JP2001340751A - Emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To form an emulsion composition safe to a human body, keeping the functions and stability. SOLUTION: The emulsion composition compounded with >=1 kind of clay minerals and salts or further the emulsion composition compounded with >=1 kind of glycerrhizate, hydroxy-fatty acid, polyglycerol, polyethylene glycol, phenoxyethanol, 1,2-pentanediol, amino acid, peptide, protein and diethoxyethyl succiniate is prepared by emulsification using a method consisting in arranging a structure in a first passage so as to introduce the jet flow of fluid along the first passage and to introduce the fluid to the flow controlled along a fresh passage and determining the directions of the first passage and the fresh passage in such a manner that shearing force and cavitation are generated in the fluid.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an emulsion composition which is safe, has excellent sensory properties, and has good stability. Specifically, the present invention relates to an emulsified composition which does not use an emulsifier or an emulsifying agent referred to as a surfactant, or uses only a small amount thereof, and has enhanced safety from the viewpoint of preservation.

[0002]

2. Description of the Related Art Emulsified compositions are used for foodstuffs, drinking water, pharmaceuticals,
It is widely used in cosmetics, personal belongings, paints, inks, toners, and photographic photosensitive materials. In particular, food, drinking water, pharmaceuticals, and cosmetics are products that have a direct effect on the human body and require safety. For this reason, the development of safe emulsifiers and improvements in emulsification technology have led to a decrease in the amount of emulsifiers used.Also, some safe emulsifiers have been developed and used in the market. Some harmful substances are not available due to laws and regulations. However, the safety of emulsifying agents is far from completely solved, and many of the emulsifying agents currently used are still used today even in animal experiments and those that have actually been reported to have harmful effects on humans. Have been. Further, it is considered that the emulsifying action itself does not have a very good effect on the human body, and emulsification using only an emulsifying agent has various problems.

[0003] In addition, if some emulsifying agents are not used,
Alternatively, a technology for preparing an emulsified composition by using a small amount of an emulsifying agent has been disclosed, but the compounding components are complicated,
There are sensory limitations and problems with long-term stability.
Various high-pressure emulsifiers have been developed. For example, there are microfluidizers described in U.S. Pat. No. 4,533,254 and Gorin, but there is room for improvement in problems such as rapid wear of parts and emulsification ability. There are also restrictions on the combinations of the ingredients.

[0004] Clay minerals are used in emulsion compositions,
It is known in JP-A-5-192560 and the like,
In particular, it is known that an emulsified composition can be prepared without using a surfactant. The use of deep water is disclosed in Japanese Patent Application Laid-Open No. 10-182346. Also, seawater has already been marketed as a raw material for cosmetics.

[0005]

SUMMARY OF THE INVENTION The present inventor aims to produce a safer emulsified composition without using an emulsifying agent as much as possible, and to ensure sufficient sensory and stability. Aimed at.

[0006]

To achieve this object, several methods are conceivable, but the effect that can be expected with only one means is small. As a result of intensive studies, the present inventors have solved the problem from the two aspects of the emulsification method and the components to be blended without using an emulsifying agent or minimizing the amount used, and have achieved a safer and more functional solution than ever before. Thus, an emulsified composition effective in terms of stability and stability could be obtained. In addition, by selecting a preservative, while maintaining the preservative,
Safety was improved.

The inventor of the present invention has various means for achieving the object. First, the inventor considers that the capacity of the emulsifier is important. It has been found that the emulsification method described has capabilities not found in previous emulsifiers. As a result of further study using this emulsification method, it was found that blending of one or more clay minerals and salts is a method for solving the problem.
Further, it is an object of the present invention to utilize the combination of one or more amino acids, peptides, proteins, glycyrrhizinate, hydroxy fatty acids, polyglycerin, polyethylene glycol, diethoxyethylphenoxyethanol succinate, and 1,2 pentanediol. It has been found that more advanced achievements are possible.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION First, an emulsification method is described in Japanese Patent Application Laid-Open No. 9-507791, that is, the following method.

