JP2001139442A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a liquid composition for the oral cavity capable of eliminating a stiff feeling in the mouth after use and good in feeling of use. SOLUTION: This liquid composition for the oral cavity is characterized as comprising a cationic polymer, a cationic bactericide and a polyhydric alcohol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid oral composition containing a cationic polymer and a cationic bactericide and having a good feeling in use.

[0002]

2. Description of the Related Art Conventionally, a technique for improving the retention of a drug in the oral cavity and suppressing plaque formation, and a technique for coating a tooth surface with a specific drug or the like have been proposed. Techniques for suppressing bacterial adhesion have been studied, and the following proposals have been made. An oral composition comprising a cationic polymer and a non-cationic antibacterial agent (JP-A-10-17446). An oral composition containing polyvinylpyrrolidone (Japanese Patent Application Laid-Open No. 7-509216).

[0003] As described above, conventionally, a cationic polymer is mainly blended into an oral composition to coat a tooth surface, or to retain a non-cationic disinfectant or a cationic disinfectant on the tooth surface. Research has been carried out on technologies to improve the appearance of plaque, which is an important factor in oral diseases such as dental caries and periodontal disease, by suppressing the adhesion of oral bacteria to the tooth surface, Techniques for preventing oral diseases by blending a polymer and a cationic bactericide are known.

[0004] However, an oral composition containing a cationic polymer and a cationic bactericide has a unique strong stiffness on the oral mucosa after use. These are not mentioned in the above study,
This unique strong feeling of stiffness, considering the usual use of mouthwash and brushing for the prevention of oral diseases,
Since it causes discomfort and discomfort after use, there is a major problem in use, and it is not suitable for daily oral care.

[0005] Therefore, there is a demand for a product having a good feeling of use, which eliminates the feeling of stiffness after use.

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and provides a liquid oral composition containing a cationic polymer and a cationic bactericide, which has a high feeling of use, eliminating the feeling of stiffness in the mouth after use. The purpose is to provide.

[0007]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, have found that a polyhydric alcohol is used in combination with a cationic polymer and a cationic germicide. As a result, the present inventors have found that a strong rough feeling on the oral mucosa and the like can be eliminated, and a useful liquid oral composition having a good feeling in use can be obtained, and the present invention has been accomplished.

Hereinafter, the present invention will be described in further detail. The liquid oral composition of the present invention is characterized by containing a cationic polymer, a cationic bactericide and a polyhydric alcohol.

As the cationic polymer, cationized dextran, cationized cellulose, cationized polyvinylpyrrolidone, cationized polyamide, cationized polymethacrylate, cationized polyacrylamide,
Copolymers of cationized polymethacrylate and acrylamide, cationized starch, cationized amylose, cationized guar gum, cationized agar and the like are used.

As the cationized dextran, those having a nitrogen content of 0.5 to 3% (mass percentage, the same applies hereinafter) are preferable, and specifically, cationized dextran CDC-L, manufactured by Meito Sangyo Co., Ltd. CDC-3M, CDC-H and the like.

As the cationized cellulose, those having a nitrogen content of 1 to 2.5% are good, and specifically, Leogard G, GP, GPS, KGP, M manufactured by Lion Corporation.
GP, MLP, Polymer JR-125, JR-400, JR-3 manufactured by Union Carbide Corporation
0M, Cell Coat L-20 manufactured by NSC Japan
0, H-100 and the like.

As the cationized polyvinyl pyrrolidone, G.P. A. GA Corporation's GAFQUAT
743, 745. Examples of the cationized polyamide include Hymoloc Q-101 manufactured by Kyoritsu Organic Co., Ltd., and examples of the cationized polymethacrylate include Sumifloc FC-A and FC-B manufactured by Sumitomo Chemical Co., Ltd., and cationized polyacrylamide. As Sanfloc C-450 and C-454 manufactured by Sanyo Chemical Industry Co., Ltd .; Hymoloc M-966 manufactured by Kyoritsu Organic Co., Ltd .;
Examples of L, cationized polyacrylamide, and a copolymer of cationized polymethacrylate and acrylamide include Hymoloc MP-373 manufactured by Kyoritsu Organic Co., Ltd., and Sumifloc FC-200 and FC-C manufactured by Sumitomo Chemical Co., Ltd. These cationic polymers may be used alone or in combination of two or more.

