JP2001321433A - Sticking material for skin and emergency adhesive plaster using the same as well as laminating material for chafing from walking - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a sticking material for a skin performing excellent cushionability and liquid absorbability by sticking the material to a wound site and having a plaster layer including good anchorability to a support, an emergency adhesive plaster and a sticking material for chafing from walking. SOLUTION: This sticking material for the skin is obtained by forming a hydrocolloidal layer as the plaster on one surface of the support formed of a cloth made of at least one type selected from the group consisting of a linear saturated polyester, polyurethane, synthetic rubber, a linear saturated polyester film and the like. In this case, the linear saturated polyester preferably has a Tg of 80 deg.C or lower. It is preferable to use a mixed dispersing element of an elastomer component and a moisture absorbable substance as the hydrocolloidal layer. The sticking material is used as a pad for a wound part, and can, thus, be used as the emergency adhesive plaster or the sticking material for the chafing from walking.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch for skin, an emergency bandage using the same, and a patch for rubbing shoes, and more particularly, for rubbing floors, rubbing shoes, pressure sores, surgical wounds, cuts and abrasions. The present invention relates to a patch for skin to be applied to a site to reduce pain and heal a wound, and to a patch for emergency bandages and shoes.

[0002]

2. Description of the Related Art Emergency adhesive plasters, dressings, cushion sheets, and the like are used as skin adhesives to be applied to floor rubbing parts, shoe rubbing parts, pressure sores, and the like. Since such a patch cannot sufficiently absorb body fluid, it may not only completely improve the symptoms but also worsen the symptoms. So in recent years,
As a skin patch suitable for such a bodily fluid exudation part, a hydrocolloid dressing material using a hydrocolloid layer for a skin contact part has been developed and used.

[0003] The hydrocolloid dressing material has a skin adhesive layer having a body fluid absorbing property as a plaster layer on one side of a support film. The plaster layer not only absorbs body fluid exuding from the application site due to its liquid absorption property, but also has a property of flowing due to body temperature during application, so-called cold flow property, so that the skin surface shape of the application site It gradually comes into close contact with the skin and has good skin adhesion.

[0004] However, a commercially available hydrocolloid dressing material has been developed with an emphasis on the liquid absorption properties of a plaster layer that comes into contact with the skin surface. In comparison, plasters composed of hydrocolloids tend to lack anchoring properties with a support that supports (holds) the hydrocolloid. In other words, the hydrocolloid plaster has poor adhesive properties as compared with rubber-based adhesives and acrylic-based adhesives that are generally used as medical adhesives, and the skin adhesiveness is due to the cold flow property as described above. is there.

[0005] Therefore, the hydrocolloid plaster has a drawback of poor adhesion to a support, so-called anchoring property. Therefore, a separator which is usually laminated to cover and protect the surface of the hydrocolloid layer must be used. When peeled and removed, the hydrocolloid layer may be transferred onto the separator.

[0006]

As described above, a skin patch having a hydrocolloid layer has excellent liquid absorbency at a wound site, particularly at a site where a body fluid exudes, but has an anchoring property. In fact, it has not been sufficiently studied about a support having good anchoring properties, and the present inventors have attempted to solve these problems by providing a support having an excellent anchoring property to a plaster made of a hydrocolloid. Was considered.

[0007]

DISCLOSURE OF THE INVENTION The present invention has been made to solve the above-mentioned problems, and it is intended to use a specific support to peel off a separator at the time of use or to apply it from the skin surface after absorbing liquid. It has been found that even when the material is peeled off, the anchoring property between the support and the plaster layer is improved, and the present invention has been completed.

That is, the present invention relates to a linear saturated polyester,
An object of the present invention is to provide a skin patch comprising a hydrocolloid layer formed on at least one surface selected from a cloth selected from the group consisting of polyurethane and synthetic rubber and a linear saturated polyester film. In particular, the linear saturated polyester preferably has a glass transition temperature of 80 ° C. or lower, and the formed hydrocolloid layer preferably uses a mixed dispersion of an elastomer component and a hygroscopic substance.

