JP2000355543A - Therapeutic agent for external use for trichophytosis unguium with aspirin as the main ingredient - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a safe and highly curative agent for trichophytosis unguium. SOLUTION: This agent, with high curative effect for trichophytosis unguium, is obtained by dissolving aspirin in a polyethylene glycol in the proportion of 5-10 wt.%; wherein the therapeutic effect is further increased by addition of benzoic acid or salicyclic acid to treat affected part(s) of trichophytosis unguium in 1 or 2 week(s) use. Furthermore, there is no problem to be found in terms of safety.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external therapeutic agent for tinea unguium, in which aspirin is dissolved in polyethylene glycol.

[0002]

2. Description of the Related Art Conventionally, many antibiotics and synthetic compounds have been developed as therapeutic agents for tinea unguium, but at present, there is no safe and effective therapeutic agent in terms of effects and side effects. Aspirin (acetylsalicylic acid) has a common sense as an internal medicine, and has no knowledge as an external preparation for the treatment of tinea unguium.

[0003]

In the prior art, the treatment of tinea unguium has a low effect with an external preparation, and it has been usual to use an internal preparation in combination, but the side effects are large.

According to the present invention, by dissolving aspirin in polyethylene glycol, this drug can penetrate into the nail and the vicinity of the boundary between the nail and the skin, and is said to have a great effect on the treatment of tinea unguium. It was completed by discovering an unexpected use and realized a safe and highly effective therapeutic agent.

[0005]

[Means to Solve the Problem] There has been a long-awaited demand for a drug that is safe and has a high healing effect. The healing effect was improved.

Aspirin was created in the 1800's, is listed in the Japanese Pharmacopoeia No. 3 in Japan, and is widely used as an antipyretic analgesic. In recent years, effects such as antiplatelet drugs have been recognized in addition to nervous system pharmacological action. In each case, their knowledge of internal medicine is fixed.

Aspirin is a white plate-like or needle-like crystalline powder that must be processed into a fine powder to be applied as an external preparation, which is extremely difficult. Has become easier.

[0008] Depending on the molecular weight of polyethylene glycol, there is a liquid to an ointment depending on the molecular weight. Therefore, a liquid external preparation and an ointment external preparation can be prepared.

[0009] To reinforce the therapeutic effect, adding benzoic acid to a solution of aspirin in polyethylene glycol or further adding salicylic acid can promote healing depending on the symptoms.

The present invention finds an unknown cure effect of aspirin on tinea unguium as described above and dissolves it in polyethylene glycol, so that the main component easily penetrates into the affected area and is safe and large for the treatment of tinea unguium. It has been completed by the discovery of an unexpected application that has an effect. The pharmacological effect, effective amount, administration method, matters for formulation, safety, and clinical effect will be described below.

[0011]

[Pharmacological effect] When aspirin is dissolved in polyethylene glycol and applied to the affected area of tinea unguium, after application for 1 to 2 weeks, the newly extended nail becomes normal, and after about 2 to 3 months the nail grows Heal to normal nail condition.
By blending benzoic acid and salicylic acid, the healing effect can be enhanced.

[0012]

[Effective amount] 95g polyethylene glycol in 100g total amount
It is effective when the amount of aspirin is 5 g to 10 g and the amount is from g to 90 g. When 5 g of benzoic acid and 5 g of salicylic acid are further added, the healing effect is enhanced. In this case, the amount of polyethylene glycol is reduced so that the total amount becomes 100 g.

[0013]

[Administration method] Apply to affected area once or twice a day for 1-2 weeks.

[0014]

[Materials for Formulation] Aspirin, a needle-like crystalline powder, is weighed in an appropriate amount and dissolved in an appropriate amount of polyethylene glycol to prepare a formulation. In some cases, appropriate amounts of benzoic acid and salicylic acid are weighed, added to the above preparation, and dissolved to prepare a preparation. Depending on the molecular weight of the polyethylene glycol, it can be formulated into a liquid or ointment.

[0015]

[Safety]

[0013]

[Administration method] When applied to the affected area according to the method, a single dose is generally about 1 g, and 0.05 g to about 0.05 g of aspirin.
0.1 g. The usual oral dose of aspirin as an antipyretic analgesic is 0.5 g for adults and 1.5 g per day.
The safety as a dermal agent is considered to be sufficient.

[0016]

[Effectiveness of clinical trial as an example] June, 1992-1994
During May, a preliminary clinical trial was conducted on 50 patients who agreed with the physician for the study. 30 out of 50
In the name, cloudiness was recognized on the nail, and this was designated as A. Ten people were clouded and thickened. The remaining 10 people are thickened and slightly deformed. This is C. A
Is a preparation containing 10% aspirin in a carrier, B is a preparation containing 5% aspirin and 5% benzoic acid, and C is a preparation containing 5% aspirin, 5% benzoic acid and 5% salicylic acid. Tried for two weeks. All use liquid preparations. Two weeks later, the new part of the nail was A,
Both B and C became normal and markedly improved. After about 2 to 3 months when the nails grew, at least 6 months later healed to a normal nail state. The judgment of the effect depends on the judgment of the doctor.

As described above, the present invention has been completed by discovering an unexpected use of a formulation obtained by dissolving aspirin in polyethylene glycol, which is safe and has a great effect in the treatment of tinea unguium.

Claims (3)

[Claims] A topical therapeutic agent for tinea unguium, wherein aspirin (acetylsalicylic acid) is dissolved in polyethylene glycol. 2. An external treatment for tinea unguium, wherein the agent according to claim 1 is supplemented with benzoic acid as an auxiliary agent. 3. An external treatment for tinea unguium, wherein salicylic acid is added to the agent according to claim 2.