JP2001114628A - Agent for changing color of skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an agent for changing color of the skin, capable of solving an inconvenience and a controversial point occurring in the case of browning the skin of the human body by irradiation with sunlight and artificial ultraviolet rays, etc., and changing the color of the skin of the whole body including the face into a desired brown readily, safely and actively. SOLUTION: This agent for changing color of the skin comprises norbixin as a main component and should be orally administered for each small amount every day.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a skin discoloring agent useful as an oral cosmetic. The skin discoloring agent can easily, safely, and actively change the skin to brown as a healthy color by ingesting orally.

[0002]

2. Description of the Related Art As a recent trend, sunburn is considered to be a symbol of health. This is because people who are active in the field tend to tan easily, and the skin turns brown when sunbathing is long known as one of the health promotion methods. For this reason, as one fashion, the number of people who try to be exposed to direct sunlight or artificial ultraviolet rays to make their skin brown is increasing.
In addition, cosmetics applied to the skin to adjust the color tone,
Widely sold.

However, when the skin is exposed directly to natural sunlight or when the skin is artificially irradiated with ultraviolet rays or the like, the irradiation tends to be passive. For this reason, it is difficult to adjust the color tone, and the desired brown color cannot be obtained in many cases. In particular, in the case of a person whose skin color is relatively white, even if a person wants to tan, the skin often turns red and cannot reach brown. In addition, there are portions that are tanned, portions that are not tanned, and portions that are not tanned, resulting in shading of the skin color.

[0004] In addition, if the skin is irradiated too much, the skin becomes inflamed and irritated, and after a few days, the skin of the skin peels off and its appearance deteriorates. Furthermore, not only these inconveniences, but also excessive exposure to ultraviolet rays, stains,
It is a well-known fact that freckles can cause skin cancer in severe cases. At the same time, it is difficult for a busy person to receive moderately continuous sunlight or artificially irradiate ultraviolet rays or the like.

[0005] For this reason, there has been a demand for a technique capable of easily and safely adjusting the skin color to a brown color as a healthy color and maintaining it as desired.

[0006]

SUMMARY OF THE INVENTION The present invention overcomes the above-mentioned problems in the conventional method and easily, safely, and positively changes the color of the skin of the entire body, including the face, as a healthy color. It is an object of the present invention to provide a skin discoloring agent as a cosmetic that changes the color of the skin.

[0007]

Means for Solving the Problems The present inventor, who has emigrated from Japan to Brazil in South America, has focused on the use of carotenoid pigments obtained from the seeds of Benica (Bixa orellana) to solve the above problems. . In other words, in the past, the Amazon Indians wondered that birds with originally white feathers sometimes turn reddish brown, and after careful observation, they found that they had eaten red alder seeds. It is also said that when Europeans went to explore the Amazon and lived with the Indians, they ate their food together and turned reddish-brown. The inventor himself participated 12 years ago in a poultry farming association in order to strengthen the color of chicken meat by collaborating to grind the almonds into small pieces and add them to the feed.

[0008] Based on such knowledge and experience, the present inventor found that when he took an extract of the seeds of Acacia catechu, the skin color changed. Based on this recognition, as a result of further research, they found that the oral color of norbixin, a kind of carotenoid pigment obtained from red alder seeds, caused the skin to turn brown.
In particular, by appropriately adjusting the dose and the duration of the dose, a desired color tone can be obtained, and by stopping the dose, the skin color can be easily returned to the original skin color. . The present invention has been completed based on such findings.

That is, the gist of the present invention resides in an oral skin discoloring agent characterized by containing norbixin as an essential component. By taking this skin discoloration agent orally, a healthy brown tan (e.g., pale tan, pale yellow-red-brown, light-brown and tan) can be given to the user. Give skin.

[0010] Norbixin is the main pigment component of the water-soluble atner conventionally marketed as an edible pigment. That is, water-soluble annatto is a red-brown to brown liquid, lump, powder or paste-like substance obtained by hydrolyzing a red coating of the seeds of Beninoki, and its main pigment component is an alkali salt of norbixin. (Eg, potassium or sodium salts). The content as norbixin is usually about 1% by weight when the water-soluble annatto is liquid,
It is around 0% by weight (sometimes more). As food coloring, water-soluble annatto is used exclusively,
For example, as a cheese color, it is used for coloring cheese, butter, ice cream, and the like, and particularly for coloring the surface of a wiener sausage because of its excellent dyeing power. Recently, even if absorbed into the body, it has no effect on the human body and has excellent coloring power. Therefore, it has been proposed to use this as a safe toner for electrophotography (Japanese Patent Laid-Open No. Hei 5
-216278).

[0011] As described above, water-soluble annatto is originally used as a coloring agent for food additives and has high safety. And no specific toxicity tests confirmed that no abnormalities or disorders were observed.

[0012] The skin discoloring agent of the present invention may be solely its essential component, norbixin alone, but is usually prepared in an appropriate dosage form together with an acceptable carrier so as to be easily taken orally. The use of water-soluble annatto itself requires the administration of large amounts to achieve the desired discoloration, in which case side effects such as diarrhea and vomiting may be observed, which is not preferred. Therefore, norbixin used as an essential component of the skin discoloring agent of the present invention is substantially pure
(Approximately 95-98%). Norbixin may be an alkali salt, but usually, free norbixin is preferably used.