The amount of the cationic polymer is 0.0025 to 2% of the total composition, preferably 0.005 to 0.5%.
5% is desirable. If it is less than 0.0025%, a sufficient plaque formation inhibitory effect may not be obtained, and if it exceeds 2%, the viscosity may be increased to make the compounding difficult, and the rough feeling may not be eliminated.

[0014] Cationic fungicides include alkylpyridinium salts, monolong chain alkyltri short chain alkylammonium salts, monolong chain alkyldi short chain alkylbenzylammonium salts, alkylphenylethoxyethyl dishort chain alkylbenzylammonium salts, and chlorhexidine salts. And the like. As alkylpyridinium salts, cetylpyridinium salts, laurylpyridinium salts, etc., as mono-long-chain alkyltri-short-chain alkylammonium salts, lauryltrimethylammonium salts,
Examples of mono-long-chain alkyldi-short-chain alkylbenzylammonium salts such as myristyltrimethylammonium salt and cetyltrimethylammonium salt include lauryldimethylbenzylammonium salt, benzalkonium salt and stearyldimethylbenzylammonium salt, and alkylphenylethoxyethyldishort-chain alkyl. The benzylammonium salt includes benzethonium salt and the like, and the chlorhexidine salt includes chlorhexidine gluconate and chlorhexidine hydrochloride. These salts include chloride, bromide and iodide. These cationic fungicides can be used alone or in combination of two or more.

The amount of the cationic bactericide is preferably 0.001 to 1%, more preferably 0.01 to 0.5% of the whole composition. If it is less than 0.001%, a sufficient plaque formation inhibitory effect may not be obtained, and if it exceeds 1%, oral irritation or bitterness may be caused.

The polyhydric alcohols include glycerin, propylene glycol, polyethylene glycol and the like, and also sorbitol, xylitol, maltitol,
Sugar alcohols such as erythritol, mannitol and lactitol can be blended. These polyhydric alcohols can be used alone or in combination of two or more.

In particular, glycerin, which is a trihydric alcohol,
It is preferable to mix one or more of sorbitol and xylitol which are sugar alcohols.

The compounding amount of the polyhydric alcohol is desirably 0.5 to 40%, particularly preferably 1.0 to 30% of the whole composition. 0.
If it is less than 5%, it may not be possible to eliminate the rough feeling on the oral mucosa, and if it is more than 40%,
Stickiness after use may occur, and the feeling of use may deteriorate. The blending amount of the polyhydric alcohol having the best feeling in use is 1 to 15% of the whole composition.

The liquid oral composition of the present invention comprises a liquid dentifrice,
Mouthwash, mouth freshener, can be prepared and applied as a concentrated type mouthwash, but the oral composition of the present invention, in addition to the above-mentioned components, may be appropriately used usually according to the dosage form. Optional ingredients can be blended, for example, thickeners, pH adjusters, preservatives, sweeteners, surfactants, flavors,
A coloring agent and the like can be blended.

As thickeners, xanthan gum, carrageenan, sodium carboxymethylcellulose, hydroxyethylcellulose, sodium alginate, polyvinyl alcohol, etc., and as pH adjusters, citric acid and its salts, phosphoric acid and its salts, carbonic acid and its salts,
Organic acids and salts thereof, such as malic acid and salts thereof, acetic acid and salts thereof, saccharin sodium and stevioside as sweeteners, and parabens as preservatives can be added.

Further, as the non-cationic antibacterial agent, halogenated diphenyl ethers such as triclosan, halogenated salicylanilide, halogenated carbanilide, organic acid esters, phenolic compounds and the like can be blended.
In addition, active ingredients such as tranexamic acid, dextranase, protease, mutanase, lysozyme, glycyrrhizin salts, glycyrrhetin salts, and vitamins can be blended.

