JP2001500486A - Ｒａｒアンタゴニストとｒｘｒアゴニストとの治療学的組合せおよびその使用 - Google Patents
Ｒａｒアンタゴニストとｒｘｒアゴニストとの治療学的組合せおよびその使用Info
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- JP2001500486A JP2001500486A JP10511906A JP51190698A JP2001500486A JP 2001500486 A JP2001500486 A JP 2001500486A JP 10511906 A JP10511906 A JP 10511906A JP 51190698 A JP51190698 A JP 51190698A JP 2001500486 A JP2001500486 A JP 2001500486A
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Landscapes
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| US2477296P | 1996-08-28 | 1996-08-28 | |
| US60/024,772 | 1996-08-28 | ||
| PCT/US1997/015155 WO1998008546A2 (en) | 1996-08-28 | 1997-08-28 | Therapeutic combinations of rar antagonists and rxr agonists and use thereof |
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| JP2001500486A true JP2001500486A (ja) | 2001-01-16 |
| JP2001500486A5 JP2001500486A5 (https=) | 2005-04-07 |
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| JP10511906A Ceased JP2001500486A (ja) | 1996-08-28 | 1997-08-28 | Ｒａｒアンタゴニストとｒｘｒアゴニストとの治療学的組合せおよびその使用 |
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| US (2) | US6130230A (https=) |
| EP (1) | EP0928200B1 (https=) |
| JP (1) | JP2001500486A (https=) |
| AT (1) | ATE236654T1 (https=) |
| AU (1) | AU731060B2 (https=) |
| CA (1) | CA2263817A1 (https=) |
| DE (1) | DE69720745T2 (https=) |
| ES (1) | ES2196361T3 (https=) |
| IL (1) | IL128723A0 (https=) |
| NO (1) | NO990912L (https=) |
| WO (1) | WO1998008546A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012506998A (ja) * | 2008-10-28 | 2012-03-22 | フェネックス ファーマシューティカルス アーゲー | オーファン核内受容体ｒａｒ関連オーファン受容体ガンマ（ｎｒ１ｆ３）活性を調節するための新規リガンドの同定方法 |
| JP2019517557A (ja) * | 2016-06-10 | 2019-06-24 | アイオー セラピューティクス インコーポレイテッド | 癌免疫療法のための受容体選択的レチノイドおよびレキシノイド化合物および免疫調節因子 |
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| WO2000018885A1 (en) | 1998-09-29 | 2000-04-06 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
| CA2254429A1 (en) * | 1998-11-19 | 2000-05-19 | Tully Michael Underhill | Compositions for promoting chondrogenesis |
| AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| US6436993B1 (en) * | 1999-07-13 | 2002-08-20 | The Salk Institute For Biological Studies | Use of RAR antagonists as modulators of hormone mediated processes |
| CA2402413A1 (en) * | 2000-03-14 | 2001-09-20 | The University Of Western Ontario | Compositions and methods for affecting osteogenesis |
| AU4866201A (en) * | 2000-04-13 | 2001-10-30 | Pierre Chambon | Compositions and methods for use in modulating immune system function |
| WO2001092578A2 (en) * | 2000-05-26 | 2001-12-06 | Board Of Trustees Of The University Of Illinois | Reagents and methods for identifying and modulating expression of genes regulated by retinoids |
| US6713515B2 (en) | 2000-09-13 | 2004-03-30 | Bristol Myers Squibb Company | Retinoic acid receptor antagonists as promoters of angiogenesis |
| EP1478384A2 (en) * | 2001-06-11 | 2004-11-24 | Ludwig Institute For Cancer Research | Method for increasing the survival of dopamine secreting cells |
| IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| WO2003062404A1 (en) | 2002-01-25 | 2003-07-31 | Gamida-Cell Ltd. | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
| US20040097587A1 (en) * | 2002-03-27 | 2004-05-20 | Arbiser Jack L | Compositions and methods of treatment of ulcerating diseases, burns, and related conditions |
| JP4473491B2 (ja) * | 2002-05-28 | 2010-06-02 | 株式会社資生堂 | 毛穴縮小剤 |
| US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
| US20050112123A1 (en) * | 2003-10-06 | 2005-05-26 | Vaughan Michael R. | Methods of treating proteinuria |
| GB2411115A (en) * | 2004-02-19 | 2005-08-24 | Medical Res Council | Retinoic acid antagonists for the treatment of oesophageal disorders |
| WO2006030442A2 (en) | 2004-09-16 | 2006-03-23 | Gamida-Cell Ltd. | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
| US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
| EP2329817A1 (en) * | 2009-09-04 | 2011-06-08 | Ernst-Moritz-Arndt-Universität Greifswald | Retinoic acid receptor antagonists, miR-10a inhibitors and inhibitors of HOXB1 or HOXB3 repressors for treating pancreatic cancer |
| AU2012272642B2 (en) * | 2011-06-24 | 2017-09-07 | Gri Bio, Inc. | Prevention and treatment of inflammatory conditions |
| HK1202581A1 (en) | 2012-02-13 | 2015-10-02 | Gamida-Cell Ltd. | Mesenchymal stem cells conditioned medium and methods of generating and using the same |
| US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
| US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
| WO2015026990A2 (en) | 2013-08-20 | 2015-02-26 | University Of Washington Through Its Center For Commercialization | Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydrolase |
