JP2001503620A - インターロイキン遺伝子の発現を阻害するオリゴマー - Google Patents
インターロイキン遺伝子の発現を阻害するオリゴマーInfo
- Publication number
- JP2001503620A JP2001503620A JP52044698A JP52044698A JP2001503620A JP 2001503620 A JP2001503620 A JP 2001503620A JP 52044698 A JP52044698 A JP 52044698A JP 52044698 A JP52044698 A JP 52044698A JP 2001503620 A JP2001503620 A JP 2001503620A
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- polypurine
- oligomer
- group
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
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- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
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- Biomedical Technology (AREA)
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- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/740,215 | 1996-10-25 | ||
| US08/740,215 US5874566A (en) | 1996-10-25 | 1996-10-25 | Il-15 triplex oligonucleotides |
| PCT/US1997/015397 WO1998018812A1 (en) | 1996-10-25 | 1997-08-29 | Oligomers which inhibit the expression of interleukin genes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001503620A true JP2001503620A (ja) | 2001-03-21 |
| JP2001503620A5 JP2001503620A5 (https=) | 2005-06-16 |
Family
ID=24975523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52044698A Ceased JP2001503620A (ja) | 1996-10-25 | 1997-08-29 | インターロイキン遺伝子の発現を阻害するオリゴマー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5874566A (https=) |
| EP (1) | EP0937099A4 (https=) |
| JP (1) | JP2001503620A (https=) |
| KR (1) | KR20000052806A (https=) |
| AU (1) | AU720110B2 (https=) |
| CA (1) | CA2269722A1 (https=) |
| WO (1) | WO1998018812A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192935B1 (en) * | 1993-03-08 | 2007-03-20 | Amgen Inc. | Polynucleotides encoding epithelium-derived T-cell factor and uses thereof |
| US6087172A (en) * | 1997-10-31 | 2000-07-11 | Hisamitsu Pharmaceutical Co., Inc. | Ribozymes targeted to human IL-15 mRNA |
| IL126919A0 (en) * | 1998-11-05 | 1999-09-22 | Univ Ben Gurion | Antisense oligomer |
| WO2000001851A1 (en) * | 1998-07-07 | 2000-01-13 | Hisamitsu Pharmaceutical Co., Inc. | Antisense oligonucleotides targeted to il-15 |
| US5985663A (en) * | 1998-11-25 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of interleukin-15 expression |
| GB9910119D0 (en) * | 1999-04-30 | 1999-06-30 | Novartis Ag | Organic compounds |
| US8568766B2 (en) * | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| EP1326892A2 (en) | 2000-10-12 | 2003-07-16 | University of Rochester | Compositions that inhibit proliferation of cancer cells |
| AU2002320630A1 (en) | 2001-07-17 | 2003-03-03 | University Of Florida | Detecting and treating reproductive tract disorders |
| EP1572168B1 (en) | 2002-02-06 | 2010-05-26 | Vicor Technologies, Inc. | Anti-infarction molecules |
| AU2003253580A1 (en) * | 2002-02-26 | 2003-11-17 | University Of Minnesota | Variants of nedd4l associated with hypertension and viral budding |
| AU2003257181A1 (en) | 2002-08-05 | 2004-02-23 | University Of Rochester | Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof |
| US9233120B2 (en) | 2002-11-15 | 2016-01-12 | Jyant Technologies | Anti-CCL25 and anti-CCR9 antibodies for the prevention and treatment of cancer and cancer cell migration |
| US8512701B2 (en) | 2002-11-15 | 2013-08-20 | Morehouse School Of Medicine | Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration |
| US8658377B2 (en) | 2002-11-15 | 2014-02-25 | Morehouse School Of Medicine | Detecting cancer with anti-CCL25 and anti-CCR9 antibodies |
| EP2567976B1 (en) | 2005-03-23 | 2017-07-19 | Genmab A/S | Antibodies against CD38 for treatment of multiple myeloma |
| US7476733B2 (en) * | 2005-03-25 | 2009-01-13 | The United States Of America As Represented By The Department Of Health And Human Services | Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease |
| EP1934244A2 (en) * | 2005-10-06 | 2008-06-25 | Emthrax LLC | Methods and compositions relating to anthrax spore glycoproteins as vaccines |
| EP2392647A1 (en) | 2005-10-14 | 2011-12-07 | MUSC Foundation For Research Development | Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy |
