JP2001288116A - Active oxygen resistant composition and method of producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an active oxygen resistant composition which is not deactivated when prepared in production processes and stored, and is easily prepared as an oily pharmaceutical and to provide a method of producing the active oxygen resistant composition easily and stably at low cost. SOLUTION: This active oxygen resistant composition comprising a substance containing one or more components selected from the group, yeast and edible lees as raw materials, wherein a superoxide dismutase-like (SOD-like) substance is added as an additive, and the method of producing the active oxygen resistant composition is provided.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition for suppressing active oxygen and a method for producing the same.

[0002]

2. Description of the Related Art There are many reports that active oxygen-suppressing compositions are extremely effective for maintaining and promoting health, and for preventing and treating diseases and aging. It is being diversified in the field.

[0003] Active oxygen and lipid peroxide (hereinafter referred to as active oxygen and the like) produced in the human body and SOD (Super Oxisid)
There is the following knowledge about the relationship with the enzyme called e Dismutase). Excessive production of active oxygen in the body causes not only adult diseases such as arteriosclerosis and cancer, but also allergic diseases such as atopy and asthma, autoimmune diseases, and other intractable diseases. SOD protects human body tissue from destruction by erasing the excess active oxygen and the like.
Therefore, SOD can be said to be an enzyme that plays an important role in maintaining a healthy body without disease. Nevertheless, since SOD gradually decreases with age, adults tend to lack this. Incidentally, in the case of adults, adult diseases frequently occur around the age of 40 due to lack of SOD. In addition, when excessive active oxygen or the like is generated in the body due to chronic or acute stimulation or ingestion or intrusion of a chemical substance, the above-mentioned various diseases are caused due to insufficient SOD. This has been demonstrated recently in the field of medicine. Therefore, SOD has attracted attention in various fields including medicine.

[0004] Substances having an SOD-like action (hereinafter referred to as SOD-like substances) are contained in various animals and plants, and have recently been chemically synthesized. There have been reports that as a result of clinical administration of this SOD-like substance to the human body orally or by injection, a reliable disease prevention or treatment effect has begun to appear. In particular, SOD-like substances embodied in the form of health foods, oral medicines, and the like are desirable because they are easily used universally. Naturally, naturally occurring SOD-like substances are better than chemically synthesized ones in that they do not have various side effects. Also, considering that animal lipids are a major cause of adult diseases, natural SOD
Among the similar substances, it can be said that plant substances are safer than animal ones.

[0005] Formulations and substances containing SOD-like substances and having an excellent effect are described in addition to the plant nutrients disclosed in Japanese Patent No. 1366268 (publicly known document 1) and JP-A-63-79834. (Publicly known document 2) and
An active oxygen suppressing substance described in No. 9421 (Publication 3) is known. The preparations and substances found in these documents are as follows.

[0006] The plant-based nutrient disclosed in Patent Document 1 is a vegetable nutrient consisting of sesame oil and soybean oil obtained by mixing green tea powder with brown rice powder and soybean powder that have been roasted and roasted, and adding a small amount of koji mold to the powder. The active ingredient is extracted by immersion in a mixed oil for about 4 days, the precipitate is removed by centrifugation, and the remaining oil is encapsulated in a capsule such as gelatin. Known Document 1
As an effect of the preparation, not only contains a large amount of SOD but also activates many vitamins, and has the effect of enhancing vitality and activity of the living body.

[0007] The active oxygen suppressing substance disclosed in the known document 2 is obtained by roasting a plant seed or its germ, then adding a microorganism to the roasted ferment, fermenting the roasted plant oil, and then subjecting the plant oil obtained from the roasted plant to the fermented product. It is added to. The active oxygen-suppressing substance of Document 2 is to add vitamin C, a derivative of vitamin C, or a plant body containing these, as necessary. Known Document 2 points out that the activity of the active oxygen-suppressing substance, which is an active ingredient, is low in the preparation of Document 1 due to a problem in a method of processing a plant as a raw material, and it is said that this was improved. That is, the invention of the known document 2 not only aims to prevent the deactivation of the active oxygen suppressing substance and to reduce the molecular weight of the active ingredient by slowly roasting the plant as a raw material with far infrared rays, but also to reduce the roasted raw material. It is said that the activity of the active oxygen inhibitor is remarkably improved by fermenting the active ingredient to promote free lower molecular weight.

