JP2001500872A - ジチオエーテルを用いたカルボプラチンの毒減少効果 - Google Patents
ジチオエーテルを用いたカルボプラチンの毒減少効果Info
- Publication number
- JP2001500872A JP2001500872A JP10514414A JP51441498A JP2001500872A JP 2001500872 A JP2001500872 A JP 2001500872A JP 10514414 A JP10514414 A JP 10514414A JP 51441498 A JP51441498 A JP 51441498A JP 2001500872 A JP2001500872 A JP 2001500872A
- Authority
- JP
- Japan
- Prior art keywords
- carboplatin
- dithioether
- administered
- dimesna
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.式 R1−(CH2)n−S−S−(CH2)m−R2 (I) (式中、 R1及びR2のそれぞれがSO3H又はPO3H2を意味し、かつ m及びnのそれぞれが1、2、3又は4を意味する)で表されるジチオエーテ ル又は薬剤として受け入れられるその塩を、カルボプラチンとの組合せで患者に 実質的に同時か、又は引き続いて投与することにより、 ジチオエーテルとカルボプラチンが患者の血液中に共存し、かつ ジチオエーテルがカルボプラチンの毒を軽減するように作用することを特徴と するジチオエーテル又は薬剤として受け入れられるその塩の使用。 2.ジチオエーテルが、カルボプラチン投与の前に患者に投与されることを特徴 とする請求項1記載の使用。 3.ジチオエーテルが、カルボプラチン投与の5分乃至1時間前に投与されるこ とを特徴とする請求項2記載の使用。 4.ジチオエーテル及びカルボプラチンが、共に静脈又は経口のどちらかに投与 されることを特徴とする請求項1乃至3いずれか記載の使用。 5.投与されるジチオエーテルとカルボプラチンの重量割合が、25:1乃至7 00:1であることを特徴とする請求項1乃至4いず れか記載の使用。 6.シチオエーテルが、式(I)で表され、m及びnが1乃至3を表す化合物の ナトリウム塩を意味することを特徴とする請求項1乃至5いずれか記載の使用。 7.ジチオエーテルが、式(I)で表され、m及びnが2を表し、R1及びR2が SO3Hを表す化合物のナトリウム塩であるジメスナを意味することを特徴とす る請求項6記載の使用。 8.ジメスナが、カルボプラチンの15乃至30分前に投与されることを特徴と する請求項7記載の使用。 9.請求項1、6又は7記載のカルボプラチン及びジチオエーテルを含むことを 特徴とする癌患者の投与に適した組成物。 10.pHが2乃至6の無菌で注射可能の水溶液又は懸濁液であることを特徴とす る請求項9記載の組成物。 11.ジチオエーテルとカルボプラチンの重量割合が、25:1乃至700:1で あることを特徴とする請求項10記載の組成物。 12.請求項9乃至11いずれか記載の癌治療用組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2643096P | 1996-09-23 | 1996-09-23 | |
US60/026,430 | 1996-09-23 | ||
PCT/GB1997/002582 WO1998011898A1 (en) | 1996-09-23 | 1997-09-23 | Reducing toxic effects of carboplatin using dithioethers |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009030370A Division JP2009143950A (ja) | 1996-09-23 | 2009-02-12 | ジチオエーテルを用いたカルボプラチンの毒減少効果 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001500872A true JP2001500872A (ja) | 2001-01-23 |
Family
ID=21831779
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10514414A Pending JP2001500872A (ja) | 1996-09-23 | 1997-09-23 | ジチオエーテルを用いたカルボプラチンの毒減少効果 |
JP2009030370A Pending JP2009143950A (ja) | 1996-09-23 | 2009-02-12 | ジチオエーテルを用いたカルボプラチンの毒減少効果 |
JP2013103975A Pending JP2013155200A (ja) | 1996-09-23 | 2013-05-16 | ジチオエーテルを用いたカルボプラチンの毒減少効果 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009030370A Pending JP2009143950A (ja) | 1996-09-23 | 2009-02-12 | ジチオエーテルを用いたカルボプラチンの毒減少効果 |
JP2013103975A Pending JP2013155200A (ja) | 1996-09-23 | 2013-05-16 | ジチオエーテルを用いたカルボプラチンの毒減少効果 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0957920B1 (ja) |
JP (3) | JP2001500872A (ja) |
CN (1) | CN1129432C (ja) |
AT (1) | ATE210987T1 (ja) |
AU (1) | AU712548B2 (ja) |
CA (1) | CA2263166C (ja) |
DE (1) | DE69709404T2 (ja) |
DK (1) | DK0957920T3 (ja) |
ES (1) | ES2170414T3 (ja) |
PT (1) | PT957920E (ja) |
WO (1) | WO1998011898A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008513503A (ja) * | 2004-09-21 | 2008-05-01 | バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド | 医薬用ジスルフィド塩 |
