JP2001170153A - Tablet composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a tablet composition containing a carbonate and/or a bicarbonate, an organic acid and a moisture and having a water activity value at 25 deg.C of 0.54 or less. SOLUTION: The tablet composition has high stability and can prevent bulging of a packaging material due to generation of a carbon dioxide when the composition is packaged by the material.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a tablet composition which foams when poured into water, and more particularly to a tablet composition which is suitably used for room aroma and the like.

[0002]

2. Description of the Related Art The volatile components of fragrances and essential oils are aroma, deodorant, antibacterial, antifungal, sterilizing,
It has a repelling and attracting effect on living things, and has recently been widely applied to diversion and aromacology. In such a situation, the method of volatilizing a fragrance or essential oil while foaming it for a certain period of time in a container filled with water as a foaming tablet can temporarily produce a strong fragrance and enjoy the color and the sound of foaming It is effective as a method.

[0003] However, the foamed carbon dioxide formulation decomposes while emitting carbon dioxide gas and water in the presence of moisture, and the produced water causes a chain reaction, so that the decomposition may suddenly start during storage. In order to prevent this problem, it is necessary to thoroughly control the moisture in the raw material and the humidity during the production, and to package the film in a film having a low water vapor permeability. On the other hand, moderate water is used to adjust tablet hardness, prevent tableting capping and improve tableting properties during production, and is extremely effective for coloring pigments and dissolving water-soluble components. A small amount of water is sprayed at the time of mixing the powder to form granules or used as tablets. In such a case, decomposition occurs over time depending on the amount of water and the state of water, and the packaging material swells due to the generation of carbon dioxide gas. The degree is remarkable as the temperature increases. Depending on the amount and condition of water, it does not occur until after several months even at 50 ° C, or it decomposes at room temperature for more than half a year, so it is difficult to predict the decomposition beforehand. This is a major obstacle to management.

In order to solve this problem, a method of quantifying the amount of water in the composition is considered. However, depending on the composition, heating at 100 ° C. or more is required for the quantification of water, Some decompose or volatilize and disappear,
It is difficult to accurately determine the water content.

[0005] The present invention has been made in order to improve the above circumstances, and has as its object to provide a tablet composition which can prevent swelling of a packaging material due to generation of carbon dioxide during storage.

[0006]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, the generation of carbon dioxide gas due to moisture and aging is more affected by the state of water than the amount of water, In other words, it was found that it is desirable to use a parameter that correlates to the amount of free water in water, depending on whether the contained water is in the state of free water, bound water, or bound water, and as a result of further study The water activity of the carbon dioxide foam formulation was measured, and it was found that the value of the water activity was extremely effective in predicting the generation of carbon dioxide over time. That is, if the composition is set such that the water activity value at 25 ° C. of the powder to which water is added is 0.54 or less, good stability can be ensured over a long period of time while maintaining good tableting properties. The present inventors have found that swelling of a packaging material due to generation of carbon dioxide can be prevented, and have accomplished the present invention.

Accordingly, the present invention provides a tablet composition containing a carbonate and / or bicarbonate, an organic acid, and water and having a water activity value at 25 ° C. of 0.54 or less.

Hereinafter, the present invention will be described in more detail.
The tablet composition of the present invention contains a carbonate and / or bicarbonate, and an organic acid, and foams and dissolves when charged into water.

Here, as the carbonate used in the present invention, anhydrous sodium carbonate and anhydrous potassium carbonate are desirable. As the bicarbonate, sodium bicarbonate and potassium bicarbonate are preferable. Also, sodium carbonate may be mixed with sodium hydrogen carbonate to form a sesquisalt.

The organic acid to be reacted with the carbonate is not particularly limited, but dl-malic acid having high water solubility is desirable in order to obtain a suitable foaming property. Citric acid has a high deliquescence and tends to have poor shape retention. Succinic acid and fumaric acid have low solubility in water and are liable to produce insolubles, but their use is not excluded.

Usually, the carbonate and the organic acid react in equimolar amounts, but are mild on the alkaline side and remarkably react on the acidic side. In the present invention, the pH after the reaction is preferably in the range of 8.0 to 4.0 in order to maintain appropriate foaming properties.

