JP2001064122A5 - - Google Patents

Description

[0007]
In the composition for external use on the skin of the present invention, in addition to the hair-growing component which is the above-mentioned essential component, it is possible to contain an optional component usually used in an external preparation for skin. Such optional components include, for example, hydrocarbons such as squalane, vaseline, microcrystalline wax, jojoba oil, esters such as carnauba wax , octyldodecyl oleate, triglycerides such as olive oil, beef tallow, coconut oil, etc. Fatty acids such as stearic acid, oleic acid and ritinoleic acid, higher alcohols such as oleyl alcohol, stearyl alcohol and octyl dodecanol, anionic surfactants such as sulfosuccinic acid ester and sodium polyoxyethylene alkyl sulfate, and amphoteric resins such as alkyl betaine salts Surfactants, cationic surfactants such as dialkyl ammonium salts, sorbitan fatty acid esters, fatty acid monoglycerides, etc. L. B. Nonionic surfactants, polyhydric alcohols such as polyethylene glycol, glycerin and 1,3-butanediol, thickeners / gelling agents, antioxidants, UV absorbers, colorants, preservatives, powders Etc. can be illustrated. Among them, particularly preferred is a component that adds an effect of removing sebum to the composition for external application to the skin, and is a component with low irritation. Such a component is because it has an effect of removing sebum, which is said to contribute to hair loss and the like, from the scalp and assisting the function of the hair growth component. That is, it is preferable that the skin external preparation of the present invention has a sebum removing effect. As such sebum removing components, H. L. B. There can be exemplified a nonionic surfactant is preferably 10 to 18, polyoxyethylene coconut oil derived fatty acid glyceryl as such nonionic surfactants can be exemplified particularly preferred. Examples of such polyoxyethylene palm oil-derived fatty acid glyceryl include polyoxyethylene (7) palm oil fatty acid glyceryl (Hyber oil HE, manufactured by Kyosho Fine Chemical Co., Ltd.) and polyoxyethylene (10) caprylic acid / glyceryl caprate ( Henkel Japan Co., Ltd., Cethiol HE 810) can be exemplified as a preferable commercial product. The preferred content of these sebum removing components is 0.05 to 5% by weight with respect to the total composition for external use on the skin. Besides this, it is also preferable to add 0.05 to 1% by weight of polyoxyethylene hydrogenated castor oil as a solubilizer or emulsifier. Further, it is advantageous to contain 0.01 to 0.1% by weight of terpenes such as l-menthol and stimulants such as capsicum tincture as a component imparting a refreshing sensation, from the point that the feeling of use can be recognized. In order to provide a refreshing feeling while securing safety, it is preferable to contain ethanol in an amount of 10 to 40% by weight based on the total composition for external use on the skin. The dermatological composition of the present invention has no problem whether it is a solubilized dosage form or an emulsifier form. These compositions for external use on skin can be manufactured according to a conventional method.

[0009]
(3) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized in that the above composition for external use on the skin is impregnated in the above-mentioned support. Here, the skin external preparation in the present invention means a shall apply the flowable composition for external use on the skin, cosmetics, cleansers, is intended to mean the generic term for skin external pharmaceutical. In the skin outside dosage of the present invention, impregnation of the support of the external composition for skin is about 1 to 5 times is preferable relative to the weight of the support. The external preparation for skin thus obtained can be administered by putting only on the part of the scalp where it is necessary to apply the composition for external use, so that the hair growth component can be administered at unnecessary places to exert an undesirable effect. The nature is also extremely low, and additionally, when it contains a sebum removing component, sebum and the like which are undesirable to be present on the scalp can be wiped off and removed. This can help the action of the hair growth component. As a preferable application of the external preparation for skin of the present invention, the external composition for external use can be topically and intensively applied to alopecia areata etc. in addition to ordinary thin hair, eyebrows and alopecia, and so it is preferable. In addition, as a method of use, the external preparation of the present invention can be applied to the application site for several minutes and used as a pack, which is also within the technical scope of the present invention. Furthermore, the individual packaging form is convenient for carrying and suitable as a skin external preparation for travel.

