JP2001131081A - Eraser of superoxide and drink - Google Patents

Eraser of superoxide and drink

Info

Publication number
JP2001131081A
JP2001131081A JP31790299A JP31790299A JP2001131081A JP 2001131081 A JP2001131081 A JP 2001131081A JP 31790299 A JP31790299 A JP 31790299A JP 31790299 A JP31790299 A JP 31790299A JP 2001131081 A JP2001131081 A JP 2001131081A
Authority
JP
Japan
Prior art keywords
superoxide
yeast
scavenger
broth
drink
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP31790299A
Other languages
Japanese (ja)
Inventor
Eizo Ito
栄三 伊東
Naoki Ito
直樹 伊東
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHINEI FERUMENTEKKU KK
Original Assignee
SHINEI FERUMENTEKKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHINEI FERUMENTEKKU KK filed Critical SHINEI FERUMENTEKKU KK
Priority to JP31790299A priority Critical patent/JP2001131081A/en
Publication of JP2001131081A publication Critical patent/JP2001131081A/en
Priority to US09/929,066 priority patent/US6805887B2/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/66—Proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
    • A23L11/60—Drinks from legumes, e.g. lupine drinks
    • A23L11/65—Soy drinks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Abstract

PROBLEM TO BE SOLVED: To obtain an eraser of a superoxide, not unstable as a conventional superoxide dismutase, and comprising an inexpensively available material, and further to provide a drink. SOLUTION: The eraser of the superoxide, and the drink are characterized by an included component extracted from a liquid obtained by cooling a soup of cereals, adding yeast to the cooled soup, leaving the soup with the yeast while feeding oxygen, and heating and sterilizing the resultant liquid.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【０００１】[0001]

【産業上の利用分野】本発明は、スーパーオキサイド消
去剤および飲料に関するものである。The present invention relates to a superoxide scavenger and a beverage.

【０００２】[0002]

【従来の技術】スーパーオキサイドすなわち酸素分子の
一電子還元で生じるラジカルO２ −は、生体内において
重要な防御因子として作用することが知られている。例
えば、細菌、ウィルス、異物等が生体内に侵入すると好
中球、単球、マクロファージなどの食細胞が活性化して
遊走能や食作用という動的な機能が発現し、その結果ラ
イソゾーム酵素やスーパーオキサイドが産出されて分泌
されるが、これらは貧食物の融解および殺菌に直接又は
間接に関与し、身体を外敵から守る。2. Description of the Related Art It is known that superoxide, that is, a radical O 2 — generated by one-electron reduction of an oxygen molecule, acts as an important protective factor in vivo. For example, when bacteria, viruses, foreign substances, and the like enter the living body, phagocytes such as neutrophils, monocytes, and macrophages are activated, and dynamic functions such as migration ability and phagocytosis are expressed. As a result, lysosomal enzymes and super Oxides are produced and secreted, which are directly or indirectly involved in the melting and disinfection of poor foods and protect the body from foreign enemies.

【０００３】その反面、スーパーオキサイドは、生体内
に過剰に存在すると様々な組織障害をもたらす。通常、
生体内で生成するスーパーオキサイドは、呼吸で吸収さ
れる酸素の約１％以下であり、これが細胞内に含まれて
いるスーパーオキサイドジスムターゼ（SOD）の触媒作
用により逐次消去されているが、老人の身体のように酵
素作用が低下している場合においては消去が不十分にな
ってスーパーオキサイド濃度が高くなり、これが関節リ
ュウマチやベーチェット病などの組織障害や、スーパー
オキサイドまたはそれにより生成する過酸化脂質が原因
の心筋梗塞、脳卒中、白内障、シミ、ソバカス、しわ、
糖尿病、動脈硬化、肩こり、冷え性などを起こす。[0003] On the other hand, superoxide causes various tissue disorders when present in an excessive amount in a living body. Normal,
The amount of superoxide generated in the body is less than about 1% of oxygen absorbed by respiration, which is sequentially eliminated by the catalysis of superoxide dismutase (SOD) contained in cells. In cases where the enzymatic action is reduced, such as in the body, the elimination is insufficient and the superoxide concentration increases, which results in tissue damage such as rheumatoid arthritis and Behcet's disease, and superoxide or the lipid peroxide produced by it. Myocardial infarction, stroke, cataract, spots, freckles, wrinkles,
Causes diabetes, arteriosclerosis, stiff shoulders, and chills.

