JP2000333651A - Oral liquid formulation for physical fatigue - Google Patents
Oral liquid formulation for physical fatigueInfo
- Publication number
- JP2000333651A JP2000333651A JP11145720A JP14572099A JP2000333651A JP 2000333651 A JP2000333651 A JP 2000333651A JP 11145720 A JP11145720 A JP 11145720A JP 14572099 A JP14572099 A JP 14572099A JP 2000333651 A JP2000333651 A JP 2000333651A
- Authority
- JP
- Japan
- Prior art keywords
- physical fatigue
- concentration
- oral liquid
- liquid formulation
- fatigue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012669 liquid formulation Substances 0.000 title abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 30
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 10
- 229930006000 Sucrose Natural products 0.000 claims abstract description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 10
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000001630 malic acid Substances 0.000 claims abstract description 10
- 235000011090 malic acid Nutrition 0.000 claims abstract description 10
- 239000005720 sucrose Substances 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 3
- 235000019629 palatability Nutrition 0.000 abstract description 13
- 238000012360 testing method Methods 0.000 description 12
- 239000000126 substance Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 6
- 235000019640 taste Nutrition 0.000 description 6
- 239000000243 solution Substances 0.000 description 4
- 239000012085 test solution Substances 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102220547770 Inducible T-cell costimulator_A23L_mutation Human genes 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000011496 sports drink Nutrition 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Landscapes
- Non-Alcoholic Beverages (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、肉体疲労時の嗜好
性を向上させた内服液剤に関する。[0001] The present invention relates to an oral liquid preparation having improved palatability during physical fatigue.
【０００２】[0002]
【従来の技術】従来、運動などによる肉体疲労時には甘
味の強い物が好まれることは経験上知られている。これ
は、生体が運動負荷によって起こるエネルギー不足状態
を正常に戻そうとして、エネルギー源となるグルコース
などを含有する甘味物質を選択しているものと考えられ
ている。堀尾らは人の運動による風味嗜好性変化につい
て検討しており、肉体疲労時にはショ糖の嗜好性が有意
に上昇することを報告している（日本味と匂い学会誌 3
(1)37-45,1996）。2. Description of the Related Art It has been known from experience that a substance having a strong sweetness is preferred during physical fatigue due to exercise or the like. This is thought to be due to the fact that the living body is trying to restore the energy-deficient state caused by the exercise load to a normal state, and has selected a sweet substance containing glucose or the like as an energy source. Horio et al. Examined changes in taste preference due to human exercise, and reported that sucrose preference increased significantly during physical fatigue (Japanese Journal of Taste and Odor Science 3).
(1) 37-45, 1996).
【０００３】一方、一般的に元来腐敗味である酸味物質
は、元来毒物の味である苦味物質とともに忌避物質と言
われている(Nippon Shokuhin Kogyo Gakkaisi 41(3)241
-248,1994)。[0003] On the other hand, sour substances, which are naturally spoiled in nature, are said to be repellent substances together with bitter substances, which are naturally tastes of toxic substances (Nippon Shokuhin Kogyo Gakkaisi 41 (3) 241).
-248, 1994).
【０００４】また、新生児に酸味含有果物、ヨーグルト
などをなめさせると明らかに忌避の表示を示すというPf
affmannらの研究（Annal N.Acad.Sci.290,18-34,1977）
から、酸味物質の嗜好性は経験、教育や学習によって向
上するものと考えられている。[0004] In addition, when a newborn baby is licked with a sour-containing fruit, yogurt, or the like, a clear indication of repellency is displayed.
affmann et al. (Annal N. Acad. Sci. 290, 18-34, 1977)
Therefore, it is considered that the taste of sour substances is improved by experience, education and learning.
【０００５】従来、肉体疲労時の栄養補給を目的に甘味
に重点を置いた風味で多数のドリンク剤などが製品化さ
れているが、必ずしも疲労状態での嗜好性が優れている
とは言えなかった。Conventionally, many drinks and the like have been commercialized with a flavor that emphasizes sweetness for the purpose of nutritional supplementation during physical fatigue, but it cannot be said that the palatability in a fatigue state is always excellent. Was.
