JP2001224334A - Beauty food containing amino acid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a beauty food which exhibits a higher beauty effect than those of conventional beauty foods. SOLUTION: This amino acid beauty food contains L-proline, L-alanine and glycine in amounts of 30 to 50 pts.wt., 20 to 50 pts.wt., and 10 to 50 pts.wt., respectively.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an amino acid-containing cosmetic food containing three kinds of amino acids, L-proline, L-alanine and glycine, which are main amino acids of human skin collagen, at a specific ratio.

[0002]

2. Description of the Related Art Conventionally, various amino acids have been used in various compositions for medicinal purposes and for maintaining and promoting health. Examples of such uses include, for example, "blood glucose regulators" (JP-A-4-95026, oral administration, rectal administration, administration by injection), and improvements in organic compounds (JP-A-5-252).
No. 13747, oral administration), “Adrenaline and noradrenaline secretion promoting composition” (JP-A-6-3364)
No. 32, oral administration, rectal administration, administration by injection, administration by infusion), “Amino acid nutrition composition” (Japanese Unexamined Patent Publication No.
198748, oral administration), "Amino acid composition and use thereof" (JP-A-9-52828, oral administration) and the like.

[0003] With particular reference to JP-A-9-52828, which is mentioned last, it contains essential amino acids valine, leucine, isoleucine, lysine, threonine, methionine, histidine, phenylalanine and tryptophan or derivatives thereof. Amino acid composition agent "(Claim 1), and in particular, the content of each essential amino acid is 5-20% by weight of valine, 5-20% of leucine
Wt%, isoleucine 5-20 wt%, lysine 3-20
Wt%, threonine 5-20 wt%, methionine 3-2
0% by weight, histidine 2-10% by weight, phenylalanine 1-10% by weight, (and) tryptophan 1-10
Amino acid composition (according to claim 2), wherein the composition is 5 to 30% by weight of arginine (and non-essential amino acids), 5 to 30% by weight of glutamine and 2 to 10% by weight of proline (claim 4) (claim 4). Is disclosed.

[0004] In addition, regarding the eating effect of such an amino acid composition, "People in need of the amino acid composition most particularly are elderly, middle-aged and elderly with gastrointestinal disorders, and those who have undergone gastrointestinal surgery. It is a person with poor digestion and absorption, etc. Of course, even if ingested by healthy people, it is an amino acid that composes protein, so nutrition is even better.
In particular, the liver function is improved, and it becomes stronger against virus infection such as a cold, and as a result, an improvement in immunity and the like can be expected. Further, skin diseases such as rough skin and dry skin are improved. The most important nutrient for us is protein, which is digested in the gastrointestinal tract by ingestion and takes about 3-5 hours to be absorbed from the small intestine as an amino acid. (Paragraph 0020 of the same publication, "Detailed description of the invention")
In addition, (a) "The amino acid composition is more effective when taken continuously for a certain period of time to relieve physical fatigue. If you train your body every day in rehabilitation or the like, It is sufficient to take a certain amount of the amino acid composition every day, and the same may be applied to improve the skin condition. ", (B)" The amino acid composition of this embodiment can be used in a wheelchair for a spinal injured person. You can relieve muscle fatigue in hard training people,
Blood tests of patients undergoing various types of rehabilitation who are hospitalized for cerebrovascular disorders can confirm the effects of before and after taking the amino acid composition. In addition, the person with dermatosis can recover the symptoms. (C) "Physical fatigue can hardly be expected to be accelerated by individual amino acid administration, and is effective only in the case of an amino acid composition having a specific composition. It has the effect of improving the built-in function of the agent. As a result, it has a remarkable effect of improving the symptoms for people with poor skin condition "(paragraphs 0025 to 27). The amino acid composition of the embodiment has the following advantages: (1) it is possible to accelerate the recovery of physical fatigue when the human body is loaded, and (2) it is possible to accelerate the recovery of human mental fatigue. (3) It can improve liver function, (4) it is strong against virus infection such as cold, and as a result, it can improve immunity, etc. (5) It improves skin condition Can do That. (6) physical condition, a wide variety of such appetite can be improved items. "Is described as (same paragraph 0028).