Further, the present invention relates to a pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer on one side of a support, wherein the above-mentioned skin adhesive is placed as a pad for a wound in the central region of the pressure-sensitive adhesive applied surface. It is intended to provide a characteristic first-aid bandage.

[0010] Further, the above-mentioned adhesive material for skin is placed as a pad for a wound portion in the center area of the adhesive-coated surface of an adhesive sheet having an adhesive layer on one surface of a support. Another object of the present invention is to provide a patch for rubbing shoes for treatment.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The skin patch of the present invention uses, as a support for holding a hydrocolloid layer, a cloth made of one selected from linear saturated polyester, polyurethane and synthetic rubber, or a linear saturated polyester film. . Here, the cloth refers to a cloth-like cloth such as a woven cloth, a nonwoven cloth, and a knitted cloth. Since the cloth has irregularities on the surface and is not flat, the plaster layer cuts into the inside of the cloth from the surface to generally improve the anchoring property. However, among them, the cloth made of the above-mentioned specific material has good compatibility with the hydrocolloid component, and is expected to improve the anchoring property.

On the other hand, when a film is used as a support, the surface of the film is smooth, so that the anchoring property cannot be expected to be improved as much as that of a fabric. In fact, polyolefin films such as polypropylene, polyethylene, and ethylene / vinyl acetate copolymer, polyurethane films such as polyether-based polyurethane and polyester-based polyurethane, and thermoplastic elastomer films such as polyether-polyamide, have a hydrocolloid layer. Practical anchoring properties cannot be obtained between films, and only linear saturated polyester films can exhibit the effects of the present invention.

Although the polyester film has a good anchoring property with the hydrocolloid layer used in the present invention, the aromatic polyester film represented by polyethylene terephthalate tends to have poor stretchability and flexibility. When used as a skin patch to be applied to the skin surface such as a curved part or a bent part, floating or peeling during application,
It is not preferable because discomfort occurs. In addition, flexibility can be imparted by reducing the thickness, but it is not preferable because handleability in the manufacturing process is poor and mechanical strength is insufficient. Therefore, as the film that can be used as the support in the present invention, it is preferable to use a linear saturated polyester film having both stretchability and flexibility and appropriate mechanical strength.

As described above, the linear saturated polyester which can be used in the present invention is not particularly limited, but is specifically represented by a solvent-soluble grade (trade name: Byron, manufactured by Toyobo Co., Ltd.). Glass transition temperature is 80 ℃
Below, preferably those in the range of 5 to 70 ° C are desirable,
Further, it is preferably non-crystalline in order to provide elasticity, flexibility, and supple texture.

Further, it is preferable that two kinds of linear saturated polyesters are blended and used, instead of using one kind, and specifically, a low glass transition temperature having a glass transition temperature of 5 to 15 ° C. Temperature linear saturated polyester and a high glass transition temperature linear saturated polyester having a glass transition temperature of 45 to 80 ° C. in a ratio of 1: 9 to 9: 1,
Most preferably, it is desirable to use them in a blending ratio of 5: 5 (weight ratio).

The material which can be used as the fabric for the support of the present invention can be selected from linear saturated polyesters, polyurethanes and synthetic rubbers. Polyether polyurethane, polyester polyurethane, or the like can be used as the polyurethane. As the synthetic rubber, rubber components such as styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, polyether polyester, and polyether polyamide can be used.

The above-mentioned support having a cloth shape has a basis weight of 10 to 70 g / m ² , preferably 30 to 50 g / m ² .
² range, 10 to 50μ for film
m, preferably in the range of 15 to 35 μm, is desirable in terms of anchoring properties and maintenance of flexibility.

In the present invention, the hydrocolloid layer formed on one side of the support fabric or the support film has a liquid absorbing property and a cold flow property. In the present invention, cold flow refers to the property of having "plastic flow" at a temperature close to the skin temperature of a human body and adhering to the skin. In the present invention, the plaster having a cold flow property is 40 to 80% of the thickness before the load is applied after 72 hours, preferably 5 to 50% in the test method described below.
It causes plastic deformation of about 0% to 80%.