1. A method for generating an emulsifying action in a fluid, the method comprising directing a jet stream of fluid along a first path and directing the fluid into a controlled flow along a new path. Disposing a structure within said first passage, wherein the first passage and the new passage are oriented such that shear forces and cavitation occur in the fluid. 2. The method of claim 1, further comprising orienting the first passage and the new passage substantially diametrically. 3.1 The method of claim 1, further comprising forming a consistent stream into a cylindrical stream surrounding the jet stream. 4.1 The method according to 1, wherein the disposed structure comprises a reflective surface. 5.4. The method of claim 4, wherein the reflective surface is substantially hemispherical. 6.4. The method of claim 4, wherein the reflective surface is substantially tapered. 7.4 The method according to claim 4, wherein the reflection surface is formed at an end of a well. 8.7 The method according to claim 7, further comprising adjusting the pressure in the well.

9.7. The method according to 9.7, further comprising adjusting a distance from the opening of the well to the reflection surface. The method of claim 10.7, further comprising means for changing the size of the well opening. 11.7. The method according to 11.7, wherein the controlled flow as it emerges from the well is directed to constantly flow out of the well opening in an annular sheet. 12.11. The method according to 12.11, further comprising guiding the refrigerant to flow in an annular shape in a direction opposite to the flow in the annular sheet shape. 13. A method used to stabilize a warm emulsion immediately after completion of emulsification, in which the emulsion is constantly discharged from an outlet at the end of an emulsion production mechanism, and the emulsified fluid is discharged in a direction substantially opposite to the flow of the emulsion. A method comprising letting the refrigerant flow out in close proximity to allow heat exchange. 14. The method according to 14.13, further comprising forming the flow of the emulsion into a thin annular layer flow when the emulsion flows out of the emulsion production mechanism. 15. The method of claim 13, further comprising the step of forming the flow as a thin annular layer when the refrigerant is flowing opposite to the emulsion. 16. The method according to claim 13, wherein the refrigerant comprises a liquid or a gas that may be mixed with the emulsion.

17. The method according to 17.13, wherein the flow of the emulsion and the refrigerant is generated when the annular valve is opened. 18. A method for emulsifying a first fluid component in a second fluid component, wherein the first fluid component is supplied to the cavity in a substantially stagnant state, and the second fluid component is jetted into the first fluid component. A method wherein the fluid temperature and the jet flow rate are selected such that cavitation is generated by hydraulic separation at the interface of both fluids towards the fluid components. 19. The method according to claim 18, wherein the second fluid component comprises a continuous phase in an emulsified or dispersed system. 20. The method according to claim 18, wherein the first fluid component comprises a discontinuous phase in an emulsified system. 21. The method according to claim 18, wherein the first fluid component comprises a solid discontinuous phase in a dispersion.

22. The method according to claim 18, wherein the first fluid component is supplied to an annular reaction chamber and a jet stream is jetted therefrom through an outlet of an orifice opening into the annular reaction chamber. A method consisting of: 23. Use according to claim 18, wherein after completion of the emulsification by hydraulic separation, the product is passed through an orifice for another emulsification. 24. Use according to claim 18, comprising, after completion of the emulsification by hydraulic separation, directing the product to the next processable reaction chamber. 25. The method according to 24, comprising adding additional ingredients to the emulsion in the next processable reaction chamber. 26. The method according to claim 24, which comprises applying a refrigerant to the next processable reaction chamber for quenching and stabilizing the emulsion. 27. The method according to claim 24, wherein the next processable reaction chamber comprises an absorption cell to which a jet stream of the product is directed.

