JP2001220303A - Viscous sterilizing composition, sterilizing material using the composition, and method of applying the material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a viscous sterilizing composition having a higher sterilizing activity than conventional compositions, capable of sustaining the sterilizing activity, soft to the skin, and suitable for practical applications. SOLUTION: This viscous sterilizing composition comprises a lower alcohol, a carboxyvinyl polymer, an alkanolamine, and water, wherein the composition contains at least one kind of emollient agent selected from a group comprising chlorhexidine gluconate, a succinic acid oligoester with polypropylene glycol, dioctyl succinate, and decyl succinate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a viscous disinfectant composition used for disinfecting and disinfecting the skin of fingers and the like, a disinfecting material using the same, and a method for using the same. Employees engaged in food processing, such as central kitchens and supermarket backyards, restaurants and cafes, izakaya, and other food-related industries, hotels, school lunches, and other food-related industries. The present invention relates to a viscous disinfectant composition suitable for disinfecting and disinfecting the skin of fingers and the like of a member, a disinfectant using the same, and a method for using the same.

[0002]

2. Description of the Related Art A germicidal disinfectant for fingers is required to have a strong bactericidal activity and low irritancy to hand skin. These include cleaning agents containing disinfectants, inverse soaps, disinfecting alcohols, and the like.

[0003] A detergent containing a disinfectant is a detergent in which various disinfectants are added to the detergent to perform disinfection at the same time as hand washing. For detergents based on anionic surfactants, trichlorohydroxydiphenyl ether (triclosan), isopropylmethyl is used. Phenol or the like is used. In addition, in detergents based on nonionic surfactants, in addition to these disinfectants, cationic surfactants such as benzalkonium chloride and benzethonium chloride are used, but these cationic surfactants are used after use. It has the disadvantage that the feel of the hand skin is not smooth.

[0004] Inverse soaps include benzalkonium chloride and benzethonium chloride, which exert a strong bactericidal activity against general bacteria including food poisoning bacteria and have low toxicity, and are widely used in the field of food hygiene. I have. However, when used together with soap, or when dirt or organic substances are present, the sterilizing effect is reduced. Therefore, there is a drawback in that the fingers must be washed and then thoroughly rinsed before use.

[0005] The alcohol for disinfection is mainly composed of ethanol, and has an advantage that its bactericidal action is hardly affected by organic substances and metal ions. However, since the sterilizing power decreases when the ethanol concentration decreases, it is necessary to use after thoroughly wiping off the moisture of the hands, and there is a disadvantage that it is difficult to maintain the sterilizing power due to evaporation of alcohol. I have.

Accordingly, the present applicant has solved a viscous fungicide composition for disinfecting a hand, which contains ethanol, carboxyvinyl polymer, alkanolamine, and water at a predetermined ratio, which has solved the above-mentioned disadvantages. (Japanese Patent Publication No. 7-29884). This has the advantage of having a sustained bactericidal activity and a smooth feel of the hand skin after use.

[0007]

Recently, with the growing demand for cleanliness of consumers, the medical industry, the food manufacturing industry, etc.
There is a demand for the development of a germicidal disinfectant for fingers having high germicidal activity.
In particular, in the medical industry, there is a pressing need to prevent hospital-acquired infection, which has become a social problem, and there is a great deal of interest in disinfectants that have high bactericidal activity. On the other hand, no matter how high the disinfecting power is, if it is not suitable for actual use due to strong irritation to the hand skin, inconvenience such as rough skin, or low viscosity, etc. It does not respond.

The present invention has been made in view of such circumstances, and has a viscous fungicide composition which has a higher bactericidal activity and can maintain the bactericidal activity, is gentle on the skin, and is suitable for practical use. The purpose is to provide goods.

[0009]

According to the present invention, there is provided a viscous fungicidal composition comprising a lower alcohol, a carboxyvinyl polymer, an alkanolamine, and water. A first aspect is a viscous fungicide composition containing chlorhexidine gluconate and at least one emollient selected from the group consisting of polypropylene glycol oligosuccinate succinate, dioctyl succinate and decyl succinate.

[0010] In a second aspect of the present invention, there is provided a sterilizing and disinfecting material obtained by impregnating a nonwoven fabric with the above viscous sterilizing agent composition.