When the amount of the organic acid is large, the powder adheres to the mortar or punch when the tablet is compressed, so that the total amount of the carbonate and the organic acid is 30% by mass or more and 70% by mass or less. desirable. If it exceeds 70% by mass, powder adhesion becomes remarkable, and if it is less than 30% by mass, tableting properties are good, but there is a possibility that the foaming force may be lost.

When a fragrance is required, for example, when the tablet composition of the present invention is used for applications such as room temperature fragrances, it is preferable to add a fragrance component. Examples of the fragrance component include various fragrance materials, essential oils, etc., which emit a fragrance by volatilizing, change the mood, deodorize, antibacterial, antifungal,
There is no particular limitation as long as it has a disinfecting and repelling / attracting action for living things, but in the form of the present invention, those having an aroma or aromacological action are desirable.

Specifically, the fragrance component includes hydrocarbons such as aliphatic hydrocarbons, terpene hydrocarbons and aromatic hydrocarbons, alcohols such as aliphatic alcohols, terpene alcohols and aromatic alcohols, aliphatic ethers, Ethers such as aromatic ethers, aliphatic oxides, oxides such as terpene oxides, aliphatic aldehydes, terpene aldehydes, hydrogenated aromatic aldehydes, thioaldehydes, aldehydes such as aromatic aldehydes, aliphatic ketones, Ketones such as terpene ketone, hydrogenated aromatic ketone, aliphatic cyclic ketone, non-benzene aromatic ketone, aromatic ketone, acetal, ketal, phenol, phenol ether, fatty acid, terpene carboxylic acid, hydrogen Aromatic carboxylic acids, acids such as aromatic carboxylic acids, acid amides , Aliphatic lactone, cyclic lactone,
Terpene lactones, hydrogenated aromatic lactones, lactones such as aromatic lactones, aliphatic esters, furan carboxylic acid esters, aliphatic cyclic carboxylic acid esters,
Synthetic fragrances such as esters such as aromatic carboxylic esters, nitromusks, nitriles, amines, pyridines, quinolines, pyrroles, nitrogen-containing compounds such as indole,
Natural fragrances from animals and plants, and compounded fragrances containing natural fragrances and / or synthetic fragrances can be mentioned.
Species can be used alone or in combination of two or more.

More specifically, for example, published by Kagaku Kogyo Nippo, 1996, Motoichi Indo (synthetic fragrance chemistry and product knowledge),
1969, Stefan Arctander
NARCTAMDER) (Perfume and Flavor Chemicals <Perfume and Flav>
or Chemicals>) or the like can be suitably used. The main fragrances are shown below.

Aldehydes C6 to C12, anisaldehyde, acetal R, acetophenone, acetylsedrene, adoxal, allyl amyl glycolate, allyl cyclohexane propionate, alpha damascon,
Beta-damascon, delta-damascon, ambrette lid, ambroxane, amylcinamic aldehyde, amyl cinnamaldehyde dimethyl acetal, amyl valeriananate, amyl salicylate, isoamyl acetate, isoamyl salicylate, aurantiol, acetyljurugenol, vacdanol, Benzyl acetate, benzyl alcohol, benzyl salicylate, bergamyl acetate, bornyl acetate, butyl butyrate, paratertiary butyl cyclohexanol, paratertiary butyl cyclohexyl acetate, ortho tertiary butyl cyclohexanol, benzaldehyde, benzyl formate, caliform , Kashmelan, carvone, cedroambar, cedrill acetate, Dror, Serisuto lid, cinnamic alcohol, cinnamic aldehyde, Shisujasumon, citral, citral dimethyl acetal, Shitorasaru, citronellol, citronellyl acetate, citronellyl formate, citronellyl nitrile, Shikurasetto, cyclamen aldehyde,
Cyclaprop, caron, coumarin, cinnamyl acetate, delta C6-C13 lactone, dimethylbenzylcarbinol, dihydrojasmon, dihydrolinalool, dihydromyrcenol, dimetol, dimyrcetol, diphenyl oxide, ethyl wanillin, jugenol, fluitate, fentyl alcohol, Phenylethyl phenyl acetate, garaki solid, gamma C6-C13 lactone, geraniol, geranyl acetate, geranyl formate, geranyl nitrile, hedion, helional, heliotropin, cis-3-hexenol, cis-3-hexenyl acetate, cis-3 -Hexinyl salicylate, hexylcinamic aldehyde, hexyl salicylate, hyacinth dimethyl acetal, Idotropic alcohol, hydroxycitronellal, indole, innone, isobornyl acetate, isocyclocitral, iso-E super, isoyugenol, isononyl acetate, isobutyl quinoline, jasmar, jasmolactone, jasmofilan, koabon, rigstral, lilial , Lime oxide, limonene, linalool, linalool oxide, linalyl acetate and the like.