28. A device for reducing pressure fluctuations in an emulsifying cell guided from a fluid line by a high-pressure pump, comprising a coiled tube in a fluid line between a high-pressure pump and an emulsifying cell, wherein the tube has an internal volume and a wall. A device consisting of a thickness, a coil diameter, and a coil winding configuration that allow them to just absorb pressure fluctuations and withstand the high pressure generated by the pump. 29. The apparatus according to claim 28, further comprising a shell having a port around the coil tube through which a heat multiplier or a refrigerant can pass. 30. A nozzle used for an emulsion manufacturing mechanism, comprising two main bodies having flat surfaces that abut each other, and at least one main body is formed with a groove forming an orifice in the nozzle, and the flat surface is formed by engraving. Is that when the two bodies are brought into close contact with sufficient force, the flow of liquid is sufficiently flat to be confined to the orifice. 31. The nozzle according to item 30., wherein the surface on which cavitation occurs is formed in the groove. 32. The nozzle according to claim 30, wherein the wall surface of the groove is coated.

33. The method according to claim 32, wherein the coating material is made of diamond or a polar or non-polar substance. 34. An absorption cell used for an emulsion production mechanism, having an open end at one end for receiving a jet fluid having two immiscible components, and a reflection surface provided at the other end of the reaction chamber for reversing a jet flow. And a mechanism for adjusting the distance from the open end of the reaction chamber to the reflecting surface. 35. 35. The absorption cell according to claim 34, wherein the reflective surface is replaceable for various uses. 36. The absorption cell according to claim 34, further comprising a removable nest inserted into the open end of the reaction chamber, wherein the nest has an orifice having a diameter smaller than an inner wall of the reaction chamber. Absorption cell. 37. The absorption cell according to claim 34, comprising a nested insert that can be exchanged for different applications.

38. A unitary emulsion production structure comprising a continuum of couplings that can be connected to one another in various ways, each of at least one of said couplings having an annular male sealing surface formed at one end of the coupling, An annular female seal surface formed at the other end of the coupling, and formed between the male seal surface and the female seal surface so that liquid flows from the upstream coupling to the downstream coupling. And a port for supplying a supply liquid to the coupling and removing the liquid from the coupling, at least some of the openings through which the liquid flows are narrow enough to form a jet stream, and the sealing surface Is simply smooth enough to maintain a seal that does not leak when the coupling is sufficiently connected with the force compressed along the length of the structure. Type emulsion production structure. 39. The structure according to 39.38, wherein the reaction chamber in which the processing is performed is formed as a single body formed between one male sealing surface of the upstream coupling and one female sealing surface of the downstream coupling. Type emulsion production structure. 40. The structure according to claim 40, wherein in some of the couplings, the orifice extends from one end of the coupling to the other.

41. The structure according to 41.38, wherein the structure is provided with an absorption cell at one end of the structure. 42. The structure according to claim 42, wherein one of the couplings extends into the other coupling to form a small annular opening for generating an annular flow layer of refrigerant. A single emulsion production structure. 43. The structure of claim 43, wherein some ports in the coupling are used for CIP / SIP cleaning and / or sterilization procedures. 44. The method of claim 44.4, comprising injecting the additional component into a space adjacent the reflective surface in the direction of the substantially controlled fluid new passage. 45 An apparatus for use in an emulsified manufacturing structure, comprising: a coupling; and an orifice support including an emulsified orifice with both ends directed into other components of the structure, the orifice support comprising a coupling. Equipped inside, the position of both ends is reversed by rotating the support,
In addition, a device configured such that each of its ends is selectively an inlet or outlet of an orifice depending on its position.