Further, the third aspect of the present invention is a method of using the disinfectant for disinfecting the above disinfectant.

That is, the present inventors have further improved the bactericidal activity of the above-mentioned viscous fungicide composition for hand sterilization proposed by the present applicant (hereinafter referred to as “conventional fungicide composition”). The main purpose was to conduct intensive research. In the process, it was recalled that a bactericide other than ethanol and an emollient were added to the conventional bactericide composition. Therefore, first, benzalkonium chloride, benzethonium chloride, and diaminoethylglycine hydrochloride, which are bactericides, were added, and although bactericidal activity was improved, disadvantages such as reduced viscosity and cloudiness were observed. Was found to be unsuitable for actual use. Next, chlorhexidine gluconate showing a good bactericidal activity against Gram-positive spore-forming bacteria (such as Bacillus subtilis), which is less bactericidal than the above-mentioned benzalkonium chloride or the like, but is difficult to sterilize with an aqueous ethanol solution, was examined. It has been found that various coexisting substances such as the above reduce the bactericidal activity, lower the viscosity, and cause cloudiness. Therefore, as a result of repeated experimental studies to find an emollient agent that does not reduce bactericidal activity even when combined with chlorhexidine gluconate, at least one member selected from the group consisting of polypropylene glycol oligosuccinate succinate, dioctyl succinate and decyl succinate With the emollient agent of the present invention, the present inventors have ascertained that lowering of the viscosity and white turbidity do not occur, and at the same time, have realized that not only prevention of a decrease in germicidal power but also improvement of germicidal power has been achieved, and the present invention has been achieved.

[0013] Among the viscous fungicide compositions described above, as long as they contain at least one natural extract of an aloe extract and a luffa extract, in addition to the above-mentioned effects, they have a moisturizing effect and an anti-moisturizing effect. It has been found that it is particularly preferable as a viscous fungicide composition for fingers because it also has an inflammatory effect.

The viscous fungicidal composition of the present invention is intended mainly for use on the skin of fingers and the like, but is not limited thereto.

[0015]

Next, an embodiment of the present invention will be described.

The viscous fungicidal composition of the present invention (hereinafter simply referred to as "fungicidal composition") comprises a lower alcohol, a carboxyvinyl polymer, an alkanolamine, water, chlorhexidine gluconate, and a specific emollient. It is obtained using an agent.

The lower alcohol used in the present invention includes ethanol, isopropanol, denatured alcohol and the like. Examples of the denatured alcohol include geraniol, octaacetylated sucrose, phenylethyl alcohol, brucine, linanol, diethyl phthalate, linalool acetate, benzyl acetate, a 10% by mass solution of denatonium benzoate alcohol, and flavor HN.
o. And various denatured ethanols modified with a denaturant such as No. 14. These can be used alone or 2
A combination of more than one species may be used. In the case of commercially available products, those having an alcohol concentration of 60 to 100% by mass (hereinafter abbreviated as "%") are preferably used. Particularly, ethanol is preferably used from the viewpoint of safety and oral toxicity.

The mixing ratio of the lower alcohol is 3% in the whole disinfectant composition from the viewpoint of disinfecting power and drying property.
Preferably, it is set in the range of 0 to 95%. That is, if it is less than 30%, the bactericidal power and quick-drying property tend to be poor, and if it exceeds 95%, it tends to be unfavorable in terms of odor, safety and hypoallergenicity of the skin. In addition,
It is preferably set in the range of 50 to 80% in consideration of the balance of bactericidal power, dryness, odor, safety, skin hypoallergenicity and the like.

Examples of the carboxyvinyl polymer used in the present invention include an acidic high molecular weight compound having a carboxyl group bonded to a multibranched main chain.

This is a thickener (gelling agent) for a lower alcohol aqueous solution, and has the advantages of excellent usability and leaving no sticky feeling. And it is used from the viewpoint of the persistence of the germicidal activity of the bactericide composition and the hypoallergenicity of the skin. Further, it acts to appropriately control the volatility of the alcohol in the germicide composition due to the body temperature of the finger or the like, in other words, the contact time with the finger or the like.

The number average molecular weight of the carboxyvinyl polymer is preferably in the range of 800,000 to 5,000,000, particularly preferably in the range of 1,000,000 to 4,000,000. That is, if the content is within the above range, the viscosity of the obtained fungicide composition becomes particularly good.

