JP2001104482A - Double chamber type prefilled syringe - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a double chamber type prefilled syringe wherein a liquid, or the like, is hard to leak from the syringe at the time of transport or the preparation for usage, and also, a mixing operation at the time of usage can be easily and surely performed. SOLUTION: This double chamber type prefilled syringe 1 is equipped with an external cylinder 2 and a first gasket 11, a second gasket 12, and a third gasket 13 which are housed in the external cylinder 2. Also, the prefilled syringe 1 is equipped with a plunger 4, an injection needle, a first housing section 21 which is formed between the first gasket 11 and the external cylinder 2, a powdery drug 6 which is housed in the first housing section 21, and a space 23 which is formed between the first gasket 11 and the second gasket 12. In addition, the prefilled syringe 1 is equipped with a second housing section 22 which is formed between the second gasket 12 and the third gasket 13, and a liquid 7 for dissolving the powdery drug is housed in the second housing section 22. The first gasket 11 is equipped with a hollow needle 28, which penetrates the second gasket 12 by the movement of the second gasket 12 to the tip end side, and allows the first housing section 21 to communicate with the second housing section 22.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a two-chamber prefilled syringe. Specifically, a powdered or lyophilized drug and a drug dissolving liquid for dissolving the drug are stored separately, and the drug is dissolved in the dissolving liquid at the time of use, and then administered. The present invention relates to a two-chamber prefilled syringe that can be used.

[0002]

[Prior art]

BACKGROUND OF THE INVENTION A so-called prefilled syringe filled with a drug may be easily decomposed or deteriorated at an early stage if a plurality of components constituting an injection are mixed with each other. Divided into rooms,
2. Description of the Related Art There is a two-chamber prefilled syringe that accommodates a predetermined component and its solution, dispersion, or other liquid component in a separated state. As a two-chamber prefilled syringe, it is required that liquid and the like do not leak from the syringe during transportation and preparation for use, and that the mixing operation during use can be performed easily and reliably.

[0003]

Therefore, the present invention relates to
The present invention provides a two-chamber pre-filled syringe which is a chamber-type pre-filled syringe, in which a liquid or the like hardly leaks from the syringe at the time of transportation and preparation for use, and in which mixing operation at the time of use can be performed easily and reliably.

[0004]

The object of the present invention is achieved by an outer cylinder having a needle mounting portion on the distal end side, a first gasket slidably housed in the outer cylinder, A second gasket slidable in the outer cylinder and located at a rear end side of the first gasket; and a second gasket slidable in the outer cylinder and rearward of the second gasket. A third gasket arranged at a side position, a plunger attached to a rear end of the third gasket, an injection needle attached to the injection needle attachment portion, and a first gasket. A first storage portion formed between a front side and the outer cylinder; a powdery or lyophilized drug stored in the first storage portion; a rear portion of the first gasket and the second gasket; A space formed between the front of the outer cylinder and the outer cylinder; A two-chamber prefill including a second storage portion formed between the rear of the skeet, the front of the third gasket, and the outer cylinder, and a drug dissolving liquid stored in the second storage portion. A syringe, wherein the first gasket includes a through passage, a hollow needle attached to the through passage in a liquid-tight manner, a rear end protruding from the first gasket, and having a cutting edge at a rear end; The hollow needle penetrates the second gasket by moving the second gasket toward the distal end side, and the two chambers can communicate with the first storage portion and the second storage portion. It is a type prefilled syringe.

In order to achieve the object of the present invention, an outer cylinder having an injection needle mounting portion at the distal end side, a first gasket slidably housed in the outer cylinder, A second gasket that is slidable on the rear side of the first gasket, and a position that is slidable in the outer cylinder and is on the rear end side of the second gasket. A third gasket, a plunger attached to the rear end of the third gasket, a seal cap hermetically attached to the injection needle attachment portion, and a front of the first gasket. A first storage portion formed between the first gasket and the outer cylinder; a powdery or freeze-dried medicine stored in the first storage portion; a rear portion of the first gasket and a second gasket; A space formed between the front and the outer cylinder, A second chamber including a second storage portion formed between the rear of the second gasket, the front of the third gasket, and the outer cylinder; and a drug dissolving liquid stored in the second storage portion. A mold prefilled syringe, wherein the first gasket has a through-passage, a hollow needle attached to the through-passage in a liquid-tight manner, a rear end protruding from the first gasket, and having a cutting edge at a rear end. The hollow needle penetrates the second gasket by moving the second gasket toward the distal end side, and is capable of communicating with the first storage portion and the second storage portion, and The first gasket is a two-chamber prefilled syringe having a check valve that inhibits the flow of the liquid from the first storage section to the second storage section.

