマット変換機能を有する流体制御装置 |
JP2007069211A (ja) * | 2006-11-27 | 2007-03-22 | Furukawa Electric Co Ltd:The | マイクロ化学反応装置の製造方法 |
JP2007083235A (ja) * | 2006-11-27 | 2007-04-05 | Furukawa Electric Co Ltd:The | マイクロ化学反応装置 |
JP2007105729A (ja) * | 2006-11-27 | 2007-04-26 | Furukawa Electric Co Ltd:The | マイクロ化学反応装置 |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6426226B1 (en) | 1997-10-10 | 2002-07-30 | Laboratory Catalyst Systems Llc | Method and apparatus for screening catalyst libraries |
DE19822077A1 (de) * | 1998-05-16 | 1999-11-18 | Studiengesellschaft Kohle Mbh | Kombinatorisches Verfahren zur Herstellung und Charakterisierung von kristallinen und amorphen Materialbibliotheken im Mikrogramm-Maßstab |
US6240790B1 (en) * | 1998-11-09 | 2001-06-05 | Agilent Technologies, Inc. | Device for high throughout sample processing, analysis and collection, and methods of use thereof |
BR9915268A (pt) * | 1998-11-12 | 2001-08-07 | Bp Chem Int Ltd | Método e aparelho para separação de bibliotecas de catalizadores |
US7491677B2 (en) | 1999-01-15 | 2009-02-17 | Basf Catalysts Llc | Combinatorial synthesis |
US6749814B1 (en) | 1999-03-03 | 2004-06-15 | Symyx Technologies, Inc. | Chemical processing microsystems comprising parallel flow microreactors and methods for using same |
AU1476601A (en) | 1999-11-09 | 2001-06-06 | Sri International | Array for the high-throughput synthesis, screening and characterization of combinatorial libraries, and methods for making the array |
DE19959974A1 (de) * | 1999-12-13 | 2001-06-21 | Basf Ag | Verfahren zur Herstellung von Materialbibliotheken durch elektrochemische Abscheidung |
US6627445B1 (en) | 1999-12-15 | 2003-09-30 | Uop Llc | Process for simultaneously evaluating a plurality of catalysts |
US6342185B1 (en) | 1999-12-15 | 2002-01-29 | Uop Llc | Combinatorial catalytic reactor |
US6770245B2 (en) | 1999-12-15 | 2004-08-03 | Uop Llc | Multiple parallel processing assembly |
US6576196B1 (en) | 1999-12-15 | 2003-06-10 | Uop Llc | Multiple parallel catalytic reactor assembly |
CA2327419C (fr) | 1999-12-15 | 2009-01-13 | Uop Llc | Reacteur catalytique combinatoire |
US6776963B1 (en) | 1999-12-15 | 2004-08-17 | Uop Llc | Multiple parallel catalytic reactor assembly |
US6368865B1 (en) | 1999-12-15 | 2002-04-09 | Uop Llc | Combinatorial process for performing catalytic chemical reactions |
DE10004816A1 (de) | 2000-02-04 | 2001-08-09 | Hte Gmbh | Verfahren und Vorrichtung zur kombinatorischen Herstellung und Testung von Materialbibliotheken durch photoakustische Analysemethoden |
US6627571B1 (en) * | 2000-03-01 | 2003-09-30 | Symyx Technologies, Inc. | Method and system for the situ synthesis of a combinatorial library of supported catalyst materials |
DE10012847A1 (de) | 2000-03-16 | 2001-09-27 | Hte Gmbh | Verfahren und Vorrichtung zur kombinatorischen Herstellung und Testung von Materialbibliotheken durch Anwendung mindestens zweier Analysemethoden |
US6755364B2 (en) | 2000-07-07 | 2004-06-29 | Symyx Technologies, Inc. | Methods and apparatus for mechanical treatment of materials such as catalysts |
DE10036633B4 (de) * | 2000-07-27 | 2005-03-10 | Hte Ag The High Throughput Exp | Anordnung in modularer Bauweise und Verfahren zur paralellen Testung einer Mehrzahl von Bausteinen einer Materialbibliothek |
WO2002014854A1 (fr) * | 2000-08-14 | 2002-02-21 | Chevron U.S.A. Inc. | Utilisation de reacteurs a microcanaux en chimie combinatoire |
GB2366793B (en) * | 2000-09-13 | 2005-03-09 | Imperial College | Chemical processing system and method |
US6923939B1 (en) | 2001-07-05 | 2005-08-02 | Uop Llc | Heat activated membrane introduction apparatus and method for screening materials |
US6974665B2 (en) | 2001-09-06 | 2005-12-13 | University Of Nebraska | In situ screening to optimize variables in organic reactions |
US6808685B2 (en) | 2001-09-17 | 2004-10-26 | Uop Llc | Apparatus and method for generating a plurality of isolated effluents |
US7063982B1 (en) | 2002-03-12 | 2006-06-20 | Uop Llc | Process of vaporizing and reacting a liquid feed |
US6989131B2 (en) | 2002-03-12 | 2006-01-24 | Uop Llc | Catalytic reactor with integral evaporator |
US20030173205A1 (en) | 2002-03-12 | 2003-09-18 | Arne Karlsson | Process vessel with integral evaporator |
US6949267B2 (en) | 2002-04-08 | 2005-09-27 | Engelhard Corporation | Combinatorial synthesis |