[0005] In developing an amino acid-containing beauty food, the results of actually testing the amino acid composition disclosed in the above-mentioned Japanese Patent Application Laid-Open No. 9-52828 are reported as follows. In other words, the results of the questionnaire survey show that amino acids have a beautiful skin effect and physical condition improving effect, and that the results of measurement of skin condition using physicochemical instruments show that "the amino acid intake group and the control group clearly There is a difference, and depending on the item, the effect according to the amount of intake was recognized. It can be said that the improvement effect of the skin can be said to be demonstrated from these measurements. " Application to Beauty Food ", published by Kenko Sangyo Shimbun Co., Ltd." Food and Development "Vol. 34 No. 10 ('99 -N
o. 10) pp. 6-8).

[0006]

However, at present, beauty foods are always required to have a higher cosmetic effect, and the present invention provides a more effective amino acid to meet such demand. It is intended to provide a contained beauty food.

[0007]

Means for Solving the Problems The present inventor has conducted intensive studies to achieve the object described in the preceding section, and as a result, obtained three kinds of amino acids, L-proline, L-alanine and glycine, which are main amino acids of human skin collagen. It has been found that eating and drinking at a ratio close to that of human skin collagen improves the condition of the skin and hair, and the present invention has been completed based on such findings.

That is, the present invention relates to L-proline and L-proline.
The present invention relates to a beauty food containing amino acid, which contains alanine and glycine in a proportion of 30 to 50 parts by weight, 20 to 50 parts by weight, and 10 to 50 parts by weight, respectively.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.

The composition of the amino acid which is an essential component in the amino acid-containing beauty food of the present invention is, as described above, 3 to 50 parts by weight of L-proline, 20 to 50 parts by weight of L-alanine, and 10 to 50 parts by weight of glycine. It is. here,
L-proline includes not only L-proline (in a narrow sense) but also L-proline.
-Hydroxyproline is a general term (broad definition).

[0011] The amino acid-containing cosmetic food of the present invention is characterized in that
In addition to using the above amino acids in the above-described ratios, the amino acids can be prepared by a conventional method using appropriate additives. Such additives include fruit juice, dextrin, sugar (fructose-glucose liquid sugar, sucrose), acidulants, flavorings, and other collagen that improves texture, thickening polysaccharides and agar (for jelly beverages). And the other three amino acids, vitamins, minerals, royal jelly, propolis, honey, and dietary fiber, which are usually used as components of health foods.

There is no particular limitation on the product form of the amino acid-containing cosmetic food of the present invention, and any form can be used as long as it can be ingested (fed). Such forms include powders, granules, tablets using appropriate excipients,
Examples thereof include liquids (drinks, jelly drinks, etc.) and candy (chocolate, etc.). In the extreme case of the product form, a mere powder mixture (powder) of the above three amino acids in the above ratio can be mentioned. In the case of a powder, it may be drunk with water as it is as a powder, may be wrapped in an oblate, or may be dissolved in water, milk, juice or the like.

The effect of the present invention for improving skin and hair condition is as follows:
It can be achieved by ingesting three amino acids, which are essential components, in the above ratio at a total of 1 g or more per day (average adult female). If the amount is smaller than this, the desired effect cannot be obtained.
On the other hand, the effect is not expected to be improved even if excessively consumed, so that the daily intake can be up to about 20 g. Therefore, the content of the amino acid which is an essential component in the amino acid-containing beauty food of the present invention is an amount that can satisfy such intake. The effect of improving the condition of the skin and hair according to the present invention is, of course, observed in men, and it is needless to say that the target subjects of the amino acid-containing beauty food of the present invention include not only women but also men. No.

[0014]

The present invention will be further described below with reference to examples and test examples.

Example 1 (Preparation of fruit juice soft drink (jelly drink)) Three kinds of amino acids (L-proline, L-alanine and glycine) as essential components, thigh juice and saccharides (fructose dextrose, sucrose) ), Agar, acidulants, flavors, thickening polysaccharides,
Jelly drinks (books) are prepared using other amino acids (L-leucine, L-arginine, L-isoleucine, L-valine, L-glutamic acid), collagen, vitamins (VC and VE) and distilled water in the usual manner. Amino acid-containing beauty food of the invention).

The total amount of amino acids in 200 g of this jelly beverage is 1.0 g, and the total amount of three essential amino acids is 0.8 g (0.4 g of L-proline, 0.3 g of L-alanine and 0 g of glycine). .1g).

Inspection Example 1 The effect of the amino acid-containing cosmetic food of the present invention on the condition of skin and hair was examined by a questionnaire method in comparison with conventional products.

(A) Beauty food to be tested and daily intake (1) As a product of the present invention, 400 g of a jelly beverage prepared by the method described in Example 1 was tasted daily (total of amino acids per day). 2.0 g).

