JP2001340737A - Emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve the safety of an emulsion composition to a human body by utilizing none or a slight amount of an emulsifier while keeping the functions and stability. SOLUTION: The emulsion composition compounded with polyglycerol and/or polyethylene glycol is prepared by emulsification using a method consisting in arranging a structure in a first passage so as to introduce the jet flow of fluid along the first passage and to introduce the fluid to the flow controlled along a fresh passage and determining the directions of the first passage and the fresh passage in such a manner that shearing force and cavitation are generated in the fluid.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an emulsifying composition which is stable, safe and highly functional without using an emulsifier or a surfactant, which is called an emulsifier or a surfactant.

[0002]

2. Description of the Related Art Emulsified compositions are used for foodstuffs, drinking water, pharmaceuticals,
It is widely used in cosmetics, personal belongings, paints, inks, toners, and photographic photosensitive materials. In particular, food, drinking water, pharmaceuticals, and cosmetics are products that have a direct effect on the human body and require safety. For this reason, the development of safe emulsifiers and improvements in emulsification technology have led to a decrease in the amount of emulsifiers used.Also, some safe emulsifiers have been developed and used in the market. Some harmful substances are not available due to laws and regulations. However, the safety of emulsifying agents is far from completely solved, and many of the emulsifying agents currently used are still used today even in animal experiments and those that have actually been reported to have harmful effects on humans. Have been. Further, it is considered that the emulsifying action itself does not have a very good effect on the human body, and emulsification using only an emulsifying agent has various problems.

[0003] In addition, if some emulsifying agents are not used,
Alternatively, a technology for preparing an emulsified composition by using a small amount of an emulsifying agent has been disclosed, but the compounding components are complicated,
There are sensory limitations and problems with long-term stability.
Various high-pressure emulsifiers have been developed. For example, there are microfluidizers described in U.S. Pat. No. 4,533,254 and Gorin, but there is room for improvement in problems such as rapid wear of parts and emulsification ability. There are also restrictions on the combinations of the ingredients.

[0004]

The inventor of the present invention prepares an emulsified composition without using an emulsifying agent or by using a small amount of an emulsifying agent while ensuring sufficient sensory and stability. By doing so, the purpose was to improve safety for the human body.

[0005]

Means for Solving the Problems The present inventor has various means for achieving the object, but firstly, the capacity of the emulsifier is considered to be important. 9-50
It has been found that the emulsification method described in JP-A-7791 has a capability not available in conventional emulsifiers. As a result of investigations for maximizing the use of this emulsification method, it was found that blending polyglycerin and / or polyethylene glycol is a method for solving the problem.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS An emulsification method is disclosed in
The emulsification method described in JP 507791 A, that is, the following method is used.

1. A method used to generate an emulsifying action in a fluid such that a jet stream of fluid is directed along a first path and directed to a controlled flow along a new path. Disposing a structure within said first passage, wherein the first passage and the new passage are oriented such that shear forces and cavitation occur in the fluid. 2. The method of claim 1, further comprising orienting the first passage and the new passage substantially diametrically. 3.1 The method of claim 1, further comprising forming a consistent stream into a cylindrical stream surrounding the jet stream. 4.1 The method according to 1, wherein the disposed structure comprises a reflective surface. 5.4. The method of claim 4, wherein the reflective surface is substantially hemispherical. 6.4. The method of claim 4, wherein the reflective surface is substantially tapered. 7.4 The method according to claim 4, wherein the reflection surface is formed at an end of a well. 8.7 The method according to claim 7, further comprising adjusting the pressure in the well.