The amount of the fragrance component is not particularly limited.
Desirably, the content is 0.4% by mass or more and 1.5% by mass or less. 0.4
If the amount is less than 1.5% by mass, the volatilization amount is not sufficient, and if the amount exceeds 1.5% by mass, the tableting property may be rapidly reduced.

In the present invention, a water-soluble binder may be blended in order to improve tableting properties. An example of the water-soluble binder is polyethylene glycol. The average molecular weight of the polyethylene glycol is desirably 2,000 to 6,000.
For the purpose of improving tableting properties, an average molecular weight of 2,000 or more is required. However, when the molecular weight becomes high, in the presence of an inorganic salt, the fragrance solubilized by the surfactant after foaming and dissolution is easily separated. Could be. This separation of the fragrance becomes more remarkable as the amount of water to be dissolved is smaller and the blending amount of polyethylene glycol is larger. Therefore, 10
When dissolving the carbonated effervescent tablet in 0 to 200 ml of water, polyethylene glycol 4000
By blending 4% by mass, it is possible to obtain an effect of improving tableting properties and an effect of preventing separation of a flavor after foam dissolution.

In the present invention, it is preferable that the surfactant is blended to form a film of the surfactant on the water surface during dissolution so as to prevent carbon dioxide gas from scattering at the time of foaming. Further, when the carbonated foamed tablet is dissolved in water, it is effective for solubilizing the flavor in water. As the surfactant, a nonionic surfactant is preferable because it is hardly affected by water quality.
Since the foaming property of the surfactant is increased by foaming of carbon dioxide gas, the amount of the surfactant is sufficient in the amount of about 100 to 1000 ppm. However, the cationic surfactant adheres to the glass container, Anionic surfactants and nonionic surfactants, which are less susceptible to the effects of water quality, are preferred because they react with dyes such as the above. Specifically, a secondary alcohol ethoxylate having an addition mole number of ethylene oxide of about 9 to 11 is preferable.

The present invention is characterized by containing water. Since water acts as a binder in the composition, it has an effect of maintaining the tablet hardness at a certain strength or more, and is desirably added in the range of 0.1% by mass or more and less than 3.0% by mass. It is preferable to add the water by spraying the powder mixture little by little. In this case, when a solution in which a dye or a water-soluble component is dissolved is added, a change in color tone that occurs during storage of the tablet can be reduced. In addition, when water is added, it is preferable to add the powder to the powder mixture obtained by removing the organic acid from the carbonate and / or bicarbonate, and then add and mix the organic acid, followed by tableting.

The water activity at 25 ° C. of the tablet composition of the present invention is adjusted to 0.54 or less. More preferably, it is adjusted to 0.1 or more and 0.54 or less. In this case, if the water activity value is less than 0.1, the tablet hardness is low, and chipping or cracking may occur during production, or capping may occur during tableting. Here, the water activity value is 25 ° C.,
The ratio of sample vapor pressure to pure water vapor pressure at 65% relative humidity.