The test method for the cold flow property is about 36 m
The plaster sample (hydrocolloid layer) cut to a thickness of 0.8 mm to 2.5 mm in thickness was applied with a load of 20 g (14 gf / cm ² , 13.5) in the thickness direction of the plaster under an atmosphere of 40 ° C.
mmφ weight), and the thickness after 72 hours is 10 m
Measure with a dial gauge of mφ terminal. At the time of measurement, the measurement is performed within 10 seconds after the load is removed and no creep recovery occurs.

In the present invention, the hydrocolloid layer is used in an amount of 0.1 from the viewpoint of liquid absorption and maintenance of cohesion (prevention of adhesive residue).
It is formed so as to have a thickness of 1 to 2 mm, preferably 0.2 to 1 mm. In addition, the hydrocolloid layer is thicker at the central part when viewed in plan, and the peripheral part is made thinner than the central part so as to have a different thickness, thereby preventing unnecessary moisture absorption from the peripheral side part. It is also preferable from the viewpoint.
In particular, the thickness at the center is 0.2 to 1 mm, preferably 0.1 mm.
3 to 0.7 mm. If the thickness of the central part is too thick, there is not enough flexibility to follow the movement of the skin surface when applied to the skin surface, and it may float during use, and if it is too thin, oozing of body fluids When affixed to a site, there is a possibility that sufficient liquid absorbency is not exhibited. On the other hand, if the thickness of the peripheral portion is too large, the moisture absorption from the side portion increases, and the liquid absorbing property of the body fluid and the like of the hydrocolloid layer is reduced, and the edge portion is easily turned up during application and is too thin. Sufficient adhesiveness to the skin surface cannot be ensured or wrinkles tend to occur during application.

The thickness of the hydrocolloid layer formed on the peripheral portion may be made uniform, but it is possible to prevent the edge portion from being turned up during application, and to prevent wrinkles or the like during application or application to the skin surface. In order to sufficiently adhere and fix the skin adhesive layer, it is preferable that the thickness of the skin adhesive layer formed on the peripheral portion is inclined so as to gradually decrease toward the edge.

The above-mentioned hydrocolloid layer is preferably formed of a material similar to a so-called hydrocolloid dressing material in order to impart liquid absorbing properties and cold flow properties. Specifically, it is desirable to be a mixed dispersion of the elastomer component and the hygroscopic substance, and the ratio thereof is 40 to 70% by weight of the elastomer component and 30 to 6% by weight of the hygroscopic substance.
0% by weight, preferably 50 to 65% by weight: approximately the same amount such as 35 to 50% by weight, or a slight increase in the amount of the water-absorbing substance is sufficient for the adhesion to the skin and the appropriate shape retention (from the side It is desirable from the viewpoint of preventing the plaster from protruding).

Such an elastomer component is a component that imparts a suitable cohesiveness and shape retention property to the hydrocolloid layer, and specifically includes polyisobutylene, polyisoprene, an acrylic polymer, and styrene / isoprene / styrene block. Examples thereof include polymers, and one or more of these can be used. Other elastomer components that can be used include polybutadiene, styrene / butadiene / styrene block copolymer, natural rubber, silicone-based polymer containing polymethylsiloxane as a main component, and polyvinyl ether-based polymer.

On the other hand, the hygroscopic substance is a component that imparts a liquid absorbing property to the hydrocolloid layer, and specifically, sodium carboxymethylcellulose, dextrin, pectin,
Examples thereof include gelatin, and one or more of these can be used. Other hygroscopic substances that can be used include carboxymethylcellulose calcium, hydroxypropylcellulose, guar gum, locust bean gum, xanthan gum, sodium alginate, calcium alginate, carrageenan,
There are collagen, polyvinylpyrrolidone and the like.

In the hydrocolloid layer of the present invention,
If necessary, various bactericides and antibacterial agents such as acrinol, benzalkonium chloride, and silver compounds can be appropriately compounded. By combining these components,
It is possible to effectively prevent suppuration caused by invasion of various bacteria from the outside.