【０００４】例えば、特許第２６６７９５９号等には、
スーパーオキサイドジスムターゼを含有する化粧品が提
案されている。しかしながら、実際には、スーパーオキ
サイドジスムターゼを含有する化粧品は、この酵素が熱
に不安定で失活しやすいため、また著しく高価であるた
め、成功していない。[0004] For example, Japanese Patent No. 2667959 and the like disclose:
Cosmetics containing superoxide dismutase have been proposed. However, in practice, cosmetics containing superoxide dismutase have been unsuccessful because the enzyme is heat-labile and susceptible to inactivation and is significantly more expensive.

【０００５】スーパーオキサイド消去作用を有する物質
をスーパーオキサイドジスムターゼ以外に求める試みは
特開昭６４−５０８７７号公報に記載されており、そこ
では、黄芬中のバイカレインが利用されている。しかし
ながら、バイカレインは黄芬中に僅かしか含まれておら
ず、これを抽出してもきわめて高価なものとなってしま
う。[0005] An attempt to find a substance having a superoxide scavenging action other than superoxide dismutase is described in JP-A-64-50877, in which baicalein in Huangfen is used. However, baicalein is contained only a little in Huangfen, and its extraction is extremely expensive.

【０００６】[0006]

【発明が解決しようとする課題】本発明の目的は、従来
のスーパーオキサイドジスムターゼのように不安定でな
く、しかも安価に入手できる物質からなるスーパーオキ
サイド消去剤、および飲料を提供することにある。SUMMARY OF THE INVENTION An object of the present invention is to provide a superoxide scavenger comprising a substance which is not as unstable as conventional superoxide dismutase and which can be obtained at low cost, and a beverage.

【０００７】[0007]

【課題を解決するための手段】上記の課題は、下記
（１）〜（５）のいずれかの構成の本発明によって解決
できる。 （１） 穀類の煮汁を冷却した後、酵母を添加し、酸素
を供給しながら放置し、この後加熱殺菌して得た液体か
ら抽出された成分を含むスーパーオキサイド消去剤。 （２） 穀類が豆類である上記（１）のスーパーオキサ
イド消去剤。 （３） 上記（１）または（２）のスーパーオキサイド
消去剤を含有する飲料。 （４） 穀類の煮汁を冷却した後、酵母を添加し、酸素
を供給しながら放置し、この後加熱殺菌して得た液体で
ある飲料。 （５） 穀類が豆類である上記（４）の飲料。The above object can be attained by the present invention having any one of the following constitutions (1) to (5). (1) A superoxide scavenger containing a component extracted from a liquid obtained by cooling a cereal broth, adding yeast, leaving it while supplying oxygen, and then heating and sterilizing. (2) The superoxide scavenger of (1) above, wherein the cereals are beans. (3) A beverage containing the superoxide scavenger of (1) or (2). (4) A drink which is a liquid obtained by cooling cereal broth, adding yeast, leaving oxygen supplied, and then sterilizing by heating. (5) The beverage according to (4), wherein the cereals are beans.

【０００８】[0008]

【発明の効果】本発明のスーパーオキサイド消去剤は、
80℃以上の熱を加えても安定であり、しかも穀類を主た
る原材料としているので従来のスーパーオキサイド消去
剤と比べて安価である。The superoxide scavenger of the present invention comprises:
It is stable even when heated to 80 ° C or higher, and is cheaper than conventional superoxide scavengers because it uses cereals as its main raw material.

【０００９】[0009]

【発明の実施の形態】本発明のスーパーオキサイド消去
剤は、穀類の煮汁を冷却した後、酵母を添加し、酸素を
供給しながら放置し、この後加熱殺菌して得た液体から
抽出された成分を含む。BEST MODE FOR CARRYING OUT THE INVENTION The superoxide scavenger of the present invention was extracted from a liquid obtained by cooling a cereal broth, adding yeast, leaving it to supply oxygen, and then sterilizing by heating. Contains ingredients.