Emulsifiers embodying the above emulsification method include DeBEE and miniDeBEE manufactured by BEE Japan.
These can be used. This emulsification method has a strong emulsifying power of twice or more as compared with other conventional methods using a rotary shearing force, a method using ultrasonic waves, and a similar high-pressure emulsifying machine. The need for use is reduced. The emulsifying action is present in almost all substances, and the term "emulsifying agent" as used herein means an emulsifying action to some extent, which is generally called an emulsifier or a surfactant. Of course, considering the gist of the present invention, the processing pressure is 1000 kg.
/ Cm ² or more. In addition to the strong emulsifying power, there is little wear due to vibrations and collisions, and there is an advantage in terms of running cost and maintenance. In this respect, there is a practical use value. In addition, there are models that usually require pre-emulsification but do not require pre-emulsification depending on the device. In other emulsifiers, when trying to approximate the ability to the emulsification method used in the present invention, once emulsified, also emulsified, the method may be repeated several times,
Although the state of emulsification is somewhat improved, it cannot be equivalent to the emulsified composition of the present invention. As described above, in other high-pressure emulsification methods, the abrasion due to vibration and collision is larger than that of the emulsification method of the present invention, but this defect is further enlarged by repeated emulsification. In addition, there are problems in terms of time and costs.

Using this emulsification method, one of the clay minerals
The incorporation of more than one species and salts is consistent with the gist of the present invention. By using the above emulsification method, a stable emulsified composition can be prepared simply by blending the clay mineral, but by adding salts, the blending amount of the clay mineral can be reduced, and other blending raw materials can be used. Restrictions are also reduced, and the range of sensory options that can be selected is expanded.

As the clay mineral to be used, a water-swellable clay mineral is used. Specific examples include natural or synthetic laponite and smectite such as montmorillonite, bentonite, saponite and hectorite. Also, swelling mica or the like can be used. As commercial products, Vegum, Wenger, Kunipia, Laponite,
It may be used because it is sold under a trade name such as Smecton. These may be used alone or in appropriate combinations of two or more. The compounding amount varies depending on the type, amount and use of other raw materials, but is usually 0.001 to 2.0%.

The salts are not particularly limited, and various inorganic salts may be used. In general, for skin external preparations, seawater, seawater dry matter, deep water, deep water dry matter, seaweed dry matter,
Seaweed extract and the like can be used. Deep water refers to seawater at a depth of 200m or more in seawater, which is not affected by recent marine pollution and is clean and rich in nutrients. Because of the ease of water intake, it is collected off the coast of Kochi, Toyama, and Kumanonada, Mie. Further, those obtained by selectively reducing only sodium hydroxide (or sodium) from deep water or seawater have high utility value.

In order to further improve emulsifiability in addition to the above-mentioned components and emulsifying method, glycyrrhizinate, hydroxy fatty acid, polyglycerin, polyethylene glycol, amino acid, peptide, protein, clay mineral, diethoxy succinate It is preferable to mix one or more kinds of ethyl. The glycyrrhizic acid derivative includes monoammonium glycyrrhizinate, dipotassium glycyrrhizinate, trisodium glycyrrhizinate, and the like. One or more of these may vary depending on the type, amount, use, etc. of the other ingredients, but 5% by weight in the emulsion composition. % Or less. Even if the content exceeds 5% by weight, an increase in the emulsifying action and the effect of improving the emulsion stability cannot be expected, and the cost increases and the cost becomes uneconomical.

Although various substances are known as hydroxy fatty acids, they have 12 to 22 carbon atoms and may be unsaturated, saturated or branched. The position and number of hydroxyl groups are not particularly limited. If the number of carbon atoms is small, the safety is generally poor, and if the carbon number is unsaturated, there may be a problem in stability. The amount of the compound is determined in consideration of the use and the like. The range of the amount is not particularly limited.

Polyglycerin is a polymer of glycerin. When used in the present invention, the average degree of polymerization varies from 2 to 1 depending on the type, amount and use of other ingredients.
In 2, the amount is preferably 50% or less, and it is also preferable to mix two or more types of polyglycerin having different average degrees of polymerization. In the case of polyglycerin having a large average degree of polymerization, the viscosity is high, so that the blending amount is naturally limited.

Polyethylene glycol also varies depending on the type, amount and use of the other ingredients, but has an average molecular weight of 600 to 800,000, preferably an amount of 40% or less, and two or more kinds having different average polymerization degrees. It is also preferable to mix polyethylene glycol. When the average molecular weight is large like polyglycerin, the amount is limited. Further, the total amount of polyglycerin and polyethylene glycol is preferably 1% to 60% in the present invention. Further, the average molecular weight is 10,000 to 80000
A small amount of polyethylene glycol of 0 does not make the emulsified composition functionally heavy, and is particularly suitable when used as an external preparation for skin. The use of a plurality of the above-mentioned raw materials is more stable and broadens the range of sensuality, and produces favorable results.