[0008] The active oxygen suppressing substance disclosed in the known document 3 is obtained by roasting a cereal raw material composed of rice germ or wheat germ and soybean at a temperature of 100 ° C or less, and then adding koji to the fermented powder and fermenting it. It is added to a mixed oil of an oil collected from sesame after low temperature roasting and an oil collected from raw sesame as described above. The ratio of the mixed oil to the total amount of the fine powder and the mixed oil is set to 60 to 95%. Known Document 3 discloses the active oxygen-suppressing substance of Document 2 that significantly suppresses the production of active oxygen and lipid peroxide in a test tube, but has a weak penetrating power into a fat-rich cell membrane in a human body. It is pointed out that the inhibitory effect of the period is not always effective.
As a countermeasure, the invention of the known document 3 adds a large amount of mixed oil as described above. The active oxygen-suppressing substance thus sufficiently converted into an oil has a high affinity for the active-oxygen-suppressing substance and the cell membrane, and sufficiently reaches the inside of a cell such as a diseased part. Therefore, it is said that the active oxygen suppressing substance disclosed in the known document 3 can obtain almost the expected effect.

[0009]

Among the above-mentioned known documents 1 to 3, the active oxygen suppressing substance of document 3 is the most excellent.
The reason is that the plant raw material is free-molecule activated by low-temperature roasting at a low temperature of 100 ° C. or less, it is further free-moleculated by fermentation, and oil collected from low-temperature roasted sesame This is because they effectively utilize the ingredients and add a mixed oil of this and oil collected from raw sesame to the fine powder after fermentation to sufficiently convert it into an oil solution. . In particular, the low-temperature roasting method of the vegetable raw material is preferable because the deactivation of the active oxygen suppressing substance can be avoided more than the conventional high-temperature roasting method.

However, the low-temperature roasting method is relatively inferior in the state of the art and cannot be said to be a perfect means. That is, in the case of the roasting method, inactivation is inevitably generated regardless of whether the temperature is low or high. Experiments have shown that during the low-temperature roasting process, a considerable amount of the active oxygen inhibitor is deactivated. On the other hand, the active oxygen suppressing substance is deactivated during storage. Therefore, the active oxygen suppressing substance almost loses the above-mentioned functions and effects in the case of storing it for a long time. As a countermeasure, fine powders of plants that are not subjected to roasting, fermentation, etc. are added to low-molecular-weight active oxygen-suppressing substances, but they have not produced sufficient results to improve inactivation. .

Further, with regard to the active oxygen suppressing composition, it is difficult to reduce the cost of the product when various additives are added to expensive raw materials. Another object is to prepare such a composition by simple means.

[0012]

SUMMARY OF THE INVENTION The present invention has been made to solve the above technical problems. Accordingly, an object of the present invention is to provide an active oxygen-suppressing composition that does not deactivate during the manufacturing process or during storage or a sufficient active-oxygen-suppressing composition that can be converted into an oil, and the cost of such an active oxygen-suppressing composition. An object of the present invention is to provide a method capable of easily and stably producing these active oxygen suppressing compositions.

[0013]

The active oxygen suppressing composition according to claim 1 of the present invention is characterized by the following means for achieving the intended purpose. That is, the active oxygen suppressing composition according to claim 1 is composed of a substance containing at least one of edible waste and yeast as a raw material, and an additive is added to the composition to contain a SOD-like substance. Features.

The active oxygen suppressing composition according to a second aspect of the present invention is characterized in that, in the first aspect, the SOD-like substance is reduced in molecular weight.

The active oxygen suppressing composition according to a third aspect of the present invention is characterized in that the composition according to the first or second aspect is made oil by adding an oil material.

According to a fourth aspect of the present invention, there is provided the active oxygen suppressing composition according to any one of the first to third aspects, wherein an activity stabilizer is added to maintain the activity of the SOD-like substance. It is characterized by.

The active oxygen suppressing composition according to a fifth aspect of the present invention is the composition according to any one of the first to fourth aspects, further comprising an oligosaccharide as another additive.