ES2199080B1 (es) * | 2002-07-16 | 2005-02-16 | Universidad Politecnica De Valencia | Soporte rotatorio y aparato para la caracterizacion multiple espectroscopica de muestras de materiales solidos. |
DE10234564B4 (de) * | 2002-07-25 | 2005-06-02 | Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh | Biosensor |
US7141217B2 (en) | 2002-12-05 | 2006-11-28 | Uop Llc | Elevated pressure apparatus and method for generating a plurality of isolated effluents |
US7267987B2 (en) | 2003-01-06 | 2007-09-11 | Uop Llc | Process and assembly for simultaneously evaluating a plurality of catalysts |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4099923A (en) * | 1977-01-17 | 1978-07-11 | The Standard Oil Company | Automatic catalytic screening unit |
JP2769205B2 (ja) * | 1989-09-16 | 1998-06-25 | 株式会社日立製作所 | 粒子状物質の分析方法、その装置及びこれを利用した超純水製造管理システム |
US6063633A (en) * | 1996-02-28 | 2000-05-16 | The University Of Houston | Catalyst testing process and apparatus |
-
1998
- 1998-10-08 AU AU94494/98A patent/AU736438B2/en not_active Ceased
- 1998-10-08 BR BR9812909-0A patent/BR9812909A/pt not_active IP Right Cessation
- 1998-10-08 CA CA002306256A patent/CA2306256A1/fr not_active Abandoned
- 1998-10-08 EP EP98947652A patent/EP1019713A1/fr not_active Withdrawn
- 1998-10-08 WO PCT/GB1998/003023 patent/WO1999019724A1/fr not_active Application Discontinuation
- 1998-10-08 PL PL98339834A patent/PL339834A1/xx unknown
- 1998-10-08 NZ NZ503731A patent/NZ503731A/en unknown
- 1998-10-08 CN CN98811935A patent/CN1281551A/zh active Pending
- 1998-10-08 ID IDW20000662A patent/ID24631A/id unknown
- 1998-10-08 KR KR1020007003828A patent/KR20010031021A/ko not_active Application Discontinuation
- 1998-10-08 JP JP2000516226A patent/JP2001520380A/ja active Pending
-
2000
- 2000-04-06 NO NO20001787A patent/NO20001787L/no not_active Application Discontinuation
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002540386A (ja) * | 1999-03-23 | 2002-11-26 | ハーン−シッカート−ゲゼルシャフト フュア アンゲヴァンテ フォルシュンク エー ファウ | フォーマット変換機能を有する流体制御装置 |
US6855293B1 (en) | 1999-03-23 | 2005-02-15 | Hahn-Schickard-Gesellschaft Fuer Angewandte Forschung E.V. | Fluids manipulation device with format conversion |
JP2007069211A (ja) * | 2006-11-27 | 2007-03-22 | Furukawa Electric Co Ltd:The | マイクロ化学反応装置の製造方法 |
JP2007083235A (ja) * | 2006-11-27 | 2007-04-05 | Furukawa Electric Co Ltd:The | マイクロ化学反応装置 |
JP2007105729A (ja) * | 2006-11-27 | 2007-04-26 | Furukawa Electric Co Ltd:The | マイクロ化学反応装置 |
JP4532458B2 (ja) * | 2006-11-27 | 2010-08-25 | 古河電気工業株式会社 | マイクロ化学反応装置 |
JP4630263B2 (ja) * | 2006-11-27 | 2011-02-09 | 古河電気工業株式会社 | マイクロ化学反応装置 |
JP4630264B2 (ja) * | 2006-11-27 | 2011-02-09 | 古河電気工業株式会社 | マイクロ化学反応装置の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
AU9449498A (en) | 1999-05-03 |
KR20010031021A (ko) | 2001-04-16 |
NZ503731A (en) | 2001-05-25 |
PL339834A1 (en) | 2001-01-02 |
EP1019713A1 (fr) | 2000-07-19 |
BR9812909A (pt) | 2002-02-05 |
NO20001787D0 (no) | 2000-04-06 |
CA2306256A1 (fr) | 1999-04-22 |
CN1281551A (zh) | 2001-01-24 |
NO20001787L (no) | 2000-06-09 |
ID24631A (id) | 2000-07-27 |
AU736438B2 (en) | 2001-07-26 |
WO1999019724A1 (fr) | 1999-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2001520380A (ja) | 触媒評価のための触媒ライブラリの照射活性化およびスクリーニング並びにそのための反応器 | |
US6426226B1 (en) | Method and apparatus for screening catalyst libraries | |
JP2002530647A (ja) | 触媒ライブラリをスクリーニングする方法および装置 | |
Senkan et al. | Discovery and optimization of heterogeneous catalysts by using combinatorial chemistry | |
CA2267908C (fr) | Spectrometres de masse et procedes de criblage rapide de librairies de materiaux differents | |
Jandeleit et al. | Combinatorial materials science and catalysis | |
US6623968B1 (en) | Parallel flow reactor and apparatus for testing catalysts | |
EP0991930B1 (fr) | Porte-echantillon a haute densite destine a l'analyse de prelevements biologiques | |
US7374942B2 (en) | Process and apparatus for the combinatorial production and testing of catalyst material libraries by using at least two analytical methods | |
WO2001044801A2 (fr) | Procede permettant d'analyser simultanement plusieurs catalyseurs | |
MXPA00003522A (en) | Radiation activation and screening of catalyst libraries for catalyst evaluation and reactors therefor | |
AU2395900A (en) | Assay device comprising mixed probes |