The amount of carboxyl groups in the carboxyvinyl polymer molecule is 55.0 in the whole molecule.
Is preferably in the range of from 5 to 65.0%, particularly preferably 57.0%.
It is in the range of 7-63.4%.

The blending ratio of the carboxyvinyl polymer is 0.1 to 2% in the whole fungicide composition in consideration of the stability, useability, smoothness of fingers after use, etc. of the fungicide composition. 0.05% is preferable, and particularly preferably 0.15 to 0.15 in view of usability and smoothness of fingers after use.
The range is 0.70%.

The alkanolamine used in the present invention includes, for example, monoethanolamine, diethanolamine, triethanolamine, diisopropanolamine and the like. These may be used alone or in combination of two or more. Among them, triethanolamine is preferred from the viewpoint of persistence of the bactericidal activity and the viscosity of the bactericide composition.

These alkanolamines are neutralizing agents for the carboxyvinyl polymer, and can neutralize the carboxyvinyl polymer while maintaining appropriate viscosity.

The mixing ratio of the alkanolamine is preferably in the range of 0.01% to 2.0%, more preferably in the range of 0.06% to 1.50% of the whole fungicide composition. That is, the pH value of the bactericide composition of the present invention is 5 from the viewpoint of improving bactericidal activity, hypoallergenicity of the skin, and viscosity.
Since it is preferably set to about 8 to 8 and particularly to about 5 to 7, it is preferable to set the above range in consideration of the compounding amount of the carboxyvinyl polymer showing acidity and the like.

The water used in the present invention includes pure water, purified water, distilled water, soft water, tap water and the like. Above all, pure water and purified water are preferably used.

The mixing ratio of the water is preferably in the range of 5 to 50%, particularly preferably in the range of 30 to 50%, of the whole fungicide composition.

The chlorhexidine gluconate used in the present invention is not particularly limited, and various chlorhexidine gluconates can be used. A chlorhexidine gluconate having a concentration of 20% (for example, chlorhexidine gluconate 20 manufactured by Mutual Pharmaceutical Co., Ltd.) is commercially available and is preferably used.

Although this product is inferior to bactericidal activity than benzalkonium chloride and benzethonium chloride, it exhibits good bactericidal activity against Gram-positive spore-forming bacteria (Bacillus subtilis) which are difficult to sterilize with an aqueous ethanol solution. is there. Therefore, there is an aspect of supplementing the bactericidal power of the conventional bactericide composition.

The proportion of chlorhexidine gluconate is preferably in the range of 0.05 to 0.50% of the whole fungicide composition when the active ingredient concentration is 20%. That is, if it is less than 0.05%, the bactericidal effect against Gram-positive spore-forming bacteria such as Bacillus subtilis tends to be poor, and if it exceeds 0.50%, it is not preferable in terms of cost and the like. In addition, when it is used for fingers in consideration of the sterilization effect, cost, etc., it is usually 0.10.
It is used in the range of ０．２0.25%.

Specific emollients used in the present invention are polypropylene glycol succinate oligoester, dioctyl succinate and decyl succinate. These may be used alone or in combination of two or more. Of these, polypropylene glycol succinate oligoester and dioctyl succinate are preferably used from the viewpoint of skin hypoallergenicity and bactericidal activity.

The polypropylene glycol succinate oligoester in the above specific emollient is an oligoester of polypropylene glycol and succinic acid, and is, for example, Cosmall 102 (Nippon Oil & Fat Co., Ltd.) represented by the following chemical formula (1). Manufacture, number average molecular weight: 2451.
1) and the like.

[0034]

Embedded image

Dioctyl succinate among the above-mentioned specific emollients is represented by the following chemical formula (2).

[0036]

Embedded image CH ₃ CH (CH ₂ CH ₃ ) (CH ₂ ) ₃ CH ₂ -OCOCH ₂ CH ₂ COO-CH ₂ (CH ₂ ) ₃ CH (CH ₂ CH ₃ ) CH ₃ … (2)

Further, decyl succinate of the above specific emollient is represented by the following chemical formula (3).