The method for producing an active oxygen suppressing composition according to claim 6 of the present invention is characterized by the following means for solving the problem in order to achieve the intended object. That is, the method according to claim 6 includes a raw material preparation step and a SOD-like substance containing step, and in the raw material preparation step, one or more of yeast and edible scum is selected and used as part or all of the raw material, S
In the OD-like substance containing step, an additive is added to the raw material to add S
It is characterized by containing an OD-like substance.

The method for producing the active oxygen suppressing composition according to claim 7 of the present invention is characterized by the following means for achieving the intended object. That is, the method according to claim 7 includes a raw material preparation step, a SOD-like substance containing step, a fermentation step, an oiling step, and an activity stabilization step, and in the raw material preparation step, one or more of yeast and edible waste are selected. And use this as part or all of the raw material,
In the OD-like substance containing step, an additive is added to make the SOD-like substance contained in the raw material, and in the fermentation step, the raw material is fermented to produce a fermented product, and in the oiling step, the oiling material is added to the fermented material. This is converted to an oil solution, and in the activity stabilization step, the raw material preparation step, fermentation step,
One or more of the oiling steps,
SOD at least once at any time before and after the step
It is characterized by adding an activity stabilizer of the like substance.

[0020] In the method for producing an active oxygen suppressing composition according to claim 8 of the present invention, in the method according to claim 6 or 7, the low molecular weight SOD-like substance without deactivation is contained in the SOD-like substance containing step. It is characterized by making it.

[0021]

When the active oxygen-suppressing composition according to the present invention is administered to humans and reaches the inside of cells, excessive active oxygen and the like produced in the body are eliminated, so that human body tissue is prevented from being destroyed. This is a substance that is useful in preventing and treating various diseases and illnesses, and is particularly indispensable for measures against adult diseases and intractable diseases. Among the active oxygen-suppressing compositions according to the present invention, those that have been reduced in molecular weight or made into oils have good permeability to cell membranes, and have excellent effects because they sufficiently reach the inside of cells. obtain. Among the active oxygen suppressing compositions according to the present invention, those in which the deactivation of the SOD-like substance is prevented by the active stabilizer, that is, those containing a large amount of the active SOD-like substance are harmful active oxygen and lipid peroxide. It has a high function to eliminate odor and its effect is remarkable.

The raw material of the active oxygen suppressing composition according to the present invention is basically at least one of yeast and edible scum. An SOD-like substance is contained by adding an additive thereto. In this case, when the raw material is edible waste, the cost of the active oxygen suppressing composition can be significantly reduced.

The method for producing the active oxygen suppressing composition according to the present invention is basically based on a raw material preparation step and a SOD-like substance containing step. That is, since the method basically requires only these two steps, the active oxygen suppressing composition can be easily produced. In addition, if a fermentation step, an oiling step, an activity stabilization step, and the like are added to both steps, stable production of a useful and useful active oxygen suppressing composition can be realized. Of course, these steps do not have any particular difficulty and the equipment cost does not increase.

[0024]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of an active oxygen suppressing composition and a method for producing the same according to the present invention will be described below.

One of the raw materials used in the present invention is edible waste. The edible waste referred to here means human or animal ingestion of various types of waste (waste, husk, and scum) generated in the food manufacturing process, beverage manufacturing process, alcoholic beverage manufacturing process, pharmaceutical manufacturing process, and other processes. It is a generic term for what is said to be harmless. Specific examples of such food waste include used yeast, sake waste (eg, sake lees), tofu waste (okara), cereal waste (eg, bran), fruit squeeze, vegetable squeeze.・ Edible oil scum and starch scum can be mentioned. These food debris, when viewed as foods for human or animal consumption,
The composition contains at least one of minerals, ash, and dietary fiber. Some of these are rich in useful and useful ingredients. Among these, SOD
Some of them contain a similar substance, and others function as an activity stabilizer described later. Another of the raw materials used in the present invention is unused yeast (this does not correspond to edible waste). Specific examples thereof include brewer's yeast, baker's yeast, sake yeast (koji), and wine yeast.
In the present invention, one or more of edible waste and yeast are indispensable raw materials. Therefore, edible waste and / or yeast are used as the main raw materials. In other words, the raw material is only food waste, only yeast, or a mixture of food waste and yeast. In the case of a raw material composed of a mixture of edible waste and yeast, the edible waste may be used yeast and the yeast may be unused yeast.