(2) As a comparative product, the above Example 1 was used.
The amino acid composition of L-arginine 24 parts by weight, L
-10 parts by weight of isoleucine, 18 parts by weight of L-leucine,
10 parts by weight of L-valine, 20 parts by weight of L-lysine hydrochloride,
L-methionine 18 parts by weight, L-threonine 24 parts by weight, L-histidine monohydrate 16 parts by weight, L-proline 16 parts by weight, L-phenylalanine 10 parts by weight, L-tryptophan 10 parts by weight and L-glutamine 24 A jelly drink prepared in the same manner as in the example except that the amount was changed to parts by weight was used. The jelly drink was also tasted at 400 g per day (the total amount of amino acids per day was:
2.0 g).

(B) Subjects to be examined Monitors were recruited from healthy women and used as subjects.

(C) Method of implementation The subjects were arbitrarily divided into two groups, one group containing the jelly beverage of the present invention (the product of the present invention), and the other group containing the comparative control product. As described above, a daily tasting was performed for 28 days so that the daily amino acid intake was 2.0 g.

Questionnaires were given to the subjects before the tasting, 14 days after the tasting, and 28 days after the tasting.
The contents of the questionnaire were common to each group. The tasting was started from the beginning of November 1999. Questionnaire is 2000
Those collected by mid-January were considered valid.

(D) Method of Analyzing Answer Results Questionnaires conducted before the start of the tasting, 14 days after the tasting, and 28 days after the tasting were totaled for each question, and the frequency of each option of the respondent to each question was obtained.

Furthermore, in order to make a numerical study, questions regarding the condition of skin, hair and health are given by +2 points for "I am worried", +1 point for "I am somewhat worried", and "Either" The average value and standard deviation for each item were calculated by quantifying 0 points for "not say", -1 point for "not much trouble", and -2 points for "not troubled". This average value is referred to as “problem degree”. Also, in the question after the tasting, "I got better" +2 points, "I got a little better" +1 point, "I can't say either" 0 points, "I got a little worse" -1 point, and " It got worse "-
It was quantified as two points and the average value and standard deviation for each item were calculated. This average value is called “improvement degree”.

In the comparison between the groups, the difference between the average values of the two groups was tested using this numerical value, and a significant difference was obtained. For the test of the difference between the average values, two types of equations were used depending on the presence or absence of equal variance.

Also, only those who answered "sensitive skin" or "slightly sensitive skin" were extracted from each group, and the same analysis as above was performed on the answer results on the skin 28 days later. Regarding other skin characteristics, statistics were not calculated because the number of cases was small, and individual cases were viewed to extract features.

(E) Analysis results (1) Jelly drink of the present invention: (1a) 19 respondents within the time limit.

(1b) Questionnaire before tasting (face sheet portion); regarding skin condition, "dry skin", "normal skin"
Or about the same number of people who answered "mixed skin"
Few responded. "Sensitive skin" for sensitivity
Or half of those who answered "Slightly sensitive skin" combined.

With regard to the daily rhythm and sleep, there was a tendency to be scattered among those who answered "Somely regular (taking)" and those who answered "Slightly irregular (slightly lacking sleep)". Regarding nutritional balance and dietary intake, many respondents answered, "I am a little careful" or "Eat (morning, lunch and dinner) every day." Regarding food orientation, both "oily things" and "fresh things" are "sometimes eaten."
There were many answers. As for drinking, almost the same number of people had drinking habits and those who did not. When it came to smoking, the majority said they would not. Responses were diversified for health food. Regarding health foods that have been eaten, many respondents answered "vitamin C" or "calcium".

(1c) Questionnaire before tasting (skin, hair and health condition): Regarding the condition of the skin, the value of the degree of problem regarding “skin dryness” and “T-zone greasyness” was high (= Many were worried). Conversely, “slack face line”, “dullness”, “stain”, “wrinkle”,
The value of the degree of problem was low in each of the items of "fine wrinkles around eyes", "allergic dermatitis" and "itch" (= many were not worried).

Regarding the condition of the hair, there are no items with a high degree of problem, such as “many split ends”, “white hair”, “no hair volume”, “hair does not grow” and “fewer hair”.
Of each item was low.

(1d) Questionnaire 14 days after tasting (skin, hair and health condition);
The value of the degree of improvement was higher in each item of "skin gloss", "skin roughness", and "foundation glue" (= condition improved). In addition, there was no item whose value of the degree of improvement was extremely low (= the state became worse).