[0038]

Embedded image CH ₃ (CH ₂ ) ₃ CH ₂ -OCOCH ₂ CH ₂ COO-H (3)

These specific emollients are intended to smooth the skin of fingers and the like and to act as a sebum component supplier. And when it mix | blends in the germicidal composition of this invention, it also acts as the function which improves bactericidal power. In addition, with these specific emollients, the germicidal composition of the present invention can be made turbid without any suspended matters or precipitates. Furthermore, unless discolored by a coloring agent such as a dye, the disinfectant composition is colorless and transparent, has a desired viscosity, and exhibits a desired disinfecting power.

The mixing ratio of the above specific emollient is preferably in the range of 0.05 to 5.0%, more preferably in the range of 0.15 to 0.25%, of the whole fungicide composition. . That is, if it is less than 0.05%, there is a tendency that sufficient skin hypoallergenicity and bactericidal effect cannot be obtained,
If it exceeds 5.0%, it is not preferable in terms of cost and the like.

The bactericide composition of the present invention may further contain, in addition to the above-mentioned components, any of a skin irritation-reducing agent, a fragrance, a dye, a metal corrosion inhibitor, an antioxidant, etc. within a range not to impair the object of the present invention. May be added.

Examples of the skin irritation-reducing agent include aloe extract, luffa extract, perilla extract, sage extract and the like. Among them, the aloe extract and the luffa extract are preferable since they can impart a moisturizing effect and an anti-inflammatory effect. And the mixing ratio of these natural extracts is
It is preferably in the range of 0.03 to 0.30%, particularly preferably in the range of 0.05 to 0.20% of the whole fungicide composition.

The bactericide composition of the present invention obtained by using each of the above-mentioned components exhibits bactericidal activity derived from lower alcohol and chlorhexidine gluconate, and the bactericidal activity is shown by polypropylene glycol oligoester succinate, dioctyl succinate. And decyl succinate enhanced by at least one emollient. Therefore, it has higher sterilizing power than before. In addition, as a result of the enhancement of the sterilizing power, it is possible to realize the expansion of the sterilizing target. In addition, there are no drawbacks such as a decrease in viscosity and generation of cloudiness, and the product is suitable for practical use. Then, since a film of the alkanolamine salt of the carboxyvinyl polymer due to the neutralization of the carboxyvinyl polymer and the alkanolamine is formed on the surface of the skin such as a finger, the evaporation of the lower alcohol is suppressed, resulting in a high level. Sterilization power can be maintained. In addition, the specific emollient agent reduces irritation to the skin such as fingers and prevents inconvenience such as rough skin. Furthermore, chlorhexidine gluconate can maintain the viscosity and can reduce the blending amount of the carboxyvinyl polymer.

The viscosity of the fungicide composition of the present invention at 25 ° C. is usually preferably in the range of 2,000 to 50,000 mPa · s, and particularly preferably in the range of 2,000 to 30,0 mPa · s.
The range is 00 mPa · s. That is, when the viscosity is low, when used as a bactericide composition for fingers, even when placed on the palm, because it is a liquid of smooth, spills, or it will flow down between the fingers, it is uneconomical At the same time, it is difficult to spread the fungicide composition evenly between the palm, the back of the hand, and the fingers, so that high sterilizing power cannot be sufficiently exerted. The viscosity is usually adjusted depending on the type, the amount, and the like of the carboxyvinyl polymer.

The fungicide composition of the present invention can be used by an appropriate method, for example, using a dispenser. Specifically, a dedicated dispenser containing the bactericide composition of the present invention is placed in a kitchen, kitchen, toilet, vanity stand, etc., and each time it is used, about 1
By placing ２2 ml on the palm and rubbing both hands, it can be evenly distributed on the skin of the palm, the back of the hand, the fingers, between the fingers, the wrist, etc., and sterilization and disinfection can be performed.

The bactericide composition of the present invention is provided by being filled in a plastic container, a container with a pump, a pouch, a tube or the like. In addition, it can be provided individually with a considerable amount (1 to 2 ml) used each time, individually wrapped and provided with portability.

The germicidal composition of the present invention can be impregnated into a non-woven fabric to form a germicidal disinfectant.
Can sterilize and disinfect. Food sterilizers, coffee shops, restaurants, hotels, izakayas, school meals, central kitchens, counters for supermarkets, refrigerators, storages, tables, desks, vanities, toilet seats And the like having a hard surface. Further, the disinfectant of the present invention can be used as a towel, a wet tissue or the like.