【００１０】本発明のスーパーオキサイド消去剤は、２
O２ −＋２H＋→H２O２＋O２の反応によりスーパーオキ
サイドを消去するものと考えられるが、原料植物体中の
いかなる成分がスーパーオキサイドを消去するのかはま
だ解明されていない。The superoxide scavenger of the present invention comprises 2
It is thought that superoxide is eliminated by the reaction of O 2 − + 2H + → H 2 O 2 + O 2 , but it is not yet clarified which component in the raw material plant eliminates superoxide.

【００１１】本発明のスーパーオキサイド消去剤を製造
するに当たって、用いる穀類としては、マメ、イネ、ム
ギ、トウモロコシ、ヒエアワ、キビなどが好ましい。マ
メとしては、ダイズ、インゲンマメ、アズキ、ナンキン
マメ、ソラマメ、エンドウ、ナタマメ、ササゲなどを好
ましく用いることができる。これら穀類の煮汁は、穀類
１に対して、重量で１〜20倍の水を加え、これを30分以
上、好ましくは30分〜５時間煮沸し、その後、放冷して
得られた液体を濾過することによって得られる。[0011] In producing the superoxide scavenger of the present invention, the cereals to be used are preferably beans, rice, wheat, corn, flower, millet and the like. As the beans, soybeans, kidney beans, adzuki beans, peanuts, broad beans, peas, beans, cowpea, and the like can be preferably used. The cereal broth is obtained by adding 1 to 20 times the weight of water to cereal 1 and boiling it for 30 minutes or more, preferably 30 minutes to 5 hours, and then allowing the liquid obtained by cooling to cool. Obtained by filtration.

【００１２】上記の煮汁に酵母を添加し、そして、この
酵母を添加した煮汁を、酸素を供給しながら１〜６ヶ月
程度放置する。酵母としては、Saccharomyces（サッカ
ロミセス）属に属する酵母等、例えばビール酵母、ワイ
ン酵母、清酒酵母、パン酵母等を用いることが好まし
い。[0012] Yeast is added to the above broth, and the broth to which the yeast has been added is left for about 1 to 6 months while supplying oxygen. As the yeast, yeast belonging to the genus Saccharomyces (Saccharomyces), such as brewer's yeast, wine yeast, sake yeast, and baker's yeast, are preferably used.

【００１３】好ましい態様としては、室温で、まず試験
管に上記煮汁を10ml程度入れ、これに上記酵母を添加し
て、１〜10日放置して第１中間液を得、ついでフラスコ
に上記煮汁を100ml入れ、この煮汁内に上記の第１中間
液を添加して、１〜10日放置して第２中間液を得、最後
に、タンクの中に100リットルの煮汁を入れ、この煮汁
の中に上記の第２中間液を入れて、１〜６ヶ月程度放置
して、スーパーオキサイド消去剤原液を得るのがよい。In a preferred embodiment, at room temperature, about 10 ml of the above-mentioned broth is first put into a test tube, the above-mentioned yeast is added thereto, and the mixture is left for 1 to 10 days to obtain a first intermediate solution. Into the broth, add the first intermediate solution to the broth and leave it for 1 to 10 days to obtain a second intermediate solution. Finally, put 100 liters of broth in the tank, It is preferable to put the above-mentioned second intermediate solution in the container and leave it for about 1 to 6 months to obtain a stock solution of a superoxide scavenger.

【００１４】得られたスーパーオキサイド消去剤原液
を、70〜130℃程度の温度で、２秒〜60分程度加熱して
殺菌する。この殺菌されたスーパーオキサイド消去剤原
液はそのままでもスーパーオキサイド消去剤として用い
ることができるが、必要に応じて濃縮し、さらに減圧乾
燥し、乾燥エキスとして用いる。The obtained stock solution of superoxide erasing agent is sterilized by heating at a temperature of about 70 to 130 ° C. for about 2 seconds to 60 minutes. The sterilized stock solution of superoxide scavenger can be used as it is as a superoxide scavenger, but if necessary, it is concentrated, dried under reduced pressure, and used as a dry extract.