In order to regulate the water activity value to 0.54 or less, it is desirable to adjust the amount of water and mix an inorganic salt that retains the water as water of crystallization. That is, in order to ensure the water activity value of the present invention in a composition in which water, carbonate and / or bicarbonate, an organic acid, and a fragrance component that is further blended as desired, anhydrous magnesium sulfate is blended. Is preferred. Anhydrous magnesium sulfate is water-soluble, and the aqueous solution of the carbon dioxide foam tablet is transparent, and hardly produces insoluble matter. It should be noted that although quick lime and hemihydrate gypsum have a similar effect, they are insoluble in water and become turbid or precipitate after dissolution in water, but their use is not excluded.

The magnesium sulfate is magnesium sulfate having a pentahydrate or less, preferably, a monohydrate having a ratio of 50%.
The following anhydrous magnesium sulfate is desirable. If the salt is 6 or more, the function of adjusting the water activity value may be significantly reduced.

Here, the use of magnesium sulfate prevents the stickiness of the powder generated due to the blending of the fragrance, improves the powder fluidity at the time of tableting, and prevents the powder from adhering to the punch and die during tableting. It is also preferable from the viewpoint of preventing and maintaining good solubility in water during use.

That is, an effervescent tablet is formed into a tablet by putting a certain amount of powder into a cylindrical portion generally called a die and pressing with a punch. Industrially, tableting is performed continuously, but when the fluidity of the powder composition is low, the filling amount of the powder into the mortar varies, and a constant tablet weight cannot be obtained. Occurs. The addition of liquid fragrances and essential oils may cause stickiness of the powder, stick to punches and dies during tableting, cause irregularities on the surface of the tableted formulation, and reduce weight. In an extreme case, there is a problem that the tablet cannot be removed with the punch attached. To prevent these, flow improvers are used, and hydroxymethyl cellulose, urea, calcium silicate, and cyclodextrin are known. In particular, with respect to hydrophobic liquid substances such as fragrances and essential oils, porous calcium sulfate having a large surface area and cyclodextrin as an inclusion compound are highly effective in retaining fragrances and preventing stickiness of powder. However, since the solubility in water is low, there is a problem that when the tablet is dissolved in water at the time of use, the transparency of the liquid is impaired, and insolubles adhere to the container and become dirty. In particular, 1L such as a cup
In indoor fragrances used by dissolving in a small amount of water in the following containers, water-insoluble flow improvers are restricted in terms of formulation,
There is a problem that a large amount of fragrance cannot be blended. In order to solve this problem, a fluidity improver that is water-soluble and can suppress powder stickiness due to blending of a hydrophobic liquid such as a fragrance without impairing the transparency of the liquid after dissolving the tablet is desired. However, by adding magnesium sulfate to the powder composition, it is possible to reduce the fluidity of the powder due to the addition of a hydrophobic liquid such as a fragrance and to improve the adhesion of the powder to a punch and a die during tableting. It was confirmed that the solubility when using the tablet in water and the transparency of the liquid after dissolution were not impaired.

It is preferable that the content of magnesium sulfate is 5% by mass or more and 40% by mass or less from the viewpoint that the above effects can be effectively exhibited.

When a pigment is added to the tablet composition of the present invention,
It is colored when foamed and dissolved in water, and you can enjoy the color with the scent. The pigment is not particularly limited, but is preferably a water-soluble direct dye, acid dye, or disperse dye.

Further, the tablet composition of the present invention may contain components conventionally used in various tablets, for example, sodium sulfate and the like.

The tablet composition of the present invention is preferably packaged and stored in a packaging material. In this case, the water vapor permeability of the tablet packaging material used in the present invention is 40 ° C., 80 to 80 ° C.
It is preferably 0.6 g / m ² · day or less under the condition of 100% RH. If the composition has a water vapor permeability exceeding this condition, the composition absorbs moisture and the water activity value increases during storage, and the carbonic acid content increases. Decomposition into gas may occur, causing the packaging container to swell or burst. Examples of the film exhibiting the water vapor permeability of the present invention include an aluminum laminated film, and examples of the film having transparency include a PET (polyethylene terephthalate) film subjected to a glass vapor deposition treatment.