The SOD-like substance to be contained in the active oxygen inhibitory composition in the present invention, in addition to flavonoids, polyphenols, tannins, tocopherol vitamin B _1, those known or well-known. Therefore, indispensable additives in the present invention are SOD-like substances themselves and / or substances containing SOD-like substances. S
For substances containing OD-like substances, cereals, fruits, vegetables, seeds, tea leaves, mushrooms, seaweeds, algae (including chlorella), trees, bamboo, bamboo grass, grass (including herbs) A substance containing a SOD-like substance is selected from the above. Also,
In some cases, parts such as bark, pericarp, flowers, leaves, stems, roots, buds, germs, bran, and juice are taken out and used as an additive.
Including SOD-like substances (flavonoids, polyphenols, tannins, tocopherol, vitamin B _1, etc.), such as the rich in rice, wheat, barley, soybeans, red beans, corn, Job's tears, pea seeds and tea leaves (green tea ) ・ Seaweed ・
Chlorella and the like are desirable additives, and citrus juice such as citron juice is also a desirable additive. As is clear from this description, the additive may be any of liquid, powder, and granules. In the case of a SOD-like substance, it is extracted from a natural raw material.

With respect to the activity stabilizer of the SOD-like substance,
A representative example is trehalose.
Trehalose is a non-reducing disaccharide widely found in nature and is harmless to the human body. It is said that trehalose of animals and plants has a function of protecting itself from obstacles such as freezing, heat and drying. Trehalose has also been found to have a stabilizing effect on SOD-like activity in plants. In addition, vitamin C, vitamin E, maltose and the like can also be used as this kind of activity stabilizer.

Other additives other than the above include bacteria (eg, bifidobacteria, lactic acid bacteria, and other useful and safe bacteria) and oligosaccharides.

As can be understood from the above description, the active oxygen suppressing composition of the present invention is composed of a substance containing at least one of edible scum and yeast as a raw material.
It contains an OD-like substance. The following is a description of a specific mode in this case. A substance containing an SOD-like substance but not subjected to a SOD-like substance. A substance containing a SOD-like substance and containing a SOD-like substance activity stabilizer, but not subjected to a SOD-like substance molecular weight reduction treatment. A substance containing a SOD-like substance and subjected to a molecular weight reduction treatment so as not to deactivate the SOD-like substance. A substance containing a SOD-like substance, which has been subjected to a low-molecular-weight treatment so that a SOD-like substance activity stabilizer is added to prevent deactivation.

In the above, the molecular weight of the SOD-like substance contained therein is reduced. When reducing the molecular weight of the SOD-like substance in the raw material, the raw material is roasted by using any energy such as far infrared rays, ultrasonic waves, high frequencies, and low frequencies.
More specifically, in one example, the material is irradiated with far-infrared rays to roast it, in another example, ultrasonic energy is applied to the material to roast it, and in another example, far-infrared rays and ultrasonic waves are applied. And roast the ingredients using both. When roasting, set the processing temperature (roasting temperature) to 40 ° C to 100 ° C, preferably 50 ° C.
In addition to keeping the temperature at ~ 95 ° C, slowly roast the raw material without burning it. According to such roasting, the SOD-like substance (high-molecular substance) in the raw material is cut off from the polymerization and becomes low-molecular. Since the SOD-like substance after the low molecular weight is in a free state without polymerization, it can be taken into cells. After roasting, the raw material is pulverized into powder or granules, but the raw material may be finely ground before roasting. Are also
The SOD-like substance activity stabilizer is added before and / or during roasting. The activity stabilizer in this case is one or more of the above-mentioned ones, but it is desirable that trehalose is not lacking. The SOD-like substance activity stabilizer added to the raw material is
During the roasting, many SOD-like substances maintain an activated state because the SOD-like activity is stabilized to prevent the deactivation of the SOD-like substance. This SOD-like substance activity stabilizer may be added to the raw material after roasting. In addition, the above-mentioned ones which are not subjected to the molecular weight reduction treatment are also finely crushed and used.