It is preferable that the first storage section is a decompression chamber. Further, the opening of the hollow needle on the first storage portion side is orthogonal to the central axis of the outer cylinder or 9 °.
Preferably, it is formed so as to be inclined at 0 degrees or more. Further, it is preferable that the second gasket includes a thin portion for hollow needle penetration. Further, it is preferable that the medicine storage syringe includes a plunger locking means. Preferably, the second gasket includes a thin hollow needle pierceable portion. further,
It is preferable that the hollow needle is not exposed from the rear end face of the gasket when the second gasket is pierced.

[0007]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a two-chamber prefilled syringe of the present invention. FIG. 1 is an external view of an embodiment of a two-chamber pre-filled syringe of the present invention, FIG. 2 is a cross-sectional view of the two-chamber pre-filled syringe shown in FIG. 1, and FIG. FIG. 3 is a sectional view taken along line A. FIGS. 4 and 5 are explanatory views for explaining the operation of the two-chamber prefilled syringe shown in FIGS.

[0008] The two-chamber prefilled syringe 1 of the present invention
An outer cylinder 2 having a needle mounting portion 25 on the distal end side, a first gasket 11 slidably housed in the outer cylinder 2,
A second gasket 12 slidable in the outer cylinder 2 and located at a position on the rear end side of the first gasket 11;
A third gasket 13 slidable in the outer cylinder 2 and located at a position on the rear end side of the second gasket 12;
It is formed between the plunger 4 attached to the rear end of the third gasket 13, the injection needle 5 attached to the injection needle attachment part 25, and the front of the first gasket 11 and the outer cylinder 2. A first storage section 21, a powdery or lyophilized drug 6 stored in the first storage section 21, a rear side of the first gasket 11, a front side of the second gasket 12, and the outer cylinder 2;
And the second gasket 12
A second storage portion 22 formed between the rear of the third gasket 13 and the front of the third gasket 13 and the outer cylinder 2, and a drug dissolving liquid 7 stored in the second storage portion 22. Then, the first gasket 11 is attached to the through passage 27 and the through passage in a liquid-tight manner, and the rear end protrudes from the first gasket 11,
A hollow needle 28 having a cutting edge 28a at the rear end is provided. The hollow needle 28 penetrates the second gasket 12 by moving the second gasket 12 toward the distal end, and the first storage portion 21
And the second storage portion 22.

Therefore, a detailed description will be given with reference to the drawings. The two-chamber pre-filled syringe 1 of this embodiment has an outer cylinder 2
An injection needle previously attached to the distal end of the outer cylinder 2, an isolated first gasket 11 and a second gasket 12 slidably housed in the outer cylinder 2, and a third gasket 13 at the distal end. And a fixed plunger 4. The outer cylinder 2 is preferably made of a transparent or translucent material such as polypropylene, cyclic olefin, or glass,
It is a cylindrical body formed of a material having low oxygen permeability, and has an injection needle mounting portion 25 having an opening at the front end and tapering toward the front end, and a pair of flanges at the rear end. 26 are provided facing each other. The length of the outer cylinder 2 is preferably about 50 to 200 mm, and the capacity of the outer cylinder 2 is preferably about 1.0 to 60 ml.