9.7. The method according to 9.7, further comprising adjusting a distance from the opening of the well to the reflection surface. The method of claim 10.7, further comprising means for changing the size of the well opening. 11.7. The method according to 11.7, wherein the controlled flow as it emerges from the well is directed to constantly flow out of the well opening in an annular sheet. 12.11. The method according to 12.11, further comprising guiding the refrigerant to flow in an annular shape in a direction opposite to the flow in the annular sheet shape. 13. A method used to stabilize a warm emulsion immediately after completion of emulsification, in which the emulsion is constantly discharged from an outlet at the end of an emulsion production mechanism, and the emulsified fluid is discharged in a direction substantially opposite to the flow of the emulsion. A method comprising letting the refrigerant flow out in close proximity to allow heat exchange. 14. The method according to 14.13, further comprising forming the flow of the emulsion into a thin annular layer flow when the emulsion flows out of the emulsion production mechanism. 15. The method of claim 13, further comprising the step of forming the flow as a thin annular layer when the refrigerant is flowing opposite to the emulsion. 16. The method according to claim 13, wherein the refrigerant comprises a liquid or a gas that may be mixed with the emulsion.

17. The method according to 17.13, wherein the flow of the emulsion and the refrigerant is generated when the annular valve is opened. 18. A method for emulsifying a first fluid component in a second fluid component, wherein the first fluid component is supplied to the cavity in a substantially stagnant state, and the second fluid component is jetted into the first fluid component. A method wherein the fluid temperature and the jet flow rate are selected such that cavitation is generated by hydraulic separation at the interface of both fluids towards the fluid components. 19. The method according to claim 18, wherein the second fluid component comprises a continuous phase in an emulsified or dispersed system. 20. The method according to claim 18, wherein the first fluid component comprises a discontinuous phase in an emulsified system. 21. The method according to claim 18, wherein the first fluid component comprises a solid discontinuous phase in a dispersion.

22. The method according to claim 18, wherein the first fluid component is supplied to an annular reaction chamber, and a jet stream is jetted therefrom through an outlet of an orifice opening into the annular reaction chamber. A method consisting of: 23. Use according to claim 18, wherein after completion of the emulsification by hydraulic separation, the product is passed through an orifice for another emulsification. 24. Use according to claim 18, comprising, after completion of the emulsification by hydraulic separation, directing the product to the next processable reaction chamber. 25. The method according to 24, comprising adding additional ingredients to the emulsion in the next processable reaction chamber. 26. The method according to claim 24, which comprises applying a refrigerant to the next processable reaction chamber for quenching and stabilizing the emulsion. 27. The method according to claim 24, wherein the next processable reaction chamber comprises an absorption cell to which a jet stream of the product is directed.

28. A device for reducing pressure fluctuations in an emulsifying cell guided from a fluid line by a high-pressure pump, comprising a coiled tube in a fluid line between a high-pressure pump and an emulsifying cell, wherein the tube has an internal volume and a wall. A device consisting of a thickness, a coil diameter, and a coil winding configuration that allow them to just absorb pressure fluctuations and withstand the high pressure generated by the pump. 29. The apparatus according to claim 28, further comprising a shell having a port around the coil tube through which a heat multiplier or a refrigerant can pass. 30. A nozzle used for an emulsion manufacturing mechanism, comprising two main bodies having flat surfaces that abut each other, and at least one main body is formed with a groove forming an orifice in the nozzle, and the flat surface is formed by engraving. Is that when the two bodies are brought into close contact with sufficient force, the flow of liquid is sufficiently flat to be confined to the orifice. 31. The nozzle according to item 30., wherein the surface on which cavitation occurs is formed in the groove. 32. The nozzle according to claim 30, wherein the wall surface of the groove is coated.

33. The method according to claim 32, wherein the coating material is diamond or a polar or non-polar material. 34. An absorption cell used for an emulsion production mechanism, having an open end at one end for receiving a jet fluid having two immiscible components, and a reflection surface provided at the other end of the reaction chamber for reversing a jet flow. And a mechanism for adjusting the distance from the open end of the reaction chamber to the reflecting surface. 35. 35. The absorption cell according to claim 34, wherein the reflective surface is replaceable for various uses. 36. The absorption cell according to claim 34, further comprising a removable nest inserted into the open end of the reaction chamber, wherein the nest has an orifice having a diameter smaller than an inner wall of the reaction chamber. Absorption cell. 37. The absorption cell according to claim 34, comprising a nested insert that can be exchanged for different applications.