The active oxygen suppressing composition of the present invention may be subjected to a fermentation treatment at a raw material stage. In one example, the above is fermented, and in another example, a mixture of one or more of the above and the above is fermented. In another example, any one of the above, or
Any two or more are fermented. For fermentation, there are various means such as those utilizing microorganisms, those using fermented substances, and those using precursors of fermented substances.
Fermentation treatment may be performed for about 10 days (usually about 3 to 36 hours). In microbial fermentation, various safe anaerobic bacteria and aerobic bacteria are used in addition to fermenting bacteria. In fermentation using fermented substances, mature papaya and pineapple juice, fig skin, grape skin, young bamboo skin, etc. are used, as well as digestive enzymes such as diastase and pcreatine, and microorganisms such as protease, pepsin and trypsin. Use protein hydrolase. In addition, in fermentation using a precursor of a fermentation substance, a precursor that produces the above digestive enzyme or protein hydrolase is used. In the case of the fermentation treatment by the above means, that is, the fermentation treatment product, the polymerization is further cleaved by microorganisms or enzymes, so that the SOD-like substance is further reduced in molecular weight. The activity stabilizer described above may be added to this fermented product.

The active oxygen-suppressing composition of the present invention is prepared by converting a fermented product into an oil or a non-fermented product (non-fermented product) into an oil. The oil-forming substance in this case is an oil-based substance. The fat-based oil-forming substance is a generic term including vegetable oil, animal oil, blended oil (mixed oil), processing oil and the like. Vegetable oils include sesame oil, olive oil, corn oil, soybean oil, rapeseed oil, cottonseed oil, bran oil, palm oil, sunflower oil, coconut oil, peanut oil, and the like. Animal oils include turmeric oil (oil collected from turkey), liver oil, fish oil, and oils used in Chinese medicine. The blended oil is a blend of different vegetable oils, a blend of different animal oils, a blend of vegetable oil and animal oil, and the like. Processing oil is powdered oil. Several examples of more specific oily substances are as follows. Paste oil obtained from sesame after far infrared roasting and / or ultrasonic roasting. A mixed oil of oil collected from sesame and oil collected from raw sesame after far-infrared roasting and / or ultrasonic roasting. Turtle oil. Then, in one example, any of the oilified substances is added to the non-fermented product or the fermented product.
In another example, the oleaginized substance is added to a non-fermented product or a fermented product. In still another example, the oleaginized substance is added to a non-fermented product or a fermented product. The amount of the oil-forming substance to be added is within a range such that {B} (A + B) × 100 is 50 to 98% by weight when the non-fermented or fermented substance is A and the oil-forming substance is B. Set, but not limited to this. It is also desirable that the non-fermented product or the fermented product after the addition of the oily substance is subjected to ultrasonic treatment. As described above, the cell membrane has a high oil affinity.
What was made oil like the active oxygen suppression composition of the present invention,
It can easily pass through the cell membrane and reach the inside of the cell. In this case, the one using the oil agent is
It is desirable that the roasted extracted sesame oil has an active oxygen suppression effect, an energy recovery effect, an energy enhancement effect, and the like. An oil-based substance is also desirable because it has an energy recovery effect and an energy enhancement effect. In addition, the larger the proportion of the oiling substance is, the more sufficient the oiling is, so that it is desirable to do so. In this case, the use of an oil-forming substance can facilitate sufficient oil-forming.

With respect to the active oxygen suppressing composition of the present invention,
To this, a substance containing vitamin C and / or a derivative of vitamin C may be added. Vitamin C and its derivatives are powerful reducing substances, and themselves have an active oxygen suppressing effect. Therefore, in the case of an active oxygen suppressing composition containing these, a synergistic effect is obtained. Vitamin C and its derivatives also suppress the self-destructive action of koji and the like and stabilize the active oxygen-suppressing composition, and thus also enhance the active oxygen-suppressing action of the above-mentioned low molecular substances that have been liberated and produced. Vitamin C derivatives include salts such as sodium vitamin C and esters such as vitamin C palmitate. Vitamin C or its derivatives include young leaves and roots of barley, radish, lemon, coconut, green tea,
Spinach is an example. Also,
Those obtained by processing these and extracting necessary components can also be used.

The method of the present invention is a means for producing the active oxygen suppressing composition described above, and comprises the following steps.

In the raw material preparation step, at least one of yeast and edible scum is selected as a raw material. Of course, in this case, materials other than yeast and edible waste may be selected as raw materials. If two or more ingredients are selected,
These are mixed and stirred to obtain a homogeneous product.