The first gasket 11 has a tapered portion that decreases in diameter toward the distal end of the outer cylinder 2, a main body that extends with substantially the same outer diameter, and a liquid-tight seal with the outer cylinder 2 provided in the main body. It has one to three annular ribs in contact. And the first
The gasket 11 has a penetrating passage and a hollow needle 28 that is attached to the penetrating passage in a liquid-tight manner, has a rear end protruding from the first gasket 11, and has a cutting edge 28a at the rear end. The opening of the hollow needle 28 on the first storage portion side is formed so as to be orthogonal or inclined at least 90 degrees with respect to the center axis of the outer cylinder. Specifically, the tip 28b of the hollow needle 28
Is formed so that the distal end opening is orthogonal to the center axis of the outer cylinder by bending. However, the present invention is not limited to this, and the hollow needle may be configured such that the end on the first storage section side is a sealing end and a side hole is provided. By adopting such an opening form, the shape is such that entry of the medicine 6 into the inside during storage, transportation, or the like is inhibited. A recess for accommodating the tip of the hollow needle 28 is formed at the tip of the first gasket 11. In this embodiment, the hollow needle 2
8 is located substantially at the center of the gasket. The rear end surface of the first gasket 11 is a flat surface orthogonal to the center axis of the outer cylinder 2. The hollow needle 28 may be a metal needle or a plastic needle.
As an outer diameter of about 1-2 mm, as an inner diameter,
About 0.3 to 1.8 mm, the length is 5 to 15 m
About m is preferable. Further, it is preferable that the hollow needle 28 is fixed to the first gasket 11 with an adhesive so as not to move during the piercing operation of the second gasket 12.

The second gasket 12 has a main body extending substantially at the same outer diameter, and two annular ribs which come into liquid-tight contact with the outer cylinder 2 provided on the main body. Then, the second gasket 12 is connected to the first gasket 11 at the distal end.
In this embodiment, a hollow needle guiding concave portion 12a extending a predetermined depth from the distal end face is provided at a position corresponding to the hollow needle disposing position of the first gasket 11 at the center of the distal end portion. In this embodiment, a hollow needle leading recess 1 extending a predetermined depth from the rear end face in the center of the front end portion in this embodiment.
2b, and the thin portion between the hollow needle guiding concave portion 12a and the hollow needle leading concave portion 12b is a hollow needle piercing portion 12b.
c. In this way, by making the hollow needle pierceable portion 12c thin, it becomes easy to pierce the second gasket 12 with the hollow needle 28, and the hollow needle 28 can be made short. Further, as shown in FIG. 4, even when the hollow needle 28 pierces the second gasket 12, the cutting edge of the hollow needle 28
It is preferable not to protrude from the rear end face. In other words, in a state where the hollow needle 28 moves to the tip end side of the second gasket 12, penetrates the second gasket 12, and communicates the first storage section 21 and the second storage section 22,
The cutting edge of the hollow needle 28 is preferably located in the hollow needle leading-out recess 12b. This prevents the cutting edge of the hollow needle 28 from damaging the third gasket 13.

The length of the second gasket 12 is 5
The thickness of the thin hollow needle pierceable portion 12c is preferably about 1 to 5 mm.
Note that the hollow needle 28 may penetrate the entire second gasket 12 without providing the thin hollow needle piercing portion 12c. Further, when the front end surface of the second gasket 12 contacts the rear end surface of the first gasket 11, the first gasket 11 is formed so that a gap is not formed between them.
It is preferable to have a shape corresponding to the rear end face,
In this embodiment, the surface is flat. However, the present invention is not limited to this. Even if the distal end surface of the second gasket 12 is tapered toward the distal end, and the rear end surface of the first gasket 11 is formed as a concave portion whose diameter decreases toward the distal end, the converse is true. May be.

The third gasket 13 has a main body extending substantially at the same outer diameter, and two annular ribs which are in liquid-tight contact with the outer cylinder 2 provided on the main body. The length of the third gasket 13 is preferably about 5 to 20 mm. When the front end surface of the third gasket 13 contacts the rear end surface of the second gasket 12,
It is preferable that the second gasket 12 has a shape corresponding to the rear end surface so that a gap is not formed between the two as much as possible. In this embodiment, the second gasket 12 has a flat surface. But,
The present invention is not limited to this, and the distal end surface of the third gasket 13 may be tapered to reduce the diameter toward the distal end, and the rear end surface of the second gasket 12 may be formed as a concave portion reducing the diameter toward the distal end, or vice versa. . As the first gasket 11, the second gasket 12, and the third gasket 13, rubber having elasticity (for example, butyl rubber, latex rubber, silicone rubber, or the like), synthetic resin (for example, SBS)
Elastomer, SEBS elastomer, polyolefin elastomer, etc.).

