JP2000516343A - キャピラリー電気泳動酵素イムノアッセイ - Google Patents
キャピラリー電気泳動酵素イムノアッセイInfo
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- JP2000516343A JP2000516343A JP10534679A JP53467998A JP2000516343A JP 2000516343 A JP2000516343 A JP 2000516343A JP 10534679 A JP10534679 A JP 10534679A JP 53467998 A JP53467998 A JP 53467998A JP 2000516343 A JP2000516343 A JP 2000516343A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44747—Composition of gel or of carrier mixture
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
- G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
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- Urology & Nephrology (AREA)
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.アッセイを実施する方法であって、以下の工程を包含する、方法: (a)第1の反応物およびサンプルを、電気泳動媒体を含むチャネルに導入する 工程であって、該サンプルが、 生体認識部分(biorecognition portion)、および 第2の反応物部分、を含む、競合剤(competitor) を含み、 ここで、該第1の反応物および該第2の反応物部分は、反応して検出可能な生成 物を形成または枯渇させる(deplete)、工程; (b)該チャネルの長さに沿って、該検出可能な生成物を該チャネルに沿って移 動させるのに十分な電位をかける(impose)工程;ならびに (c)該検出可能な生成物を検出する工程。 2.以下のさらなる工程を包含する、請求項1に記載の方法: (d)前記チャネル中で形成または枯渇した前記検出可能な生成物の量を、定量 的に測定する工程。 3.請求項1に記載の方法であって、ここで、前記第1の反応物または前記第2 の反応物部分のうちの一方が、酵素を含み、かつ、該第1の反応物または該第2 の反応物部分のうちの他方が、酵素基質を含む、方法。 4.工程(a)の前に、以下のさらなる工程を包含する、請求項1に記載の方法 : (i)固定化された反応物と分析物とを溶液中で接触させる工程; (ii)該溶液に、前記競合剤を添加する工程;および (iii)該溶液のアリコートを用いる工程であって、該アリコートが、該サン プルを規定する、工程。 5.前記固定化された反応物が、固定化された抗体である、請求項4に記載の方 法。 6.前記サンプルが、免疫反応の結果である、請求項1に記載の方法。 7.前記免疫反応が、競合反応である、請求項6に記載の方法。 8.請求項1に記載の方法であって、ここで、前記サンプルが、分析物−競合剤 複合体をさらに含み、ここで、該分析物−競合剤複合体が、分析物と前記競合剤 との会合により形成される、方法。 9.請求項8に記載の方法であって、ここで、工程(b)が、前記競合剤と前記 分析物−競合剤複合体とを分離させるのに十分な電流をかける工程をさらに包含 する、方法。 10.前記分析物が荷電している、請求項8に記載の方法。 11.前記分析物−競合剤複合体が、荷電改質剤(charge modifier)を含む、 請求項8に記載の方法。 12.請求項1に記載の方法であって、ここで、前記生体認識部分が、以下から なる群から選択される、方法:抗体、抗原、酵素、ペプチド、ペプチド核酸、オ リゴヌクレオチド、デオキシリボ核酸、リボ核酸、ビオチン、およびそれらの相 補的結合複合体、レクチンおよびそれらの相補的炭水化物結合複合体、ならびに 細胞レセプター結合タンパク質およびそれらの相補的結合生成物。 13.請求項1に記載の方法であって、工程(a)で用いられる前記チャネルが 、前記サンプルを導入する前に、前記第1の反応物を含む、方法。 14.工程(c)の前に、以下のさらなる工程を含む、請求項1に記載の方法: 前記競合剤と前記第1の反応物とを、前記検出可能な生成物が形成または枯渇 するのに十分な時間にわたって接触させた後に、前記電位を除くことによって、 前記チャネルを0の電位に供する工程。 15.請求項14に記載の方法であって、前記チャネルを0の電位に供する工程 の後で、かつ工程(c)の前に、以下の工程をさらに包含する、方法: 該チャネルの長さに沿って、該検出可能な生成物を該チャネル中で移動させる のに十分な時間にわたって、該電位を再びかける(re-impose)工程。 16.請求項1に記載の方法であって、ここで、前記サンプルが、異なる生体認 識部分を含む1つ以上の競合剤を含む、方法。 17.請求項16に記載の方法であって、ここで、1つ以上の第1の反応物が、 前記チャネル内に導入される、方法。 18.請求項17に記載の方法であって、ここで、複数の検出可能な生成物が、 形成または枯渇される、方法。 19.アッセイを実行する方法であって、以下の工程を包含する、方法: (a)分析物と、生体認識部分および第2の反応部分を含む競合剤とを含む容器 内で、結合反応を実施する工程; (b)電位をかけて、サンプルを、該容器から該容器と連通しているチャネル内 に移動させる工程であって、該チャネルが、第1の反応物を含む、工程; (c)該第2の反応部分および該第1の反応物により、検出可能な生成物を形成 または枯渇させる工程;ならびに (d)該検出可能な生成物を検出する工程。 20.請求項19に記載の方法であって、以下のさらなる工程を包含する、方 法: (d)前記チャネル内で形成または枯渇した前記検出可能な生成物の量を、定量 的に測定する工程。 21.請求項19に記載の方法であって、ここで、前記第1の反応物または前記 第2の反応物部分のうちの一方が、酵素を含み、そして、該第1の反応物または 該第2の反応物部分のうちの他方が、酵素基質を含む、方法。 22.請求項19に記載の方法であって、ここで、前記生体認識部分が、以下か らなる群から選択される、方法:抗体、抗原、酵素、ペプチド、ペプチド核酸、 オリゴヌクレオチド、デオキシリボ核酸、リボ核酸、ビオチン、およびそれらの 相補的結合複合体、レクチンおよびそれらの相補的炭水化物結合複合体、ならび に細胞レセプター結合タンパク質およびそれらの相補的結合生成物。 