The raw materials of the nonwoven fabric constituting the disinfectant of the present invention include cellulosic materials such as cotton, protein materials such as wool or silk, and chemically polymerized materials such as rayon, polyester and acrylic. Can be Among them, cellulosic materials and chemically polymerized materials are preferred.

Next, examples will be described together with comparative examples.

[0050]

Examples 1 to 4 and Comparative Examples 1 to 4 In order to examine the presence or absence of chlorhexidine gluconate and a specific emollient, prescribed components are blended in a prescribed ratio as shown in Tables 1 and 2 below. As a result, a desired fungicide composition was prepared. And about the obtained germicidal composition of the Example and the comparative example, as shown below, appearance (transparency, suspended matter), germicidal test A, B, smoothness of hand skin after use, viscosity Was measured and evaluated, and the results are shown in the same table.

[Appearance] The appearance of the fungicide composition was evaluated as follows based on its transparency and the presence or absence of suspended matter. *: Transparency ：: Colorless and transparent. ×: Cloudy. *: Suspended matter ○: Suspended matter and sediment are not observed. ×: Suspended matters and precipitates are observed.

[Bactericidal test A] Escherichia coli ( Escherichia coli IFO-12734) was used as a test bacterium, and the test was performed according to the following procedure according to the carrier method. 1. Escherichia coli IFO-12734 2. Operation and evaluation method 2-1. Approximately 24 bacteria were tested in NB (Nutrient Broth) medium.
Incubate for hours. 2-2. The number of bacteria in the test solution was measured to obtain a test bacterial solution (the bacterial solution concentration at this time was 2.46 × 10 ⁸ cells / ml). 2-3. Membrane filter (0.
45μm GRIDDED DUREPORE STERILE SPAK, Millipor
e Corporation), put 50 ml of sterile water in advance, take 0.1 ml of a 10,000-fold dilution of the test bacterial solution, and filter. 2-4. Transfer the filtered membrane filter onto a sterile petri dish, and uniformly contact the membrane filter with 0.1 ml of the reagent filter with a conical rod for 1 minute. 2-5. Use the above filter with SCD-LP (Soybean-Casein
Digest Agar with Lecithin & Polysorbate 80) Place on an agar medium and culture for 24 hours. 2-6. After culturing, the number of colonies that have developed is counted, and this is defined as the number of bacteria after contact with the reagent agent. 2-7. The sterilizing power is calculated by the following formula. Bactericidal activity (%) = [(number of bacteria before contact with reagent agent-number of grown colonies) / number of bacteria before contact with reagent agent] x 100 2-8. The bactericidal activity is shown in the following table. ：: Those having a sterilizing power of more than about 70%. B: Bactericidal activity is approximately 60 to 70%. Δ: Bactericidal activity is approximately 50 to 60%. X: The germicidal activity is approximately 40 to 50%. XX: Bactericidal activity is generally less than 40%.

[Bactericidal Test B] Staphylococcus aureus ( Staphylococc
us aureus ) IFO-12732] according to the carrier method according to the following procedure. 1. Test bacteria Staphylococcus aureus IFO-12732 2. Operation and evaluation method 2-1. Approximately 24 bacteria were tested in NB (Nutrient Broth) medium.
Incubate for hours. 2-2. The number of bacteria in the test solution was measured and used as the test bacterial solution (the concentration of the bacterial solution at this time was 2.24 × 10 ⁸ cells / ml). 2-3. Membrane filter (0.
45μm GRIDDED DUREPORE STERILE SPAK, Millipor
e Corporation), put 50 ml of sterile water in advance, take 0.1 ml of a 1000-fold dilution of the test bacterial solution, and filter. 2-4. Transfer the filtered membrane filter onto a sterile petri dish, and uniformly contact the membrane filter with 0.1 ml of the reagent filter with a conical rod for 1 minute. 2-5. Use the above filter with SCD-LP (Soybean-Casein
Digest Agar with Lecithin & Polysorbate 80) Place on an agar medium and culture for 24 hours. 2-6. After culturing, the number of colonies that have developed is counted, and this is defined as the number of bacteria after contact with the reagent agent. 2-7. The sterilizing power is calculated by the following formula. Bactericidal activity (%) = [(number of bacteria before contact with reagent agent-number of grown colonies) / number of bacteria before contact with reagent agent] x 100 2-8. ：: Those having a sterilizing power of more than about 99%. ：: Those having a sterilizing power of about 98 to 99%. Δ: Bactericidal activity is approximately 97 to 98%. X: The bactericidal activity is about 95 to 97%. XX: Bactericidal activity is generally less than 95%.