The patch for skin of the present invention has the above-mentioned composition as an essential component, and the support holding the hydrocolloid layer is made of a material having both elasticity and flexibility. It can be attached and used without giving.

Further, in the present invention, the above-mentioned skin patch is used as a pad for a wound portion, and is placed in the central region of the pressure-sensitive adhesive surface of the pressure-sensitive adhesive sheet to be used as an emergency bandage. In other words, conventional first-aid bandages generally use gauze or non-woven cloth as the pad, but it is not enough to absorb liquid, prevent adhesion to wounds, and prevent bacteria from entering. I couldn't say it, and improvement was requested.

Since the emergency bandage of the present invention having the above-mentioned structure uses a skin patch having a hydrocolloid layer as a wound pad, it has excellent liquid absorbing properties and cold flow properties. It can be tightly fixed to the skin surface and can prevent the invasion of various germs from outside. In addition, since the hydrocolloid layer absorbs the liquid and keeps the skin contact surface in a wet state, a so-called wet healing effect works to promote the healing of the wound and clean the wound. Further, since the hydrocolloid layer does not adhere to the wound, the exfoliation from the skin surface is smooth, and the wound is not re-damaged.

The pressure-sensitive adhesive sheet used for the above-mentioned first aid bandage has a pressure-sensitive adhesive layer on one side of a support, and the support is not particularly limited, and may be a polyvinyl chloride film, a polyethylene film, a polypropylene film, ethylene /
A propylene copolymer film, an ethylene / vinyl acetate copolymer film, a polyurethane film, foams and fabrics made of various plastics, and the like can be used.
Among these, it is preferable to employ a support selected from a polyvinyl chloride film, a polyolefin film, and a plastic fabric in terms of slipperiness and waterproofness when clothes or sheets come into contact. The thickness of the support is usually in the range of about 30 to 150 μm, preferably about 50 to 100 μm, so that an emergency bandage which does not hinder flexibility and minimizes discomfort at the time of application can be obtained.

The pressure-sensitive adhesive formed on the pressure-sensitive adhesive sheet is
It is not particularly limited as long as it is generally used as a medical adhesive, and for example, a hydrophobic adhesive such as an acrylic ester adhesive or a rubber adhesive, a silicone adhesive, or a vinyl ether adhesive is appropriately used. be able to.

Further, in the present invention, it is possible to provide a patch for shoe rubbing which is used for preventing or treating shoe rubbing by placing the above-mentioned patch for skin on the central area of the pressure-sensitive adhesive-coated surface of the above-mentioned pressure-sensitive adhesive sheet. it can.

In other words, a patch, strip, or emergency band-aid adhesive patch having the above-mentioned structure is applied to the skin surface such as the upper part of the heel of the foot, the side of the little finger, and the side of the thumb where the shoe is easily rubbed. When attached, it is possible to prevent the occurrence of shoe rubbing by the cushioning action of the hydrocolloid layer.
In addition, when applied to the skin surface where the shoe rubs, the cushioning effect of the hydrocolloid layer can reduce pain and absorb body fluid exuding from the rubbing part of the shoe, so it is also excellent in treating shoe rub. Can be demonstrated. The shape of the adhesive material for shoe rubbing may be appropriately processed into an arbitrary shape such as a circular shape, an elliptical shape, and a rectangular shape.However, in the case of the adhesive material for shoe rubbing, it is similar to the first-aid bandage in terms of handleability. It can also be processed in the shape of.

The following is an example of a specific production method for obtaining the skin patch and the first-aid bandage of the present invention.

The material for forming the above-mentioned hydrocolloid layer is extruded in a bar shape or extruded to a certain thickness on one side of a separator made of a plastic sheet or paper having one side subjected to a release treatment, thereby performing extrusion coating.