The third gasket 13 is provided with a concave portion extending inward from the rear end thereof. In the concave portion, as shown in FIG. 2, the tip 41 of the plunger 4 is inserted. 4 is configured not to be detached from the third gasket 13. Plunger 4
Includes a main body portion 42 having a cross-shaped cross section and extending in the axial direction, a disc portion 43 for pressing provided at a rear end portion, and a rib 44 provided in the middle of the main body portion. In the syringe 1 of this embodiment, the upper part of the distal end face in FIG.
The plunger stopper member 45 is provided so that the lower end of the rear end surface contacts the rib 44 of the plunger 4. If the plunger stopper member 45 is not removed, the plunger 4 will not move to the distal end side.

And a two-chamber prefilled syringe 1
A first storage section 21 formed between the front of the first gasket 11 and the outer cylinder 2; a powdery or lyophilized drug 6 stored in the first storage section 21; A space 23 formed between the rear of the gasket 11, the front of the second gasket 12, and the outer cylinder 2, and between the rear of the second gasket 12, the front of the third gasket 13, and the outer cylinder 2. It has a second storage part 22 formed and a drug dissolving liquid 7 stored in the second storage part 22. The capacity of the first storage section 21 varies depending on the amount of medicine to be stored, but is preferably about 1 to 20 ml, and the capacity of the space 23 is preferably about 1 to 5 ml. Part 2
The value of 2 varies depending on the amount of the drug dissolving liquid to be stored, but is preferably about 1 to 20 ml. First storage unit 2
As the powdered or freeze-dried medicine 6 stored in 1, medicines such as various vitamins, antibiotics, vasodilators, and inotropic agents, nutrients, and the like are used. Further, as the drug dissolving liquid 7, distilled water for injection, physiological saline, or the like is used. And the first storage section 21 and the space 23 are
It may be a decompression space. This facilitates the liquid injection operation. In this case, the outer cylinder 2 and the plunger 4 require a plunger stopper mechanism. In addition, the injection needle comprises a needle tube having a puncture blade surface at the distal end, a hub attached to the rear end of the needle tube, and a cap whose rear end is fitted to the hub. is there.

Next, the operation of the two-chamber prefilled syringe 1 will be described with reference to FIGS. The plunger stopper member 45 is removed from the two-chamber prefilled syringe 1 in the state shown in FIG.
The air inside moves to the first storage portion 21, and the hollow needle 28 fixed to the first gasket 11 pierces the thin hollow needle pierceable portion 12 c of the second gasket 12, The storage section 21 and the second storage section 22 communicate with each other. Further, by pushing the plunger 4, as shown in FIG. 4, the liquid for dissolving the medicine in the second storage portion 22 gradually becomes
After moving into the first storage section 21, the third gasket 13 comes into contact with the second gasket 12 as shown in FIG. 5, and the entire amount of the drug dissolving liquid is stored in the first storage section 21. Flows into. Then, by shaking the syringe 1, the drug is dissolved in the drug solution without fail, and the preparation for administration is completed. Then, after removing the cap of the injection needle and removing the air in the first storage portion 21 of the syringe 1, the patient is punctured and the plunger 4 is pushed, whereby the syringe 1 is pushed by the third gasket 13. , The second gasket 12 and the first gasket 11 move forward,
Is administered to the patient.