【０００６】[0006]
【発明が解決しようとする課題】本発明の目的は、運動
などによる肉体疲労時に生体が要求する、肉体疲労時の
嗜好性を向上した内服液剤を提供することを目的とす
る。SUMMARY OF THE INVENTION It is an object of the present invention to provide a liquid medicine for oral administration which is required by a living body at the time of physical fatigue due to exercise or the like and has improved palatability at the time of physical fatigue.
【０００７】[0007]
【課題を解決するための手段】本発明者らは、上記目的
を達成するためにヒトの疲労モデルにより種々検討した
結果、特定の甘味と酸味を特定の濃度バランスで配合す
ることにより、肉体疲労時の嗜好性が有意に上昇するこ
とを見出し本発明を完成した。Means for Solving the Problems The present inventors have conducted various studies with a human fatigue model in order to achieve the above object, and as a result, by blending a specific sweetness and sourness in a specific concentration balance, physical fatigue has been achieved. The present inventors have found that the palatability at the time increases significantly and completed the present invention.
【０００８】すなわち本発明は、０．０３７５M以上の
濃度のショ糖、および０．００１M以上の濃度のクエン
酸またはリンゴ酸を配合し、ショ糖のモル濃度（mol/
l）をｘ、クエン酸またはリンゴ酸のモル濃度（mol/l）
をｙとしたときの数値が、That is, according to the present invention, a sucrose having a concentration of 0.0375 M or more and a citric acid or malic acid having a concentration of 0.001 M or more are blended, and the molar concentration of sucrose (mol /
l) is x, molar concentration of citric acid or malic acid (mol / l)
When y is
【０００９】[0009]
【式２】ｙ＜−０．０６６７ｘ＋０．０５ の関係にあることを特徴とする、肉体疲労時用内服液
剤。である。[Formula 2] An internal liquid for physical fatigue, wherein y <−0.0667x + 0.05. It is.
【００１０】[0010]
【発明の実施の形態】本発明において使用できるクエン
酸またはリンゴ酸は、それぞれ塩を用いることもでき
る。本発明でのクエン酸またはリンゴ酸の配合量は、
０．００１Ｍ以上の濃度範囲であり、０．００２５Ｍ以
上が特に好ましい。これらの範囲を外れると肉体疲労時
の嗜好性の向上がはかれないからである。DESCRIPTION OF THE PREFERRED EMBODIMENTS Citric acid or malic acid which can be used in the present invention may each be a salt. The amount of citric acid or malic acid in the present invention is:
The concentration range is 0.001M or more, and 0.0025M or more is particularly preferable. This is because if the content is out of these ranges, the palatability at the time of physical fatigue cannot be improved.
【００１１】本発明で配合するショ糖は肉体疲労時の嗜
好性の点から０．０３７５Ｍ以上の濃度である必要があ
り、０．１１Ｍ以上が好ましい。[0011] The sucrose compounded in the present invention must have a concentration of 0.0375M or more, preferably 0.11M or more, from the viewpoint of palatability during physical fatigue.
【００１２】さらに、クエン酸またはリンゴ酸のモル濃
度をｙ、ショ糖のモル濃度をｘとしたときの数値がFurther, when the molar concentration of citric acid or malic acid is y and the molar concentration of sucrose is x,
【００１３】[0013]
【式３】ｙ＜−０．０６６７ｘ＋０．０５ の関係になる範囲である必要があり、[Equation 3] y must be within the range of −0.0667x + 0.05.
【００１４】[0014]
【式４】ｙ＜−０．０１６７ｘ＋０．０１２５ の関係になる範囲が特に好ましい。## EQU4 ## A range that satisfies the relationship of y <−0.0167x + 0.0125 is particularly preferable.
【００１５】この濃度範囲は通常のドリンク剤、飲料な
どで使用されている濃度と比較して、特に低い濃度であ
る。This concentration range is particularly low as compared with the concentrations used in ordinary drinks, beverages and the like.
【００１６】本発明の内服液剤は肉体疲労の改善に有効
な成分（ビタミン類、タウリン、生薬類など）を配合す
ることができ、また必要に応じて他の添加剤、例えば賦
形剤、ｐＨ調製剤、清涼化剤、懸濁化剤、消泡剤、粘稠
剤、溶解補助剤、着色剤、橋味橋臭剤、界面活性剤、香
料などを混合して、常法により液剤とすることができ
る。The oral liquid preparation of the present invention can contain components (vitamins, taurine, crude drugs, etc.) effective for improving physical fatigue, and if necessary, other additives such as excipients, pH, etc. Mix the preparation, freshener, suspending agent, defoamer, thickener, solubilizer, colorant, Hashimi bridge odor, surfactant, fragrance, etc. to make a liquid preparation by the usual method. be able to.