The skin discoloring agent of the present invention can be prepared into various dosage forms suitable for oral administration, such as powders, granules, tablets, capsules and syrups. Carriers used in these preparations include water, vegetable oil, talc, lactose,
Examples include various substances suitable for oral administration, such as sucrose and corn starch, and, if necessary, various additives such as ascorbic acid, citric acid, tartaric acid, vitamins, and yeast extract. . For example, when preparing a capsule, norbixin may be filled in a hard capsule alone or with a solid carrier such as talc or lactose, or norbixin may be filled in a soft capsule with a liquid carrier such as a vegetable oil such as olive oil or sunflower oil. . The content of norbixin per unit dose is 40% by weight or more.

[0014] The skin discoloring agent of the present invention, in view of its use,
An appropriate dose may be taken at the right time, but it is usually taken orally regularly every day. By appropriately adjusting the dose, the skin of the whole body, including the face, can be easily and safely and actively turned into a pale yellow-red-brown, yellow-brown or pale tan, light brown to dark brown, It can be changed to the color of If you stop taking it, it will fade easily,
Within a few days you can return to your original skin color.

Generally speaking, in an adult weighing 50 to 70 kg, 50 to 800 mg of norbixin per dose
(Especially, 100 to 500 mg) orally every day three times a day in the morning, noon, and evening, changes in blood color on the face and limbs are observed within 5 to 10 days, and about 3
Changes to the desired healthy light tan or tan, light tan or light brown color within a week. At this point, if the dose is reduced to about half and the dose is continued, the healthy color is maintained. In addition, if you stop taking, after stopping, 5-1
You can return to the original background in about 0 days.

As a standard example, taking the case of an adult female (Oriental) weighing 50 kg, generally two or three capsules each containing 300 mg of norbixin (free) per capsule, Dosing is continued orally three times a day in the morning, day, and night. In 5 to 7 days, a change in blood color is observed on the face and limbs, and in about 15 to 20 days, a healthy wheat color is exhibited. When the desired color is reached, the dose can be substantially halved, and if the dose is continued, the color can be maintained. Also, if necessary, the dosage can be appropriately adjusted to change the color to a desired healthy color and maintain it.

The relationship between the dose of the skin discoloring agent of the present invention and the degree of discoloration resulting therefrom largely varies among individuals such as race, age, gender, and weight. In any case, the desired health color is
Since it depends on the preference of the individual, the specific dose of the skin color-changing agent of the present invention may be appropriately determined by the individual taking the drug in consideration of the above general description and the description of the standard examples. In this regard, it is a remarkable advantage that the active ingredient norbixin is an extremely safe substance and does not exert any harmful effects, at least within the range of normal use as the skin discoloring agent according to the present invention. I can say.

[0018]

The following examples are provided to enhance the understanding of the present invention, but the technical scope of the present invention should not be construed as being limited to these examples.

Example 1 (Preparation of pure norbixin) Into 2 L of 0.25 N sodium hydroxide solution at room temperature, 3
Soak the seeds of 00 g of the alder tree without crushing.
Stir for about 20 minutes and stop stirring when the seed surface becomes dark brown. Then, filter with a cloth like gauze,
Separate the seed portion from the norbixin solution. Next, transfer the norbixin solution to another beaker and stir for 0.2
Neutralize with 5N hydrochloric acid solution. Further, when a hydrochloric acid solution is added until pH 2, norbixin crystallizes. The obtained crystallized norbixin mixture is filtered through a filter paper for qualitative analysis, and the norbixin residue is dried in a dryer at 70 to 80 ° C. for about 5 to 8 hours until the water content becomes about 2%. The dried norbixin is ground to form norbixin powder.
As a result, 21 g of pure norbixin (about 95-98%)
Is obtained.

Example 2 (Preparation of Skin Discoloring Agent) (1) Hard Capsule 200 mg to 500 mg of norbixin powder is mixed with 200 mg of lactose and filled into hard capsules. Alternatively, 200 mg to 500 mg of norbixin powder (pure product) is directly filled in a hard capsule. (2) Soft capsules 200 mg to 500 mg of norbixin powder, 100 mg
Mix with ~ 500 mg of vegetable oil (eg olive oil, sunflower oil) and fill into soft capsules.

Example 3 (Taking Example) Subjects: Three Caucasian females (25 years old, 23 years old, 20 years old) and 2 Orientals (25 years old, 23 years old). 2 capsules each for breakfast, lunch and dinner for subjects without skin diseases or allergies
(Containing 300 mg of norbixin per capsule). Oriental women had changes in face and limb color around day 5, and white women had changes in face and limb color around day 7. With continued use of the same dose, both white and oriental women turned their entire body, including their faces, to brown or tan, peaking around day 20. After reducing the dose by half and continuing to take it, the whole body remained healthy.

[0022]

As described above, according to the present invention, the skin color of the whole body can be easily, safely and actively adjusted by taking a small amount of a skin discoloring agent containing norbixin orally daily. It can be changed to reddish brown, tan or light tan or light brown.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 17/00 A61P 17/00 (72) Inventor Kazuyuki Kawagoe Brazil, Sao Paulo, Sao Paulo, Perdisses, Lua Santarem・ Numbello 242 F term (reference) 4C076 AA55 AA56 BB01 CC18 DD30Z EE53F 4C083 AA111 AA112 AD621 AD622 BB51 CC50 DD14 EE06 EE10 EE11 4C206 AA01 AA02 DA36 MA57 MA72 NA14 ZA89

Claims (4)

[Claims] 1. An oral skin discoloring agent comprising norbixin as an essential component. 2. At least 40% by weight per unit dose
The skin discoloring agent according to claim 1, which contains norbixin. 3. The skin discoloring agent according to claim 1, which comprises norbixin together with an acceptable carrier. 4. The skin discoloring agent according to claim 1, which is prepared as a capsule.