The amino acids which can be used in the present invention are alanine,
Arginine, asparagine, aspartic acid, titrulline, L-glutamic acid, L-glutamic acid, glutamine, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, ornithine, proline, phenylalanine, serine, threonine, tryptophan, tyrosine, valine, etc. Can be exemplified. These are L
Regardless of the form, D form, or DL mixture, salts of these amino acids may be used. The blending amount is not particularly limited, but some have poor solubility, and the concentration is adjusted depending on the properties and other blending raw materials. In addition, the use of a mixture of amino acids may be more suitable for the purpose of the present invention than the single amino acid.

[0026] There are a wide variety of proteins and peptides, and when used in the present invention, there are some proteins and peptides required in large amounts to be selected. When the molecular weight is large, an allergic reaction may occur depending on the person, and it may not be possible to formulate the compound depending on the use or the user. Examples of proteins include eggs, milk, casein, collagen, soybean, wheat, corn, and the like. The peptide may be obtained by hydrolyzing these.
Diethoxyethyl succinate is usually added in an amount of 0.1 to 30%.

The addition of phenoxyethanol and / or 1,2-pentanediol in addition to the above-mentioned components and the emulsification method makes the gist of the present invention more effective in terms of safety. This is because emulsifying compositions often contain a preservative, but especially for external preparations for skin, paraoxybenzoic acid esters, which have excellent efficacy and safety, such as a broad antibacterial spectrum, are widely used, but are sensitive. Such a person has a drawback that it may cause skin troubles when the person has a burning sensation or particularly in a sensitive user such as atopic dermatitis. In addition, paraoxybenzoic acid esters are concerned with environmental hormones, and are required to meet various demands of users, which contributes to the improvement of safety which is the gist of the present invention. Phenoxyethanol and 1,2 pentanediol may be commercially available products, but it is desirable to use purified products from the gist of the present invention. Phenoxyethanol is preferably 0.05 to 2.0%, and 1,2 pentanediol is preferably 0.1 to 10.0%. , 2 pentanediol is desirably used in combination. Furthermore, when 1,3 butylene glycol is also used in combination, safety and antibacterial properties are improved.

These may be mixed with other raw materials to form an emulsified composition. Among them, water-soluble polymers reduce the amount of emulsifier used depending on the amount and method of blending,
It is possible to reduce the amount of specific raw materials, and the range of selectable functions and physical properties is expanded. Water-soluble polymers to be used include starch, locust bean gum, guar gum, agar, alginic acid, carrageenan, arabic gum, karaya gum, tragacanth gum, peptin, dextrin, chitin, pullulan, xanthan gum, dextran, polyvinyl alcohol, sodium polyacrylate, carboxy Methyl cellulose, methyl cellulose, hydroxyethyl cellulose and the like are used.

The amount of the water-soluble polymer varies depending on various factors such as the type and molecular weight of the polymer, the coexisting raw material, and the use of the emulsion composition, but is preferably 0.001 to 5.0%. Depending on the type of the water-soluble polymer or the use of the emulsified composition, the water-soluble polymer may be added after being treated by the emulsification method of the present invention, and a better result may be obtained by mixing with a disper or the like. The timing of addition is determined in consideration of these conditions.

The other raw materials are not particularly limited, but the advantage of using this emulsification method is that no emulsifying agent is required or only a small amount is required, which is to enhance safety. From this, it is consistent with the gist of the present invention that the other raw materials also have high safety. In addition, since the particle diameter generally becomes smaller, the viscosity (hardness) tends to be higher than that of a normal emulsification method. Gives good results.