Next, the two-chamber prefilled syringe of the present invention shown in FIG. 6 will be described. FIG. 6 is a sectional view of another embodiment of the two-chamber prefilled syringe of the present invention,
FIG. 7 and FIG. 8 are explanatory diagrams for explaining the operation of the two-chamber prefilled syringe shown in FIG. The two-chamber prefilled syringe 50 of this embodiment includes an outer cylinder 52 having a needle mounting portion on the distal end side, a first gasket 61 slidably housed in the outer cylinder 52, and an outer cylinder 52. A second gasket 62 disposed at a position slidable on the rear end side of the first gasket 61, and a position slidable in the outer cylinder 52 and positioned on the rear end side of the second gasket 62; , A plunger 54 attached to the rear end of the third gasket, and a seal cap 55 air-tightly attached to the injection needle attachment portion.
A first storage portion 71 formed between the front of the first gasket 61 and the outer cylinder 52; a powdery or lyophilized drug 56 stored in the first storage portion 71; A space 73 formed between the rear of the gasket 61, the front of the second gasket 62, and the outer cylinder 52, and between the rear of the second gasket 62, the front of the third gasket 63, and the outer cylinder 52 The formed second storage portion 72 and the second storage portion 7
2 is provided with a drug dissolving liquid 57 stored in the liquid 2. The first gasket 61 is provided with a penetrating path and a hollow needle 78 which is attached to the penetrating path in a liquid-tight manner, has a rear end protruding from the first gasket 61 and has a cutting edge at the rear end. Moves through the second gasket 62 toward the distal end side of the second gasket 62 and passes through the first storage portion 71.
The first gasket 61 has a length that allows communication between the first storage portion 72 and the second storage portion 72, and the first gasket 61 is a non-return that inhibits the flow of liquid from the first storage portion 71 to the second storage portion 72. It has a valve.

A detailed description will be given with reference to the drawings. The two-chamber pre-filled syringe 50 of this embodiment has an outer cylinder 5
2, a seal cap 55 airtightly attached to the tip of the outer cylinder 52, and an isolated first gasket 61 and a second gasket 62 slidably housed in the outer cylinder 52.
And a plunger 54 to which a third gasket 63 is fixed at the end. The outer cylinder 52 is a cylindrical body formed of a transparent or translucent material such as polypropylene, cyclic olefin, or glass, preferably, of a material having low oxygen permeability. A pair of flanges 76 are provided at the rear end of the injection needle attachment portion, which is tapered toward the rear. The length of the outer cylinder 52 is preferably about 50 to 200 mm, and the capacity of the outer cylinder 52 is 1 to
About 60 ml is suitable.

The first gasket 61 has a tapered portion that decreases in diameter toward the distal end of the outer cylinder 52, a main body that extends with substantially the same outer diameter, and a liquid tight seal with the outer cylinder 52 provided in the main body. It has one to three annular ribs in contact. And
The first gasket 61 is provided with a penetrating passage, and a hollow needle 78 attached to the penetrating passage in a liquid-tight manner, with a rear end protruding from the first gasket 61 and having a cutting edge at the rear end. The distal end of the hollow needle 78 is located slightly inside the first gasket 61, as shown in FIG. 7, and the first gasket 61 is provided with a check valve so as to cover the distal end of the hollow needle 78. 58 are provided. The check valve comprises a sheet-like valve body 58a housed in a recess formed at the tip of the first gasket 61, and a plate-like member 58b having a liquid flow opening fixed to the recess. As shown, when the liquid flows into the first storage section 71, the sheet-shaped valve element is in close contact with the plate-shaped member, and is provided between the sheet-shaped member and the distal end of the hollow needle 78 and at the peripheral edge of the plate-shaped member. The liquid flows in from the opening provided, and conversely, when the first storage section 71 side becomes positive pressure, as shown in FIG.
And the outflow of the liquid from the first storage portion 71 is hindered. Note that, similarly to the above-described embodiment, the distal end of the hollow needle 78 may be curved. In this embodiment, the hollow needle 78 is located substantially at the center of the gasket. In addition, the first gasket 6
The rear end face of 1 is a flat surface orthogonal to the center axis of the outer cylinder 52.