Further, as a surfactant, a betaine acetate-type amphoteric surfactant such as alkyldimethylamide betaine acetate, N-fatty acid acyl-N-carboxymethyl-N-
Imidazoline-type amphoteric surfactants such as hydroxyethylethylenediamine salt, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester,
Non-ionic surfactants such as polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, and polyoxyethylene polyoxypropylene copolymer can be added.

As the fragrance, peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, Mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris Natural flavors such as concrete, absolute peppermint, absolute rose and orange flower, and menthol, carvone, anethole, cineole, methyl salicylate, cinamic aldehyde, eugenol, thymol, linalool, linal acetate, limonene, melon Ton, menthyl acetate,
Pinene, octylaldehyde, citral, pulegone,
Single flavors such as Calvir acetate and anisaldehyde, and further, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methylanthranilate, ethylmethylphenylglycidate, vanillin,
Undecalactone, hexanal, ethyl alcohol,
Strawberry flavor, which is a compounded flavor containing single flavor and / or natural flavor such as propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate,
Known flavors used in oral compositions such as apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, tropical fruit flavor, butter flavor, milk flavor, and fruit mix flavor can be used. Not limited to fragrances. The blending amount is not particularly limited, but it is preferable to use 0.000001 to 1% of the above-mentioned fragrance material in the composition as in many known examples. In addition, it is preferable to use 0.05 to 2.0% as a flavoring perfume prepared by mixing the above flavoring materials in the composition.

In each case, the conventionally used components can be used at ordinary doses.

The pH of the oral composition of the present invention is usually from 4.5 to 9.0.

[0026]

EFFECT OF THE INVENTION The composition for liquid oral cavity of the present invention has a good feeling in use since the feeling in the mouth after use is eliminated.

[0027]

EXAMPLES The present invention will be specifically described below with reference to experimental examples and examples, but the present invention is not limited to the following examples.

[Experimental Example] As an experiment for eliminating the feeling of stiffness in the mouth after use, the components shown in Table 1 were subjected to human use tests according to the following methods and evaluated. Table 1 shows the results. (Method) (1) Eating and drinking and oral cleaning after dinner on the day before the test were stopped, and the test was performed from 9:00 am on the day of the test. (2) About 5 ml of a liquid dentifrice containing the components shown in Table 1 was put in the mouth, and brushing was carried out for 2 minutes using the usual method. (3) After brushing and discharging, add about 10 ml of liquid toothpaste
The mouth was washed for 0 seconds. (4) After the ejection, a sensory evaluation was made on the feeling of rough in the mouth according to the following evaluation criteria. (Evaluation Criteria) Evaluation of Roughness in Mouth 5 Points: No Roughness 4 Points: Little Roughness 3 Points: Neither Can Two Points: Somewhat Roughness 1 Point: Roughness 1

[0029]

[Table 1]

From the results shown in Table 1, the liquid oral composition of the present invention containing a cationic polymer, a cationic bactericide and a polyhydric alcohol eliminates the stiffness in the mouth and has a good feeling in use. It was confirmed that it was a thing.

An embodiment will be described below. In addition, all% in each example is a mass percentage. The fragrance in the examples,
Fragrances having the formulations shown in Table 2 were prepared, and the compounding amounts shown in each example were imparted.

[0032]

[Table 2]

Example 1 Mouthwash Cationized dextran (CDC-H) 0.01% chlorhexidine gluconate 0.01 sorbitol 5 ethanol 5 citric acid 0.05 sodium citrate 0.3 stevia 0.01 glycyrrhizic acid Dipotassium 0.02 Polyoxyethylene polyoxypropylene block polymer 0.8 Perfume B 0.3 Water Balance meter 100.0%

Example 2 Mouthwash Cationized cellulose (Cellcoat L-200) 0.05% Benzalkonium chloride 0.02 Glycerin 8 Ethanol 8 Disodium hydrogen phosphate 0.05 Sodium dihydrogen phosphate 0. 3 Stevia 0.01 Sodium ascorbate 0.1 Polyoxyethylene hydrogenated castor oil (EO60) 0.2 Fragrance A 0.1 Water Balance meter 100.0%