【００１５】本発明の清涼飲料は、上記スーパーオキサ
イド消去剤原液を重量％で１〜10％程度、特に５〜10％
程度含有することが好ましい。The soft drink of the present invention comprises the above-mentioned stock solution of superoxide scavenger in an amount of about 1 to 10% by weight, particularly 5 to 10%.
It is preferable to contain it.

【００１６】[0016]

【実施例】本スーパーオキサイド消去剤を製造するにあ
たって、穀類としては、マメである大豆を選択した。ま
ず、大豆600gを300リットルの水につけ、10時間放置し
た。この後、100リットルの水を加えて、鍋で５時間煮
沸した。この後、自然に冷却して、大豆を取り除き、約
200リットルの煮汁を得た。EXAMPLES In producing this superoxide scavenger, soybeans, which are beans, were selected as cereals. First, 600 g of soybeans were immersed in 300 liters of water and left for 10 hours. Thereafter, 100 liters of water was added, and the mixture was boiled in a pan for 5 hours. After this, cool naturally and remove the soybeans, about
200 liters of broth were obtained.

【００１７】この煮汁10mlを試験管に入れ、これに清酒
酵母を添加し、室温にて２日間放置して第１中間液を得
た。このとき、ときどき撹拌して、液内に酸素を供給し
た。10 ml of this broth was placed in a test tube, and sake yeast was added thereto, and the mixture was left at room temperature for 2 days to obtain a first intermediate liquid. At this time, the mixture was stirred occasionally to supply oxygen into the liquid.

【００１８】ついで、上記の煮汁100mlをフラスコ内に
入れ、これに上記の第１中間液を添加し、室温にて２日
間放置して、第２中間液を得た。このときも、液をとき
どき撹拌して酸素を供給した。ついで、得られた第２中
間液を残りの煮汁内に入れ、１ヶ月間放置した。このと
きも液をときどき撹拌して酸素を供給した。Next, 100 ml of the above-mentioned broth was placed in a flask, the first intermediate solution was added thereto, and the mixture was left at room temperature for 2 days to obtain a second intermediate solution. Also at this time, the liquid was stirred occasionally to supply oxygen. Then, the obtained second intermediate liquid was put into the remaining broth and left for one month. At this time, the liquid was stirred occasionally to supply oxygen.

【００１９】得られた液体を、保健所指導の食品の加熱
殺菌法に従い、85℃で、30分加熱して殺菌して、本発明
のスーパーオキサイド消去剤原液を得た。以上のように
して得られたスーパーオキサイド消去剤原液を用いて、
下記のようにしてスーパーオキサイド消去活性を求め
た。The obtained liquid was sterilized by heating at 85 ° C. for 30 minutes according to the heat sterilization method for foods instructed by public health centers to obtain a stock solution of a superoxide scavenger of the present invention. Using the stock solution of superoxide quencher obtained as described above,
The superoxide erasing activity was determined as follows.

【００２０】１．測定法 ヒポキサンチン−キサンチンオキシダーゼ系でスーパー
オキサイド（活性酸素）を発生させ、これに測定する試
料を添加し、スピントラップ法を用いて得られたESR
（電子スピン共鳴）スペクトルの信号強度からスーパー
オキサイド消去活性（SOSA）を求めた。なお、金属不純
物除去のため、DETAPAC（di-ethylene triamine penta
acetic acid）を添加した。 ２．測定機器と測定条件 日本電子製ESR JES−REIXを使用し下記の条件で測定し
た。 観 測 磁 場：３３５．４±５ｍＴ マイクロ波出力 ： ８ｍＷ 磁 場 変 調 幅： ０．０７９ｍＴ 掃 引 時 間 ： ２min マイクロ波周波数：１００ｋＨｚ 1. Measurement method Superoxide (active oxygen) is generated by hypoxanthine-xanthine oxidase system, the sample to be measured is added to this, and the ESR obtained by using the spin trap method
Superoxide scavenging activity (SOSA) was determined from the signal intensity of the (electron spin resonance) spectrum. To remove metal impurities, DETAPAC (di-ethylene triamine penta
acetic acid) was added. 2. Measurement equipment and measurement conditions Measurement was performed under the following conditions using JEOL ESR JES-REIX. Observation magnetic field: 335.4 ± 5 mT Microwave output: 8 mW Magnetic field modulation width: 0.079 mT Sweep time: 2 min Microwave frequency: 100 kHz