[Smoothness of hand skin after use] A: Very smooth feel is felt. ：: Good smooth feel is felt. Δ: Slightly smooth feel was felt. ×: No smooth feel is felt.

[Measurement of Viscosity] The viscosity of the reagents (bactericide compositions of Examples and Comparative Examples) at 25 ° C.
The measurement was carried out according to JIS Z 8803 "Viscosity measurement method using a single cylindrical rotary viscometer" using a model viscometer Model BL (manufactured by Tokimec (formerly Tokyo Keiki)).

[0056]

[Table 1]

[0057]

[Table 2]

From the results shown in Tables 1 and 2, the fungicide compositions of Examples 1 to 4 using chlorhexidine gluconate and a specific emollient in combination with those of Comparative Example 1 using neither of them. It can be seen that the germicidal activity is particularly good as compared with the germicidal compositions and the germicidal compositions of Comparative Examples 2, 3, and 4 using only one of them. Also, the appearance of the fungicide composition of the example product and the smoothness of the hand skin after use,
It can be seen that good results were also obtained for the viscosity.

[0059]

Example 1, Examples 5 to 7 As lower alcohols, ethanol, isopropanol, modified geraniol ethanol, flavor H-No. In order to study the case where 14 denatured ethanol was used, a desired bactericide composition was prepared by mixing predetermined components at a predetermined ratio as shown in Table 3 below. And about the obtained disinfectant composition of an Example, appearance (transparency, a floating substance), disinfection test A, B, smoothness of the hand skin after use, and
The viscosity was measured and evaluated, and the results are shown in the same table.

[0060]

[Table 3]

From the results shown in Table 3, as lower alcohols,
Ethanol, isopropanol, geraniol modified ethanol or flavor H-No. All the germicidal compositions of Examples 1 and 5 to 7 using 14 denatured ethanol showed good results in appearance, bactericidal power, smoothness of hand skin after use, and viscosity of the germicidal composition. It can be seen that it has been obtained.

[0062]

Example 1, Comparative Examples 5 to 13 In order to examine the relationship between chlorhexidine gluconate and various emollients,
As shown in the following Tables 4 and 5, predetermined components were blended in a predetermined ratio to prepare a target fungicide composition. And about the obtained disinfectant composition of the Example and the comparative example, appearance (transparency, suspended matter), disinfection test A, B, smoothness of hand skin after use, and viscosity are used similarly to the above. The measurement was evaluated and the results are shown in the same table.

[0063]

[Table 4]

[0064]

[Table 5]

From the results of Tables 4 and 5, it can be seen from Comparative Examples 5 to 5 that use emollients other than the above specific emollients.
It can be seen that the thirteen product germicidal compositions are inferior in terms of bactericidal activity and the like to the germicidal composition of Example 1 using the specific emollient. More specifically, when isononyl isononanoate, isotridecyl isononanoate, neopentyl glycol di-2-ethylhexanoate, and hydrolyzed collagen are used as emollients (Comparative Example 5,
6 items, 7 items, 12 items) do not produce suspended matter, sediment, etc.
Although clear and viscous products without turbidity can be obtained, their bactericidal activity is poor, indicating that they lack practicality. When octyldodecyl lactate and polyglyceryl monoisostearate were used (Comparative Examples 8 and 11)
Does not produce suspended matters, precipitates, etc., but becomes cloudy, opaque, viscous, has poor bactericidal activity, and lacks practicality. When diisopropyl adipate and coconut oil fatty acid polyoxyethylene glyceryl were used (Comparative Examples 9 and 10), they became transparent and viscous with suspended matters and precipitates, and their sterilizing power was It turns out that it is very poor and lacks practicality. In addition, when coconut oil fatty acid collagen peptide potassium was used (Comparative Example 13), suspended solids, precipitates, etc. were generated, and became cloudy, opaque and viscous. It turns out that it lacks.