The hollow needle 78 may be a metal needle or a plastic needle. The outer diameter of the hollow needle 78 is about 1 to 2 mm, and the inner diameter is 0.3 to 1.8.
It is preferable that the length is about mm and the length is about 5 to 15 mm. Further, it is preferable that the hollow needle 78 is fixed to the first gasket 61 with an adhesive so as not to move during the piercing operation of the second gasket 62. The second gasket 62 includes a main body that extends with substantially the same outer diameter, and two annular ribs that are in liquid-tight contact with the outer cylinder 52 provided on the main body. Then, the second gasket 62
Is a portion corresponding to the hollow needle disposition position of the first gasket 61 at the distal end, in this embodiment, a hollow needle guiding recess 62a extending a predetermined depth from the distal end surface at the center of the distal end, The first gasket 61 has a hollow needle guide recess 62b extending a predetermined depth from the rear end surface at a position corresponding to the hollow needle disposition position, in this embodiment, at the center of the front end portion. The concave portion 62a and the hollow needle leading-out concave portion 62b
The thin portion between them is a hollow needle pierceable portion 62c.
In this way, by making the hollow needle pierceable portion 62c thin, it becomes easy to pierce the second gasket 62 with the hollow needle 78, and the hollow needle 78 can be made short. Furthermore, as shown in FIG. 7, it is preferable that the cutting edge of the hollow needle 78 does not protrude from the rear end face of the second gasket 62 even when the hollow needle 78 penetrates the second gasket 62. In other words, the hollow needle 78 moves to the tip side of the second gasket 62,
It is preferable that the cutting edge of the hollow needle 78 be located in the hollow needle outlet concave portion 62b in a state where the first storage portion 71 and the second storage portion 72 are communicated with each other through the gasket 62 of the first embodiment. By doing so, the cutting edge of the hollow needle 78 does not damage the third gasket 63.

The length of the second gasket 62 is 5
The thickness is preferably about 20 mm, and the thickness of the thin hollow needle pierceable portion 62c is preferably about 1 to 5 mm.
Note that the hollow needle 78 may penetrate the entire second gasket 62 without providing the thin hollow needle penetrable portion 62c. Further, when the front end surface of the second gasket 62 contacts the rear end surface of the first gasket 61, the first gasket 61 is formed so that a gap is not formed between them.
It is preferable to have a shape corresponding to the rear end face,
In this embodiment, the surface is flat. However, the present invention is not limited to this, and even if the distal end surface of the second gasket 62 is formed into a tapered shape whose diameter is reduced toward the distal end, and the rear end surface of the first gasket 61 is formed as a concave portion whose diameter is reduced toward the distal end, the converse is true. May be.

The third gasket 63 has a main body extending substantially at the same outer diameter, and two annular ribs in liquid-tight contact with the outer cylinder 52 provided on the main body. And
The length of the third gasket 63 is preferably about 5 to 20 mm. Further, when the front end surface of the third gasket 63 contacts the rear end surface of the second gasket 62,
The second gasket 62 preferably has a shape corresponding to the rear end face so that a gap is not formed between the two as much as possible. In this embodiment, the shape is flat. But,
However, the present invention is not limited to this, and the distal end surface of the third gasket 63 may be tapered to reduce the diameter toward the distal end, and the rear end surface of the second gasket 62 may be a concave portion reducing the diameter toward the distal end, or vice versa. . As the first gasket 61, the second gasket 62, and the third gasket 63, rubber having elasticity (eg, butyl rubber, latex rubber, silicone rubber, etc.), synthetic resin (eg, SBS)
Elastomer, SEBS elastomer, polyolefin elastomer, etc.). The third gasket 63 is provided with a concave portion extending inward from the rear end thereof. In the concave portion, the tip of the plunger 54 is inserted as shown in FIG.
However, it is configured not to separate from the third gasket 63.

The plunger 54 includes a main body 82 extending in the axial direction having a cross-shaped cross section, a disc 83 for pressing provided at the rear end, and a rib 74 provided in the middle of the main body. . In the syringe 50 of this embodiment, FIG.
A plunger stopper member 75 is provided so that the upper end of the front end surface of the plunger contacts the flange of the outer cylinder 52 and the lower end of the rear end surface contacts the rib 74 of the plunger 54. If the plunger stopper member 75 is not removed, the plunger 54 will not move to the distal end side. The two-chamber prefilled syringe 50 includes a first storage portion 71 formed between the front of the first gasket 61 and the outer cylinder 52,
And a space 73 formed between the rear of the first gasket 61, the front of the second gasket 62, and the outer cylinder 52.
And the rear of the second gasket 62 and the third gasket 6
2 and a second storage portion 7 formed between the front of
2 and the drug dissolving liquid 5 stored in the second storage 72
7 is provided.