Example 3 Liquid Toothpaste Cationized Cellulose (Cellcoat L-200) 0.05% Cetylpyridinium Chloride 0.05 Glycerin 10 Ethanol 10 Citric Acid 0.05 Sodium Citrate 0.3 Stevia 0.01 Tranexamic Acid 0.05 Polyoxyethylene cetyl ether (EO20) 0.2 Fragrance A 0.5 Water Balance meter 100.0%

Example 4 Liquid Toothpaste Cationized Cellulose (Cellcoat L-200) 0.1% Benzethonium Chloride 0.02 Glycerin 12 Ethanol 8 Citric Acid 0.05 Sodium Dihydrogen Phosphate 0.3 Stevia 0.01 Poly Oxyethylene hydrogenated castor oil (EO60) 0.2 Perfume A 0.1 Water Balance meter 100.0%

Example 5 Mouthwash Cationized Cellulose (Cellcoat L-200) 0.01% Benzalkonium chloride 0.01 Glycerin 2 Xylitol 10 Ethanol 8 Saccharin sodium 0.002 Sodium bicarbonate 0.5 Sodium hydroxide 0.1 Sodium fluoride 0.2 Perfume C 0.3 Water Balance meter 100.0%

Example 6 Mouthwash Cationized cellulose (Cellcoat L-200) 0.1% Benzalkonium chloride 0.08 Glycerin 5 Sorbitol 3 Saccharin sodium 0.01 Citric acid 0.5 Sodium hydroxide 0.1 Polyoxyethylene hydrogenated castor oil (EO40) 0.2 dextranase 0.18 mutanase 0.15 fragrance D 0.2 water balance meter 100.0%

Example 7 Concentrated Mouthwash Cationic Dextran (CDC-H) 1.5% Cetylpyridinium Chloride 0.1 Glycerin 20 Ethanol 30 Tocopherol Acetate 0.3 Saccharin Sodium 0.05 Malic Acid 1 Sodium Malate 1.5 Polyoxyethylene lauryl ether (EO20) 2 Triclosan 0.1 Fragrance E 1.0 Water Balance meter 100.0%

Example 8 Mouth Refresher Cationized Cellulose (Leogard GP) 1.0% Chlorhexidine Gluconate 0.05 Glycerin 12 Sorbitol 10 Saccharin Sodium 0.01 Sodium Bicarbonate 0.5 Sodium Carbonate 0.1 Polyoxyethylene Hardened castor oil (EO60) 0.2 Ethanol 45 Propylene glycol 0.5 Perfume B 1.5 Water Balance meter 100.0%

Example 9 Mouthwash Ethanol 5.5% Glycerin 4.0 Citric Acid 0.02 Sodium Citrate 0.15 Stevia 0.01 Cetylpyridinium Chloride 0.05 Stearyl Dimethylbenzylammonium 0.015 Cation cellulose (Serukoto L-200) 0.015 polyoxyethylene cetyl ether (EO20) 0.15 tranexamic acid 0.05 perfume C 0.3 water remaining 100.0%

Example 10 Mouthwash Ethanol 7.0% Glycerin 1.0 Xylitol 0.5 Sodium Citrate 0.15 Stevia 0.01 Cetylpyridinium Chloride 0.05 Stearyl Dimethylbenzylammonium Chloride 0.01 Cationization cellulose (Serukoto L-200) 0.02 polyoxyethylene hardened castor oil (EO60) 0.2 tranexamic acid 0.05 perfume A 0.3 water remaining 100.0%

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Takao Yokoo 1-3-7, Honjo, Sumida-ku, Tokyo F-term in Lion Corporation (reference) 4C083 AA112 AA122 AB292 AB322 AC102 AC111 AC122 AC132 AC302 AC432 AC622 AC692 AC742 AC812 AC862 AD052 AD131 AD132 AD242 AD472 AD532 AD642 AD662 BB41 BB48

Claims (1)

[Claims] 1. A liquid oral composition comprising a cationic polymer, a cationic bactericide and a polyhydric alcohol.