| US8080534B2 (en) * | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| EP3034083B1 (en) | 2006-09-21 | 2020-12-09 | University of Rochester | Antisense oligonucleotides for use in treating myotonic dystrophy |
| US8999317B2 (en) | 2006-11-01 | 2015-04-07 | University Of Rochester | Methods and compositions related to the structure and function of APOBEC3G |
| KR20090089462A (ko) | 2006-12-11 | 2009-08-21 | 유니버시티 오브 유타 리써치 파운데이션 | 병적 혈관형성 및 혈관 투과성을 치료하기 위한 조성물 및 방법 |
| WO2009026496A1 (en) * | 2007-08-22 | 2009-02-26 | University Of Southern California | Grp78 and tumor angiogenesis |
| AU2008296478B9 (en) * | 2007-08-28 | 2015-03-19 | The Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| US8557767B2 (en) | 2007-08-28 | 2013-10-15 | Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| WO2010070380A2 (en) | 2007-12-03 | 2010-06-24 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health | Doc1 compositions and methods for treating cancer |
| US20090233993A1 (en) * | 2008-03-06 | 2009-09-17 | Burnham Institute For Medical Research | Compositions and methods for inhibiting gsk3 activity and uses thereof |
| US20110262395A1 (en) | 2008-05-08 | 2011-10-27 | University Of Utah Research Foundation | Sensory receptors for chronic fatigue and pain and uses thereof |
| US20120070443A1 (en) | 2008-12-02 | 2012-03-22 | University Of Utah Research Foundation | Pde1 as a target therapeutic in heart disease |
| US20100286762A1 (en) * | 2009-03-18 | 2010-11-11 | Musc Foundation For Research Development | Compositions and Methods for Ameliorating Clinical Electrical Disturbances |
| WO2011031974A1 (en) | 2009-09-10 | 2011-03-17 | Southern Research Institute | Acridine analogs in the treatment of gliomas |
| US20110207789A1 (en) | 2010-02-19 | 2011-08-25 | Ye Fang | Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents |
| CN103608680A (zh) | 2010-12-14 | 2014-02-26 | 詹姆士·W·里拉尔德 | 抗cxcl13抗体和抗cxcr5抗体在恶性肿瘤的治疗或检测中的用途 |
| US9970002B2 (en) | 2012-12-12 | 2018-05-15 | Massachusetts Institute Of Technology | Compositions and methods for functional nucleic acid delivery |
| EP3071590A4 (en) | 2013-11-21 | 2017-07-19 | SeNA Research, Inc. | Methods for structural determination of selenium derivatized nucleic acid complexes |
| MX383117B (es) | 2014-07-31 | 2025-03-13 | Anji Pharmaceuticals Inc | Péptidos miméticos de la apoe y mayor potencia para depurar el colesterol en plasma. |
| US10723794B2 (en) | 2015-03-18 | 2020-07-28 | University Of South Carolina | Anti-CcL8 antibodies and uses thereof |
| AU2017306422A1 (en) | 2016-08-03 | 2019-01-31 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | TLR9 targeted therapeutics |
| WO2019051355A1 (en) | 2017-09-08 | 2019-03-14 | Ohio State Innovation Foundation | NEW MICROARN INHIBITOR THERAPY FOR SYSTEMIC LUPUS ERYTHEMATOSUS |
| US20240083990A1 (en) | 2021-01-26 | 2024-03-14 | Universite Brest Bretagne Occidentale | Novel stim1 splicing variants and uses thereof |
| US12492245B2 (en) | 2021-09-21 | 2025-12-09 | University Of South Carolina | Anti-CCL8 antibodies and treatment of lung injury by CCL8 inhibition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
-
1996
- 1996-10-25 US US08/740,215 patent/US5874566A/en not_active Expired - Fee Related
-
1997
- 1997-08-29 EP EP97941396A patent/EP0937099A4/en not_active Withdrawn
- 1997-08-29 AU AU43314/97A patent/AU720110B2/en not_active Ceased
- 1997-08-29 JP JP52044698A patent/JP2001503620A/ja not_active Ceased
- 1997-08-29 KR KR1019990703625A patent/KR20000052806A/ko not_active Ceased
- 1997-08-29 WO PCT/US1997/015397 patent/WO1998018812A1/en not_active Ceased
- 1997-08-29 CA CA002269722A patent/CA2269722A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000052806A (ko) | 2000-08-25 |
| CA2269722A1 (en) | 1998-05-07 |
| WO1998018812A1 (en) | 1998-05-07 |
| AU4331497A (en) | 1998-05-22 |
| AU720110B2 (en) | 2000-05-25 |
| US5874566A (en) | 1999-02-23 |
| EP0937099A4 (en) | 2005-01-19 |
| EP0937099A1 (en) | 1999-08-25 |
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