[0011]
Example 1
The composition for external application to the skin of the present invention was produced according to the formulation shown below. That is, the formulated components were solubilized by stirring at room temperature to obtain composition 1 for external use on the skin of the present invention. The product was impregnated with 3 mL of this into a 4-fold folded 15 cm × 15 cm non-woven fabric (about 1 g), and the laminate was sealed with a three-way seal to obtain a skin external preparation 1 of the present invention. Using a comparative example in which the skin external preparation 1 and the skin external composition 1 were simply filled in a bottle using a total of 20 people in the paneler group 1 suffering from thin hair, a three month use test was performed. The thin hair improvement effect by the skin external preparation was evaluated by ++: remarkable improvement, +: apparent improvement, ±: slight improvement. As a result, the skin external preparation 1 of the present invention was ++ 2 people, +7 people, ± 1 person, while in the comparative example, it was +4 people, ± 6 people. From this, it can be seen that by taking the form of the external preparation for skin of the present invention, the effect of the hair growth component can be more effectively exhibited.
(Composition for external use on skin 1)
Cholay extract 0.01 weight part hawthorn extract 0.01 weight part Sansha extract 0.01 weight part Polyporsterone A 0.01 weight part ethynyl estradiol 0.01 weight part l-menthol 0.05 weight part 1,3- Butanediol 5 parts by weight methyl paraben 0.1 part by weight polyoxyethylene (60) hydrogenated castor oil 0.1 part by weight ethanol 30 parts by weight water 64.7 parts by weight

[0014]
Example 4
The composition for external application to the skin of the present invention was produced according to the formulation shown below. That is, the formulated components were solubilized by stirring at room temperature to obtain composition 4 for external use on the skin of the present invention. The product was impregnated with 3 mL of this into a 4-fold folded 15 cm × 15 cm non-woven fabric (about 1 g), and the laminate was sealed with a three-way seal to obtain a skin external preparation 4 of the present invention. Using a comparative example in which the skin external preparation 4 and the skin external composition 4 were simply filled in a bottle, using a total of 20 people in a paneler group 1 suffering from thin hair, a three month use test was performed. The thin hair improvement effect by the skin external preparation was evaluated by ++: remarkable improvement, +: apparent improvement, ±: slight improvement. As a result, the skin external preparation 4 of the present invention was ++ 2, +7, ± 1 in contrast to the comparative example, +4 and ± 6. From this, it can be seen that by taking the form of the external preparation for skin of the present invention, the effect of the hair growth component can be more effectively exhibited.
(Composition for external use on skin 4 )
Ethinyl estradiol 0.01 parts by weight Stegmastanolmaltoside 0.04 parts by weight l-menthol 0.05 parts by weight 1,3-butanediol 5 parts by weight methyl paraben 0.1 parts by weight polyoxyethylene (60) hydrogenated castor oil 0.1 Parts by weight Ethanol 30 parts by weight Hiber oil HE 0.2 parts by weight Water 64.5 parts by weight

Claims (5)

A support, characterized by comprising impregnating a skin external set Narubutsu containing hair growth components, the sheet-like skin external agent for hair growth. Hair-growing ingredients are Chorei, hawthorn, sanshishi and aloe essence, estrogens, odd fatty acids and their derivatives, dihydroxy fatty acids and their derivatives, phytosteroids and their glycosides, ecdysteroids and their glycosides, polysulfated poly The sheet-like external skin preparation according to claim 1, characterized in that it is one or more selected from saccharides and minoxidil. The sheet-like external skin preparation according to claim 1 or 2, wherein the support is a non-woven fabric. Further characterized in that it contains sebum removal ingredient in the skin external set Narubutsu, sheet-like skin external preparation according to any one of claims 1 to 3. The sheet-like external skin preparation according to claim 4, wherein the sebum removing component is polyoxyethylene palm oil-derived fatty acid glyceryl.