38. A unitary emulsion production structure comprising a continuum of couplings that can be connected to one another in various ways, each of at least one of said couplings having an annular male sealing surface formed at one end of the coupling, An annular female seal surface formed at the other end of the coupling, and formed between the male seal surface and the female seal surface so that liquid flows from the upstream coupling to the downstream coupling. And a port for supplying a supply liquid to the coupling and removing the liquid from the coupling, at least some of the openings through which the liquid flows are narrow enough to form a jet stream, and the sealing surface Is simply smooth enough to maintain a seal that does not leak when the coupling is sufficiently connected with the force compressed along the length of the structure. Type emulsion production structure. 39. The structure according to 39.38, wherein the reaction chamber in which the processing is performed is formed as a single body formed between one male sealing surface of the upstream coupling and one female sealing surface of the downstream coupling. Type emulsion production structure. 40. The structure according to claim 40, wherein in some of the couplings, the orifice extends from one end of the coupling to the other.

A structure according to 41.38, wherein the structure is provided with an absorption cell at one end of the structure. 42. The structure according to claim 42, wherein one of the couplings extends into the other coupling to form a small annular opening for generating an annular flow layer of refrigerant. A single emulsion production structure. 43. The structure of claim 43, wherein some ports in the coupling are used for CIP / SIP cleaning and / or sterilization procedures. 44. The method of claim 44.4, comprising injecting the additional component into a space adjacent the reflective surface in the direction of the substantially controlled fluid new passage. 45 An apparatus for use in an emulsified manufacturing structure, comprising: a coupling; and an orifice support including an emulsified orifice with both ends directed into other components of the structure, the orifice support comprising a coupling. Equipped inside, the position of both ends is reversed by rotating the support,
In addition, a device configured such that each of its ends is selectively an inlet or outlet of an orifice depending on its position.

Emulsifiers embodying the above emulsification methods include DeBEE and miniDeBEE manufactured by BEE Japan.
These can be used. This emulsification method has a strong emulsifying power of twice or more as compared with other conventional methods using a rotary shearing force, a method using ultrasonic waves, and a similar high-pressure emulsifying machine. The need for use is reduced. The emulsifying action is present in almost all substances, and the term "emulsifying agent" as used herein means an emulsifying action to some extent, which is generally called an emulsifier or a surfactant. Of course, considering the gist of the present invention, the processing pressure is 1000 kg.
/ Cm ² or more. In addition to the strong emulsifying power, there is little wear due to vibrations and collisions, and there is an advantage in terms of running cost and maintenance. In this respect, there is a practical use value. In addition, there are models that usually require pre-emulsification but do not require pre-emulsification depending on the device. In other emulsifiers, when trying to approximate the ability to the emulsification method used in the present invention, once emulsified, also emulsified, the method may be repeated several times,
Although the state of emulsification is somewhat improved, it cannot be equivalent to the emulsified composition of the present invention. As described above, in other high-pressure emulsification methods, the abrasion due to vibration and collision is larger than that of the emulsification method of the present invention, but this defect is further enlarged by repeated emulsification. In addition, there are problems in terms of time and costs. Since this emulsification method is different from the conventional emulsification method, it is necessary to change the ratio and type of the raw materials to be blended.

As a result of intensive studies by the present inventors, it has been found that the incorporation of polyglycerin and / or polyethylene glycol makes the most of this emulsification method. Polyglycerin is a polymer of glycerin,
When utilized in the present invention, the average degree of polymerization is 2 to 12,
The blending amount is preferably 50% or less, and it is also preferred to blend two or more types of polyglycerin having different average degrees of polymerization. In the case of polyglycerin having a large average degree of polymerization, the viscosity is high, so that the blending amount is naturally limited.