The preparation method of the emulsified composition is as follows. The raw materials to be blended are weighed in a necessary amount, and when pre-emulsifying, the whole is heated as required and pre-emulsified, or divided into an oil phase and an aqueous phase. Then, if necessary, warm and pre-emulsify. The pre-emulsification method may be a simple stirrer depending on the case of a homodisperse or a normal emulsifier. This is emulsified by the emulsification method of the present invention. More specifically, as described above, the emulsifier includes DeBEE and miniDeBEE manufactured by BEE Japan, and these may be used. Of course, in view of the gist of the present invention, it is desirable to use at a processing pressure of 1000 kg / cm ² or more.

The examples are described in Table 1 below, and the present invention is not limited to them.

[0034]

[Table 1]

The mixture was weighed in the amount (% by weight) shown in Table 1, heated, preliminarily emulsified with a homogenizer, and emulsified with DeBEE manufactured by BEE Japan at a processing pressure of 2500 kg / cm ² . However, in Examples 2, 4, 5, 7, and 10, the purified water was 10%, and the xanthan gum of Examples 2, 4, 7, and 10 was used.
Emulsified except for gum arabic of Example 5 and purified water 10%
The liquid containing each water-soluble polymer dissolved in minutes was added while stirring with a despar.

[0036]

According to the present invention, the same formulation as in Table 1 is used in a Gaulin type emulsifier,
Processed at maximum processing pressure in a microfluidizer.
Particles of this emulsified composition (Comparative Example 1-1 was prepared by treating Example 1 with a Gaulin-type emulsifier, Comparative Example 1-2 was prepared by treating with a microfluidizer, and the same procedure was carried out in the same manner) Table 2 shows the measurement results of the diameter.

[0037]

As described above, the particle size becomes smaller as compared with those emulsified by a Gaulin-type emulsifier or a microfluidizer. This means that when trying to produce particles having the same particle size, a Gorin-type emulsifier and a microfluidizer require a large amount of an emulsifying agent, and have problems such as safety. Further, when this embodiment was actually used, it was found that the usability was good.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 N 9/10 9/10 47/02 47/02 47/04 47/04 47/10 47/10 47/12 47/12 47/14 47/14 47/18 47/18 47/42 47/42 47/46 47/46 B01F 3/08 B01F 3/08 A 5/00 5 / 00 A F term (reference) 4C076 AA16 BB01 BB31 DD27 DD28 DD34 DD38 DD39 DD41 DD43 DD45 DD63 EE27 EE30 EE31 EE51 EE57 EE58 FF43 FF67 4C083 AA082 AA111 AA112 AB051 AB271 AB372 AB441 AB442 AC022 AC172AC172 AC172 AC582 AD041 AD042 AD111 AD112 AD152 AD262 AD352 AD411 AD412 AD531 AD532 AD572 CC01 CC05 DD31 EE01 EE10 4G035 AB40 AC50 4G065 AA03 AB05Y AB11Y AB12Y AB14Y AB19Y BA07 BB01 CA02 DA01 DA02 DA06 DA09 FA02

Claims (4)

[Claims] 1. arranging a structure in said first passage to direct a jet stream of fluid along a first passage and to direct the fluid to a controlled flow along a new passage; An emulsifying composition characterized in that the first passage and the new passage are emulsified using a method oriented so that shear force and cavitation occur in the fluid, and one or more clay minerals and salts are blended. object 2. A glycyrrhizinate, hydroxy fatty acid, polyglycerin, polyethylene glycol, phenoxyethanol, 1,2-pentanediol, amino acid, peptide, protein, diethoxyethyl succinate.
The emulsion composition according to claim 1, wherein at least one kind is blended. 3. The emulsified composition according to claim 1, wherein the salt is seawater, seawater dried product, deep water, deep water dried product, seaweed dried product, or seaweed extract. 4. The emulsion composition according to claim 1, wherein the clay mineral is natural or synthetic laponite such as montmorillonite, bentonite, saponite and hectorite and smectite.