Next, a support such as a cloth made of one selected from linear saturated polyester, polyurethane and synthetic rubber, and a linear saturated polyester film is adhered to the extruded coated surface and pressurized. A hydrocolloid layer is transferred to one side of the above to prepare a patch for skin. At this time, the surface of the support in contact with the hydrocolloid layer is subjected to a corona discharge treatment or an undercoat treatment so that the hydrocolloid layer has a wettability of 400 μN / cm or more so that the hydrocolloid layer sufficiently adheres to the support surface and exhibits a strong anchoring property. It is preferable to perform the treatment so as to have the property. In addition, it is preferable that the separator be in an adhered state until it is used to cover and protect the surface of the hydrocolloid layer.

Next, a pressure-sensitive adhesive sheet was separately prepared, and the back of the support of the above-mentioned skin patch was adhered to the surface of the pressure-sensitive adhesive layer.
It is possible to obtain an adhesive material for skin that is laminated and reinforced. In this case, it goes without saying that the pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet must be adhered and laminated so as to be exposed from the peripheral edge.

Further, the first-aid bandage can be obtained by cutting the obtained adhesive material for skin before adhesive reinforcement into a pad shape, and placing this in the central region of the adhesive sheet. It is of course possible to use this as a patch for rubbing shoes.

[0038]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiments of the present invention will be specifically described below. In the following description, “parts” means “parts by weight”.

<Example 1> Each raw material was uniformly mixed according to the composition shown in Table 1 below, and the mixture was mixed with an extruder at 0.1%.
A 1-2 mm thick hydrocolloid layer was prepared.

[0040]

[Table 1]

Next, a linear saturated polyester having a glass transition temperature of 67 ° C. (manufactured by Toyobo Co., Ltd., trade name: Byron 20SS)
And a linear saturated polyester having a glass transition temperature of 7 ° C. (manufactured by Toyobo Co., Ltd., trade name: Byron 30SS) is mixed and dissolved in an equal amount with a mixed solvent of toluene / methyl ethyl ketone, coated on a separator, and dried. A film-shaped support having a thickness of 0.02 mm was produced.

The hydrocolloid layer obtained as described above was adhered to one side of a support comprising a linear saturated polyester film to prepare a skin patch of the present invention.

Finally, the obtained skin patch was 17 mm ×
Punched to a size of 30 mm, and placed on the center of the pressure-sensitive adhesive layer of a pressure-sensitive adhesive sheet in which an acrylic acid pressure-sensitive adhesive layer (40 μm thickness) was formed on one side of a soft polyvinyl chloride film (60 μm thickness). Then, the separator was coated on the surface of the hydrocolloid layer.

This was stamped into an emergency bandage having the shape shown in FIG. 1 (external size: 24 mm × 72 mm) to produce a patch for rubbing shoes of the present invention.

Comparative Example 1 Example 1 was repeated except that a polyethylene terephthalate film (0.025 mm thick) was adhered to the hydrocolloid layer in Example 1.
In the same manner as in the above, the patch for skin was punched into an emergency bandage shape shown in FIG.

Comparative Example 2 The hydrocolloid layer in Example 1 was coated with an acrylate-based adhesive antibody (0.1 m
m thickness) in the same manner as in Example 1 except that
The patch for skin was punched into the shape of an emergency bandage shown in (1).

The adhesive materials produced in each of the above Examples and Comparative Examples were used as adhesive materials for shoe rubbing, and shoe rubbing occurred.
Or they were affixed to one foot (a place where shoe rubbing occurs) of a total of 10 male and female volunteers who are likely to occur, and they were asked to wear shoes and lead their daily lives. For reference, a commercially available first-aid bandage (a pressure-sensitive adhesive sheet in which a acrylate-based pressure-sensitive adhesive layer was formed on a soft polyvinyl chloride sheet and a pad made of gauze was placed on the central area of the pressure-sensitive adhesive sheet) was used as a reference example for comparison.

Eight hours after the application, the state of rubbing of the shoes was observed in comparison with the foot to which the adhesive was not applied, and the results are shown in Tables 2 to 6. The determination was made according to the following criteria.

<Degree of transfer of the hydrocolloid layer when the separator is removed> 5 points: The hydrocolloid layer does not transfer to the separator. 4 points: The periphery of the hydrocolloid layer is transferred to the separator. 3 points: about 10% of the hydrocolloid layer is transferred to the separator. 2 points: About 50% of the hydrocolloid layer is transferred to the separator. 1 point: Most of the hydrocolloid layer is transferred to the separator.