| EP3380086B1 (en) | 2015-11-25 | 2021-10-13 | IO Therapeutics, Inc. | Cyp26-resistant rar-alpha selective agonists in the treatment of cancer |
| WO2019014468A1 (en) | 2017-07-13 | 2019-01-17 | Io Therapeutics, Inc. | RECEPTOR SUBTYPE AND RETINOID COMPOUNDS AND SELECTIVE REXINOIDS OF A FUNCTION IN COMBINATION WITH IMMUNE MODULATORS FOR ANTICANCER IMMUNOTHERAPY |
| US10363272B2 (en) | 2017-08-31 | 2019-07-30 | Io Therapeutics, Inc. | RAR selective agonists in combination with immune modulators for cancer immunotherapy |
| US12115140B2 (en) * | 2020-07-31 | 2024-10-15 | The Trustees Of Columbia University In The City Of New York | Method of treating adenoid cystic carcinoma |
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| CA2100582A1 (en) | 1991-03-18 | 1992-09-19 | David J. Mangelsdorf | Response element compositions and assays employing same |
| US5780676A (en) * | 1992-04-22 | 1998-07-14 | Ligand Pharmaceuticals Incorporated | Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors |
| US5399586A (en) * | 1993-03-11 | 1995-03-21 | Allergan, Inc. | Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity |
| EP0659045A4 (en) * | 1993-05-18 | 1997-02-26 | Inst Nat Sante Rech Med | MOUSE GENETICALLY GENERATED AND COMPRISING MODIFICATIONS IN GENES ENCODING RETINOIC ACID RECEPTOR PROTEINS. |
| US5702914A (en) * | 1994-12-21 | 1997-12-30 | The Salk Institute For Biological Studies | Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements |
| US5747661A (en) * | 1995-01-13 | 1998-05-05 | Howard Hughes Medical Institute | Retinoid-inducible response elements |
| AU4530496A (en) | 1995-01-13 | 1996-07-31 | Salk Institute For Biological Studies, The | Allosteric control of nuclear hormone receptors |
| US5559248A (en) * | 1995-04-05 | 1996-09-24 | Bristol-Myers Squibb Co. | Retinoid-like heterocycles |
| US6025388A (en) * | 1995-04-26 | 2000-02-15 | Allergan Sales, Inc. | Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids |
| US5906920A (en) | 1995-08-29 | 1999-05-25 | The Salk Institute For Biological Studies | Methods for the detection of ligands for retinoid X receptors |
| CA2276288A1 (en) | 1996-12-31 | 1998-07-09 | Laszlo Nagy | Treatment of disease states which result from neoplastic cell proliferation using ppar-gamma activators and compositions useful therefor |
| AU5727998A (en) | 1996-12-31 | 1998-07-31 | Salk Institute For Biological Studies, The | Treatment of liposarcomas using a combination of thiazolidinediones and retinoidx receptor selective agonists |
| US6387673B1 (en) | 1997-05-01 | 2002-05-14 | The Salk Institute For Biological Studies | Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds |
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1997
- 1997-08-28 CA CA002263817A patent/CA2263817A1/en not_active Abandoned
- 1997-08-28 AU AU41674/97A patent/AU731060B2/en not_active Ceased
- 1997-08-28 JP JP10511906A patent/JP2001500486A/ja not_active Ceased
- 1997-08-28 AT AT97939631T patent/ATE236654T1/de not_active IP Right Cessation
- 1997-08-28 WO PCT/US1997/015155 patent/WO1998008546A2/en not_active Ceased
- 1997-08-28 ES ES97939631T patent/ES2196361T3/es not_active Expired - Lifetime
- 1997-08-28 DE DE69720745T patent/DE69720745T2/de not_active Expired - Fee Related
- 1997-08-28 EP EP97939631A patent/EP0928200B1/en not_active Expired - Lifetime
- 1997-08-28 US US08/919,318 patent/US6130230A/en not_active Expired - Lifetime
- 1997-08-28 IL IL12872397A patent/IL128723A0/xx unknown
-
1999
- 1999-02-25 NO NO990912A patent/NO990912L/no not_active Application Discontinuation
-
2000
- 2000-07-19 US US09/619,308 patent/US6653322B1/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012506998A (ja) * | 2008-10-28 | 2012-03-22 | フェネックス ファーマシューティカルス アーゲー | オーファン核内受容体ｒａｒ関連オーファン受容体ガンマ（ｎｒ１ｆ３）活性を調節するための新規リガンドの同定方法 |
| JP2019517557A (ja) * | 2016-06-10 | 2019-06-24 | アイオー セラピューティクス インコーポレイテッド | 癌免疫療法のための受容体選択的レチノイドおよびレキシノイド化合物および免疫調節因子 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO990912L (no) | 1999-04-27 |
| DE69720745D1 (de) | 2003-05-15 |
| WO1998008546A2 (en) | 1998-03-05 |
| EP0928200A2 (en) | 1999-07-14 |
| DE69720745T2 (de) | 2004-02-26 |
| ES2196361T3 (es) | 2003-12-16 |
| AU731060B2 (en) | 2001-03-22 |
| WO1998008546A8 (en) | 2001-04-19 |
| AU4167497A (en) | 1998-03-19 |
| NO990912D0 (no) | 1999-02-25 |
| CA2263817A1 (en) | 1998-03-05 |
| EP0928200B1 (en) | 2003-04-09 |
| IL128723A0 (en) | 2000-01-31 |
| ATE236654T1 (de) | 2003-04-15 |
| US6130230A (en) | 2000-10-10 |
| WO1998008546A3 (en) | 1998-04-23 |
| US6653322B1 (en) | 2003-11-25 |
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