【００２１】本発明のスーパーオキサイド消去剤原液に
よるSOSA値は、20.1 unit／mlであった。本スーパーオ
キサイド消去活性の測定ではこれまで、水道水0.2 unit
／ml、アルカリイオン水3.8（pH8.0）、5.7（pH9.0）un
it／ml、磁気水3.6 unit／ml等の結果が得られている。
測定の再現性は±0.5 unit／mlであることから、液体同
士で比較した場合、本願のスーパーオキサイド消去剤原
液のスーパーオキサイド消去活性が高いことが確認でき
た。なお、和光純薬製スーパーオキサイドジスムターゼ
（Cu・Zu型SOD）のスーパーオキサイド消去活性は、300
0〜4000unit／mgであるが、液体と固体では現在のとこ
ろ比較できないようである。The SOSA value of the stock solution of the superoxide scavenger of the present invention was 20.1 units / ml. In the measurement of this superoxide scavenging activity, so far 0.2 units of tap water
/ Ml, alkaline ionized water 3.8 (pH 8.0), 5.7 (pH 9.0) un
Results such as it / ml and magnetic water 3.6 unit / ml were obtained.
Since the reproducibility of the measurement was ± 0.5 unit / ml, it was confirmed that the superoxide erasing agent stock solution of the present application had high superoxide erasing activity when compared between the liquids. The superoxide elimination activity of Wako Pure Chemical superoxide dismutase (Cu-Zu type SOD) was 300
It is between 0 and 4000 units / mg, but currently seems incomparable for liquids and solids.

【００２２】以上のスーパーオキサイド消去剤原液のス
ーパーオキサイド消去活性から、該スーパーオキサイド
消去剤原液、もしくはこの原液から抽出されたスーパー
オキサイド消去剤を含有する飲料を定期的に飲用すると
き、体内のスーパーオキサイドを消去し、これにより健
康維持が図れるものと推測される。From the superoxide scavenging activity of the superoxide scavenger stock solution described above, when the superoxide scavenger stock solution or the beverage containing the superoxide scavenger extracted from this stock solution is regularly consumed, the superoxide scavenger in the body is used. It is presumed that oxides are eliminated and that this can maintain health.

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Claims (5)

【特許請求の範囲】[Claims] 【請求項１】 穀類の煮汁を冷却した後、酵母を添加
し、酸素を供給しながら放置し、この後加熱殺菌して得
た液体から抽出された成分を含むスーパーオキサイド消
去剤。1. A superoxide scavenger containing a component extracted from a liquid obtained by cooling a cereal broth, adding yeast, leaving it to supply oxygen, and then sterilizing by heating. 【請求項２】 穀類が豆類である請求項１のスーパーオ
キサイド消去剤。2. The superoxide scavenger according to claim 1, wherein the cereals are beans. 【請求項３】 請求項１または２のスーパーオキサイド
消去剤を含有する飲料。3. A beverage containing the superoxide scavenger of claim 1 or 2. 【請求項４】 穀類の煮汁を冷却した後、酵母を添加
し、酸素を供給しながら放置し、この後加熱殺菌して得
た液体を含有する飲料。4. A beverage containing a liquid obtained by cooling a cereal broth, adding yeast, leaving it to supply oxygen, and then sterilizing by heating. 【請求項５】 穀類が豆類である請求項４の飲料。5. The beverage according to claim 4, wherein the cereals are beans.
JP31790299A 1999-11-09 1999-11-09 Eraser of superoxide and drink Pending JP2001131081A (en)

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