In the SOD-like substance containing step, the SOD-like substance itself and / or a substance containing the SOD-like substance is selected as an additive and added to the raw material. In this way, the raw material contains a SOD-like substance. This SOD-like substance is partially or entirely reduced in molecular weight, and is not inactivated. Specifically, this step is the one described in paragraphs [0029] and [0030]. Among these, those requiring roasting are roasted with one or more of the above-mentioned energy such as far-infrared rays, ultrasonic waves, high frequencies, and low frequencies. In particular, far-infrared roasting and ultrasonic roasting.

In the fermentation step, the raw materials are fermented to produce a fermented product. Specifically, the fermented products described in the paragraph [0031] are prepared, or the fermented products obtained by combining them are prepared. At the time of this fermentation, a means using a microorganism, a means using a fermentation substance, a means using a precursor of a fermentation substance, or the like can be arbitrarily adopted.
1].

In the oiling step, the oiling substance is added to the non-fermented product or the fermented product, and this is oilified. Specifically, any desired number of the oleaginized substances described in the paragraph [0032] are used and added to the fermentation product. In this case, the addition amount of the oil-forming substance is set within the range described above. Here, the fermented product after the addition of the oil-forming substance may be subjected to ultrasonic treatment.

The activity stabilization step is one or more of a raw material preparation step, a fermentation step, and an oiling step, and is performed at least once at any time before and after the step to stabilize the activity of the SOD-like substance. Add the agent. In other words, before or during raw material production, during raw material production, after raw material production, before fermentation, during fermentation, after fermentation, before fermentation, before oiling, during oiling, after oiling, at least once, or At one or more times at a plurality of times. Therefore, when the above-mentioned raw material is used, the activity stabilization step has been completed. Since the activity stabilization step has the same degree of freedom as described above, an activity stabilizer can be added at any time. The activity stabilizer used in this activity stabilization step is described in detail in paragraph [0027].

In the method of the present invention, the above-mentioned additives other than the raw materials may be used as additives, and these may be added to the raw materials in optional steps.

[0041]

Example 1 Spent beer yeast (powder) 1 as a raw material
34 g of matcha rich in SOD-like substance was added to 66 g as an additive, and these were homogeneously stirred to obtain an active oxygen suppressing composition.

[0042]

[Comparative Example] Among the examples shown in the above-mentioned known document 2 (Japanese Patent Application Laid-Open No. Sho 63-79834), the example No. 8 having the highest active oxygen suppression effect was purchased and used as a comparative example. And

[0043]

[Evaluation 1] The active oxygen elimination activity of each of the active oxygen suppressing compositions of Example 1 and Comparative Example was measured by an electron spin resonance (ESR) method. As a result of the measurement, the active oxygen scavenging activity of Example 1 was 1.0 × 10 ⁴ units / g, and the active oxygen scavenging activity of the comparative example was 2.7 × 10 ³ units / g. As is clear from this, the active oxygen scavenging activity of Example 1 is about four times higher than that of Comparative Example. That is, the superiority of the product of the present invention (Example 1) is recognized.

[0044]

Example 2 First, 100 g of used brewer's yeast (powder), which is a raw material, was placed in a ceramic pan,
The mixture was far-infrared roasted for 30 minutes with gentle stirring under heating at -96 ° C. Next, 3 g of seed koji was added to the roasted product, which was fermented at a temperature of 36 to 40 ° C. for 3 days to obtain a fermented product. On the other hand, 44 g of sesame was far-infrared roasted for 30 minutes in the same manner as described above, and the roasted product was finely pulverized with a stone mill. The fermented product was mixed with the fine powder roasted material thus obtained to form an oil. After that, Matcha 3 containing SOD-like substance
6 g or 20 g of citrus juice was added to the oily substance, and these were stirred homogeneously to obtain an active oxygen suppressing composition.

[0045]

[Evaluation 2] The active oxygen suppressing composition of Example 2 was also evaluated.
When the active oxygen scavenging activity was measured by the same method as described above, the value was 1.2 × 10 ⁴ units / g. The product of the present invention (Example 2) also significantly exceeds the equivalent value of the comparative example.