Polyethylene glycol also varies depending on the type, amount and use of the other ingredients, but has an average molecular weight of 600 to 800,000, preferably an amount of 40% or less, and two or more kinds having different average polymerization degrees. It is also preferable to mix polyethylene glycol. When the average molecular weight is large like polyglycerin, the amount is limited. Further, the total amount of polyglycerin and polyethylene glycol is preferably 1% to 60% in the present invention. Further, the average molecular weight is 10,000 to 80000
A small amount of polyethylene glycol of 0 does not make the emulsified composition functionally heavy, and is particularly suitable when used as an external preparation for skin.

These may be mixed with other raw materials to form an emulsified composition. Other raw materials are not particularly limited, but the advantage of using this emulsifying method is that no emulsifying agent is required or only a small amount is required, which is to enhance safety. From this, it is consistent with the gist of the present invention that the other raw materials also have high safety. Also,
Generally, since the particle diameter is small, the viscosity (hardness) tends to be higher than that of a normal emulsification method. Therefore, it is better to reduce the compounding ratio of the compound for increasing the viscosity (hardness). The result is obtained.

The method of preparing the emulsified composition is to measure the required amount of the ingredients to be blended, and to carry out pre-emulsification, heat the whole as necessary and pre-emulsify, or divide and measure the oil phase and the aqueous phase. Then, if necessary, warm and pre-emulsify. The pre-emulsification method may be a simple stirrer depending on the case of a homodisperse or a normal emulsifier. This is emulsified by the emulsification method of the present invention. More specifically, as described above, the emulsifier includes DeBEE and miniDeBEE manufactured by BEE Japan, and these may be used. Of course, in view of the gist of the present invention, it is desirable to use at a processing pressure of 1000 kg / cm ² or more.

The embodiments are described in Table 1 below, and the present invention is not limited to them.

[0021]

[Table 1]

The mixture was weighed in the amount (% by weight) shown in Table 1, heated, preliminarily emulsified with a homogenizer, and emulsified with DeBEE manufactured by BEE Japan at a processing pressure of 2500 kg / cm ² .

[0023]

According to the present invention, the same formulation as in Table 1 is used in a Gaulin type emulsifier,
Processed at maximum processing pressure in a microfluidizer.
Particles of this emulsified composition (Comparative Example 1-1 was prepared by treating Example 1 with a Gaulin-type emulsifier, Comparative Example 1-2 was prepared by treating with a microfluidizer, and the same procedure was carried out in the same manner) Table 2 shows the measurement results of the diameter.

[0024]

As described above, the particle size is smaller than that of the emulsion emulsified by a Gaulin-type emulsifier or microfluidizer. This means that when trying to produce particles having the same particle size, a Gorin-type emulsifier and a microfluidizer require a large amount of an emulsifying agent, and have problems such as safety.

A comparative example was prepared from the examples except that polyethylene glycol and polyglycerin were omitted (emulsifying conditions were the same as in the examples) (Comparative Example A). The average particle size of Comparative Example A was 542 nm, and the polyethylene glycol was polyethylene glycol. And / or that polyglycerin plays an important role. Examples 4, 5, 9, 10, 12, 1
No. 3 has a particularly good feeling in use and is most suitable for an external preparation for skin.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) B01F 3/08 B01F 3/08 A

Claims (3)

[Claims] 1. arranging a structure in said first passage to direct a jet stream of fluid along a first passage and to direct the fluid to a controlled flow along a new passage; An emulsifying composition characterized in that the first passage and the new passage are emulsified using a method oriented so as to generate shear force and cavitation in the fluid, and blended with polyglycerin and / or polyethylene glycol. 2. The polyglycerin has an average degree of polymerization of 3 to 12.
And the average molecular weight of polyethylene glycol is 600
2. The emulsified composition of claim 1, wherein 3. The polyethylene glycol has an average molecular weight of 10,000 to 800,000 and a compounding amount of 0.01 to 2.0.
3. The emulsified composition according to claim 1 or 2 which is in terms of% by weight.