The capacity of the first storage section 71 varies depending on the amount of medicine to be stored, but is preferably about 1 to 20 ml, and the capacity of the space 73 is preferably about 1 to 5 ml. The size of the second storage section 72 is preferably about 1 to 20 ml, although it differs depending on the amount of the drug dissolving liquid to be stored. As the powdered or freeze-dried medicine 56 stored in the first storage section 71, various vitamins, antibiotics, vasodilators, pharmaceuticals such as inotropic agents, and nutrients are used. Further, as the drug dissolving liquid 57, distilled water for injection, physiological saline, or the like is used. Further, as the liquid for dissolving the drug, distilled water for injection, physiological saline, or the like is used. And the 1st storage part 71 and space 73 may be a decompression space. This facilitates the liquid injection operation. In this case, the outer cylinder 52 and the plunger 54 need a plunger stopper mechanism.

The seal cap 55 airtightly attached to the tip of the outer cylinder 52 includes a cap body 55a having an opening at the center of the tip and a seal member 55b provided to close the opening of the cap body 55a. Prepare. The outer cylinder 52 is provided on the inner surface of the base end of the cap body 55a.
A female screw portion is formed which is screwed with a male screw portion formed on the outer surface of the distal end portion of the screw. The two members are tightly screwed together, so that the sealing member 55b is in close contact with the distal end surface of the outer cylinder 52 and hermetically seals the opening at the distal end of the outer cylinder 52.
Further, the seal member can be pierced by a double-ended needle type injection needle (not shown), and the cap 55 can directly mount the double-ended needle type injection needle.

Next, the operation of the two-chamber prefilled syringe 50 will be described with reference to FIGS. The two-chamber prefilled syringe 50 shown in FIG.
By removing the plunger stopper member 75 and gradually pushing the plunger 54 toward the distal end, the air in the space 73 moves to the first storage portion 71 and is fixed to the first gasket 61. The hollow needle 78 penetrates the thin hollow needle pierceable portion of the second gasket 62,
The storage section 71 and the second storage section 72 communicate with each other. further,
When the plunger 54 is pushed, as shown in FIG. 7, the drug dissolving liquid 57 in the second storage section 72 gradually moves into the first storage section 71, and eventually, as shown in FIG. As described above, the third gasket 63 is
And the entire amount of the drug dissolving liquid is
Flows into. In this state, the air in the first storage section 71 is in a compressed state. Then, when the pressing of the plunger 54 is completed, the check valve 58 is closed and the first gasket 61 moves rearward due to the expansion action of the compressed air in the first storage portion 71, and is pushed by this. In shape, the second gasket 62 and the third gasket 63 also move rearward and stop. If necessary, shake the syringe in this state to ensure that the drug and liquid are mixed. Then, by removing the seal cap 55 and attaching the injection needle to the injection needle mounting portion of the outer cylinder 52 as shown in FIG. 8, the preparation for administration is completed. Note that a double-ended needle type injection needle may be attached to the seal cap without removing the seal cap.

[0027]

According to the two-chamber prefilled syringe of the present invention, the first storage agent formed on the open end side of the outer cylinder is filled with the liquid in the second storage formed between the two gaskets. Because it is stored, liquids and the like hardly leak from the syringe at the time of transportation and preparation for use, and the mixing operation of the medicine and the drug solution can be performed only by pressing the plunger,
Administration preparation work can be performed easily and reliably.

[Brief description of the drawings]

FIG. 1 is an external view of an embodiment of a two-chamber prefilled syringe of the present invention.

FIG. 2 is a cross-sectional view of the two-chamber prefilled syringe shown in FIG.