The method for producing the tablet composition of the present invention includes:
A stabilizing inorganic salt such as a carbonate, a surfactant, and sodium sulfate is put in a mixing tank and mixed, and a fragrance and water are sprayed with stirring. Thereafter, a method in which an organic acid, magnesium sulfate, and polyethylene glycol are added and mixed is tabletted with a tableting machine, and then packaged with a film so as not to absorb moisture.

[0031]

The tablet composition of the present invention has high stability,
When packaged in a packaging material, it is possible to prevent the packaging material from swelling due to carbon dioxide generation.

[0032]

EXAMPLES The present invention will be described below in detail with reference to examples and comparative examples, but the present invention is not limited to the following examples.

Examples 1 to 19 and Comparative Examples 1 to 5
In order to examine the relationship between the water activity value of the fragrance composition, the swelling of the packaging material due to the generation of carbon dioxide gas during storage, and the tableting property during tablet molding, the samples with different water activity values were used in the following method. It was prepared by adjusting the water content of the composition (tablet).

Sample Preparation In a constant temperature and humidity room at 10 ° C. and 50% RH (low humidity condition),
To a small Henschel mixer (10 L capacity), carbonates, sodium sulfate, and dyes were added in order, calculated and weighed so that the total amount was 5 kg at the mixing ratios in Tables 1 to 3, and mixed at low speed for 1 minute while stirring, and the surface activity was increased. Agents and fragrances dispersed in water were sprayed.

Thereafter, a predetermined amount of an organic acid, polyethylene glycol and magnesium sulfate were newly added and mixed for several minutes, and stored in an aluminum laminated film to obtain a powder sample. Further, within 3 hours after preparing the powder sample, 20 kg of the powder sample was tableted using a continuous rotary tableting machine. In this case, 200 r for 1 minute so that the thickness after compression into a cylindrical shape having a filling amount of 20 g and a diameter of 35 mmφ is within 14 mm.
Tableting was performed at a tableting speed of pm. Within 1 hour after tableting, silica-deposited PET film (GL-AE manufactured by Toppan Printing Co., Ltd .;
Water vapor transmission rate at 40 ° C. and 90% RH: 0.58 g /
(m ² · day). For some samples, the temperature and humidity of the constant temperature and humidity chamber were 25 ° C and 65%.
It was manufactured as RH (high humidity condition).

[0036]

[Table 1]

[0037]

[Table 2]

[0038]

[Table 3] Sodium carbonate: Tosoh Corporation Light soda ash Surfactant: Polyoxyethylene (9) secondary alkyl ether Dye: Yellow No. 4 Fragrance: Bergamot essential oil Magnesium sulfate: Ako Kasei Co., Ltd. anhydrous magnesium sulfate MG-OK Sodium sulfate ： Shikoku Chemicals Co., Ltd. BOWSHOW AOP Polyethylene glycol: Nippon Oil & Fats Co., Ltd. PEG400
0P

Here, the water equivalent amount and the water activity value were measured by the following methods.

(1) Measurement of Moisture Equivalent Content The moisture content of the sample was determined by measuring the water content of each raw material and calculating from the mixing ratio to obtain the moisture equivalent. Note that DT
According to the A-TG simultaneous analysis, magnesium sulfate was 400
The loss on drying at 3 ° C. for 3 hours was defined as the water content of sodium carbonate and sodium sulfate at 105 ° C. for 2 hours. Further, dl-malic acid, surfactant, polyethylene glycol, coloring matter, and fragrance were measured by the Karl Fischer method. Sodium bicarbonate was determined from the loss on drying when dried in a desiccator (sulfuric acid) for 4 hours.

(2) Measurement of water activity value Using a water activity measurement system DT type manufactured by Rotronics,
The water activity value was measured after opening the package enclosed in a moisture-proof film in a thermo-hygrostat at 25 ± 1 ° C. and 65 ± 5% RH, and the average of the results obtained by measuring 5 samples per sample was taken. The value was used as the water activity value.

Next, the storage stability of the samples (tablets) packaged with the respective moisture-proof films obtained above was evaluated by the following method.