[0066]

Examples 1, 8, 9 and Comparative Examples 1, 2 In order to examine the mixing ratio of polypropylene glycol succinate oligoester, the desired components were mixed at a predetermined ratio as shown in Table 6 below. A fungicide composition was prepared. And about the obtained disinfectant composition of the Example and the comparative example, appearance (transparency, suspended matter), disinfection test A, B, smoothness of hand skin after use, and viscosity are used similarly to the above. The measurement was evaluated and the results are shown in the same table.

[0067]

[Table 6]

From the results shown in Table 6, the germicidal compositions of Examples 1, 8, and 9 in which the polypropylene glycol succinate oligoester was blended at a predetermined ratio contained the specific emollient. It can be seen that Comparative Examples 1 and 2 have higher bactericidal activity than those of the first and second germicidal compositions. Further, it can be seen that good results were also obtained with respect to the appearance of the fungicide composition of the example product, the smoothness of the skin after use, and the viscosity.

[0069]

Examples 1, 10, 11 and Comparative Examples 1, 2 In order to examine the mixing ratio of chlorhexidine gluconate, Table 7 below was used.
As shown in Table 1, a desired fungicide composition was prepared by blending predetermined components in a predetermined ratio. And about the obtained disinfectant composition of the Example and the comparative example, appearance (transparency, suspended matter), disinfection test A, B, smoothness of hand skin after use, and viscosity are used similarly to the above. Measure and evaluate,
The results are shown in the same table. Further, a bactericidal test C shown below was performed, and the results are shown in the same table.

[0070] As [germicidal test C] test bacteria Bacillus subtilis (spores) [B. subtilis (Bucillus subtilis
s ) Using IFO-13722] according to the carrier method and the following procedure. 1. Test bacteria Bacillus subtilis (spores) (Bucillus subtilis IFO-13722) 2. Operation and evaluation method 2-1. The test bacteria in SCD (Tripto-Soya Broth) medium
Incubate for 5 days. 2-2. The number of bacteria in the test solution was measured and found to be the test solution (the concentration of the solution at this time was 2.47 × 10 ⁷ cells / ml). 2-3. Membrane filter (0.
45μm GRIDDED DUREPORE STERILE SPAK, Millipor
e Corporation), put 50 ml of sterile water in advance, take 0.1 ml of a 10,000-fold dilution of the test bacterial solution, and filter. 2-4. Transfer the filtered membrane filter onto a sterile petri dish, and uniformly contact the membrane filter with 0.1 ml of the reagent filter with a conical rod for 1 minute. 2-5. Use the above filter with SCD-LP (Soybean-Casein
Digest Agar with Lecithin & Polysorbate 80) Place on an agar medium and culture for 24 hours. 2-6. After culturing, the number of colonies that have developed is counted, and this is defined as the number of bacteria after contact with the reagent agent. 2-7. The sterilizing power is calculated by the following formula. Bactericidal activity (%) = [(number of bacteria before contact with reagent agent-number of grown colonies) / number of bacteria before contact with reagent agent] x 100 2-8. The bactericidal activity is shown in the following table. ：: Those whose bactericidal activity exceeds about 80%. ：: Bactericidal activity is approximately 60 to 80%. Δ: Bactericidal activity is approximately 40 to 60%. X: Bactericidal power is about 20 to 40%. XX: Bactericidal activity is generally less than 20%.

[0071]

[Table 7]

From the results shown in Table 7, it can be seen from the results of Examples 1 and 10 that chlorhexidine gluconate was blended at a predetermined ratio.
It can be seen that the germicidal compositions of the 11 products and 11 products have higher bactericidal activity than the germicidal compositions of 1 product and 2 products of Comparative Examples. In particular, it can be seen that there is a marked difference for Bacillus subtilis (spores). Further, it can be seen that good results were also obtained with respect to the appearance of the fungicide composition of the example product, the smoothness of hand skin after use, and the viscosity.

[0073]

Examples 1, 12-15, Comparative Examples 14-17 In order to examine the relationship between chlorhexidine gluconate, various emollients, and various natural extracts, predetermined components were specified as shown in Tables 8 and 9 below. The desired fungicide composition was prepared by blending in a ratio. And about the obtained germicidal composition of an Example and a comparative example, an external appearance (transparency, a floating substance), germicidal activity test A, B, and
The smoothness and viscosity of the hand skin after use were measured and evaluated, and the results are shown in the same table. The moisturizing and anti-inflammatory effects were evaluated according to the following criteria, and the results are shown in the same table.