【００１７】[0017]
【実施例】以下、試験例により本発明を詳細に説明す
る。Hereinafter, the present invention will be described in detail with reference to test examples.
【００１８】試験例 被験者は健康な男子１２名、女子２８名計４０名で実施
した。実験開始３０分前から食事、喫煙を禁じた。運動
負荷として、自転車エルゴメーターにて、被験者の安全
性および一定時間継続できる点から、負荷強度を最大酸
素摂取量の５０％に相当する心拍数となる強度に設定
し、その心拍数に達した時から３０分間継続した。運動
による疲労は、運動後、収縮期血圧が上昇した状態で３
０分間維持することから被験者にとってかなり高い負荷
で疲労していることを確認した。Test Example The test was conducted with 12 healthy males and 28 females, for a total of 40 subjects. Food and smoking were prohibited 30 minutes before the start of the experiment. As the exercise load, the load intensity was set to a heart rate corresponding to 50% of the maximum oxygen intake, and the heart rate was reached from the viewpoint of the safety of the subject and the ability to continue for a certain period of time using a bicycle ergometer. It continued for 30 minutes from the time. Exercise fatigue can be caused by an increase in systolic blood pressure after exercise.
Since the subject was maintained for 0 minutes, it was confirmed that the subject was tired with a considerably high load.
【００１９】疲労前後に疲労による酸味感受性の判断閾
値テストおよび嗜好性テストを実施した。疲労前後によ
る各味溶液の判断閾値に違いが見られないことを確認
後、嗜好性テストを実施した。Before and after fatigue, a threshold test for judging acidity sensitivity due to fatigue and a taste test were conducted. After confirming that there was no difference in the judgment threshold of each taste solution before and after fatigue, a palatability test was performed.
【００２０】嗜好性テストは甘味物質および酸味物質を
溶解した試験溶液を恒温槽を用いて２０℃に保った試験
溶液１０mlをランダムに与えた。各溶液の呈示の間隔は
３０秒以上あけ、その間に精製水でうがいを行わせた。
嗜好度は７段階の評定嗜好尺度法を用いて、大変好き＋
３、かなり好き＋２、少し好き＋１、好きでも嫌いでも
ない±０、少し嫌い−１、かなり嫌い−２、大変嫌い−
３とし、各被験者の平均値を嗜好数値とした。In the palatability test, a test solution in which a sweet substance and a sour substance were dissolved was randomly supplied with 10 ml of a test solution kept at 20 ° C. using a thermostat. The presentation interval of each solution was 30 seconds or more, during which gargle was performed with purified water.
The degree of preference is very much like using a 7-level rating preference scale method.
3, pretty like +2, little like +1, neither like nor dislike ± 0, a little dislike -1, pretty dislike -2, very dislike-
3, and the average value of each subject was set as a preference numerical value.
【００２１】疲労前後の嗜好性の相違の有無は３元分散
分析法、下位検定はＴ検定を用いて調べた。The difference in preference before and after fatigue was examined using a three-way analysis of variance and the lower test was conducted using a T test.
【００２２】試験溶液の濃度および試験結果を図１およ
び２に、試験結果により導き出した好ましい数値範囲を
示した図を図３に、それぞれ示した。FIGS. 1 and 2 show the concentration of the test solution and the test results, and FIG. 3 shows a preferred numerical range derived from the test results.
【００２３】図から明らかなように甘味と酸味を特定の
配合比で配合した液剤は、肉体疲労時に嗜好性が向上す
ることがわかった。As is apparent from the figure, it was found that the liquid preparation in which the sweetness and the sourness were mixed at a specific mixing ratio improved the palatability at the time of physical fatigue.
【００２４】[0024]
【発明の効果】本発明により肉体疲労時に生体が要求す
る風味の内服液剤を提供することが可能となった。According to the present invention, it is possible to provide an oral liquid preparation having a flavor required by a living body at the time of physical fatigue.