<Discomfort / fitness> 5 points: No discomfort and high flexibility. 4 points: Adhered but slightly hard. 3 points: soft but lacks adhesion. 2 points: There is no feeling of adhesion and it is hard. 1 point: Very uncomfortable.

<Skin Adhesion> 5 points: Completely adhered. 4 points: The corner is turned up. 3 points: About 1/3 of the whole is peeled off. 2 points: About half of the whole is peeled off. 1 point: Drop out.

<Feeling of use> 5 points: It has cushioning properties and is effective for pain and rubbing of shoes. 4 points: Although it has cushioning properties, it has no effect on pain and rubbing of shoes. 3 points: There is no cushioning property, and there is no effect on damage or rubbing of shoes. 2 points: There is no cushioning property, and there is a feeling of discomfort during application. 1 point: There is no cushioning, and pain is felt during application.

<Remaining plaster on skin surface> 5 points: plaster did not remain on skin surface. 4 points: The plaster remained on the skin surface at about one place. 3 points: About 10% of the total amount of the plaster remained on the skin surface. 2 points: About 50% of the whole skin remained on the skin surface. 1 point: The plaster remained on the skin surface on almost the entire surface.

[0054]

[Table 2]

[0055]

[Table 3]

[0056]

[Table 4]

[0057]

[Table 5]

[0058]

[Table 6]

[0059]

The skin patch of the present invention is as described above.
Since it is formed by forming a hydrocolloid layer on one side of a specific support exhibiting an extremely excellent anchoring property improving effect, it has excellent adhesion to the skin surface, especially to the site of exuding bodily fluids, and has a plaster body When the separator that covers and protects the surface is peeled off, the hydrocolloid layer does not transfer onto the separator, and only the hydrocolloid layer does not remain on the skin surface even when peeled off from the skin surface after application. No adhesive residue phenomenon occurs).

[0060]

[Brief description of the drawings]

FIG. 1 is a plan view showing an example of the skin patch of the present invention.

FIG. 2 is a cross-sectional view of the patch for skin shown in FIG. 1 taken along line XX ′.

[Explanation of symbols]

 Reference Signs List 1 support 2 hydrocolloid layer 3 adhesive sheet (laminated body of support and adhesive layer) 31 support of adhesive sheet 32 adhesive layer

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C081 AA03 AA12 BB04 CA022 CA032 CA082 CA161 CA211 CD011 CD022 CD152

Claims (8)

[Claims] 1. A skin patch comprising a hydrocolloid layer formed on at least one surface selected from a linear saturated polyester, a cloth selected from the group consisting of polyurethane and synthetic rubber, or a linear saturated polyester film. Wood. 2. The skin patch according to claim 1, wherein the linear saturated polyester has a glass transition temperature of 80 ° C. or lower. 3. The adhesive patch for skin according to claim 1, wherein the hydrocolloid layer is a mixed dispersion of an elastomer component and a hygroscopic substance. 4. The skin patch according to claim 3, wherein the elastomer component is at least one selected from polyisobutylene, polyisoprene, an acrylic polymer, and a styrene / isoprene / styrene block copolymer. 5. The skin patch according to claim 3, wherein the hygroscopic substance is at least one selected from sodium carboxymethylcellulose, dextrin, pectin, and gelatin. 6. A pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer on one side of a support, wherein the adhesive material for skin according to claim 1 is placed as a pad for a wound on the central region of the pressure-sensitive adhesive applied surface. Emergency adhesive plaster. 7. The emergency bandage according to claim 6, wherein the support is selected from a vinyl chloride film, a polyolefin film, and a plastic fabric. 8. A pressure-sensitive adhesive sheet comprising a pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer on one surface of a support, wherein the adhesive material for skin according to claim 1 is placed as a pad for a wound portion on a central region of the pressure-sensitive adhesive applied surface. An adhesive material for shoe rubbing for prevention or treatment.