As for the condition of the hair, there was no item having a high degree of improvement. In addition, there was no item in which the value of the degree of improvement was extremely low.

As for the physical condition, the value of the degree of improvement was high for "constipation".

In the comment column, "Acne became difficult to form", "Skin condition is good", "Sleep was insufficient, but the skin did not become abnormal at all", "Elasticity and moist feeling when touching the skin" Many people commented on good effects such as "feeling hair" and "reducing hair loss". Most of the monitors who have become ill have self-analyzed that they were due to cold or work stress.

(1e) Questionnaire 28 days after tasting (skin, hair and health condition);
The degree of improvement was high in each of the items "skin luster", "skin dryness", "pimple", "skin roughness" and "foundation glue". In addition, there was no item having an extremely low improvement value.

With regard to the condition of the hair, the degree of improvement was high in the items "gloss of hair" and "hair swells". In addition, there was no item having an extremely low improvement value.

As for the physical condition, there was no item with a high degree of improvement.

In the comment column, "It became difficult to make acne", "I got better makeup", "I got foundation even if I was not sleeping enough", "I got better dry skin", "Reduced hair loss" Many people commented on good effects, such as "hair was easier to put together", "stool was improved", and "feeling of stress and fatigue". Most of the monitors who had become ill have self-analyzed the cold, dry air, and the effects of the medication they were taking.

The results of the questionnaire referred to in the above (1c) and (1e) are summarized in FIGS. 1A and 1B, respectively.

(2) Jelly drink for comparison: (2a) Fifteen respondents within the time limit.

(2b) Questionnaire before tasting (face sheet part): Regarding the condition of the skin, many answered "dry skin" or "mixed skin", and few answered "greasy skin". As for sensitivity, the number of those who answered "normal skin" and the number of people who answered "sensitive skin" or "somewhat sensitive skin" were almost the same.

Regarding the life rhythm, many answered "slightly irregular". Regarding sleep and nutritional balance, the answers were scattered. Regarding food intake, almost the same number of people answered that they "eat daily" or "eat sometimes" for breakfast, and many answered that they "eat daily" for lunch and dinner. Regarding food orientation, many respondents answered "eat often" or "eat sometimes" for "greasy foods" and "quite like" for "fresh foods". Regarding drinking, many respondents said they do not drink much. When it came to smoking, the majority said they would not. The answer was diversified for health foods. The most frequent answer was "vitamin C" for healthy foods that have been eaten.

(2c) Pre-tasting questionnaire (skin, hair and health condition): Regarding the condition of the skin, “skin dryness”, “dullness” and “stain” showed a high degree of problem. vice versa,
The degree of problem was low in each of the items of "wrinkles", "wrinkles around eyes" and "allergic dermatitis".

Regarding the condition of the hair, the degree of problem was high in "the hair was not united" and "the hair was loose".
Conversely, "many split ends", "many cuts", "white hair", "no hair volume", "hair does not grow"
The value of the degree of problem was low in each of the items "high hair" and "low hair".

As for the health condition, the value of the problem degree of "stiff shoulder" was high, and the value of the problem degree of "swelling" was low.

(2d) Questionnaire 14 days after tasting (skin, hair and health condition): There was no item with a high degree of improvement in skin condition. Conversely, the value of the degree of improvement for “skin dryness” was low.

Regarding the condition and condition of the hair, there was no item with a high degree of improvement. In addition, there was no item in which the value of the degree of improvement was extremely low.

In the comment column, changes in temperature and climate,
There were many opinions that the condition became worse due to irregular living.

(2e) Questionnaire 28 days after tasting (skin, hair and health condition): There was no item with a high degree of improvement in skin condition. Conversely, for "skin drying", the value of the degree of improvement was low.

Regarding the condition and condition of the hair, there was no item having a high degree of improvement. In addition, there was no item in which the value of the degree of improvement was extremely low.

In the comment column, changes in temperature and climate,
There were many opinions that the condition became worse due to irregular living.

The results of the questionnaire referred to in the above (2c) and (2e) are summarized and shown in FIGS. 2A and 2B, respectively.

(F) Comparison between groups In the jelly drink group of the present invention, “skin swelling”, “skin shine”, “skin drying”, “slack face line”,
The seven items of "skin roughness", "foundation glue" and "hair rustling" showed a high improvement, whereas the jelly drink group of comparisons "skin dryness" and "skin roughness" In addition, the improvement was only high in the three items of “Golden foundation glue”.