FIG. 3 is a sectional view taken along line AA of FIG. 1;

FIG. 4 is an explanatory diagram for explaining the operation of the two-chamber prefilled syringe shown in FIGS. 1 to 3;

FIG. 5 is an explanatory diagram for explaining the operation of the two-chamber prefilled syringe shown in FIGS. 1 to 3;

FIG. 6 is a sectional view of another embodiment of the two-chamber prefilled syringe of the present invention.

FIG. 7 is an explanatory diagram for explaining the operation of the two-chamber prefilled syringe shown in FIG. 6;

FIG. 8 is an explanatory diagram for explaining the operation of the two-chamber prefilled syringe shown in FIG. 6;

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Two-chamber prefilled syringe 2 Outer cylinder 4 Plunger 5 Injection needle 6 Powdery medicine 7 Liquid for dissolving medicine 11 First gasket 12 Second gasket 13 Third gasket 21 First storage part 22 Second storage Part 23 space 28 hollow needle

Claims (8)

[Claims] An outer cylinder having a syringe needle mounting portion on a distal end side;
A first gasket slidably housed in the outer cylinder;
A second gasket slidable in the outer cylinder and located at a rear end side of the first gasket; and a second gasket slidable in the outer cylinder and rearward of the second gasket. A third gasket arranged at a side position, a plunger attached to a rear end of the third gasket, an injection needle attached to the injection needle attachment portion, and a first gasket. A first storage portion formed between a front side and the outer cylinder; a powdery or lyophilized drug stored in the first storage portion; a rear portion of the first gasket and the second gasket; A space formed between the front of the second gasket and the outer cylinder; a second storage portion formed between the rear of the second gasket, the front of the third gasket, and the outer cylinder; A two-chamber type including a drug dissolving liquid stored in the second storage unit A refilled syringe, wherein the first gasket includes a through passage, a hollow needle attached to the through passage in a liquid-tight manner, a rear end protruding from the first gasket, and having a cutting edge at a rear end. The hollow needle is provided so that it can penetrate the second gasket and move between the first storage portion and the second storage portion by moving the second needle to the distal end side of the second gasket. A two-chamber prefilled syringe characterized by the above-mentioned. 2. An outer cylinder having a needle attachment portion on the distal end side,
A first gasket slidably housed in the outer cylinder;
A second gasket slidable in the outer cylinder and located at a rear end side of the first gasket; and a second gasket slidable in the outer cylinder and rearward of the second gasket. A third gasket disposed at a side position, a plunger attached to a rear end of the third gasket, a seal cap hermetically attached to the injection needle attachment portion, and the first gasket. A first storage portion formed between the front of the gasket and the outer cylinder; a powdery or lyophilized drug stored in the first storage portion; a rear portion of the first gasket; A space formed between the front of the second gasket and the outer cylinder, and a second storage portion formed between the rear of the second gasket, the front of the third gasket, and the outer cylinder. And a liquid for dissolving a drug stored in the second storage section A two-chamber prefilled syringe comprising: a first gasket, a first gasket, which is mounted in a liquid-tight manner on the through channel, a rear end protruding from the first gasket, and a cutting edge at the rear end. Equipped with a hollow needle,
The hollow needle penetrates the second gasket by moving the second gasket toward the distal end, and can communicate between the first storage section and the second storage section; Wherein the gasket is provided with a check valve that inhibits the flow of liquid from the first storage section side to the second storage section side. 3. The two-chamber prefilled syringe according to claim 1, wherein the first storage section is a decompression chamber. 4. The hollow needle according to claim 1, wherein the opening of the hollow needle on the first storage portion side is formed so as to be orthogonal to the central axis of the outer cylinder or to be inclined by 90 degrees or more. Two-room prefilled syringe. 5. The two-chamber prefilled syringe according to claim 1, wherein the second gasket has a thin portion for penetrating a hollow needle. 6. The two-chamber prefilled syringe according to claim 1, wherein the medicine storage syringe includes a plunger locking means. 7. The two-chamber prefilled syringe according to claim 1, wherein the second gasket includes a thin hollow needle pierceable portion. 8. The two-chamber prefill according to claim 1, wherein the hollow needle is not exposed from a rear end face of the gasket when the second gasket is pierced. Syringe.