Storage stability (swelling and breakage of packaging material due to generation of carbon dioxide gas during storage) A sample enclosed in a moisture-proof film was subjected to (A) 40 ° C., 75%
(B) 45 days a day in a constant temperature and constant temperature bath at RH for 6 months.
° C, 85% RH, 12 hours, 25 ° C, 65% RH, 12
40 cycles in a room where temperature and humidity change
(C) Store 5 samples at a time in a constant temperature and humidity chamber of 50 ° C and 80% RH for 3 months (recycling test) for 3 months. It was examined and evaluated according to the following criteria. The presence or absence of swelling is visually evaluated after storage at room temperature for 2 hours. If the packaging material is damaged by foaming, the presence or absence of bubbles when the packaging sample is placed in water and subjected to a reduced pressure of 0.8 hP. Was visually determined. (Judgment criteria) ：: No swelling or breakage of the packaging material was observed under any conditions. Δ: No damage was observed under any of the conditions. However,
Although not noticeable, swelling of the packaging material occurs. ×: Remarkable swelling of the packaging material occurs under any of the conditions.
Or breakage occurs.

The results are shown in Tables 4 and 5. FIG. 1 shows the relationship between the water activity value / water equivalent amount and the stability based on the results of Tables 4 and 5.

[0045]

[Table 4]

[0046]

[Table 5]

As shown in Tables 4 and 5, there is no correlation between the water activity value and the water equivalent amount. It can be seen that swelling occurs when the water activity value is higher than 0.54, which is highly related to the activity value.

Examples 20 to 24, Comparative Examples 6 to 14 A fragrance composition (tablet) having the following formulation was prepared by the following method. Formulation Sodium carbonate 21.7% dl-malic acid 28.3 Surfactant 0.075 Dye 0.001 Fragrance 0.5-1.0 Superplasticizer 0-45 Water 0.5 Polyethylene glycol 3.0 Sodium sulfate Balance Total 100.0% (Note) Sodium carbonate: Tosoh Corp. light soda ash Surfactant: Polyoxyethylene (9) secondary alkyl ether Dye: Yellow No. 4 Fragrance: Bergamot essential oil, rose essential oil Superplasticizer: Sulfuric acid Magnesium: Ako Kasei Co., Ltd. Anhydrous magnesium sulfate MG-OK Hydroxypropylcellulose cyclodextrin urea Calcium silicate: Florite Polyethylene glycol: Nippon Yushi PEG 4000P Sodium sulfate: Shikoku Chemicals Co., Ltd.

Sample Preparation In a constant temperature and humidity room at 10 ° C. and 50% RH (low humidity condition),
To a small Henschel mixer (10 L capacity), the carbonate, sodium sulfate, and the dye, which were calculated and weighed so that the total amount was 5 kg at the above mixing ratio, were sequentially added, and while mixing and stirring at low speed for 1 minute, the surfactant and the fragrance were added. The dispersion in water was sprayed.

Thereafter, a predetermined amount of an organic acid, polyethylene glycol and magnesium sulfate were newly added, mixed for several minutes, and stored in an aluminum laminated film to obtain a powder sample. Further, within 3 hours after preparing the powder sample, 20 kg of the powder sample was tableted using a continuous rotary tableting machine. In this case, 200 rpm for one minute so that the thickness after compression into a cylindrical shape with a filling amount of 20 g and a diameter of 35 mmφ is within 14 mm.
Tableting was performed at a tableting speed of m. Within 1 hour after tableting, a predetermined aluminum laminated film (silica-deposited PET film, GL-AE manufactured by Toppan Printing Co., Ltd .; water vapor transmission rate at 40 ° C., 90% RH: 0.58 g / m ² · day) And packaged with heat sealing.

In this case, the fluidity, weighing property and tableting property at the time of preparing the sample were evaluated by the following method, and the solubility of the tablet was evaluated by the following method. The results are shown in Tables 6 and 7.