【００２５】したがって、肉体疲労時の嗜好性が向上し
たドリンク剤、スポーツ飲料などを提供することが可能
になった。Accordingly, it has become possible to provide drinks, sports drinks, and the like with improved palatability during physical fatigue.
【図１】 運動前後における各濃度の溶液の嗜好度を示
した図である。なお、図中星印はｐ＜０．０５、２星印
はｐ＜０．０１を示す。FIG. 1 is a diagram showing the degree of preference of solutions of each concentration before and after exercise. In the figures, the star indicates p <0.05, and the star indicates p <0.01.
【図２】 運動前後における各濃度の溶液の嗜好度を示
した図である。なお、図中星印はｐ＜０．０５を示す。FIG. 2 is a diagram showing the degree of preference of solutions of each concentration before and after exercise. The star in the figure indicates p <0.05.
【図３】 縦軸にクエン酸またはリンゴ酸濃度、横軸に
ショ糖濃度を表し、試験から得られた、肉体疲労時に嗜
好性が向上する範囲および嗜好性の点から特に好ましい
数値範囲を表した図である。FIG. 3 shows the concentration of citric acid or malic acid on the vertical axis and the concentration of sucrose on the horizontal axis, and shows a range obtained from the test, in which the palatability is improved at the time of physical fatigue and a particularly preferable numerical range from the viewpoint of palatability. FIG.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 31/70 ６０４ Ａ２３Ｌ 2/00 Ｃ Ｆターム(参考） 4B017 LC02 LE10 LK08 LK12 4C076 AA12 DD43 DD67 FF52 4C086 AA01 AA02 EA01 MA03 MA06 MA17 MA52 NA09 4C206 AA01 AA02 DA07 MA06 MA37 MA72 NA09 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A61K 31/70 604 A23L 2/00 CF Term (Reference) 4B017 LC02 LE10 LK08 LK12 4C076 AA12 DD43 DD67 FF52 4C086 AA01 AA02 EA01 MA03 MA06 MA17 MA52 NA09 4C206 AA01 AA02 DA07 MA06 MA37 MA72 NA09
Claims (1)
び０．００１M以上の濃度のクエン酸またはリンゴ酸を
配合し、ショ糖のモル濃度（mol/l）をｘ、クエン酸ま
たはリンゴ酸のモル濃度（mol/l）をｙとしたときの数
値が、 【式１】ｙ＜−０．０６６７ｘ＋０．０５ の関係にあることを特徴とする、肉体疲労時用内服液
剤。1. A sucrose having a concentration of 0.0375 M or more and a citric acid or malic acid having a concentration of 0.001 M or more are mixed, and the molar concentration (mol / l) of sucrose is x, citric acid or malic acid. A liquid medicine for physical fatigue, characterized in that the numerical value when y represents the molar concentration (mol / l) of the formula is y <-0.0667x + 0.05.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11145720A JP2000333651A (en) | 1999-05-26 | 1999-05-26 | Oral liquid formulation for physical fatigue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11145720A JP2000333651A (en) | 1999-05-26 | 1999-05-26 | Oral liquid formulation for physical fatigue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000333651A true JP2000333651A (en) | 2000-12-05 |
Family
ID=15391582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11145720A Pending JP2000333651A (en) | 1999-05-26 | 1999-05-26 | Oral liquid formulation for physical fatigue |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2000333651A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2211334A1 (en) * | 2002-12-20 | 2004-07-01 | Masterfarm, S.L. | Nutritional supplement is for treatment of syndromes related to fatigue, including pain, muscular problems, anxiety, depression and periods of fatigue |
| JP2011148786A (en) * | 2009-12-25 | 2011-08-04 | Daiichi Sankyo Healthcare Co Ltd | Pharmaceutical liquid composition |
-
1999
- 1999-05-26 JP JP11145720A patent/JP2000333651A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2211334A1 (en) * | 2002-12-20 | 2004-07-01 | Masterfarm, S.L. | Nutritional supplement is for treatment of syndromes related to fatigue, including pain, muscular problems, anxiety, depression and periods of fatigue |
| JP2011148786A (en) * | 2009-12-25 | 2011-08-04 | Daiichi Sankyo Healthcare Co Ltd | Pharmaceutical liquid composition |
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