In each of the above-mentioned embodiments, used beer yeast (edible waste) was used as a raw material. Spent brewer's yeast is usually discarded despite its high nutritional value. Therefore, the present invention provides a significant active oxygen suppressing composition by effectively utilizing waste. In other words, there is substantially no raw material cost burden in obtaining such an active oxygen suppressing composition. Edible scum other than used brewer's yeast (eg: those already mentioned)
Most are discarded or sold at low prices, but their nutritional value is high. Therefore, an active oxygen suppressing composition made from edible waste other than used brewer's yeast as a raw material in accordance with the above-described embodiments can be made significant at low cost. On the other hand, the one using unused yeast as a raw material cannot exceed the cost of the edible waste-based one, but is sufficiently effective as an active oxygen suppressing composition. When one or more of edible scum and unused yeast is used as a raw material, one or more other edible raw materials may be combined. Regarding additives to raw materials, SO
In addition to the D-like substance itself and / or the substance containing the SOD-like substance, one or more substances may be added.

[0047]

The active oxygen suppressing composition according to the present invention comprises a substance containing at least one of edible waste and yeast as a raw material, to which an additive is added to contain a SOD-like substance. Things. Therefore, a human or animal that has taken the active oxygen-suppressing composition is cleared of excessive active oxygen and the like produced in the body, thereby avoiding destruction of body tissues. Among the active oxygen-suppressing compositions according to the present invention, those having a low molecular weight or an oily composition have good permeability to the cell membrane and thus have a remarkable active oxygen eliminating activity. Further, those containing the activity stabilizer of the SOD-like substance are difficult to deactivate the SOD-like substance during the production process or long-term storage. In particular, those in which some or all of the raw material is composed of edible waste can significantly reduce the cost of this useful and useful active oxygen suppressing composition.

The method of the present invention comprises the steps of:
At least one of yeast and edible waste is selected and used as part or all of the raw material, and at the time of the SOD-like substance containing step, an additive is added to the raw material to contain the SOD-like substance, thereby suppressing active oxygen. A composition is manufactured. According to this method, a predetermined active oxygen suppressing composition can be prepared by extremely simple means without difficulty. In the method of the present invention, in addition to the above two steps, when the active oxygen suppressing composition is prepared by adding a fermentation step, an oiling step, an activity stabilizing step, etc., the active oxygen suppressing composition having various characteristic effects becomes stable. Obtained.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 45/00 A61K 45/00 A61P 39/06 A61P 39/06 F term (Reference) 4B018 LE03 LE05 MD31 MD52 MD56 MD59 MD81 ME06 ME10 ME12 MF13 4C084 AA02 AA16 MA52 NA14 ZC021 4C086 AA01 AA02 EA01 NA14 ZA45 ZB05 ZB13 ZC20 4C087 AA01 AA02 BC11 MA52 NA14 ZC02

Claims (8)

[Claims] 1. A material comprising one or more of edible waste and yeast as raw materials.
An active oxygen-suppressing composition comprising a D-like substance. 2. The active oxygen suppressing composition according to claim 1, wherein the SOD-like substance is reduced in molecular weight. 3. The active oxygen-suppressing composition according to claim 1, wherein the composition is made oil by adding an oil material. 4. The active oxygen-suppressing composition according to claim 1, wherein an activity stabilizer is added to maintain the activity of the SOD-like substance. 5. The active oxygen suppressing composition according to claim 1, further comprising an oligosaccharide as another additive. 6. A raw material preparing step and a SOD-like substance containing step. In the raw material preparing step, at least one of yeast and edible scum is selected and used as a part or whole of the raw material, and the SOD-like substance containing In the step, a method for producing an active oxygen-suppressing composition, characterized in that an additive is added so that the raw material contains an SOD-like substance. 7. A raw material preparation step, a SOD-like substance containing step, a fermentation step, an oiling step, and an activity stabilization step. In the raw material preparation step, one or more of yeast and edible scum are selected and used. In the SOD-like substance containing step, an additive is added to make the raw material contain the SOD-like substance, and in the fermentation step, the raw material is fermented to produce a fermented product. The substance is added to the fermented product and processed into oil, and the activity stabilization step is one or more of the raw material preparation step, fermentation step and oil conversion step, and at any time before and after that step. A method for producing an active oxygen-suppressing composition, comprising adding an activity stabilizer of an SOD-like substance at least once. 8. An SOD-like substance having a low molecular weight without deactivation
The method for producing an active oxygen-suppressing composition according to claim 6 or 7, wherein the composition is contained in a similar substance-containing step.