JP2000510098A5 - - Google Patents

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Publication number
JP2000510098A5
JP2000510098A5 JP1997532954A JP53295497A JP2000510098A5 JP 2000510098 A5 JP2000510098 A5 JP 2000510098A5 JP 1997532954 A JP1997532954 A JP 1997532954A JP 53295497 A JP53295497 A JP 53295497A JP 2000510098 A5 JP2000510098 A5 JP 2000510098A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP1997532954A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000510098A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/004462 external-priority patent/WO1997036860A1/en
Publication of JP2000510098A publication Critical patent/JP2000510098A/ja
Publication of JP2000510098A5 publication Critical patent/JP2000510098A5/ja
Abandoned legal-status Critical Current

Links

JP09532954A 1996-03-29 1997-03-25 桂皮酸誘導体 Abandoned JP2000510098A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1432596P 1996-03-29 1996-03-29
US60/014,325 1996-03-29
PCT/US1997/004462 WO1997036860A1 (en) 1996-03-29 1997-03-25 Cinnamic acid derivatives and their use as integrin antagonists

Publications (2)

Publication Number Publication Date
JP2000510098A JP2000510098A (ja) 2000-08-08
JP2000510098A5 true JP2000510098A5 (enExample) 2004-12-02

Family

ID=21764797

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09532954A Abandoned JP2000510098A (ja) 1996-03-29 1997-03-25 桂皮酸誘導体

Country Status (11)

Country Link
US (1) US5852210A (enExample)
EP (1) EP0894084B1 (enExample)
JP (1) JP2000510098A (enExample)
AT (1) ATE219764T1 (enExample)
AU (1) AU2337197A (enExample)
CA (1) CA2250690A1 (enExample)
DE (1) DE69713582T2 (enExample)
DK (1) DK0894084T3 (enExample)
ES (1) ES2179318T3 (enExample)
PT (1) PT894084E (enExample)
WO (1) WO1997036860A1 (enExample)

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Publication number Priority date Publication date Assignee Title
TW460460B (en) 1997-11-04 2001-10-21 Chugai Pharmaceutical Co Ltd Heterocyclic compounds having NOS inhibitory activities
JP4064059B2 (ja) 1998-04-09 2008-03-19 明治製菓株式会社 インテグリンαVβ3拮抗剤としてのアミノピペリジン誘導体
EP1094055B1 (en) * 1998-05-25 2006-04-26 Santen Pharmaceutical Co., Ltd. Novel vinylbenzene derivatives
GB9818641D0 (en) * 1998-08-26 1998-10-21 Rh Ne Poulenc Rorer Limited Chemical compounds
US6420396B1 (en) 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6677360B2 (en) 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
IL143901A0 (en) 1998-12-23 2002-04-21 Searle & Co Use of cyclooxygenase-2- inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6291503B1 (en) 1999-01-15 2001-09-18 Bayer Aktiengesellschaft β-phenylalanine derivatives as integrin antagonists
AU6315300A (en) * 1999-07-26 2001-02-13 Shionogi & Co., Ltd. Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same
US6750219B1 (en) 1999-08-05 2004-06-15 Meiji Seika Kaisha, Ltd. Ω-amino-α-hydroxycarboxylic acid derivatives having integrin ανβ3 antagonistic activity
US20050059669A1 (en) * 1999-10-08 2005-03-17 Keiichi Ajito M-substituted benzoic acid derivatives having integrin alpha v beta 3 antagonistic activity
CA2398186A1 (en) * 2000-01-25 2001-08-02 Mitsuhiro Abe Therapeutic agent for reperfusion injury comprising integrin .alpha.v.beta.3 antagonists
RU2240826C2 (ru) 2000-02-03 2004-11-27 Эйсай Ко., Лтд. Ингибитор экспрессии интегрина
EP1289960A2 (en) * 2000-06-15 2003-03-12 Pharmacia Corporation Cycloalkyl alkanoic acids as integrin receptor antagonists
US7119098B2 (en) * 2000-06-15 2006-10-10 Pharmacia Corporation Heteroarylakanoic acids as intergrin receptor antagonists
US20040043988A1 (en) * 2001-06-15 2004-03-04 Khanna Ish Kurmar Cycloalkyl alkanoic acids as intergrin receptor antagonists
CA2464472C (en) 2001-10-22 2014-01-07 The Scripps Research Institute Antibody targeting compounds
JP2005533001A (ja) * 2002-03-04 2005-11-04 メディミューン,インコーポレーテッド インテグリンαvβ3アンタゴニストを他の物質と併用投与する癌の予防または治療方法
JP2005525368A (ja) * 2002-03-04 2005-08-25 メディミューン,インコーポレーテッド インテグリンαvβ3アンタゴニストをHMG−CoA還元酵素阻害剤またはビスフォスフォネートと併用投与する障害の予防または治療方法
WO2004058761A1 (en) * 2002-12-20 2004-07-15 Pharmacia Corporation Pyrazole compounds as integrin receptor antagonists derivatives
US20050043344A1 (en) * 2002-12-20 2005-02-24 Pharmacia Corporation Heteroarylalkanoic acids as integrin receptor antagonists derivatives
JP2006516144A (ja) * 2002-12-20 2006-06-22 ファルマシア・コーポレーション インテグリン受容体アンタゴニスト誘導体としてのチアゾール化合物
WO2004066956A2 (en) * 2003-01-30 2004-08-12 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
TWI396543B (zh) * 2005-05-12 2013-05-21 Sankyo Co 取代丙烯醯胺衍生物及含有它之醫藥組成物
EP1945262A2 (en) * 2005-10-20 2008-07-23 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
WO2008053861A1 (en) * 2006-10-30 2008-05-08 Santen Pharmaceutical Co., Ltd. Novel compound having 1,4-benzoxazin-3-one skeleton
WO2008053863A1 (en) * 2006-10-30 2008-05-08 Santen Pharmaceutical Co., Ltd. Novel compound having 1,4-benzothiazin-3-one skeleton or 3,4-dihydroquinolin-2-one skeleton
ES2413504T3 (es) 2007-12-21 2013-07-16 Ligand Pharmaceuticals Inc. Moduladores selectivos del receptor de andrógeno (SARM) y usos de los mismos
WO2010093706A2 (en) 2009-02-10 2010-08-19 The Scripps Research Institute Chemically programmed vaccination
IN2015DN00099A (enExample) 2012-07-18 2015-05-29 Univ Saint Louis
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
WO2015181676A1 (en) 2014-05-30 2015-12-03 Pfizer Inc. Carbonitrile derivatives as selective androgen receptor modulators
CN105272888B (zh) * 2014-06-24 2018-03-27 中国科学院上海药物研究所 双芳基烯烷酸类化合物及其制备方法和用途
CN108779077A (zh) 2015-12-30 2018-11-09 圣路易斯大学 作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物
BR112021020864A2 (pt) 2019-04-19 2021-12-14 Ligand Pharm Inc Formas cristalinas e métodos de produção de formas cristalinas de um composto
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
WO1993008823A1 (en) * 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
JPH07503944A (ja) * 1991-11-22 1995-04-27 イエダ リサーチ アンド デベロツプメント カンパニー リミテツド Arg−gly−asp配列の非ペプチド代替物およびそれらからなる医薬組成物
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
ES2186720T3 (es) * 1994-05-27 2003-05-16 Merck & Co Inc Composiciones para inhibir la reabsorcion osea mediada por osteoclastos.
IL118325A0 (en) * 1995-05-25 1996-10-31 Pont Merck And Pharmaceutical Integrin receptor antagonists and pharmaceutical compositions containing them

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