(G) Aggregation for each skin characteristic (i) Sensitive skin and slightly sensitive skin The number of “sensitive skin” and “slightly sensitive skin” in each group was calculated based on the number of jelly drink groups of the present invention and the comparative control. There were eight in the jelly drink group.

In the jelly drink group of the present invention, “skin swelling”, “skin luster”, “skin dryness”, “acne”, “pimple”, “T-zone greasyness” and “foundation The value of the degree of improvement for "Nori" was high. on the other hand,
In the jelly drink group of the comparison control, the value of the degree of improvement for “skin rash”, “skin shine”, “acne”, “fatiness of T zone”, “skin roughness” and “foundation glue” Was high.

(Ii) Atopic skin Since the number of atopic skin is small, individual data was confirmed and features were searched. In the jelly drink group of the present invention, there was no case showing a tendency of deterioration and no case showing improvement. On the other hand, in the jelly drink group of the comparative control, "smooth" and "acne" showed a slight improvement.

(Iii) Dry skin Since the number of cases was small, individual data was confirmed and features were searched. In the jelly drink group of the present invention, "amber", "gloss",
The improvement effect was observed in each item of "dry" and "roughness". On the other hand, in the jelly drink group of the comparative control, only a slight improvement effect was observed in one person.

(Iv) Oily skin Since the number of cases was small, individual data was confirmed and features were searched. In the jelly drink group of the present invention, "amber", "gloss",
An improvement effect was observed in each item of "dry", "acne", "pimple", "greasiness of T zone", and "foundation paste". On the other hand, in the jelly drink group of the comparative control, there was no example in which the improvement effect was observed.

(H) Comprehensive Consideration In the questionnaire survey this time, no major trouble occurred during the survey process, and the questionnaire collection was good.

Looking at the questionnaire before starting the monitor,
There were no significant differences between the groups in terms of living characteristics, and all groups seemed to have relatively good living characteristics.
Regarding skin worries, there are some differences between groups, but there are many worries about "skin dryness" and "T-zone greasyness" and few worries about "small wrinkles around eyes" Was. This may be due to the age of the monitor and seasonal factors. There was not much noticeable about hair troubles, and there were many items that were not troubled. This seems to be somewhat affected by age factors. As for physical condition, many were worried about stiff shoulders.

In the jelly drink group of the present invention and the jelly drink group of the comparative control, the value of the degree of improvement was positive in most items, and some good effects were obtained by ingesting these beauty foods. Can be considered.

Looking at the effects of the two types of beauty foods (the jelly drink of the present invention and the comparative jelly drink) on an item basis, the effects on the skin were as follows: "Hari", "Gloss", "Dry", and "Foundation glue". It was observed. For hair, the effect on "Pasatsuki" was the highest, but overall there was an impression that the effect was smaller than that on the skin. This can be interpreted as taking a longer time for the effect to appear compared to the skin. With regard to physical condition, an effect on constipation was observed. Particularly, when a person who answered "worried" was examined, it was particularly effective in the jelly drink group of the present invention. In addition to these survey items, there were some opinions in the comments that appealed the effects, such as "I was less tired" and "I feel like I got stronger."

Comparing the effects of the two types of beauty foods comprehensively, the jelly drink of the present invention is superior to the jelly drink of the comparative control. The former tended to be more effective for young age groups and women with oily skin, and the degree of improvement for acne and breakouts was high.

From the above, it will be understood that the amino acid-containing cosmetic food of the present invention is superior in cosmetic effect as compared with conventional similar products (amino acid-containing food).

[0066]

According to the present invention, it is possible to easily prepare and supply a beauty food having a greater beauty effect than conventional similar products.

[Brief description of the drawings]

FIG. 1A shows a total result of a questionnaire before tasting a jelly beverage of the present invention (Test Example 1).

FIG. 1B shows the total result of a questionnaire 28 days after the jelly beverage tasting of the present invention (Test Example 1).

FIG. 2A shows the results of questionnaire counting before a jelly drink tasting as a control (Test Example 1).

FIG. 2B shows the results of questionnaire counting 28 days after the jelly drink tasting as a control (Test Example 1).

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Mitsuru Nishikawa 1-15-1, Kyobashi, Chuo-ku, Tokyo Ajinomoto Co., Inc. F-term (reference) 4B018 LB08 LE04 MD19 ME14

Claims (1)

[Claims] 1. An amino acid-containing cosmetic food comprising L-proline, L-alanine and glycine in a proportion of 30 to 50 parts by weight, 20 to 50 parts by weight and 10 to 50 parts by weight, respectively.