JP2011514355A (ja) * | 2008-03-14 | 2011-05-06 | バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド | 肺癌、腺癌及び他の病状のための治療方法及び組成物 |
US8710095B2 (en) | 2002-04-30 | 2014-04-29 | Bionumerik Pharmaceuticals, Inc. | Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6177411B1 (en) * | 1999-02-09 | 2001-01-23 | Bionumerik Pharmaceuticals, Inc. | Method for treating heavy metal poisoning |
AU2001253919B2 (en) | 2000-04-26 | 2006-12-14 | Government Of The United States, D/B/A Department Of Veterans Affairs | Administration of a thiol-based chemoprotectant compound |
EP1351677A4 (en) * | 2001-01-19 | 2009-08-19 | Bionumerik Pharmaceuticals Inc | CANCER TREATMENT METHOD |
CN111632146B (zh) * | 2020-05-29 | 2021-09-28 | 中山大学 | Oat抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5789000A (en) * | 1994-11-14 | 1998-08-04 | Bionumerik Pharmaceuticals, Inc. | Sterile aqueous parenteral formulations of cis-diammine dichloro platinum |
-
1997
- 1997-09-23 JP JP10514414A patent/JP2001500872A/ja active Pending
- 1997-09-23 AU AU43133/97A patent/AU712548B2/en not_active Ceased
- 1997-09-23 PT PT97941110T patent/PT957920E/pt unknown
- 1997-09-23 DE DE69709404T patent/DE69709404T2/de not_active Expired - Lifetime
- 1997-09-23 CA CA002263166A patent/CA2263166C/en not_active Expired - Fee Related
- 1997-09-23 ES ES97941110T patent/ES2170414T3/es not_active Expired - Lifetime
- 1997-09-23 CN CN97198132A patent/CN1129432C/zh not_active Expired - Fee Related
- 1997-09-23 WO PCT/GB1997/002582 patent/WO1998011898A1/en active IP Right Grant
- 1997-09-23 DK DK97941110T patent/DK0957920T3/da active
- 1997-09-23 AT AT97941110T patent/ATE210987T1/de active
- 1997-09-23 EP EP97941110A patent/EP0957920B1/en not_active Expired - Lifetime
-
2009
- 2009-02-12 JP JP2009030370A patent/JP2009143950A/ja active Pending
-
2013
- 2013-05-16 JP JP2013103975A patent/JP2013155200A/ja active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8710095B2 (en) | 2002-04-30 | 2014-04-29 | Bionumerik Pharmaceuticals, Inc. | Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity |
JP2008513503A (ja) * | 2004-09-21 | 2008-05-01 | バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド | 医薬用ジスルフィド塩 |
JP2011514355A (ja) * | 2008-03-14 | 2011-05-06 | バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド | 肺癌、腺癌及び他の病状のための治療方法及び組成物 |
Also Published As
Publication number | Publication date |
---|---|
EP0957920A1 (en) | 1999-11-24 |
WO1998011898A1 (en) | 1998-03-26 |
JP2009143950A (ja) | 2009-07-02 |
ATE210987T1 (de) | 2002-01-15 |
DE69709404D1 (de) | 2002-01-31 |
ES2170414T3 (es) | 2002-08-01 |
CN1129432C (zh) | 2003-12-03 |
DK0957920T3 (da) | 2002-04-02 |
CN1230887A (zh) | 1999-10-06 |
PT957920E (pt) | 2002-06-28 |
CA2263166A1 (en) | 1998-03-26 |
AU712548B2 (en) | 1999-11-11 |
DE69709404T2 (de) | 2002-05-29 |
CA2263166C (en) | 2006-12-12 |
JP2013155200A (ja) | 2013-08-15 |
AU4313397A (en) | 1998-04-14 |
EP0957920B1 (en) | 2001-12-19 |
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