[Moisturizing action and anti-inflammatory effect] A: A remarkable moisturizing action and anti-inflammatory effect was obtained. ：: A moisturizing and anti-inflammatory effect was obtained. ×: A moisturizing effect and an anti-inflammatory effect were not obtained.

[0075]

[Table 8]

[0076]

[Table 9]

From Tables 8 and 9, it can be seen that the bactericide compositions of Examples 12 to 15 are the same as those of Example 1 in which natural extracts such as aloe extract and luffa extract are not blended with specific emollients. It can be seen that, unlike the fungicide composition, it has a remarkable moisturizing action and anti-inflammatory action. In addition, it can be seen that good results were obtained with respect to the sterilizing power and the like, similarly to the product of Example 1. On the other hand, the fungicide compositions of Comparative Examples 14 to 17 in which a natural extract such as an aloe extract or a luffa extract was blended without a specific emollient agent being blended had poor bactericidal activity. You can see that there is.

[0078]

As described above, the germicidal composition of the present invention comprises a lower alcohol, a carboxyvinyl polymer,
It contains alkanolamine, water, chlorhexidine gluconate, and at least one emollient selected from the group consisting of polypropylene glycol oligosuccinate succinate, dioctyl succinate and decyl succinate. Therefore, in addition to the bactericidal activity derived from lower alcohol and chlorhexidine gluconate, an effect of improving the bactericidal activity by using the specific emollient agent is obtained, and the bactericidal activity is higher than that of the conventional bactericide composition. . Further, by increasing the sterilizing power, it is possible to expand the sterilizing target. Further, the fungicide composition of the present invention,
Since no problems such as low viscosity and white turbidity occur, it is suitable for practical use. And because it contains a carboxyvinyl polymer and an alkanolamine, it can maintain its bactericidal activity, and because it contains the specific emollient agent, it is particularly gentle on the skin such as fingers. In addition, since chlorhexidine gluconate is contained, good viscosity can be maintained.

In particular, the aloe extract,
When a natural extract such as a loofah extract is blended, a moisturizing effect and an anti-inflammatory effect are exhibited in addition to the above effects.

The fungicide composition of the present invention is particularly excellent in human safety and environmental safety. More specifically, it can be used in food processing industries such as central kitchens, super yards, restaurants, coffee shops, and izakayas. Restaurant business, hotels,
It is suitable for disinfecting and disinfecting the skin of fingers and the like of employees engaged in the food-related industry such as school lunches.These disinfectant compositions are included in dedicated dispensers, and are used in kitchens, kitchens, toilets, vanities, etc. It is arranged and used. For example, each time about 1-2 ml is placed on the palm of each hand and both hands are rubbed and rubbed, so that it can be evenly distributed on the skin of the palm, the back of the hand, the fingers, between the fingers, the wrist, etc., and sterilization and disinfection can be performed.

Further, the disinfecting material obtained by impregnating the nonwoven fabric with the disinfectant composition of the present invention can be used for food factories, coffee shops, restaurants, hotels, izakayas, school lunches, central kitchens,
It can be used for sterilization and disinfection of worktops, refrigerators, and storages in supermarket backyards by wiping.
In addition, it is used for sterilization and disinfection of hard surfaces such as tables, desks, vanities, and toilet seats. It can also be used as a towel, wet tissue, and the like.

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Claims (4)

[Claims] 1. A viscous fungicide composition comprising a lower alcohol, a carboxyvinyl polymer, an alkanolamine and water, comprising: chlorhexidine gluconate; polypropylene glycol oligosuccinate succinate; dioctyl succinate; A viscous fungicide composition comprising at least one emollient selected from the group consisting of decyl succinate. 2. The viscous fungicide composition according to claim 1, which comprises at least one natural extract of an aloe extract and a loofah extract. 3. A sterilizing and disinfecting material obtained by impregnating a nonwoven fabric with the viscous disinfectant composition according to claim 1 or 2. 4. A method of using a disinfectant according to claim 3, wherein the disinfectant is used for disinfection.