(1) Fluidity The fluidity of the powder was measured using a three-wheeled cylinder rotation method repose angle measuring instrument manufactured by Tsutsui Physical and Chemical Instruments Co., Ltd., at a constant temperature and humidity of 20 ° C. and 50% RH and a diameter of 5 cm. 50 g of powder was placed in a 100 ml cylindrical bottle with a lid, and rotated at a speed of 3 rotations for 1 minute, and the inclination angle of the resulting powder was measured as a flow angle of repose. The powder having a flow angle of repose of 60 degrees or less with this device has no stickiness to the powder, has good flowability, and has a reduced flowability when the powder is supplied to a die of a rotary continuous tableting machine described below. Since it was confirmed that there was no variation in the weighing property without performing the measurement, the one showing the flow angle of repose in this range was marked with “○”, and the one exceeding 60 ° showed variability in measurement,
Since it was remarkable at a temperature of at least 70 ° C., it was evaluated as Δ when the temperature exceeded 60 ° and 70 ° or less, and × when the temperature exceeded 70 °.

(2) Measurability Under a condition of 10 ° C. and 50% RH, 20 kg of sample powder is put into a feeder, and three specific sets of a rotary continuous tableting machine capable of tableting 18 tablets per rotation. Seal with rubber stopper except for mortar,
It was adjusted so that only three tablets could be made in one rotation. The tablet was rotated at a speed of 12 rotations per minute, and the weight of 100 tablets was measured from 10 minutes to 13 minutes after the operation for 20 minutes. ○, ± 0.5 g when the weight of 100 tablets is within ± 0.5 g with respect to the set weight of 20.0 g per tablet.
Was judged as △ when 1 or 2 pieces were exceeded, and as × when 3 or more pieces were exceeded.

(3) Evaluation of tableting performance Under a condition of 20 ° C. and 50% RH, a rotary continuous tableting machine capable of tableting 18 tablets at a speed of 12 revolutions per minute was used.
The adhesion and appearance to the specified three sets of punches and dies after continuous tableting for 10 minutes were evaluated, and the tableting properties over 20 minutes were evaluated according to the following criteria. ：: No noticeable adhesion to punches and dies was observed, and no noticeable unevenness was observed on the tablet surface. Δ: At least one of adhesion to a punch and a die, and irregularities on the tablet surface is recognized, but slight. X: At least one of adhesion to a punch and a die or irregularities on the tablet surface is observed, and the degree is remarkable.

(4) Solubility The tablets were taken out of the package, placed in a 300 ml beaker containing water of 150 ml at 20 ° C., and foamed and dissolved.
The solution was allowed to stand at room temperature and observed 24 hours later, and visually evaluated according to the following criteria. ：: No insoluble matter was observed, and the liquid was transparent. Δ: Some insolubles precipitated or floated. Or the liquid is cloudy and not transparent. X: Many insolubles are observed. Or the liquid is extremely cloudy.

[0056]

[Table 6]

[0057]

[Table 7] HPC: hydroxypropylcellulose CD: cyclodextrin

[Brief description of the drawings]

FIG. 1 is a graph showing the degree of stability of a tablet in relation to the water activity value of a flavor composition (tablet) and the amount of water equivalent.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Shiro Nakano 1-3-7 Honjo, Sumida-ku, Tokyo Inside Lion Corporation (72) Inventor Hiroko Tsukamoto 1-3-7, Honjo, Sumida-ku, Tokyo F-term in Lion Corporation (reference) 4C080 AA04 BB02 BB03 CC01 HH05 JJ03 KK03 LL09 MM11 MM12 MM13 MM14 MM15 MM16 MM17 MM18 NN01 NN14 QQ20 4H011 AA02 AA03 BA01 BB22 BC06 BC03 DA03 DB03 DC05 DC03 DC03 DC03 DC03 DC03 BC10 BC23 CA56 CA99 DA15 EA31 EA36

Claims (4)

[Claims] 1. It contains a carbonate and / or bicarbonate, an organic acid and water, and has a water activity value of 0.54 at 25 ° C.
A tablet composition comprising: 2. The tablet composition according to claim 1, which is packaged in a packaging material having a water vapor transmission rate of 0.6 g / m ² · day or less at 40 ° C. and 80 to 100% relative humidity. 3. The tablet composition according to claim 1, which comprises magnesium sulfate. 4. The tablet composition according to claim 1, which contains a fragrance component and is for room aroma.