23.請求項19に記載の方法であって、工程(a)が、固定化された反応物を さらに含む容器内で前記反応を実施する工程をさらに包含する、方法。 24.請求項23に記載の方法であって、ここで、前記固定化された反応物が、 固定化された抗体である、方法。 25.請求項19に記載の方法であって、ここで、工程(a)で用いられる前記 チャネルが、前記サンプルを導入する前に、前記第1の反応物を含む、方法。 26.請求項19に記載の方法であって、工程(c)の前に、以下のさらなる工 程を包含する、方法: 前記競合剤と前記第1の反応物とを、前記検出可能な生成物が形成または枯渇 するのに十分な時間にわたって接触させた後に、前記電位を除くことによって、 前記チャネルを0の電位に供する工程。 27.請求項26に記載の方法であって、前記チャネルを0の電位に供する工程 の後で、かつ工程(c)の前に、以下の工程さらに包含する、方法: 該チャネルの長さに沿って、該検出可能な生成物を該チャネル中で移動させる のに十分な時間にわたって、該電位を再びかける工程。 28.チャネルを備える分析装置であって、該チャネルが、以下を含む、装置: 電気泳動媒体、および 競合剤の第2の反応部分と反応させるための第1の反応物であって、検出可能 な生成物を形成または枯渇させるための生体認識部分を含む、第1の反応物。 29.請求項28に記載の装置であって、前記チャネルを横切る電位をかけるお よび中断するための電気泳動装置をさらに備える、装置。 30.請求項29に記載の装置であって、前記検出可能な生成物を検出するため の検出器をさらに備える、装置。 31.請求項30に記載の装置であって、検出された前記検出可能な生成物の量 を定量的に測定するための定量分析器(quantitator)をさらに備える、装置。 32.前記チャネルが、キャピラリーである、請求項28に記載の装置。 33.請求項29に記載の装置であって、ここで、前記競合剤と前記第1の反応 物とが、該チャネル内で間隔を空けられており、その結果、前記電気泳動装置に よって前記チャネルの長さに沿って電場を印加すると、該競合剤または該第1の 反応物が、該チャネル内で移動して、該第1の反応物を、該競合剤の前記第2の 反応部分と反応させ、前記検出可能な生成物を形成または枯渇させる、装置。 34.結合反応を実施するためのサンプル注入ゾーンとチャネルとを備える分析 装置であって、該サンプル注入ゾーンが該チャネルと連通しており、そして該チ ャネルが、以下を含む、装置: 電気泳動媒体、および 生体認識部分を含む競合剤の第2の反応部分と反応させて、検出可能な生成物 を形成または枯渇させるための、第1の反応物。 35.請求項34に記載の装置であって、前記チャネルを横切る電位をかけるお よび中断するための電気泳動装置をさらに備える、装置。 36.請求項35に記載の装置であって、前記検出可能な生成物を検出するため の検出器をさらに備える、装置。 37.請求項34に記載の装置であって、先端を備え、該先端が、前記サンプル 注入ゾーンおよび前記チャネルを備える、装置。 38.請求項37に記載の装置であって、前記先端が、複数の独立したサンプル 注入ゾーンおよびチャネルを備える、装置。 39.請求項34に記載の装置であって、前記サンプル注入ゾーンが、固定化さ れた反応物を含む、装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/792,933 | 1997-01-22 | ||
US08/792,933 US5958202A (en) | 1992-09-14 | 1997-01-22 | Capillary electrophoresis enzyme immunoassay |
PCT/US1998/001156 WO1998032010A1 (en) | 1997-01-22 | 1998-01-21 | Capillary electrophoresis enzyme immunoassay |
Related Child Applications (1)
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JP2002337258A Division JP2003202322A (ja) | 1997-01-22 | 2002-11-20 | キャピラリー電気泳動酵素イムノアッセイ |
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JP2000516343A true JP2000516343A (ja) | 2000-12-05 |
JP3476837B2 JP3476837B2 (ja) | 2003-12-10 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP53467998A Expired - Fee Related JP3476837B2 (ja) | 1997-01-22 | 1998-01-21 | キャピラリー電気泳動酵素イムノアッセイ |
JP2002337258A Withdrawn JP2003202322A (ja) | 1997-01-22 | 2002-11-20 | キャピラリー電気泳動酵素イムノアッセイ |
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JP2002337258A Withdrawn JP2003202322A (ja) | 1997-01-22 | 2002-11-20 | キャピラリー電気泳動酵素イムノアッセイ |
Country Status (4)
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US (1) | US5958202A (ja) |
EP (1) | EP0954749A1 (ja) |
JP (2) | JP3476837B2 (ja) |
WO (1) | WO1998032010A1 (ja) |
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Also Published As
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US5958202A (en) | 1999-09-28 |
EP0954749A1 (en) | 1999-11-10 |
JP2003202322A (ja) | 2003-07-18 |
WO1998032010A1 (en) | 1998-07-23 |
JP3476837B2 (ja) | 2003-12-10 |
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